On the public citation graph

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

https://doi.org/10.2174/138920108786786402

0 signed · 256 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4072650openalex-extracted

Preferential Precipitation for Reducing Acidic Variant Contentin Monoclonal Antibody Pools

inferred← citeshttps://doi.org/10.2139/ssrn.4812100openalex-extracted

An Integrated Protocol Based on Workflows of Imaged Capillary Isoelectric Focusing (Icief) for In-Depth Protein Heterogenous Characterization: High-Efficient Fractionation and Online Mass Spectrometry Detection

inferred← citeshttps://doi.org/10.1002/0471140864.ps0810s69openalex-snapshot

Isolation of Monoclonal Antibody Charge Variants by Displacement Chromatography

inferred← citeshttps://doi.org/10.1002/9780470571224.pse509openalex-snapshot

Analytical Characterization of Proteins and Peptides

inferred← citeshttps://doi.org/10.1002/9781118116555.ch11openalex-snapshot

Utilization of Mass Spectrometry for the Structural Characterization of Biopharmaceutical Protein Products

inferred← citeshttps://doi.org/10.1002/9781118229019.ch8openalex-snapshot

Characterization of Monoclonal Antibody Variants and Glycosylation

inferred← citeshttps://doi.org/10.1002/9781118530009.ch16openalex-snapshot

Rapid Analysis of Charge Heterogeneity of Monoclonal Antibodies by Capillary Zone Electrophoresis and Imaged Capillary Isoelectric Focusing

inferred← citeshttps://doi.org/10.1002/9781118940648.ch15openalex-snapshot

Product Analysis of Biosimilar Antibodies

inferred← citeshttps://doi.org/10.1002/9781119313786.ch12openalex-snapshot

HPLC and UHPLC for Biopharmaceutical Analysis

inferred← citeshttps://doi.org/10.1002/9781119371779.ch10openalex-snapshot

Monitoring Quality of Critical Reagents Used in Ligand Binding Assays with Liquid Chromatography Mass Spectrometry ( LC ‐ MS )

inferred← citeshttps://doi.org/10.1002/9781119371779.ch16openalex-snapshot

Characterization of Protein Therapeutics by Mass Spectrometry

inferred← citeshttps://doi.org/10.1002/9783527615636.ch03openalex-snapshot

Ion‐Exchange Chromatography (HPIC)

inferred← citeshttps://doi.org/10.1002/9783527651610.ch4bopenalex-snapshot

Cation‐Exchange Chromatography ( HPIC )

inferred← citeshttps://doi.org/10.1002/9783527675272.ch07openalex-snapshot

Analytical Methods Used to Characterize Fc‐Fusion Proteins

inferred← citeshttps://doi.org/10.1002/9783527812707.ch4openalex-snapshot

Die Gradientelution ionischer Verbindungen

inferred← citeshttps://doi.org/10.1002/9783527812745.ch4openalex-snapshot

Gradient Elution of Ionic Compounds

inferred← citeshttps://doi.org/10.1002/biot.201400052openalex-snapshot

Avoiding antibody aggregation during processing: Establishing hold times

inferred← citeshttps://doi.org/10.1002/biot.201700133openalex-snapshot

Integrated Chromatographic Platform for Simultaneous Separation of Charge Variants and Aggregates from Monoclonal Antibody Therapeutic Products

inferred← citeshttps://doi.org/10.1002/bit.22561openalex-snapshot

Isomerization in the CDR2 of a monoclonal antibody: Binding analysis and factors that influence the isomerization rate

inferred← citeshttps://doi.org/10.1002/bit.24511openalex-snapshot

Controlling trisulfide modification in recombinant monoclonal antibody produced in fed‐batch cell culture

inferred← citeshttps://doi.org/10.1002/bit.27267openalex-snapshot

Side‐by‐side comparability of batch and continuous downstream for the production of monoclonal antibodies

inferred← citeshttps://doi.org/10.1002/bit.27905openalex-snapshot

Assessment of quality attributes for adeno‐associated viral vectors

inferred← citeshttps://doi.org/10.1002/bit.28257openalex-snapshot

Preferential precipitation of acidic variants from monoclonal antibody pools

inferred← citeshttps://doi.org/10.1002/bit.28406openalex-snapshot

Digital by design approach to develop a universal deep learning AI architecture for automatic chromatographic peak integration

inferred← citeshttps://doi.org/10.1002/bit.28605openalex-snapshot

Developing an ultra‐intensified fed‐batch cell culture process with greatly improved performance and productivity

