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Terpenoid synthase structures: a so far incomplete view of complex catalysis

https://doi.org/10.1039/c2np20059g

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Enzyme Mechanisms for Triterpene Cyclization: New Pieces of the Puzzle

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Structural Basis for the Exceptional in vivo Efficacy of Bisphosphonate Drugs

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Conversion of Squalene to the Pentacarbocyclic Hopene

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Engineering Cotton (+)-δ-Cadinene Synthase to an Altered Function: Germacrene D-4-ol Synthase

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Identification and functional analysis of bifunctional ent ‐kaurene synthase from the moss Physcomitrella patens

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Gibberellin biosynthesis in bacteria: Separate ent ‐copalyl diphosphate and ent ‐kaurene synthases in Bradyrhizobium japonicum

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The Structural Basis of Chain Length Control in Rv1086

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Structure of Isoprene Synthase Illuminates the Chemical Mechanism of Teragram Atmospheric Carbon Emission

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Structure and Mechanism of the Magnesium-Independent Aromatic Prenyltransferase CloQ from the Clorobiocin Biosynthetic Pathway

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Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases

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Interactions of a hybrid insulin/insulin-like growth factor-I analog with chimeric insulin/type I insulin-like growth factor receptors.

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Effect of site-directed mutagenesis of conserved aspartate and arginine residues upon farnesyl diphosphate synthase activity.

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Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes

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Crystal Structure of a Squalene Cyclase in Complex with the Potential Anticholesteremic Drug Ro48-8071

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Crystal Structure of Recombinant Farnesyl Diphosphate Synthase at 2.6-.ANG. Resolution

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Mechanism of the pyrophosphate migration in the enzymic cyclization of geranyl and linalyl pyrophosphates to (+)- and (-)-bornyl pyrophosphates

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Abietadiene Synthase Catalysis: Conserved Residues Involved in Protonation-Initiated Cyclization of Geranylgeranyl Diphosphate to (+)-Copalyl Diphosphate

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Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants ,

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Role of Arginine-304 in the Diphosphate-Triggered Active Site Closure Mechanism of Trichodiene Synthase,

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Structure and Reaction Geometry of Geranylgeranyl Diphosphate Synthase from Sinapis alba,

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X-ray Crystal Structure of Aristolochene Synthase from Aspergillus terreus and Evolution of Templates for the Cyclization of Farnesyl Diphosphate,

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Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates,

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Truncation of Limonene Synthase Preprotein Provides a Fully Active ‘Pseudomature' Form of This Monoterpene Cyclase and Reveals the Function of the Amino-Terminal Arginine Pair

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Structural Elucidation of Cisoid and Transoid Cyclization Pathways of a Sesquiterpene Synthase Using 2-Fluorofarnesyl Diphosphates

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Structural Biology and Chemistry of the Terpenoid Cyclases

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Enzymic cyclization of geranyl pyrophosphate to bornyl pyrophosphate. Role of the pyrophosphate moiety

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Bifunctional Abietadiene Synthase: Free Diffusive Transfer of the (+)-Copalyl Diphosphate Intermediate between Two Distinct Active Sites

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Cation−π Interaction in the Polyolefin Cyclization Cascade Uncovered by Incorporating Unnatural Amino Acids into the Catalytic Sites of Squalene Cyclase

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An Oxidosqualene Cyclase Makes Numerous Products by Diverse Mechanisms: A Challenge to Prevailing Concepts of Triterpene Biosynthesis

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A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase

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Effect of Isotopically Sensitive Branching on Product Distribution for Pentalenene Synthase: Support for a Mechanism Predicted by Quantum Chemistry

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Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch

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Pentalenene Synthase. Histidine-309 Is Not Required for Catalytic Activity

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Demonstration of Germacrene A as an Intermediate in 5-Epi-aristolochene Synthase Catalysis

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Designed divergent evolution of enzyme function

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inferredcites →https://doi.org/10.1039/b108995copenalex-snapshot

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inferredcites →https://doi.org/10.1039/b306867fopenalex-snapshot

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inferredcites →https://doi.org/10.1039/c0cc02960bopenalex-snapshot

Electrostatic effects on (di)terpene synthase product outcome

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Functional plasticity of paralogous diterpene synthases involved in conifer defense

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inferredcites →https://doi.org/10.1073/pnas.232591099openalex-snapshot

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inferredcites →https://doi.org/10.1073/pnas.93.13.6841openalex-snapshot

Identifying functional domains within terpene cyclases using a domain-swapping strategy.

inferredcites →https://doi.org/10.1073/pnas.93.26.15018openalex-snapshot

Regulation of product chain length by isoprenyl diphosphate synthases

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inferredcites →https://doi.org/10.1074/jbc.273.24.14891openalex-snapshot

Monoterpene Synthases from Common Sage (Salvia officinalis )

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Sesquiterpene Synthases from Grand Fir (Abies grandis)

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Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis

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Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti*

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Crystal Structure of Human Squalene Synthase

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Interaction with the Small Subunit of Geranyl Diphosphate Synthase Modifies the Chain Length Specificity of Geranylgeranyl Diphosphate Synthase to Produce Geranyl Diphosphate

