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Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1096-9896(199901)187:1<112::aid-path250>3.0.co;2-3openalex-snapshot
The p53 pathway
inferredcites →https://doi.org/10.1016/j.bcp.2004.03.045openalex-snapshot
CBP and p300: HATs for different occasions
inferredcites →https://doi.org/10.1016/j.molcel.2004.11.002openalex-snapshot
DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms
inferredcites →https://doi.org/10.1016/s0065-230x(08)60785-xopenalex-snapshot
p53 and Human Cancer: The First Ten Thousand Mutations
inferredcites →https://doi.org/10.1016/s0092-8674(00)81871-1openalex-snapshot
p53, the Cellular Gatekeeper for Growth and Division
inferredcites →https://doi.org/10.1016/s0378-1119(00)00040-8openalex-snapshot
Cell-cycle regulation of the DNA topoisomerase IIα promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation
inferredcites →https://doi.org/10.1038/nsmb740openalex-snapshot
Regulation of the p300 HAT domain via a novel activation loop
inferredcites →https://doi.org/10.1038/sj.onc.1201867openalex-snapshot
Mutant p53 protein expression interferes with p53-independent apoptotic pathways
inferredcites →https://doi.org/10.1038/sj.onc.1202314openalex-snapshot
Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy
inferredcites →https://doi.org/10.1038/sj.onc.1202472openalex-snapshot
Down-regulation of cyclin B1 gene transcription in terminally differentiated skeletal muscle cells is associated with loss of functional CCAAT-binding NF-Y complex
inferredcites →https://doi.org/10.1038/sj.onc.1202494openalex-snapshot
The cyclin B2 promoter depends on NF-Y, a trimer whose CCAAT-binding activity is cell-cycle regulated
inferredcites →https://doi.org/10.1038/sj.onc.1208615openalex-snapshot
The p53 pathway: positive and negative feedback loops
inferredcites →https://doi.org/10.1038/sj.onc.1209061openalex-snapshot
Repression of the MSP/MST-1 gene contributes to the antiapoptotic gain of function of mutant p53
inferredcites →https://doi.org/10.1073/pnas.92.11.5154openalex-snapshot
Human TAFII31 protein is a transcriptional coactivator of the p53 protein.
inferredcites →https://doi.org/10.1073/pnas.92.24.11264openalex-snapshot
Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.
inferredcites →https://doi.org/10.1073/pnas.95.9.5166openalex-snapshot
An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control
inferredcites →https://doi.org/10.1074/jbc.272.29.18367openalex-snapshot
E2F-mediated Growth Regulation Requires Transcription Factor Cooperation
inferredcites →https://doi.org/10.1074/jbc.274.42.29677openalex-snapshot
p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor
inferredcites →https://doi.org/10.1074/jbc.275.4.2979openalex-snapshot
Transcriptional Activation of the MDR1 Gene by UV Irradiation
inferredcites →https://doi.org/10.1074/jbc.m003360200openalex-snapshot
Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73
inferredcites →https://doi.org/10.1074/jbc.m006052200openalex-snapshot
NF-Y Mediates the Transcriptional Inhibition of thecyclin B1, cyclin B2, and cdc25CPromoters upon Induced G2 Arrest
inferredcites →https://doi.org/10.1074/jbc.m201405200openalex-snapshot
Physical Interaction with Human Tumor-derived p53 Mutants Inhibits p63 Activities
inferredcites →https://doi.org/10.1074/jbc.m202040200openalex-snapshot
Abrogation of the S Phase DNA Damage Checkpoint Results in S Phase Progression or Premature Mitosis Depending on the Concentration of 7-Hydroxystaurosporine and the Kinetics of Cdc25C Activation
inferredcites →https://doi.org/10.1074/jbc.m205573200openalex-snapshot
Identification of Direct p73 Target Genes Combining DNA Microarray and Chromatin Immunoprecipitation Analyses
inferredcites →https://doi.org/10.1074/jbc.m210065200openalex-snapshot
Interactions between p300 and Multiple NF-Y Trimers Govern Cyclin B2 Promoter Function
inferredcites →https://doi.org/10.1074/jbc.m304606200openalex-snapshot
Dynamic Recruitment of NF-Y and Histone Acetyltransferases on Cell-cycle Promoters
inferredcites →https://doi.org/10.1091/mbc.e02-09-0600openalex-snapshot
Requirement for Down-Regulation of the CCAAT-binding Activity of the NF-Y Transcription Factor during Skeletal Muscle Differentiation
inferredcites →https://doi.org/10.1093/nar/24.1.147openalex-snapshot
p53 gene mutation: software and database
inferredcites →https://doi.org/10.1093/nar/24.21.4281openalex-snapshot
Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein
inferredcites →https://doi.org/10.1093/nar/26.1.200openalex-snapshot
p53 gene mutation: software and database
inferredcites →https://doi.org/10.1093/nar/26.5.1135openalex-snapshot
A survey of 178 NF-Y binding CCAAT boxes
inferredcites →https://doi.org/10.1096/fj.00-0128comopenalex-snapshot
A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53‐null mammary epithelial cell mode .