inferred← citeshttps://doi.org/10.1002/btpr.1548openalex-snapshot

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

inferred← citeshttps://doi.org/10.1002/btpr.2089openalex-snapshot

Tailoring recombinant protein quality by rational media design

inferred← citeshttps://doi.org/10.1002/btpr.2327openalex-snapshot

Impact of cell culture on recombinant monoclonal antibody product heterogeneity

inferred← citeshttps://doi.org/10.1002/btpr.2444openalex-snapshot

Evaluation of heavy chain C‐terminal deletions on productivity and product quality of monoclonal antibodies in Chinese hamster ovary (CHO) cells

inferred← citeshttps://doi.org/10.1002/btpr.3395openalex-snapshot

A novel method for continuous chromatographic separation of monoclonal antibody charge variants by combining displacement mode chromatography and step elution

inferred← citeshttps://doi.org/10.1002/btpr.3487openalex-snapshot

A comparison of different intensified upstream processes highlighting the advantage of WuXi Biologics' Ultra‐high Productivity platform ( WuXiUP TM ) in improved product quality and purification yield

inferred← citeshttps://doi.org/10.1002/elps.201100611openalex-snapshot

Applications of imaged capillary isoelectric focussing technique in development of biopharmaceutical glycoprotein‐based products

inferred← citeshttps://doi.org/10.1002/elps.201500219openalex-snapshot

Characterization of acidic and basic variants of IgG1 therapeutic monoclonal antibodies based on non‐denaturing IEF fractionation

inferred← citeshttps://doi.org/10.1002/elps.201900195openalex-snapshot

Analysis of four therapeutic monoclonal antibodies by online capillary isoelectric focusing directly coupled to quadrupole time‐of‐flight mass spectrometry

inferred← citeshttps://doi.org/10.1002/elps.202200165openalex-snapshot

Rapid multi‐attribute characterization of intact bispecific antibodies by a microfluidic chip‐based integrated icIEF‐MS technology

inferred← citeshttps://doi.org/10.1002/elps.202300221openalex-snapshot

Isolation and characterization of rabies monoclonal antibody charge variants

inferred← citeshttps://doi.org/10.1002/elsc.202000094openalex-snapshot

A novel twin‐column continuous chromatography approach for separation and enrichment of monoclonal antibody charge variants

inferred← citeshttps://doi.org/10.1002/jps.22545openalex-snapshot

A new roadmap for biopharmaceutical drug product development: Integrating development, validation, and quality by design

inferred← citeshttps://doi.org/10.1002/jps.23403openalex-snapshot

Compatibility and Stability of Pertuzumab and Trastuzumab Admixtures in i.v. Infusion Bags for Coadministration

inferred← citeshttps://doi.org/10.1002/jps.24435openalex-snapshot

Improving Trastuzumab’s Stability Profile by Removing the Two Degradation Hotspots

inferred← citeshttps://doi.org/10.1002/jssc.201300558openalex-snapshot

Poly(ethylene glycol)‐based monolithic capillary columns for hydrophobic interaction chromatography of immunoglobulin G subclasses and variants

inferred← citeshttps://doi.org/10.1002/pro.173openalex-snapshot

Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody

inferred← citeshttps://doi.org/10.1002/prp2.604openalex-snapshot

Physicochemical analysis and biological characterization of FKB327 as a biosimilar to adalimumab

inferred← citeshttps://doi.org/10.1002/sscp.202200142openalex-snapshot

High‐efficient characterization of complex protein drugs by imaged capillary isoelectric focusing with high‐resolution ampholytes

inferred← citeshttps://doi.org/10.1002/sscp.202200160openalex-snapshot

Imaged capillary isoelectric focusing employing fluorocarbon and methylcellulose coated fused silica capillary for characterization of charge heterogeneity of protein biopharmaceuticals

inferred← citeshttps://doi.org/10.1007/164_2026_855openalex-snapshot

Introduction to PBPK Modelling: Core Concepts for Small and Large Molecules

inferred← citeshttps://doi.org/10.1007/7355_2015_5005openalex-snapshot

Characterization of Therapeutic Proteins

inferred← citeshttps://doi.org/10.1007/978-1-4939-6361-4_20openalex-snapshot

Ion-Exchange Chromatography to Analyze Components of a Clostridium difficile Vaccine

inferred← citeshttps://doi.org/10.1007/978-1-61779-921-1_23openalex-snapshot

Identification of Asp Isomerization in Proteins by 18O Labeling and Tandem Mass Spectrometry

inferred← citeshttps://doi.org/10.1007/978-1-62703-992-5_30openalex-snapshot

Ion Exchange-High-Performance Liquid Chromatography (IEX-HPLC)