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A Single Residue Switch for Mg2+-dependent Inhibition Characterizes Plant Class II Diterpene Cyclases from Primary and Secondary Metabolism

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The Primary Diterpene Synthase Products of Picea abies Levopimaradiene/Abietadiene Synthase (PaLAS) Are Epimers of a Thermally Unstable Diterpenol

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Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis

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Enzymes Encoded by the Farnesyl Diphosphate Synthase Gene Family in the Big Sagebrush Artemisia tridentata ssp. spiciformis

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Crystal Structure of Octaprenyl Pyrophosphate Synthase from Hyperthermophilic Thermotoga maritima and Mechanism of Product Chain Length Determination

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Crystal Structures of Undecaprenyl Pyrophosphate Synthase in Complex with Magnesium, Isopentenyl Pyrophosphate, and Farnesyl Thiopyrophosphate

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Crystal Structure of Type-III Geranylgeranyl Pyrophosphate Synthase from Saccharomyces cerevisiae and the Mechanism of Product Chain Length Determination

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The Crystal Structure of Human Geranylgeranyl Pyrophosphate Synthase Reveals a Novel Hexameric Arrangement and Inhibitory Product Binding

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X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis

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Genomic Organization of Plant Terpene Synthases and Molecular Evolutionary Implications

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Functional Characterization of Nine Norway Spruce TPS Genes and Evolution of Gymnosperm Terpene Synthases of the TPS-d Subfamily

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Identification and Functional Characterization of Monofunctionalent-Copalyl Diphosphate andent-Kaurene Synthases in White Spruce Reveal Different Patterns for Diterpene Synthase Evolution for Primary and Secondary Metabolism in Gymnosperms

inferredcites →https://doi.org/10.1104/pp.110.168799openalex-snapshot

Structure and Mechanism of an Arabidopsis Medium/Long-Chain-Length Prenyl Pyrophosphate Synthase

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Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function

inferredcites →https://doi.org/10.1105/tpc.107.057885openalex-snapshot

A Novel Pathway for Sesquiterpene Biosynthesis fromZ,Z-Farnesyl Pyrophosphate in the Wild TomatoSolanum habrochaites

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Structure of a Heterotetrameric Geranyl Pyrophosphate Synthase from Mint ( Mentha piperita ) Reveals Intersubunit Regulation

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The family of terpene synthases in plants: a mid‐size family of genes for specialized metabolism that is highly diversified throughout the kingdom

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Domain loss has independently occurred multiple times in plant terpene synthase evolution

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Divergent evolution of oxidosqualene cyclases in plants

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Chimeras of Two Isoprenoid Synthases Catalyze All Four Coupling Reactions in Isoprenoid Biosynthesis

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Structure and Function of a Squalene Cyclase

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Structural Basis for Cyclic Terpene Biosynthesis by Tobacco 5-Epi-Aristolochene Synthase

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Homodimeric Hexaprenyl Pyrophosphate Synthase from the Thermoacidophilic Crenarchaeon Sulfolobus solfataricus Displays Asymmetric Subunit Structures

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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A Concise Route to the Strongylophorines

inferred← citeshttps://doi.org/10.1002/ange.201711444openalex-snapshot

Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds

inferred← citeshttps://doi.org/10.1002/ange.201812216openalex-snapshot

Eine verzweigte Diterpenkaskade: der Mechanismus der Spinodien‐Synthase aus Saccharopolyspora spinosa

inferred← citeshttps://doi.org/10.1002/ange.201813722openalex-snapshot

Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis

inferred← citeshttps://doi.org/10.1002/ange.202301601openalex-snapshot

Methylierung nicht‐aktivierter Alkene mit modifizierten Methyltransferasen zur Diversifizierung von Terpenoiden

inferred← citeshttps://doi.org/10.1002/ange.202401669openalex-snapshot

Discovery, Structure, and Engineering of a cis‐Geranylfarnesyl Diphosphate Synthase

inferred← citeshttps://doi.org/10.1002/ange.202416441openalex-snapshot

Unlocking Oxetane Potential: Modular Synthetic Platform for the Concise Synthesis of Acyclic Oligo‐Isoprenoids and Terpenoids

inferred← citeshttps://doi.org/10.1002/ange.4023427openalex-snapshot

Ligand‐Controlled Chemodivergent Telomerization and Hydrofunctionalization of Isoprene With Hydrazones Under Ni Catalysis

inferred← citeshttps://doi.org/10.1002/anie.201301362openalex-snapshot

High‐Throughput Screening for Terpene‐Synthase‐Cyclization Activity and Directed Evolution of a Terpene Synthase

inferred← citeshttps://doi.org/10.1002/anie.201402087openalex-snapshot

Entropy is Key to the Formation of Pentacyclic Terpenoids by Enzyme‐Catalyzed Polycyclization

inferred← citeshttps://doi.org/10.1002/anie.201407883openalex-snapshot

Terpenoid Biosynthesis Off the Beaten Track: Unconventional Cyclases and Their Impact on Biomimetic Synthesis

inferred← citeshttps://doi.org/10.1002/anie.201602476openalex-snapshot

A Concise Route to the Strongylophorines

inferred← citeshttps://doi.org/10.1002/anie.201711444openalex-snapshot

Diverged Plant Terpene Synthases Reroute the Carbocation Cyclization Path towards the Formation of Unprecedented 6/11/5 and 6/6/7/5 Sesterterpene Scaffolds