inferredcites →https://doi.org/10.1101/gr.947203openalex-snapshot
Genome-Wide In Silico Identification of Transcriptional Regulators Controlling the Cell Cycle in Human Cells
inferredcites →https://doi.org/10.1126/science.1068999openalex-snapshot
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells
inferredcites →https://doi.org/10.1128/mcb.16.7.3789openalex-snapshot
Cyclin A Expression Is under Negative Transcriptional Control during the Cell Cycle
inferredcites →https://doi.org/10.1128/mcb.21.5.1874-1887.2001openalex-snapshot
A Subset of Tumor-Derived Mutant Forms of p53 Down-Regulate p63 and p73 through a Direct Interaction with the p53 Core Domain
inferredcites →https://doi.org/10.1128/mcb.25.9.3737-3751.2005openalex-snapshot
Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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The Abl1 Tyrosine Kinase and p53 are Key Players in Doxorubicin-Induced Cardiomyopathy and Their Cell Death Signaling Differs in Atrial and Ventricular Cardiomyocytes
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Gain‐of‐Function Mutants of p53 and Their Role in Tumourigenesis
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Enhancing Chemotherapy of p53‐Mutated Cancer through Ubiquitination‐Dependent Proteasomal Degradation of Mutant p53 Proteins by Engineered ZnFe‐4 Nanoparticles
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Role of lncRNAs in aging and age‐related diseases
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DNA damage sensible engineered promoter for cellular biosensing of cytotoxicity
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Cell fate regulation governed by p53: Friends or reversible foes in cancer therapy
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High prevalence of p53 exon 4 mutations in soft tissue sarcoma
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CKAP4 and mutant p53 cooperatively abrogate cell cycle checkpoint to induce genotoxic resistance in ovarian cancer
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Innovative Drug and Prodrug Candidates in Cancer Treatment Targeting TP53 Mutations: Challenge and Hope
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Protumorigenic overexpression of stathmin/Op18 by gain-of-function mutation in p53 in human hepatocarcinogenesis
inferred← citeshttps://doi.org/10.1002/hep.27207openalex-snapshot
Prosurvival function of the cellular apoptosis susceptibility/importin-α1 transport cycle is repressed by p53 in liver cancer
inferred← citeshttps://doi.org/10.1002/humu.22514openalex-snapshot
TP53 Mutants in the Tower of Babel of Cancer Progression
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Binding of RFX2 and NF‐Y to the testis‐specific histone H1t promoter may be required for transcriptional activation in primary spermatocytes
inferred← citeshttps://doi.org/10.1002/jcb.23400openalex-snapshot
Links between mutant p53 and genomic instability
inferred← citeshttps://doi.org/10.1002/jmr.975openalex-snapshot
A combined atomic force microscopy imaging and docking study to investigate the complex between p53 DNA binding domain and Azurin
inferred← citeshttps://doi.org/10.1002/med.21266openalex-snapshot
DNA‐Binding Small Molecules as Inhibitors of Transcription Factors
inferred← citeshttps://doi.org/10.1002/mnfr.201800530openalex-snapshot
Identification of a Novel Function of Resveratrol and Genistein as a Regulator of β2‐Adrenergic Receptor Expression in Skeletal Muscle Cells and Characterization of Promoter Elements Required for Promoter Activation
inferred← citeshttps://doi.org/10.1002/path.2971openalex-snapshot
Gain‐of‐function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K‐ras
inferred← citeshttps://doi.org/10.1002/path.2988openalex-snapshot
Mutant p53 gain of function is interwoven into the hallmarks of cancer
inferred← citeshttps://doi.org/10.1002/path.5677openalex-snapshot
What do we need to know and understand about p53 to improve its clinical value?