inferred← citeshttps://doi.org/10.1007/978-3-030-00710-2_3openalex-snapshot

Protein Stability and Characterization

inferred← citeshttps://doi.org/10.1007/978-3-031-30023-3_3openalex-snapshot

Stability and Characterization of Protein- and Nucleotide-Based Therapeutics

inferred← citeshttps://doi.org/10.1007/978-3-642-01144-3_39openalex-snapshot

Structural Characterization of Antibodies by Mass Spectrometry

inferred← citeshttps://doi.org/10.1007/978-94-007-1257-7_13openalex-snapshot

Quality Issues Arising from Post-translational Modification of Recombinant Antibodies

inferred← citeshttps://doi.org/10.1007/s00216-014-8108-xopenalex-snapshot

Post-translational structural modifications of immunoglobulin G and their effect on biological activity

inferred← citeshttps://doi.org/10.1007/s00253-014-5596-8openalex-snapshot

Effect of sodium butyrate on the assembly, charge variants, and galactosylation of antibody produced in recombinant Chinese hamster ovary cells

inferred← citeshttps://doi.org/10.1007/s00253-015-6617-yopenalex-snapshot

Elucidating the effects of arginine and lysine on a monoclonal antibody C-terminal lysine variation in CHO cell cultures

inferred← citeshttps://doi.org/10.1007/s00253-016-7749-4openalex-snapshot

Elucidating the effects of pH shift on IgG1 monoclonal antibody acidic charge variant levels in Chinese hamster ovary cell cultures

inferred← citeshttps://doi.org/10.1007/s00253-017-8301-xopenalex-snapshot

Identification of multiple sources of the acidic charge variants in an IgG1 monoclonal antibody

inferred← citeshttps://doi.org/10.1007/s00253-017-8650-5openalex-snapshot

Insights into the generation of monoclonal antibody acidic charge variants during Chinese hamster ovary cell cultures

inferred← citeshttps://doi.org/10.1007/s10337-018-3627-9openalex-snapshot

Development and Validation of Salt Gradient CEX Chromatography Method for Charge Variants Separation and Quantitative Analysis of the IgG mAb-Cetuximab

inferred← citeshttps://doi.org/10.1007/s11095-009-0045-6openalex-snapshot

Stability of Protein Pharmaceuticals: An Update

inferred← citeshttps://doi.org/10.1007/s11095-011-0534-2openalex-snapshot

Characterization of the Isomerization Products of Aspartate Residues at Two Different Sites in a Monoclonal Antibody

inferred← citeshttps://doi.org/10.1007/s11095-011-0536-0openalex-snapshot

Elucidation of Degradants in Acidic Peak of Cation Exchange Chromatography in an IgG1 Monoclonal Antibody Formed on Long-Term Storage in a Liquid Formulation

inferred← citeshttps://doi.org/10.1007/s11095-012-0860-zopenalex-snapshot

Characterization of Therapeutic Monoclonal Antibodies Reveals Differences Between In Vitro and In Vivo Time-Course Studies

inferred← citeshttps://doi.org/10.1007/s11095-013-0977-8openalex-snapshot

Aggregation and Chemical Modification of Monoclonal Antibodies under Upstream Processing Conditions

inferred← citeshttps://doi.org/10.1007/s12272-016-0818-5openalex-snapshot

Effects of carboxypeptidase B treatment and elevated temperature on recombinant monoclonal antibody charge variants in cation-exchange chromatography analysis

inferred← citeshttps://doi.org/10.1007/s13361-012-0531-7openalex-snapshot

Mass Spectrometric Distinction of In-Source and In-Solution Pyroglutamate and Succinimide in Proteins: A Case Study on rhG-CSF

inferred← citeshttps://doi.org/10.1007/s40259-021-00488-5openalex-snapshot

Comparability of Biologics: Global Principles, Evidentiary Consistency and Unrealized Reliance

inferred← citeshttps://doi.org/10.1007/s40259-023-00581-xopenalex-snapshot

Consistency of Product Quality for SB5, an Adalimumab Biosimilar

inferred← citeshttps://doi.org/10.1007/s40259-025-00718-0openalex-snapshot

Interrogation of Structure–Activity Relationships in Charge Variants of Therapeutic IgG2s Enabled by Free-Flow Isoelectric Focusing Fractionation

inferred← citeshttps://doi.org/10.1007/s40268-019-0264-1openalex-snapshot

Assessing the Extended In-Use Stability of the Infliximab Biosimilar PF-06438179/GP1111 Following Preparation for Intravenous Infusion

inferred← citeshttps://doi.org/10.1007/s40268-024-00485-3openalex-snapshot

Comparative Analytical Evaluation of the Proposed Biosimilar FYB206 and its Reference Medicinal Product Keytruda®

inferred← citeshttps://doi.org/10.1016/b978-0-08-100296-4.00003-8openalex-snapshot