inferred← citeshttps://doi.org/10.1002/anie.201812216openalex-snapshot

A Branched Diterpene Cascade: The Mechanism of Spinodiene Synthase from Saccharopolyspora spinosa

inferred← citeshttps://doi.org/10.1002/anie.201813722openalex-snapshot

Unprecedented [5.5.5.6]Dioxafenestrane Ring Construction in Fungal Insecticidal Sesquiterpene Biosynthesis

inferred← citeshttps://doi.org/10.1002/anie.202301601openalex-snapshot

Methylation of Unactivated Alkenes with Engineered Methyltransferases To Generate Non‐natural Terpenoids

inferred← citeshttps://doi.org/10.1002/anie.202401669openalex-snapshot

Discovery, Structure, and Engineering of a cis‐Geranylfarnesyl Diphosphate Synthase

inferred← citeshttps://doi.org/10.1002/anie.202416441openalex-snapshot

Unlocking Oxetane Potential: Modular Synthetic Platform for the Concise Synthesis of Acyclic Oligo‐Isoprenoids and Terpenoids

inferred← citeshttps://doi.org/10.1002/anie.4023427openalex-snapshot

Ligand‐Controlled Chemodivergent Telomerization and Hydrofunctionalization of Isoprene With Hydrazones Under Ni Catalysis

inferred← citeshttps://doi.org/10.1002/cbic.201200651openalex-snapshot

Identification and Characterization of Bacterial Diterpene Cyclases that Synthesize the Cembrane Skeleton

inferred← citeshttps://doi.org/10.1002/cbic.201402443openalex-snapshot

Characterization of the Gene Cluster CYP264B1‐geoA from Sorangium cellulosum So ce56: Biosynthesis of (+)‐Eremophilene and Its Hydroxylation

inferred← citeshttps://doi.org/10.1002/cbic.201500417openalex-snapshot

New Sesquiterpene Oxidations with CYP260A1 and CYP264B1 from Sorangium cellulosum So ce56

inferred← citeshttps://doi.org/10.1002/cbic.201700443openalex-snapshot

Protonation‐Initiated Cyclization by a Class II Terpene Cyclase Assisted by Tunneling

inferred← citeshttps://doi.org/10.1002/cbic.201700445openalex-snapshot

Identification of Chimeric αβγ Diterpene Synthases Possessing both Type II Terpene Cyclase and Prenyltransferase Activities

inferred← citeshttps://doi.org/10.1002/cbic.201700508openalex-snapshot

Tandem Biocatalysis Unlocks the Challenging de Novo Production of Plant Natural Products

inferred← citeshttps://doi.org/10.1002/cbic.201800120openalex-snapshot

Chimeric Terpene Synthases Possessing both Terpene Cyclization and Prenyltransfer Activities

inferred← citeshttps://doi.org/10.1002/cbic.202100464openalex-snapshot

New Trends and Future Opportunities in the Enzymatic Formation of C−C, C−N, and C−O bonds

inferred← citeshttps://doi.org/10.1002/cbic.202100465openalex-snapshot

Engineering of a Plant Isoprenyl Diphosphate Synthase for Development of Irregular Coupling Activity

inferred← citeshttps://doi.org/10.1002/cbic.202200211openalex-snapshot

Heterocyclic and Alkyne Terpenoids by Terpene Synthase‐Mediated Biotransformation of Non‐Natural Prenyl Diphosphates: Access to New Fragrances and Probes

inferred← citeshttps://doi.org/10.1002/cbic.202300518openalex-snapshot

Terpene Synthases in the Biosynthesis of Drimane‐Type Sesquiterpenes across Diverse Organisms

inferred← citeshttps://doi.org/10.1002/cctc.201300285openalex-snapshot

Targeted Engineering of Cyclooctat‐9‐en‐7‐ol Synthase: A Stereospecific Access to Two New Non‐natural Fusicoccane‐Type Diterpenes

inferred← citeshttps://doi.org/10.1002/cctc.201300733openalex-snapshot

Production of Macrocyclic Sesqui‐ and Diterpenes in Heterologous Microbial Hosts: A Systems Approach to Harness Nature’s Molecular Diversity

inferred← citeshttps://doi.org/10.1002/cctc.201700734openalex-snapshot

Selectivity in the Cyclization of Citronellal Introduced by Squalene Hopene Cyclase Variants

inferred← citeshttps://doi.org/10.1002/cjoc.202100663openalex-snapshot

Distinctive Cassane Diterpenoids Corroborated Biogenetic Evolutionary Process from Caesalpinia mimosoides with Anti‐renal Fibrosis Activity

inferred← citeshttps://doi.org/10.1002/fbe2.12021openalex-snapshot

Combination of protein engineering and metabolic engineering to enhance (+)‐nootkatone production in Saccharomyces cerevisiae

inferred← citeshttps://doi.org/10.1002/ijch.201800006openalex-snapshot

Gold(I)‐Catalysis for the Synthesis of Terpenoids: From Intramolecular Cascades to Intermolecular Cycloadditions