inferred← citeshttps://doi.org/10.1007/978-1-4939-6631-8_74-1openalex-snapshot
Cell Cycle Machinery and Its Alterations in Pancreatic Cancer
inferred← citeshttps://doi.org/10.1007/978-1-4939-7193-0_74openalex-snapshot
Cell Cycle Machinery and Its Alterations in Pancreatic Cancer
inferred← citeshttps://doi.org/10.1007/978-1-62703-236-0_11openalex-snapshot
Mutant p53 in Cell Adhesion and Motility
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Gain-of-Function p53
inferred← citeshttps://doi.org/10.1007/978-94-017-9211-0_3openalex-snapshot
Cooperation of p53 Mutations with Other Oncogenic Alterations in Cancer
inferred← citeshttps://doi.org/10.1007/978-94-017-9211-0_4openalex-snapshot
p53: Its Mutations and Their Impact on Transcription
inferred← citeshttps://doi.org/10.1007/978-94-017-9211-0_5openalex-snapshot
Transcriptional Regulation by Mutant p53 and Oncogenesis
inferred← citeshttps://doi.org/10.1007/978-94-017-9211-0_6openalex-snapshot
p53 Mutation in the Genesis of Metastasis
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Technological Developments in lncRNA Biology
inferred← citeshttps://doi.org/10.1007/s00018-011-0910-4openalex-snapshot
Chromosome instability and deregulated proliferation: an unavoidable duo
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Functional and transcriptomic analyses of the NF-Y family provide insights into the defense mechanisms of honeybees under adverse circumstances
inferred← citeshttps://doi.org/10.1007/s00109-024-02499-5openalex-snapshot
Polo-like kinase 2 targeting as novel strategy to sensitize mutant p53-expressing tumor cells to anticancer treatments
inferred← citeshttps://doi.org/10.1007/s00299-009-0693-3openalex-snapshot
MicroRNA expression profiles in conventional and micropropagated strawberry (Fragaria × ananassa Duch.) plants
inferred← citeshttps://doi.org/10.1007/s00795-012-0575-6openalex-snapshot
Overexpression of p53 protein in human tumors
inferred← citeshttps://doi.org/10.1007/s10495-026-02409-9openalex-snapshot
Revisiting tumor immunogenicity through the lens of mutant p53: Implications for cancer immunotherapy
inferred← citeshttps://doi.org/10.1007/s10549-015-3339-xopenalex-snapshot
Novel role of PELP1 in regulating chemotherapy response in mutant p53-expressing triple negative breast cancer cells
inferred← citeshttps://doi.org/10.1007/s11010-007-9503-9openalex-snapshot
The over-expression of p53 H179Y residue mutation causes the increase of cyclin A1 and Cdk4 expression in HELF cells
inferred← citeshttps://doi.org/10.1007/s11033-024-10051-4openalex-snapshot
Role of artificial intelligence in cancer detection using protein p53: A Review
inferred← citeshttps://doi.org/10.1007/s12032-023-02039-0openalex-snapshot
The crosstalk between ubiquitin-conjugating enzyme E2Q1 and p53 in colorectal cancer: An in vitro analysis
inferred← citeshttps://doi.org/10.1007/s13277-013-0871-3openalex-snapshot
Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
inferred← citeshttps://doi.org/10.1007/s13277-013-1198-9openalex-snapshot
Biological significance of promoter hypermethylation of p14/ARF gene: Relationships to p53 mutational status in Tunisian population with colorectal carcinoma
inferred← citeshttps://doi.org/10.1016/b978-0-12-374145-5.00265-5openalex-snapshot
The p53 Master Regulator and Rules of Engagement with Target Sequences
inferred← citeshttps://doi.org/10.1016/b978-0-323-99507-8.00070-6openalex-snapshot
Chromatin folding and function
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2017.04.003openalex-snapshot
MicroRNAs as Key Effectors in the p53 Network
inferred← citeshttps://doi.org/10.1016/j.aanat.2015.11.010openalex-snapshot
A bioluminescent mouse model of proliferation to highlight early stages of pancreatic cancer: A suitable tool for preclinical studies
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Proteomic Analysis Reveals GMP Synthetase as p53 Repression Target in Liver Cancer
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Interaction of mutant p53 with p73: A Surface Plasmon Resonance and Atomic Force Spectroscopy study
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NF-Y (CBF) regulation in specific cell types and mouse models
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NF-Y in cancer: Impact on cell transformation of a gene essential for proliferation
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Mutant p53 stimulates chemoresistance of pancreatic adenocarcinoma cells to gemcitabine
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Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity
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The NF-Y/p53 liaison: Well beyond repression
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Tumor suppressor p53: Biology, signaling pathways, and therapeutic targeting
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B-Myb participated in ionizing radiation-induced apoptosis and cell cycle arrest in human glioma cells
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Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway
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Molecular mechanisms underlying the regulation of tumour suppressor genes in lung cancer
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Novel C8-linked pyrrolobenzodiazepine (PBD)–heterocycle conjugates that recognize DNA sequences containing an inverted CCAAT box