Stability of monoclonal antibodies (mAbs)

inferred← citeshttps://doi.org/10.1016/b978-0-08-100623-8.00048-7openalex-snapshot

Implementation of QbD for Manufacturing of Biologics—Has It Met the Expectations?

inferred← citeshttps://doi.org/10.1016/b978-0-12-814679-8.00014-5openalex-snapshot

Advances in antibody-based biosensors in environmental monitoring

inferred← citeshttps://doi.org/10.1016/b978-0-12-822318-5.00005-3openalex-snapshot

Advanced structural elucidation of new antibody formats by mass spectrometry

inferred← citeshttps://doi.org/10.1016/b978-0-443-15842-1.00012-0openalex-snapshot

Clinical toxicity of antibody–drug conjugates

inferred← citeshttps://doi.org/10.1016/j.ab.2010.10.026openalex-snapshot

Reversible interference of Fe3+ with monoclonal antibody analysis in cation exchange columns

inferred← citeshttps://doi.org/10.1016/j.ab.2011.07.033openalex-snapshot

On-line characterization of monoclonal antibody variants by liquid chromatography–mass spectrometry operating in a two-dimensional format

inferred← citeshttps://doi.org/10.1016/j.ab.2015.12.004openalex-snapshot

Liquid chromatography–fluorescence and liquid chromatography–mass spectrometry detection of tryptophan degradation products of a recombinant monoclonal antibody

inferred← citeshttps://doi.org/10.1016/j.ab.2018.10.002openalex-snapshot

Characterization of recombinant monoclonal antibody charge variants using WCX chromatography, icIEF and LC-MS/MS

inferred← citeshttps://doi.org/10.1016/j.ab.2020.113842openalex-snapshot

Biolayer Interferometry-based FcγRIIa binding assay for a therapeutic antibody with strong effector function

inferred← citeshttps://doi.org/10.1016/j.ab.2021.114214openalex-snapshot

Characterization and monitoring of charge variants of a recombinant monoclonal antibody using microfluidic capillary electrophoresis-mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.ab.2022.114961openalex-snapshot

Cutting-edge mass spectrometry strategy based on imaged capillary isoelectric focusing (icIEF) technology for characterizing charge heterogeneity of monoclonal antibody

inferred← citeshttps://doi.org/10.1016/j.ab.2023.115302openalex-snapshot

Small conformational changes in IgG1 detected as acidic charge variants by cation exchange chromatography

inferred← citeshttps://doi.org/10.1016/j.ab.2023.115312openalex-snapshot

Imaged capillary isoelectric focusing tandem high-resolution mass spectrometry using nano electrospray ionization (ESI) for protein heterogeneity characterization

inferred← citeshttps://doi.org/10.1016/j.ab.2025.115825openalex-snapshot

Advancing protein heterogeneity analysis: Nano-flow pressure mobilization for precise icIEF fractionation and online MS detection

inferred← citeshttps://doi.org/10.1016/j.aca.2020.12.064openalex-snapshot

Fractionated charge variants of biosimilars: A review of separation methods, structural and functional analysis

inferred← citeshttps://doi.org/10.1016/j.bbapap.2020.140496openalex-snapshot

Effect of amino acids present at the carboxyl end of succinimidyl residue on the rate constants for succinimidyl hydrolysis in small peptides

inferred← citeshttps://doi.org/10.1016/j.biologicals.2019.03.006openalex-snapshot

Modifications of recombinant monoclonal antibodies in vivo

inferred← citeshttps://doi.org/10.1016/j.biologicals.2021.08.002openalex-snapshot

Similarity demonstrated between isolated charge variants of MB02, a biosimilar of bevacizumab, and Avastin® following extended physicochemical and functional characterization

inferred← citeshttps://doi.org/10.1016/j.biologicals.2021.09.001openalex-snapshot

Similarity demonstrated between isolated charge variants of MB02, a biosimilar of bevacizumab, and Avastin® following extended physicochemical and functional characterization

inferred← citeshttps://doi.org/10.1016/j.bios.2020.112110openalex-snapshot

Application of a thermophoretic immunoassay in the diagnosis of lupus using outer membrane particles from E. coli

inferred← citeshttps://doi.org/10.1016/j.bpj.2022.02.002openalex-snapshot

Low pKa of Lys promotes glycation at one complementarity-determining region of a bispecific antibody

inferred← citeshttps://doi.org/10.1016/j.cherd.2024.01.001openalex-snapshot

Countercurrent preferential precipitation of acidic variants from monoclonal antibody pools

inferred← citeshttps://doi.org/10.1016/j.chroma.2010.08.044openalex-snapshot

Separation of post-translational modifications in monoclonal antibodies by exploiting subtle conformational changes under mildly acidic conditions