inferred← citeshttps://doi.org/10.1002/jcc.25184openalex-snapshot

Molecular dynamics study of taxadiene synthase catalysis

inferred← citeshttps://doi.org/10.1002/prot.24818openalex-snapshot

Manual classification strategies in the ECOD database

inferred← citeshttps://doi.org/10.1002/slct.201600572openalex-snapshot

Substrate Pre‐Folding and Water Molecule Organization Matters for Terpene Cyclase Catalyzed Conversion of Unnatural Substrates

inferred← citeshttps://doi.org/10.1007/10_2014_283openalex-snapshot

Biosynthesis of Terpenoid Natural Products in Fungi

inferred← citeshttps://doi.org/10.1007/10_2014_295openalex-snapshot

Biosynthesis and Biological Functions of Terpenoids in Plants

inferred← citeshttps://doi.org/10.1007/10_2015_308openalex-snapshot

Enzymes for Synthetic Biology of Ambroxide-Related Diterpenoid Fragrance Compounds

inferred← citeshttps://doi.org/10.1007/978-3-030-65775-8_23openalex-snapshot

Computational Simulations for Cyclizations Catalyzed by Plant Monoterpene Synthases

inferred← citeshttps://doi.org/10.1007/978-3-319-04045-5_5openalex-snapshot

Bioproducts, Biofuels, and Perfumes: Conifer Terpene Synthases and their Potential for Metabolic Engineering

inferred← citeshttps://doi.org/10.1007/978-3-319-19144-7_4openalex-snapshot

Essential Oils as Raw Materials in the Synthesis of Anticancer Drugs

inferred← citeshttps://doi.org/10.1007/978-3-319-39126-7_1openalex-snapshot

Carotenoid Distribution in Nature

inferred← citeshttps://doi.org/10.1007/978-3-319-43676-0_6-1openalex-snapshot

Formation of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-3-319-50430-8_6openalex-snapshot

Formation of Isoprenoids

inferred← citeshttps://doi.org/10.1007/978-981-10-1085-9_5openalex-snapshot

Deciphering the Biosynthetic Pathways of Bioactive Compounds In Planta Using Omics Approaches

inferred← citeshttps://doi.org/10.1007/978-981-13-8840-8_8openalex-snapshot

Bioenergy: Plants and Products

inferred← citeshttps://doi.org/10.1007/s00217-018-3046-zopenalex-snapshot

Phytochemical and sensorial characterization of Hyssopus officinalis subsp. aristatus (godr.) Nyman (Lamiaceae) by GC–MS, HPLC–UV–DAD, spectrophotometric assays and e-nose with aid of chemometric techniques

inferred← citeshttps://doi.org/10.1007/s00239-020-09930-8openalex-snapshot

On the Evolution and Functional Diversity of Terpene Synthases in the Pinus Species: A Review

inferred← citeshttps://doi.org/10.1007/s00253-019-10008-9openalex-snapshot

Effects on varietal aromas during wine making: a review of the impact of varietal aromas on the flavor of wine

inferred← citeshttps://doi.org/10.1007/s00253-025-13540-zopenalex-snapshot

Engineering Sanghuangporus sanghuang for enhanced (-)-aristolone production via metabolic pathway optimization and terpene synthase engineering

inferred← citeshttps://doi.org/10.1007/s00284-020-01878-8openalex-snapshot

Hitherto Unknown Terpene Synthase Organization in Taxol-Producing Endophytic Bacteria Isolated from Marine Macroalgae

inferred← citeshttps://doi.org/10.1007/s00425-018-2986-7openalex-snapshot

In planta and in silico characterization of five sesquiterpene synthases from Vitis vinifera (cv. Shiraz) berries

inferred← citeshttps://doi.org/10.1007/s00425-018-3056-xopenalex-snapshot

Terpenes and isoprenoids: a wealth of compounds for global use

inferred← citeshttps://doi.org/10.1007/s00425-021-03586-4openalex-snapshot

Comparative transcriptome analysis of sesquiterpene biosynthesis and functional characterization of sesquiterpene synthases in Leonurus sibiricus L

inferred← citeshttps://doi.org/10.1007/s00425-024-04363-9openalex-snapshot

Insights into taxadiene synthase catalysis and promiscuity facilitated by mutability landscape and molecular dynamics

inferred← citeshttps://doi.org/10.1007/s00894-016-3021-1openalex-snapshot

Structure-based virtual screening of hypothetical inhibitors of the enzyme longiborneol synthase—a potential target to reduce Fusarium head blight disease

inferred← citeshttps://doi.org/10.1007/s10295-016-1802-2openalex-snapshot

Functional characterization of a geraniol synthase-encoding gene from Camptotheca acuminata and its application in production of geraniol in Escherichia coli

inferred← citeshttps://doi.org/10.1007/s10295-017-1967-3openalex-snapshot

A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli

inferred← citeshttps://doi.org/10.1007/s11030-019-10022-zopenalex-snapshot

Unexpected regio- and stereoselective [4 + 3] cycloaddition reaction of azomethine ylides with benzylidene thiazolidinediones: synthesis of pharmacologically active spiroindoline oxazepine derivatives and theoretical study