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Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells
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Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines
inferred← citeshttps://doi.org/10.1016/j.ccr.2009.11.025openalex-snapshot
Modulation of the Vitamin D3 Response by Cancer-Associated Mutant p53
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A Pin1/Mutant p53 Axis Promotes Aggressiveness in Breast Cancer
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Mutant p53 in Cancer: New Functions and Therapeutic Opportunities
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Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling
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Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo
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Gain-of-function p53R172H mutation drives accumulation of neutrophils in pancreatic tumors, promoting resistance to immunotherapy
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Triple negative breast cancer: A thorough review of biomarkers
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Targeting triple negative breast cancer: Is p53 the answer?
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p53 affects epigenetic signature on SOCS1 promoter in response to TLR4 inhibition
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Combined analysis of primary lymphoid tissues' transcriptomic response to extra-intestinal Escherichia coli (ExPEC) infection
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Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development
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Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay
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How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance
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Differences of molecular events driving pathological and radiological progression of lung adenocarcinoma
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Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
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Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks
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Transcriptome profiling identifies genes and pathways deregulated upon floxuridine treatment in colorectal cancer cells harboring GOF mutant p53
inferred← citeshttps://doi.org/10.1016/j.gene.2010.03.014openalex-snapshot
Characterization of the mouse CP27 promoter and NF-Y mediated gene regulation
inferred← citeshttps://doi.org/10.1016/j.gene.2010.10.009openalex-snapshot
NF-Y transcriptionally regulates the Drosophila p53 gene
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Synergistic modulation of p53-HMGB1 complex and its binding to DNA: The role of nanotechnology in overcoming cancer drug resistance; A literature review and in-silico analysis
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Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
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Microcurrent stimulation induces cell death in p53-mutant and 5-FU-resistant breast cancer
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Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy
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PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop
inferred← citeshttps://doi.org/10.1016/j.molonc.2016.04.001openalex-snapshot
Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition
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A rare DNA contact mutation in cancer confers p53 gain‐of‐function and tumor cell survival via TNFAIP8 induction
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Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis
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Current developments of targeting the p53 signaling pathway for cancer treatment
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Transcription factors in epithelial ovarian cancer: histotype-specific drivers and novel therapeutic targets
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Disarming mutant p53 oncogenic function
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Programmed cell death (PCD) control in plants: New insights from the Arabidopsis thaliana deathosome
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Crosstalk between long non-coding RNAs and p53 signaling pathway in colorectal cancer: A review study
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Wild type- and mutant p53 proteins in mitochondrial dysfunction: emerging insights in cancer disease
inferred← citeshttps://doi.org/10.1016/j.tcb.2010.06.005openalex-snapshot
Drug discovery and mutant p53
inferred← citeshttps://doi.org/10.1016/j.tcb.2011.04.002openalex-snapshot
To repress or not to repress: This is the guardian's question
inferred← citeshttps://doi.org/10.1016/j.tcb.2015.04.001openalex-snapshot
Hitting cancers’ weak spots: vulnerabilities imposed by p53 mutation
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Li–Fraumeni Syndrome Disease Model: A Platform to Develop Precision Cancer Therapy Targeting Oncogenic p53
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CCAAT-box binding transcription factors in plants: Y so many?