inferred← citeshttps://doi.org/10.1016/j.chroma.2011.05.061openalex-snapshot

Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography

inferred← citeshttps://doi.org/10.1016/j.chroma.2012.06.081openalex-snapshot

Simulation model for overloaded monoclonal antibody variants separations in ion-exchange chromatography

inferred← citeshttps://doi.org/10.1016/j.chroma.2012.11.060openalex-snapshot

Improving pH gradient cation-exchange chromatography of monoclonal antibodies by controlling ionic strength

inferred← citeshttps://doi.org/10.1016/j.chroma.2013.04.048openalex-snapshot

Model-based prediction of monoclonal antibody retention in ion-exchange chromatography

inferred← citeshttps://doi.org/10.1016/j.chroma.2013.08.061openalex-snapshot

Charge heterogeneity profiling of monoclonal antibodies using low ionic strength ion-exchange chromatography and well-controlled pH gradients on monolithic columns

inferred← citeshttps://doi.org/10.1016/j.chroma.2013.10.028openalex-snapshot

Highly linear pH gradients for analyzing monoclonal antibody charge heterogeneity in the alkaline range

inferred← citeshttps://doi.org/10.1016/j.chroma.2013.11.057openalex-snapshot

Modern chromatographic and mass spectrometric techniques for protein biopharmaceutical characterization

inferred← citeshttps://doi.org/10.1016/j.chroma.2014.09.051openalex-snapshot

Use of chelating agents to improve the resolution and consistency of cation-exchange chromatography of monoclonal antibodies

inferred← citeshttps://doi.org/10.1016/j.chroma.2015.06.015openalex-snapshot

Rapid analysis of charge variants of monoclonal antibodies using non-linear salt gradient in cation-exchange high performance liquid chromatography

inferred← citeshttps://doi.org/10.1016/j.chroma.2015.11.002openalex-snapshot

Capillary ion-exchange chromatography with nanogram sensitivity for the analysis of monoclonal antibodies

inferred← citeshttps://doi.org/10.1016/j.chroma.2017.02.065openalex-snapshot

Development of a fast workflow to screen the charge variants of therapeutic antibodies

inferred← citeshttps://doi.org/10.1016/j.chroma.2017.06.052openalex-snapshot

The versatility of heart-cutting and comprehensive two-dimensional liquid chromatography in monoclonal antibody clone selection

inferred← citeshttps://doi.org/10.1016/j.chroma.2017.07.059openalex-snapshot

High resolution separations of charge variants and disulfide isomers of monoclonal antibodies and antibody drug conjugates using ultra-high voltage capillary electrophoresis with high electric field strength

inferred← citeshttps://doi.org/10.1016/j.chroma.2021.462409openalex-snapshot

Monoclonal antibody charge variant characterization by fully automated four-dimensional liquid chromatography-mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.chroma.2022.463265openalex-snapshot

Application of the Steric Mass Action formalism for modeling under high loading conditions: Part 1. Investigation of the influence of pH on the steric shielding factor

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465256openalex-snapshot

Coupling cation and anion exchange chromatography for fast separation of monoclonal antibody charge variants

inferred← citeshttps://doi.org/10.1016/j.chroma.2026.467501openalex-snapshot

Deciphering complex charge heterogeneity in a glycosylated monoclonal antibody by integrated icIEF-MS and enzymatic digestion system

inferred← citeshttps://doi.org/10.1016/j.copbio.2014.06.012openalex-snapshot

Therapeutic monoclonal antibodies and consistent ends: terminal heterogeneity, detection, and impact on quality

inferred← citeshttps://doi.org/10.1016/j.ejpb.2019.12.003openalex-snapshot

Multifaceted assessment of rituximab biosimilarity: The impact of glycan microheterogeneity on Fc function

inferred← citeshttps://doi.org/10.1016/j.ejps.2018.01.016openalex-snapshot

A comprehensive approach for evaluating charge heterogeneity in biosimilars

inferred← citeshttps://doi.org/10.1016/j.ejps.2026.107680openalex-snapshot

Impact of time and temperature on glycation, oxidation, and functional stability of trastuzumab deruxtecan (ENHERTU®) in dextrose infusion bags

inferred← citeshttps://doi.org/10.1016/j.enzmictec.2016.12.003openalex-snapshot

Understanding the process-induced formation of minor conformational variants of Erwinia chrysanthemi l-asparaginase

inferred← citeshttps://doi.org/10.1016/j.greeac.2024.100122openalex-snapshot

Retracted:An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection

inferred← citeshttps://doi.org/10.1016/j.greeac.2025.100204openalex-snapshot

An integrated protocol based on workflows of imaged capillary isoelectric focusing (icIEF) for in-depth protein heterogenous characterization: High-efficient fractionation and online mass spectrometry detection

inferred← citeshttps://doi.org/10.1016/j.ijms.2011.06.006openalex-snapshot

Quantification and characterization of antibody deamidation by peptide mapping with mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.123600openalex-snapshot