inferred← citeshttps://doi.org/10.1007/s11103-020-01068-xopenalex-snapshot

Direct formation of the sesquiterpeonid ether liguloxide by a terpene synthase in Senecio scandens

inferred← citeshttps://doi.org/10.1007/s11426-016-0076-6openalex-snapshot

Recent advances in terpenoid syntheses from China

inferred← citeshttps://doi.org/10.1007/s11676-022-01542-wopenalex-snapshot

Identification of sesquiterpene synthase genes in the genome of Aquilaria sinensis and characterization of an α-humulene synthase

inferred← citeshttps://doi.org/10.1007/s12272-025-01588-4openalex-snapshot

Diterpenoids from the genus Croton and their biological activities

inferred← citeshttps://doi.org/10.1007/s12298-021-01040-zopenalex-snapshot

Genome-wide detection and classification of terpene synthase genes in Aquilaria agallochum

inferred← citeshttps://doi.org/10.1007/s13313-020-00737-1openalex-snapshot

Secondary metabolite gene clusters arrangement and conservation within the genome of Stemphylium lycopersici codes the pathways for the synthesis of specific and non-specific toxins

inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14563-9openalex-snapshot

Structural Biology of Template-Directed Catalysis by Terpene Synthases

inferred← citeshttps://doi.org/10.1016/b978-0-12-809270-5.00019-4openalex-snapshot

Biocatalysis

inferred← citeshttps://doi.org/10.1016/b978-0-12-823304-7.00001-5openalex-snapshot

Astaxanthin-biological production and regulation for enhanced yields

inferred← citeshttps://doi.org/10.1016/b978-0-32-390644-9.00127-xopenalex-snapshot

Carbon–Carbon Bond Formation Via Biocatalytic Transformations

inferred← citeshttps://doi.org/10.1016/b978-0-323-95590-4.00011-4openalex-snapshot

Metabolic engineering of green chemical biosynthesis

inferred← citeshttps://doi.org/10.1016/b978-0-444-63281-4.00014-8openalex-snapshot

The Synthesis of Seven-Membered Rings in Natural Products

inferred← citeshttps://doi.org/10.1016/b978-0-444-63475-7.00002-9openalex-snapshot

Secondary Metabolism for Isoprenoid-based Biofuels

inferred← citeshttps://doi.org/10.1016/b978-0-444-63929-5.00005-xopenalex-snapshot

Chemistry and Bioactivity of ent -Kaurene Diterpenoids

inferred← citeshttps://doi.org/10.1016/bs.mie.2018.04.023openalex-snapshot

Identification of Enzymes Involved in Sesterterpene Biosynthesis in Marine Fungi

inferred← citeshttps://doi.org/10.1016/bs.mie.2023.11.003openalex-snapshot

Methods for the preparation and analysis of the diterpene cyclase fusicoccadiene synthase

inferred← citeshttps://doi.org/10.1016/bs.mie.2024.02.006openalex-snapshot

Docking carbocations into terpene synthase active sites using chemically meaningful constraints—The TerDockin approach

inferred← citeshttps://doi.org/10.1016/bs.mie.2024.03.012openalex-snapshot

Structural biology of terpene synthases

inferred← citeshttps://doi.org/10.1016/j.abb.2017.12.007openalex-snapshot

Mutational analysis and dynamic simulation of S-limonene synthase reveal the importance of Y573: Insight into the cyclization mechanism in monoterpene synthases

inferred← citeshttps://doi.org/10.1016/j.abb.2021.108986openalex-snapshot

Transcriptome sequencing and functional characterization of new sesquiterpene synthases from Curcuma wenyujin

inferred← citeshttps://doi.org/10.1016/j.apsb.2017.12.012openalex-snapshot

Epigenetic modification in histone deacetylase deletion strain of Calcarisporium arbuscula leads to diverse diterpenoids

inferred← citeshttps://doi.org/10.1016/j.bbagen.2013.09.004openalex-snapshot

1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis

inferred← citeshttps://doi.org/10.1016/j.bbrc.2025.152271openalex-snapshot

Structural insights into monoterpene cyclisation of limonene synthase from Cannabis sativa

inferred← citeshttps://doi.org/10.1016/j.biortech.2025.133712openalex-snapshot

Metabolic flux balancing and enhanced expression of engineered Paeonia lactiflora pinene synthase for high-yield α-pinene production in Serratia marcescens HBQA7

inferred← citeshttps://doi.org/10.1016/j.cbpa.2013.01.016openalex-snapshot

Squalene hopene cyclases: highly promiscuous and evolvable catalysts for stereoselective C C and C X bond formation

inferred← citeshttps://doi.org/10.1016/j.chempr.2019.04.023openalex-snapshot

Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids

inferred← citeshttps://doi.org/10.1016/j.fbio.2026.109896openalex-snapshot

Sustainable biosynthesis of levopimaradiene, a key precursor of bioactive ginkgolides, in Escherichia coli through cross-kingdom pathway engineering

inferred← citeshttps://doi.org/10.1016/j.febslet.2014.10.031openalex-snapshot

Molecular cloning and characterization of drimenol synthase from valerian plant (Valeriana officinalis)