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p53: Balancing tumour suppression and implications for the clinic
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Reconnaissance of Allostery via the Restoration of Native p53 DNA-Binding Domain Dynamics in Y220C Mutant p53 Tumor Suppressor Protein
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Determination and Prediction of the Binding Interaction between Organophosphate Flame Retardants and p53
inferred← citeshttps://doi.org/10.1038/cdd.2010.166openalex-snapshot
NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons
inferred← citeshttps://doi.org/10.1038/cdd.2010.94openalex-snapshot
Mutant p53R175H upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells
inferred← citeshttps://doi.org/10.1038/cdd.2011.190openalex-snapshot
MicroRNA-128-2 targets the transcriptional repressor E2F5 enhancing mutant p53 gain of function
inferred← citeshttps://doi.org/10.1038/cdd.2015.133openalex-snapshot
DNA damage-induced ephrin-B2 reverse signaling promotes chemoresistance and drives EMT in colorectal carcinoma harboring mutant p53
inferred← citeshttps://doi.org/10.1038/cdd.2015.33openalex-snapshot
Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53
inferred← citeshttps://doi.org/10.1038/cddis.2013.97openalex-snapshot
Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression
inferred← citeshttps://doi.org/10.1038/cddis.2014.217openalex-snapshot
Degradation of mutant p53H175 protein by Zn(II) through autophagy
inferred← citeshttps://doi.org/10.1038/cddis.2015.191openalex-snapshot
Mutant p53-R273H mediates cancer cell survival and anoikis resistance through AKT-dependent suppression of BCL2-modifying factor (BMF)
inferred← citeshttps://doi.org/10.1038/cddis.2016.42openalex-snapshot
p53MutaGene: an online tool to estimate the effect of p53 mutational status on gene regulation in cancer
inferred← citeshttps://doi.org/10.1038/cddis.2017.376openalex-snapshot
p53-R273H upregulates neuropilin-2 to promote cell mobility and tumor metastasis
inferred← citeshttps://doi.org/10.1038/embor.2012.74openalex-snapshot
Mutant p53 interactome identifies nardilysin as a p53R273H‐specific binding partner that promotes invasion
inferred← citeshttps://doi.org/10.1038/ncb3380openalex-snapshot
Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer
inferred← citeshttps://doi.org/10.1038/ncomms4354openalex-snapshot
NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization
inferred← citeshttps://doi.org/10.1038/ncomms8389openalex-snapshot
Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
inferred← citeshttps://doi.org/10.1038/nrc2584openalex-snapshot
p53 polymorphisms: cancer implications
inferred← citeshttps://doi.org/10.1038/nrc2693openalex-snapshot
When mutants gain new powers: news from the mutant p53 field
inferred← citeshttps://doi.org/10.1038/nrc2730openalex-snapshot
The expanding universe of p53 targets
inferred← citeshttps://doi.org/10.1038/nrc3711openalex-snapshot
Unravelling mechanisms of p53-mediated tumour suppression
inferred← citeshttps://doi.org/10.1038/nrm2395openalex-snapshot
Transcriptional control of human p53-regulated genes
inferred← citeshttps://doi.org/10.1038/nsmb.1669openalex-snapshot