Interaction between preservatives and a monoclonal antibody in support of multidose formulation development

inferred← citeshttps://doi.org/10.1016/j.ijpx.2022.100155openalex-snapshot

Protein photodegradation in the visible range? Insights into protein photooxidation with respect to protein concentration

inferred← citeshttps://doi.org/10.1016/j.jbiosc.2009.09.043openalex-snapshot

Changes in the quality of antibodies produced by Chinese hamster ovary cells during the death phase of cell culture

inferred← citeshttps://doi.org/10.1016/j.jbiosc.2014.10.028openalex-snapshot

Effect of temperature shift on levels of acidic charge variants in IgG monoclonal antibodies in Chinese hamster ovary cell culture

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2015.02.026openalex-snapshot

Purification of monoclonal antibodies from clarified cell culture fluid using Protein A capture continuous countercurrent tangential chromatography

inferred← citeshttps://doi.org/10.1016/j.jchromb.2009.09.031openalex-snapshot

Identification and measurement of isoaspartic acid formation in the complementarity determining region of a fully human monoclonal antibody

inferred← citeshttps://doi.org/10.1016/j.jchromb.2014.06.018openalex-snapshot

Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping

inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.04.043openalex-snapshot

Parallel development of chromatographic and mass-spectrometric methods for quantitative analysis of glycation on an IgG1 monoclonal antibody

inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.07.023openalex-snapshot

Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques

inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.02.017openalex-snapshot

Charge variants characterization of a monoclonal antibody by ion exchange chromatography coupled on-line to native mass spectrometry: Case study after a long-term storage at +5 °C

inferred← citeshttps://doi.org/10.1016/j.jchromb.2017.12.003openalex-snapshot

Rapid preparative separation of monoclonal antibody charge variants using laterally-fed membrane chromatography

inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.10.019openalex-snapshot

Identification and quantification of product-related quality attributes in bio-therapeutic monoclonal antibody via a simple, and robust cation-exchange HPLC method compatible with direct online detection of UV and native ESI-QTOF-MS analysis

inferred← citeshttps://doi.org/10.1016/j.jchromb.2019.121814openalex-snapshot

A generic method for intact and subunit level characterization of mAb charge variants by native mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.jchromb.2020.122485openalex-snapshot

Isolation and characterization of charge variants of infliximab biosimilar HS626

inferred← citeshttps://doi.org/10.1016/j.jcoa.2021.100025openalex-snapshot

Analytical tools for the characterization of deamidation in monoclonal antibodies

inferred← citeshttps://doi.org/10.1016/j.jinf.2022.04.033openalex-snapshot

Surface electrostatic shift on spike protein decreased antibody activities against SARS-CoV-2 Omicron variant

inferred← citeshttps://doi.org/10.1016/j.jpba.2010.08.030openalex-snapshot

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations

inferred← citeshttps://doi.org/10.1016/j.jpba.2020.113251openalex-snapshot

Recent advances in LC–MS based characterization of protein-based bio-therapeutics – mastering analytical challenges posed by the increasing format complexity

inferred← citeshttps://doi.org/10.1016/j.jpba.2022.115178openalex-snapshot

Imaged Capillary Isoelectric Focusing (iCIEF) Tandem High Resolution Mass Spectrometry for Charged Heterogeneity of Protein Drugs in Biopharmaceutical Discovery

inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116410openalex-snapshot

Assessment of chemical stability of monoclonal antibody and antibody drug conjugate administered by pressurized intraperitoneal aerosol chemotherapy

inferred← citeshttps://doi.org/10.1016/j.jpba.2026.117407openalex-snapshot

Physicochemical and biological characterization of GNR-087, a Tocilizumab biosimilar

inferred← citeshttps://doi.org/10.1016/j.molimm.2009.02.002openalex-snapshot

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

inferred← citeshttps://doi.org/10.1016/j.seppur.2019.116136openalex-snapshot

Separation of monoclonal antibody charge variants using cation exchange chromatography: Resins and separation conditions optimization

inferred← citeshttps://doi.org/10.1016/j.trac.2025.118212openalex-snapshot

Recent developments of imaged capillary isoelectric focusing technology for in-depth biopharmaceutical characterization

inferred← citeshttps://doi.org/10.1016/j.vetimm.2015.02.004openalex-snapshot

Identification of a candidate therapeutic antibody for treatment of canine B-cell lymphoma