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27817openalex-snapshot

Identification and expression analysis of TPS family gene in Cannabis sativa L

inferred← citeshttps://doi.org/10.1016/j.indcrop.2021.113875openalex-snapshot

Integrating GC-MS and ssRNA-Seq analysis to identify long non-coding RNAs related to terpenoid biosynthesis in Cinnamomum camphora

inferred← citeshttps://doi.org/10.1016/j.indcrop.2022.115609openalex-snapshot

Identification of TPS-d subfamily genes and functional characterization of three monoterpene synthases in slash pine

inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121264openalex-snapshot

Expression profiling and function analysis of PmLAS highlight the involvement in regulating resin yield of Pinus massoniana

inferred← citeshttps://doi.org/10.1016/j.indcrop.2025.121808openalex-snapshot

Identification of OjGBS, a terpene synthase involved in germacrene B biosynthesis in Oenanthe javanica

inferred← citeshttps://doi.org/10.1016/j.isci.2024.109441openalex-snapshot

Transcriptome-informed identification and characterization of Planococcus citri cis- and trans-isoprenyl diphosphate synthase genes

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107921openalex-snapshot

The crystal structure of Grindelia robusta 7,13-copalyl diphosphate synthase reveals active site features controlling catalytic specificity

inferred← citeshttps://doi.org/10.1016/j.jbc.2024.108142openalex-snapshot

Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades

inferred← citeshttps://doi.org/10.1016/j.jbiotec.2016.03.051openalex-snapshot

Screening for improved isoprenoid biosynthesis in microorganisms

inferred← citeshttps://doi.org/10.1016/j.jsb.2019.04.010openalex-snapshot

The structure of (E)-biformene synthase provides insights into the biosynthesis of bacterial bicyclic labdane-related diterpenoids

inferred← citeshttps://doi.org/10.1016/j.jsb.2019.05.011openalex-snapshot

Crystal structure of F95Q epi-isozizaene synthase, an engineered sesquiterpene cyclase that generates biofuel precursors β- and γ-curcumene

inferred← citeshttps://doi.org/10.1016/j.jsb.2025.108227openalex-snapshot

The product specificities of terpinolene synthase, from cannabis sativa, reveals the plasticity of the terpene synthase active site

inferred← citeshttps://doi.org/10.1016/j.mec.2018.e00077openalex-snapshot

Whole-cell (+)-ambrein production in the yeast Pichia pastoris

inferred← citeshttps://doi.org/10.1016/j.molp.2014.12.002openalex-snapshot

The Application of Synthetic Biology to Elucidation of Plant Mono-, Sesqui-, and Diterpenoid Metabolism

inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102189openalex-snapshot

Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis

inferred← citeshttps://doi.org/10.1016/j.phytochem.2017.02.017openalex-snapshot

Converting S-limonene synthase to pinene or phellandrene synthases reveals the plasticity of the active site

inferred← citeshttps://doi.org/10.1016/j.phytochem.2017.04.018openalex-snapshot

Scent from Jasminum grandiflorum flowers: Investigation of the change in linalool enantiomers at various developmental stages using chemical and molecular methods

inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.10.020openalex-snapshot

An analysis of characterized plant sesquiterpene synthases

inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.12.003openalex-snapshot

Cytochrome P450 enzymes: A driving force of plant diterpene diversity

inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112573openalex-snapshot

Probing of the plasticity of the active site in pinene synthase elucidates its potential evolutionary mechanism

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113380openalex-snapshot

Heterologous production of Cannabis sativa-derived specialised metabolites of medicinal significance – Insights into engineering strategies

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113419openalex-snapshot

Mining, expression, and phylogenetic analysis of volatile terpenoid biosynthesis-related genes in different tissues of ten Elsholtzia species based on transcriptomic analysis

inferred← citeshttps://doi.org/10.1016/j.phytochem.2026.114945openalex-snapshot

Functional characterization of a plant germacrene D-4-ol synthase enabling the production of bioactive α-cadinol and τ-muurolol under changed catalysis conditions

inferred← citeshttps://doi.org/10.1016/j.plantsci.2016.11.006openalex-snapshot

REVIEW: Epistasis and dominance in the emergence of catalytic function as exemplified by the evolution of plant terpene synthases

inferred← citeshttps://doi.org/10.1016/j.plantsci.2020.110790openalex-snapshot

Discovery and characterization of diterpene synthases in Chamaecyparis formosensis Matsum. which participated in an unprecedented diterpenoid biosynthesis route in conifer

inferred← citeshttps://doi.org/10.1016/j.plaphy.2021.04.028openalex-snapshot

Genome-wide identification and expression analysis of terpene synthase gene family in Aquilaria sinensis

inferred← citeshttps://doi.org/10.1016/j.plaphy.2026.111401openalex-snapshot

Functional characterization identified five sesquiterpene synthases that confer terpenoid diversity in Nardostachys jatamansi

inferred← citeshttps://doi.org/10.1016/j.sajb.2023.01.011openalex-snapshot

Isolation and characterization of full-length coding sequences of gibberellic acid biosynthetic genes in coconut (Cocos nucifera L.) and their expression analysis