The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
inferred← citeshttps://doi.org/10.1038/onc.2008.324openalex-snapshot
p53 controls hPar1 function and expression
inferred← citeshttps://doi.org/10.1038/onc.2009.376openalex-snapshot
A common gain of function of p53 cancer mutants in inducing genetic instability
inferred← citeshttps://doi.org/10.1038/onc.2010.474openalex-snapshot
Mutant p53 subverts p63 control over KLF4 expression in keratinocytes
inferred← citeshttps://doi.org/10.1038/onc.2010.588openalex-snapshot
Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors
inferred← citeshttps://doi.org/10.1038/onc.2011.456openalex-snapshot
Mutant p53 drives multinucleation and invasion through a process that is suppressed by ANKRD11
inferred← citeshttps://doi.org/10.1038/onc.2011.72openalex-snapshot
Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms
inferred← citeshttps://doi.org/10.1038/onc.2012.148openalex-snapshot
Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion
inferred← citeshttps://doi.org/10.1038/onc.2012.299openalex-snapshot
The gain of function of p53 cancer mutant in promoting mammary tumorigenesis
inferred← citeshttps://doi.org/10.1038/onc.2012.334openalex-snapshot
Mutant p53 gain-of-function induces epithelial–mesenchymal transition through modulation of the miR-130b–ZEB1 axis
inferred← citeshttps://doi.org/10.1038/onc.2013.106openalex-snapshot
Gain-of-function mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells
inferred← citeshttps://doi.org/10.1038/onc.2013.287openalex-snapshot
Functions of TAp63 and p53 in restraining the development of metastatic cancer
inferred← citeshttps://doi.org/10.1038/onc.2014.191openalex-snapshot
Mutant p53 gains new function in promoting inflammatory signals by repression of the secreted interleukin-1 receptor antagonist
inferred← citeshttps://doi.org/10.1038/onc.2014.46openalex-snapshot
A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis
inferred← citeshttps://doi.org/10.1038/onc.2016.312openalex-snapshot
Neomorphic mutations create therapeutic challenges in cancer
inferred← citeshttps://doi.org/10.1038/onc.2016.51openalex-snapshot
Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex
inferred← citeshttps://doi.org/10.1038/s41388-021-01903-5openalex-snapshot
Mutant p53 elicits context-dependent pro-tumorigenic phenotypes
inferred← citeshttps://doi.org/10.1038/s41388-023-02886-1openalex-snapshot
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
inferred← citeshttps://doi.org/10.1038/s41418-017-0026-yopenalex-snapshot
The interplay between mutant p53 and the mevalonate pathway
inferred← citeshttps://doi.org/10.1038/s41418-020-00677-9openalex-snapshot
Aberrant transcriptional and post-transcriptional regulation of SPAG5, a YAP-TAZ-TEAD downstream effector, fuels breast cancer cell proliferation
inferred← citeshttps://doi.org/10.1038/s41418-022-00989-yopenalex-snapshot
Mutant p53: it’s not all one and the same
inferred← citeshttps://doi.org/10.1038/s41419-022-05408-1openalex-snapshot
Mutant p53 in cancer: from molecular mechanism to therapeutic modulation
inferred← citeshttps://doi.org/10.1038/s41419-025-08172-0openalex-snapshot
