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An Integrated Protocol Based on Workflows of Imaged Capillary Isoelectric Focusing (Icief) for In-Depth Protein Heterogenous Characterization: High-Efficient Fractionation and Online Mass Spectrometry Detection

https://doi.org/10.2139/ssrn.4812100
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Cutting-edge mass spectrometry strategy based on imaged capillary isoelectric focusing (icIEF) technology for characterizing charge heterogeneity of monoclonal antibody
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Mass Spectrometry-Based Charge Heterogeneity Characterization of Therapeutic mAbs with Imaged Capillary Isoelectric Focusing and Ion-Exchange Chromatography as Separation Techniques
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Isolation and Characterization of Monoclonal Antibody Charge Variants by Free Flow Isoelectric Focusing
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Capillary Isoelectric Focusing-Mass Spectrometry Method for the Separation and Online Characterization of Intact Monoclonal Antibody Charge Variants
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An improved capillary isoelectric focusing-mass spectrometry method for high-resolution characterization of monoclonal antibody charge variants
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Fractionation and online mass spectrometry based on imaged capillary isoelectric focusing (icIEF) for characterizing charge heterogeneity of therapeutic antibody
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Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods
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Native Liquid Chromatography and Mass Spectrometry to Structurally and Functionally Characterize Endo-Xylanase Proteoforms
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