inferred← citeshttps://doi.org/10.1016/j.sbi.2016.05.010openalex-snapshot

Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis

inferred← citeshttps://doi.org/10.1016/j.tetlet.2014.11.035openalex-snapshot

Constructive innovation of approaching bicyclo[3.2.1]octane in ent-kauranoids

inferred← citeshttps://doi.org/10.1016/j.tetlet.2023.154426openalex-snapshot

Three new phenylspirodrimanes from a conch-derived fungus Stachybotrys sp. NF02434

inferred← citeshttps://doi.org/10.1016/j.tibtech.2015.04.006openalex-snapshot

Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering

inferred← citeshttps://doi.org/10.1016/j.tibtech.2018.11.008openalex-snapshot

Discovery and Engineering of Cytochrome P450s for Terpenoid Biosynthesis

inferred← citeshttps://doi.org/10.1016/j.tplants.2017.09.014openalex-snapshot

MTPSLs: New Terpene Synthases in Nonseed Plants

inferred← citeshttps://doi.org/10.1016/j.xplc.2020.100051openalex-snapshot

Molecular Basis for Sesterterpene Diversity Produced by Plant Terpene Synthases

inferred← citeshttps://doi.org/10.1016/j.ymben.2020.03.011openalex-snapshot

Engineering chimeric diterpene synthases and isoprenoid biosynthetic pathways enables high-level production of miltiradiene in yeast

inferred← citeshttps://doi.org/10.1016/s1875-5364(22)60214-0openalex-snapshot

Biosynthesis and regulation of diterpenoids in medicinal plants

inferred← citeshttps://doi.org/10.1017/s1479262123000953openalex-snapshot

Targeted metabolite profiling and de novo transcriptome sequencing reveal the key terpene synthase genes in medicinally important plant, Couroupita guianensis Aubl

inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00206openalex-snapshot

Determinants of Enantiospecificity in Limonene Synthases

inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00762openalex-snapshot

Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c

inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00876openalex-snapshot

An Aromatic Cluster in the Active Site of epi-Isozizaene Synthase Is an Electrostatic Toggle for Divergent Terpene Cyclization Pathways

inferred← citeshttps://doi.org/10.1021/acs.biochem.2c00509openalex-snapshot

Transient Prenyltransferase–Cyclase Association in Fusicoccadiene Synthase, an Assembly-Line Terpene Synthase

inferred← citeshttps://doi.org/10.1021/acs.biochem.5b01143openalex-snapshot

Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization–Fragmentation Reaction Sequence

inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00143openalex-snapshot

Functional and Structural Characterization of a (+)-Limonene Synthase from Citrus sinensis

inferred← citeshttps://doi.org/10.1021/acs.biochem.7b00895openalex-snapshot

Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes

inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00899openalex-snapshot

Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene

inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00287openalex-snapshot

Structural and Chemical Biology of Terpenoid Cyclases

inferred← citeshttps://doi.org/10.1021/acs.jafc.3c07573openalex-snapshot

Identification and Characterization of a Nerol Synthase in Fungi

inferred← citeshttps://doi.org/10.1021/acs.jafc.4c06818openalex-snapshot

Identification and Characterization of a Fungal Monoterpene Synthase Responsible for the Biosynthesis of Geraniol

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c01176openalex-snapshot

Identification and Characterization of a Novel Multifunctional Terpene Synthase from the Pathogenic Fungus Cochliobolus heterostrophus

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c08449openalex-snapshot

Engineering Plant Terpene Synthase Pt PS30 for Enhanced Biopesticide Precursor Synthesis: Synergistic Optimization via Homologous Sequence Alignment and Structure-Guided Engineering

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00752openalex-snapshot

Unusual Sesquiterpenes from Streptomyces olindensis DAUFPE 5622

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00236openalex-snapshot

Insights into the Three-Dimensional Structure of Amorpha-4,11-diene Synthase and Probing of Plasticity Residues

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b01033openalex-snapshot

Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis

inferred← citeshttps://doi.org/10.1021/acs.joc.2c02188openalex-snapshot

Origins of Stereospecificity and Divergent Reactivity of Pd-Catalyzed Cross Coupling with α,α-Disubstituted Alkenyl Hydrazones

inferred← citeshttps://doi.org/10.1021/acs.joc.9b01996openalex-snapshot

Mimicking Halimane Synthases: Monitoring a Cascade of Cyclizations and Rearrangements from Epoxypolyprenes

inferred← citeshttps://doi.org/10.1021/acs.orglett.5b02404openalex-snapshot

Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases

inferred← citeshttps://doi.org/10.1021/acs.orglett.5c00858openalex-snapshot

The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum

inferred← citeshttps://doi.org/10.1021/acs.orglett.5c01879openalex-snapshot

Expanding the Diversity of the Terpene Skeleton and Structure through Identification of Noncanonical Class IE and IF Terpene Synthase-Formed Products

inferred← citeshttps://doi.org/10.1021/acs.orglett.6b02977openalex-snapshot

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues

inferred← citeshttps://doi.org/10.1021/acs.orglett.7b00586openalex-snapshot

(+)-Thalianatriene and (−)-Retigeranin B Catalyzed by Sesterterpene Synthases from Arabidopsis thaliana

inferred← citeshttps://doi.org/10.1021/acs.orglett.7b02653openalex-snapshot

Late-Stage Terpene Cyclization by an Integral Membrane Cyclase in the Biosynthesis of Isoprenoid Epoxycyclohexenone Natural Products