Distinct functional heterogeneity of TP53 R175 mutations in platinum-resistant ovarian cancer: unveiling molecular mechanisms and therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41420-020-00337-4openalex-snapshot
Attenuation of p53 mutant as an approach for treatment Her2-positive cancer
inferred← citeshttps://doi.org/10.1038/s41420-021-00533-wopenalex-snapshot
NF-κB is involved in the regulation of autophagy in mutant p53 cells in response to ionizing radiation
inferred← citeshttps://doi.org/10.1038/s41467-017-01117-yopenalex-snapshot
Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling
inferred← citeshttps://doi.org/10.1038/s41467-019-09695-9openalex-snapshot
Metabolic profiling of cancer cells reveals genome-wide crosstalk between transcriptional regulators and metabolism
inferred← citeshttps://doi.org/10.1038/s41467-019-10133-zopenalex-snapshot
Nucleoporin Nup155 is part of the p53 network in liver cancer
inferred← citeshttps://doi.org/10.1038/s41467-020-15608-yopenalex-snapshot
Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation
inferred← citeshttps://doi.org/10.1038/s41467-021-20928-8openalex-snapshot
The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3
inferred← citeshttps://doi.org/10.1038/s41467-022-30481-7openalex-snapshot
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients
inferred← citeshttps://doi.org/10.1038/s41568-024-00784-6openalex-snapshot
Decoding the functional impact of the cancer genome through protein–protein interactions
inferred← citeshttps://doi.org/10.1038/s41598-017-08880-4openalex-snapshot
Mutant p53 stimulates cell invasion through an interaction with Rad21 in human ovarian cancer cells
inferred← citeshttps://doi.org/10.1038/s41598-018-32195-7openalex-snapshot
Etoposide-resistance in a neuroblastoma model cell line is associated with 13q14.3 mono-allelic deletion and miRNA-15a/16-1 down-regulation
inferred← citeshttps://doi.org/10.1038/s41598-020-78682-8openalex-snapshot
Gene expression profiling in neuronal cells identifies a different type of transcriptome modulated by NF-Y
inferred← citeshttps://doi.org/10.1038/s41598-020-79530-5openalex-snapshot
MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo
inferred← citeshttps://doi.org/10.1038/s42255-022-00532-wopenalex-snapshot
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate
inferred← citeshttps://doi.org/10.1038/s44318-024-00085-6openalex-snapshot
Nuclear phosphoinositide signaling promotes YAP/TAZ-TEAD transcriptional activity in breast cancer
inferred← citeshttps://doi.org/10.1038/sj.bjc.6605335openalex-snapshot
Mutant p53 mediates survival of breast cancer cells
inferred← citeshttps://doi.org/10.1038/sj.onc.1210276openalex-snapshot
Mutant p53: from guardian to fallen angel?
inferred← citeshttps://doi.org/10.1038/sj.onc.1210277openalex-snapshot
Changing the p53 master regulatory network: ELEMENTary, my dear Mr Watson
inferred← citeshttps://doi.org/10.1038/sj.onc.1210294openalex-snapshot
Transcription regulation by mutant p53
inferred← citeshttps://doi.org/10.1038/sj.onc.1210296openalex-snapshot
Mutant p53: an oncogenic transcription factor
inferred← citeshttps://doi.org/10.1038/sj.onc.1210311openalex-snapshot
Are interactions with p63 and p73 involved in mutant p53 gain of oncogenic function?
