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Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features
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Computational design and selections for an engineered, thermostable terpene synthase
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Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.
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Novel approaches and achievements in biosynthesis of functional isoprenoids in Escherichia coli
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Enhanced C30 carotenoid production in Bacillus subtilis by systematic overexpression of MEP pathway genes
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Metabolic engineering of Bacillus subtilis for terpenoid production
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Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
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Expression, purification, and characterization of recombinant amorpha-4,11-diene synthase from Artemisia annua L.
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Amorpha-4,11-diene synthase: Mechanism and stereochemistry of the enzymatic cyclization of farnesyl diphosphate
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Unearthing the roots of the terpenome
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Expression, purification and characterization of recombinant (E)-β-farnesene synthase from Artemisia annua
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Evolving strategies for enzyme engineering
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Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis
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Malaria
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Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism
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X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity,
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Evidence for Differential Folding of Farnesyl Pyrophosphate in the Active Site of Aristolochene Synthase: A Single-Point Mutation Converts Aristolochene Synthase into an (E)-β-Farnesene Synthase
inferredcites →https://doi.org/10.1021/bi0622524openalex-snapshot
X-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and Evolution of Templates for the Cyclization of Farnesyl Diphosphate,
inferredcites →https://doi.org/10.1021/bi400898kopenalex-snapshot
Conformational Change and Ligand Binding in the Aristolochene Synthase Catalytic Cycle
inferredcites →https://doi.org/10.1021/bi401643uopenalex-snapshot
Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi -Isozizaene Synthase
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Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates,
inferredcites →https://doi.org/10.1021/cb900295gopenalex-snapshot
Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates
inferredcites →https://doi.org/10.1021/cr050286wopenalex-snapshot
Structural Biology and Chemistry of the Terpenoid Cyclases
inferredcites →https://doi.org/10.1021/ja026058qopenalex-snapshot
Pentalenene Synthase. Analysis of Active Site Residues by Site-Directed Mutagenesis
inferredcites →https://doi.org/10.1021/np050356uopenalex-snapshot
Cyclization Mechanism of Amorpha-4,11-diene Synthase, a Key Enzyme in Artemisinin Biosynthesis
inferredcites →https://doi.org/10.1038/nature04607openalex-snapshot
Designed divergent evolution of enzyme function
inferredcites →https://doi.org/10.1038/nature09628openalex-snapshot
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis
inferredcites →https://doi.org/10.1038/nbt833openalex-snapshot
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
inferredcites →https://doi.org/10.1038/ncomms7143openalex-snapshot
Emergence of terpene cyclization in Artemisia annua
inferredcites →https://doi.org/10.1038/ng1482openalex-snapshot
The 'evolvability' of promiscuous protein functions
inferredcites →https://doi.org/10.1039/c1np00060hopenalex-snapshot
Sesquiterpene synthases: Passive catalysts or active players?
inferredcites →https://doi.org/10.1039/c2np20059gopenalex-snapshot
Terpenoid synthase structures: a so far incomplete view of complex catalysis
inferredcites →https://doi.org/10.1042/bj20130041openalex-snapshot
Rational engineering of plasticity residues of sesquiterpene synthases from Artemisia annua: product specificity and catalytic efficiency
inferredcites →https://doi.org/10.1074/jbc.m800659200openalex-snapshot
X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis
inferredcites →https://doi.org/10.1093/genetics/158.2.811openalex-snapshot
Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications
inferredcites →https://doi.org/10.1093/pcp/pcp149openalex-snapshot
Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis
inferredcites →https://doi.org/10.1107/s0021889892009944openalex-snapshot
PROCHECK: a program to check the stereochemical quality of protein structures
inferredcites →https://doi.org/10.1126/science.277.5333.1815openalex-snapshot
Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase
inferredcites →https://doi.org/10.1126/science.277.5333.1820openalex-snapshot
Crystal Structure of Pentalenene Synthase: Mechanistic Insights on Terpenoid Cyclization Reactions in Biology
inferredcites →https://doi.org/10.2144/02335st03openalex-snapshot
Creating Random Mutagenesis Libraries Using Megaprimer PCR of Whole Plasmid
inferredcites →https://doi.org/10.4103/0973-7847.91118openalex-snapshot
Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective
inferredcites →https://doi.org/10.6026/97320630004421openalex-snapshot
Isolation, characterization and structural studies of amorpha – 4, 11-diene synthase (ADS3963) from Arte a L. misia annu

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Site-directed mutagenesis of β sesquiphellandrene synthase enhances enzyme promiscuity
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Combination of protein engineering and metabolic engineering to enhance (+)‐nootkatone production in Saccharomyces cerevisiae
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Amorpha-4,11-diene synthase: a key enzyme in artemisinin biosynthesis and engineering
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Dynamic coupling analysis on plant sesquiterpene synthases provides leads for the identification of product specificity determinants
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Phylogenetically distant group of terpene synthases participates in cadinene and cedrane-type sesquiterpenes accumulation in Taiwania cryptomerioides
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Cloning and functional characterization of three sesquiterpene synthase genes from Chamaecyparis formosensis Matsumura
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Side Products of Recombinant Amorpha-4,11-diene Synthase and Their Effect on Microbial Artemisinin Production
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Enzyme and Metabolic Engineering Strategies for Biosynthesis of α-Farnesene in Saccharomyces cerevisiae
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Catalytic Mechanism and Heterologous Biosynthesis Application of Sesquiterpene Synthases
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Computer-Informed Engineering: A New Class I Sesquiterpene Synthase JeSTS4 for the Synthesis of an Unusual C10-(S)-Bicyclogermacrene
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High-Level Production of Sesquiterpene Patchoulol in Saccharomyces cerevisiae
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Catalysis of amorpha-4,11-diene synthase unraveled and improved by mutability landscape guided engineering
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Kinetic studies and homology modeling of a dual-substrate linalool/nerolidol synthase from Plectranthus amboinicus
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Insights into the structure-function relations of amorpha-4,11-diene synthase
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The terpene mini-path : nouvel accès aux terpènes et exploration de l'espace chimique par une cascade enzymatique originale
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