inferred← citeshttps://doi.org/10.1016/j.xphs.2016.04.027openalex-snapshot

Evaluation of Heavy-Chain C-Terminal Deletion on Product Quality and Pharmacokinetics of Monoclonal Antibodies

inferred← citeshttps://doi.org/10.1016/j.xphs.2019.05.023openalex-snapshot

Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation

inferred← citeshttps://doi.org/10.1016/j.xphs.2020.12.027openalex-snapshot

An Approach to Bioactivity Assessment for Critical Quality Attribute Identification Based on Antibody-Antigen Complex Structure

inferred← citeshttps://doi.org/10.1016/j.xphs.2021.12.001openalex-snapshot

Physicochemical and Functional Characterization of HS016, a Biosimilar of Adalimumab (Humira)

inferred← citeshttps://doi.org/10.1021/ac2016129openalex-snapshot

Revealing a Positive Charge Patch on a Recombinant Monoclonal Antibody by Chemical Labeling and Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/ac201741wopenalex-snapshot

High Throughput Profiling of Charge Heterogeneity in Antibodies by Microchip Electrophoresis

inferred← citeshttps://doi.org/10.1021/ac402384yopenalex-snapshot

Arginine Modifications by Methylglyoxal: Discovery in a Recombinant Monoclonal Antibody and Contribution to Acidic Species

inferred← citeshttps://doi.org/10.1021/ac500497nopenalex-snapshot

Microchip Zone Electrophoresis for High-Throughput Analysis of Monoclonal Antibody Charge Variants

inferred← citeshttps://doi.org/10.1021/ac502179mopenalex-snapshot

Discovery of a Chemical Modification by Citric Acid in a Recombinant Monoclonal Antibody

inferred← citeshttps://doi.org/10.1021/ac502372ropenalex-snapshot

Semiautomated pH Gradient Ion-Exchange Chromatography of Monoclonal Antibody Charge Variants

inferred← citeshttps://doi.org/10.1021/ac9006254openalex-snapshot

Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody

inferred← citeshttps://doi.org/10.1021/ac9007557openalex-snapshot

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

inferred← citeshttps://doi.org/10.1021/ac901408jopenalex-snapshot

Multiproduct High-Resolution Monoclonal Antibody Charge Variant Separations by pH Gradient Ion-Exchange Chromatography

inferred← citeshttps://doi.org/10.1021/ac902408ropenalex-snapshot

Characterization of Antibody Charge Heterogeneity Resolved by Preparative Immobilized pH Gradients

inferred← citeshttps://doi.org/10.1021/ac902752eopenalex-snapshot

Kinetics of Chemical Degradation in Monoclonal Antibodies: Relationship between Rates at the Molecular and Peptide Levels

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03099openalex-snapshot

Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c04414openalex-snapshot

In-Depth Characterization of Acidic Variants Induced by Metal-Catalyzed Oxidation in a Recombinant Monoclonal Antibody

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c05071openalex-snapshot

Mass Spectrometry-Based Charge Heterogeneity Characterization of Therapeutic mAbs with Imaged Capillary Isoelectric Focusing and Ion-Exchange Chromatography as Separation Techniques

inferred← citeshttps://doi.org/10.1021/acs.analchem.5b00801openalex-snapshot

When Good Intentions Go Awry: Modification of a Recombinant Monoclonal Antibody in Chemically Defined Cell Culture by Xylosone, an Oxidative Product of Ascorbic Acid

inferred← citeshttps://doi.org/10.1021/acs.analchem.5b01452openalex-snapshot

Characterization of Recombinant Monoclonal Antibody Charge Variants Using OFFGEL Fractionation, Weak Anion Exchange Chromatography, and Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.analchem.5b03946openalex-snapshot

Isolation and Characterization of Monoclonal Antibody Charge Variants by Free Flow Isoelectric Focusing

inferred← citeshttps://doi.org/10.1021/acs.analchem.6b00822openalex-snapshot

Characterization of Cysteinylation and Trisulfide Bonds in a Recombinant Monoclonal Antibody

inferred← citeshttps://doi.org/10.1021/acs.analchem.8b01322openalex-snapshot

Asparagine Deamidation in a Complementarity Determining Region of a Recombinant Monoclonal Antibody in Complex with Antigen

inferred← citeshttps://doi.org/10.1021/acs.analchem.8b03773openalex-snapshot

Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.3c00991openalex-snapshot

Effect of Annealing on Visible-Bubble Formation and Stability Profiles of Freeze-Dried High Concentration Omalizumab Formulations

inferred← citeshttps://doi.org/10.1021/bc100261dopenalex-snapshot

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

inferred← citeshttps://doi.org/10.1021/bc4000564openalex-snapshot

Conjugation Site Heterogeneity Causes Variable Electrostatic Properties in Fc Conjugates

inferred← citeshttps://doi.org/10.1021/bk-2014-1176.ch003openalex-snapshot

Heterogeneity of IgGs: Role of Production, Processing, and Storage on Structure and Function

inferred← citeshttps://doi.org/10.1021/bk-2015-1201.ch007openalex-snapshot

Developability Assessment of a Proposed NIST Monoclonal Antibody

inferred← citeshttps://doi.org/10.1021/jasms.0c00446openalex-snapshot

Multiattribute Monitoring of Antibody Charge Variants by Cation-Exchange Chromatography Coupled to Native Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/jasms.2c00072openalex-snapshot