inferred← citeshttps://doi.org/10.1038/sj.onc.1210312openalex-snapshot
Interactions of mutant p53 with DNA: guilt by association
inferred← citeshttps://doi.org/10.1038/srep34575openalex-snapshot
Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS
inferred← citeshttps://doi.org/10.1038/srep44573openalex-snapshot
Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation
inferred← citeshttps://doi.org/10.1039/b911416eopenalex-snapshot
Transcriptional control of the proliferation cluster by the tumor suppressor p53
inferred← citeshttps://doi.org/10.1039/d4mh00470aopenalex-snapshot
Metal ion interference therapy: metal-based nanomaterial-mediated mechanisms and strategies to boost intracellular “ion overload” for cancer treatment
inferred← citeshttps://doi.org/10.1042/bst20150261openalex-snapshot
Novel targets and interaction partners of mutant p53 Gain-Of-Function
inferred← citeshttps://doi.org/10.1073/pnas.0909734107openalex-snapshot
A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells
inferred← citeshttps://doi.org/10.1073/pnas.2119644119openalex-snapshot
Cross-talk between mutant p53 and p62/SQSTM1 augments cancer cell migration by promoting the degradation of cell adhesion proteins
inferred← citeshttps://doi.org/10.1074/jbc.m109.094813openalex-snapshot
Mutant p53-induced Up-regulation of Mitogen-activated Protein Kinase Kinase 3 Contributes to Gain of Function
inferred← citeshttps://doi.org/10.1074/jbc.m111.221184openalex-snapshot
Protein Interactions of Phosphatase and Tensin Homologue (PTEN) and Its Cancer-associated G20E Mutant Compared by Using Stable Isotope Labeling by Amino Acids in Cell Culture-based Parallel Affinity Purification
inferred← citeshttps://doi.org/10.1074/jbc.m116.731398openalex-snapshot
E2 Ubiquitin-conjugating Enzyme, UBE2C Gene, Is Reciprocally Regulated by Wild-type and Gain-of-Function Mutant p53
inferred← citeshttps://doi.org/10.1074/jbc.ra118.003387openalex-snapshot
Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4
inferred← citeshttps://doi.org/10.1080/07391102.2023.2283793openalex-snapshot
Investigation of the impact of R273H and R273C mutations on the DNA binding domain of P53 protein through molecular dynamic simulation
inferred← citeshttps://doi.org/10.1080/10408398.2016.1231168openalex-snapshot
Absorption, metabolism, anti-cancer effect and molecular targets of epigallocatechin gallate (EGCG): An updated review
inferred← citeshttps://doi.org/10.1080/14728222.2017.1297798openalex-snapshot
Tp53 and its potential therapeutic role as a target in bladder cancer
inferred← citeshttps://doi.org/10.1080/14737140.2024.2414071openalex-snapshot
Targeted therapies for myelodysplastic syndromes/neoplasms (MDS): current landscape and future directions
inferred← citeshttps://doi.org/10.1080/15384047.2019.1685289openalex-snapshot
Co-targeting p53-R249S and CDK4 synergistically suppresses survival of hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1080/15384101.2016.1152428openalex-snapshot
Hepatic stellate cell promoted hepatoma cell invasion via the HGF/c-Met signaling pathway regulated by p53
inferred← citeshttps://doi.org/10.1080/15384101.2020.1749790openalex-snapshot
Gain of function mutant p53 protein activates AKT through the Rac1 signaling to promote tumorigenesis
inferred← citeshttps://doi.org/10.1084/jem.20192389openalex-snapshot
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
inferred← citeshttps://doi.org/10.1089/omi.2010.0084openalex-snapshot
ChIP-on-Chip Analysis of In Vivo Mutant p53 Binding To Selected Gene Promoters
inferred← citeshttps://doi.org/10.1091/mbc.e08-03-0295openalex-snapshot
Posttranslational Regulation of NF-YA Modulates NF-Y Transcriptional Activity
inferred← citeshttps://doi.org/10.1091/mbc.e12-01-0039openalex-snapshot
Molecular imaging of nuclear factor-Y transcriptional activity maps proliferation sites in live animals
inferred← citeshttps://doi.org/10.1093/abbs/gmt144openalex-snapshot
Tumor suppressor p53 and its gain-of-function mutants in cancer
inferred← citeshttps://doi.org/10.1093/annonc/mdt380openalex-snapshot
Expression of TP53 mutation-associated microRNAs predicts clinical outcome in head and neck squamous cell carcinoma patients
inferred← citeshttps://doi.org/10.1093/bfgp/elac015openalex-snapshot
Comprehensive omics studies of p53 mutants in human cancer
inferred← citeshttps://doi.org/10.1093/carcin/bgac015openalex-snapshot
Wild-type p53 suppresses formin-binding protein-17 (FBP17) to reduce invasion
inferred← citeshttps://doi.org/10.1093/carcin/bgs232openalex-snapshot
The rebel angel: mutant p53 as the driving oncogene in breast cancer
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