Investigation of Tryptic Protein Digestion in Microdroplets and in Bulk Solution

inferred← citeshttps://doi.org/10.1021/jasms.5c00058openalex-snapshot

Accelerating Characterization of Therapeutic Antibodies: A Comparative Assessment of icIEF-UV/MS and the Traditional Fractionation Workflow

inferred← citeshttps://doi.org/10.1038/s42003-018-0032-8openalex-snapshot

Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

inferred← citeshttps://doi.org/10.1038/srep20029openalex-snapshot

At least two Fc Neu5Gc residues of monoclonal antibodies are required for binding to anti-Neu5Gc antibody

inferred← citeshttps://doi.org/10.1038/srep44246openalex-snapshot

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells

inferred← citeshttps://doi.org/10.1039/c2lc21111dopenalex-snapshot

On-line electrophoretic sample clean-up for sensitive and reproducible μCE immunoassay

inferred← citeshttps://doi.org/10.1039/d2ay01670bopenalex-snapshot

Fractionation and online mass spectrometry based on imaged capillary isoelectric focusing (icIEF) for characterizing charge heterogeneity of therapeutic antibody

inferred← citeshttps://doi.org/10.1051/medsci/200925121024openalex-snapshot

Anticorps thérapeutiques et dérivés : une palette de structures pour une pléthore d’indications

inferred← citeshttps://doi.org/10.1063/1.4966708openalex-snapshot

Evaluation of effects of pH and ionic strength on colloidal stability of IgG solutions by PEG-induced liquid-liquid phase separation

inferred← citeshttps://doi.org/10.1073/pnas.1707856115openalex-snapshot

Affimer proteins inhibit immune complex binding to FcγRIIIa with high specificity through competitive and allosteric modes of action

inferred← citeshttps://doi.org/10.1080/10826068.2014.995811openalex-snapshot

Separation and analysis of charged isomers of monoclonal immunoglobulin G by ceramic hydroxyapatite chromatography

inferred← citeshttps://doi.org/10.1080/10826076.2011.619035openalex-snapshot

IMPROVED ION-EXCHANGED HPLC METHOD IN mAb USING pH GRADIENT AND ITS COMPARISON WITH cIEF

inferred← citeshttps://doi.org/10.1080/10837450.2026.2725579openalex-snapshot

Light source-dependent photooxidation of therapeutic monoclonal antibodies: a comparative study of light-emitting diode (LED) and fluorescent exposure

inferred← citeshttps://doi.org/10.1080/19420862.2016.1160179openalex-snapshot

Cysteinylation of a monoclonal antibody leads to its inactivation

inferred← citeshttps://doi.org/10.1080/19420862.2017.1313367openalex-snapshot

Unbiased in-depth characterization of CEX fractions from a stressed monoclonal antibody by mass spectrometry

inferred← citeshttps://doi.org/10.1080/19420862.2018.1438797openalex-snapshot

Analytical comparability study of recombinant monoclonal antibody therapeutics

inferred← citeshttps://doi.org/10.1080/19420862.2018.1521131openalex-snapshot

Charge variant native mass spectrometry benefits mass precision and dynamic range of monoclonal antibody intact mass analysis

inferred← citeshttps://doi.org/10.1080/19420862.2019.1578137openalex-snapshot

Charge variants characterization and release assay development for co-formulated antibodies as a combination therapy

inferred← citeshttps://doi.org/10.1080/19420862.2020.1739825openalex-snapshot

Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis

inferred← citeshttps://doi.org/10.1080/19420862.2020.1743053openalex-snapshot

Predicting Antibody Developability Profiles Through Early Stage Discovery Screening

inferred← citeshttps://doi.org/10.1080/19420862.2020.1763138openalex-snapshot

Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb

inferred← citeshttps://doi.org/10.1080/19420862.2021.1887612openalex-snapshot

Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding

inferred← citeshttps://doi.org/10.1080/19420862.2022.2151075openalex-snapshot

Restoring the biological activity of crizanlizumab at physiological conditions through a pH-dependent aspartic acid isomerization reaction

showing the first 200 of 256 · page through all 256

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.