inferred← citeshttps://doi.org/10.1021/acs.orglett.8b00121openalex-snapshot

Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase

inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.2c00023openalex-snapshot

Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence

inferred← citeshttps://doi.org/10.1021/acscatal.1c03691openalex-snapshot

Cytochrome P450-Catalyzed Biosynthesis of a Dihydrofuran Neoclerodane in Magic Mint ( Salvia divinorum )

inferred← citeshttps://doi.org/10.1021/acscatal.2c01836openalex-snapshot

Determinants of Selectivity for the Formation of Monocyclic and Bicyclic Products in Monoterpene Synthases

inferred← citeshttps://doi.org/10.1021/acscatal.2c03155openalex-snapshot

How a 10-epi-Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity

inferred← citeshttps://doi.org/10.1021/acscatal.3c03047openalex-snapshot

Decoding Catalysis by Terpene Synthases

inferred← citeshttps://doi.org/10.1021/acscatal.4c05811openalex-snapshot

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning” Method for Mechanistic Investigations of Terpene Cyclases

inferred← citeshttps://doi.org/10.1021/acscatal.5b00947openalex-snapshot

Protonation-Triggered Carbon-Chain Elongation in Geranyl Pyrophosphate Synthase (GPPS)

inferred← citeshttps://doi.org/10.1021/acscatal.7b01924openalex-snapshot

Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase

inferred← citeshttps://doi.org/10.1021/acscatal.8b00692openalex-snapshot

Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome

inferred← citeshttps://doi.org/10.1021/acschembio.0c00145openalex-snapshot

Characterization of Class IB Terpene Synthase: The First Crystal Structure Bound with a Substrate Surrogate

inferred← citeshttps://doi.org/10.1021/acschembio.0c00645openalex-snapshot

Enzymatic Plasticity Inspired by the Diterpene Cyclase CotB2

inferred← citeshttps://doi.org/10.1021/acschembio.2c00163openalex-snapshot

Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin

inferred← citeshttps://doi.org/10.1021/acschembio.5b00539openalex-snapshot

Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases

inferred← citeshttps://doi.org/10.1021/acschembio.5c00678openalex-snapshot

Expanding the Structural Diversity of Sesquarterpenes through Genome Mining of Noncanonical Class IB Terpene Synthases

inferred← citeshttps://doi.org/10.1021/acschembio.9b00218openalex-snapshot

Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product

inferred← citeshttps://doi.org/10.1021/acschembio.9b00514openalex-snapshot

Direct Evidence of an Enzyme-Generated LPP Intermediate in (+)-Limonene Synthase Using a Fluorinated GPP Substrate Analog

inferred← citeshttps://doi.org/10.1021/acsomega.8b00644openalex-snapshot

Polymers of Limonene Oxide and Carbon Dioxide: Polycarbonates of the Solar Economy

inferred← citeshttps://doi.org/10.1021/acssynbio.4c00865openalex-snapshot

Promiscuity of an Alcohol-Dependent Hemiterpene Pathway for the In Vivo Production of a Non-Natural Alkylated Tryptophan Derivative

inferred← citeshttps://doi.org/10.1021/ct500607nopenalex-snapshot

Mechanism of Assembling Isoprenoid Building Blocks 1. Elucidation of the Structural Motifs for Substrate Binding in Geranyl Pyrophosphate Synthase

inferred← citeshttps://doi.org/10.1021/ja311022sopenalex-snapshot

Probing the Mechanism of 1,4-Conjugate Elimination Reactions Catalyzed by Terpene Synthases

inferred← citeshttps://doi.org/10.1021/ja312503yopenalex-snapshot

The Fumagillin Biosynthetic Gene Cluster in Aspergillus fumigatus Encodes a Cryptic Terpene Cyclase Involved in the Formation of β-trans-Bergamotene

inferred← citeshttps://doi.org/10.1021/ja5066366openalex-snapshot

Evolutionary and Mechanistic Insights from the Reconstruction of α-Humulene Synthases from a Modern (+)-Germacrene A Synthase

inferred← citeshttps://doi.org/10.1021/ja508127qopenalex-snapshot

Complete Biosynthetic Pathway of Anditomin: Nature’s Sophisticated Synthetic Route to a Complex Fungal Meroterpenoid

inferred← citeshttps://doi.org/10.1021/ja508477eopenalex-snapshot

Biosynthesis of Lycosantalonol, a cis -Prenyl Derived Diterpenoid

inferred← citeshttps://doi.org/10.1021/jacs.0c09994openalex-snapshot

Biocatalytic Construction of Quaternary Centers by Aldol Addition of 3,3-Disubstituted 2-Oxoacid Derivatives to Aldehydes

inferred← citeshttps://doi.org/10.1021/jacs.2c09412openalex-snapshot

Discovery, Structure, and Mechanism of a Class II Sesquiterpene Cyclase

inferred← citeshttps://doi.org/10.1021/jacs.3c10603openalex-snapshot

Function and Structure of a Terpene Synthase Encoded in a Giant Virus Genome

inferred← citeshttps://doi.org/10.1021/jacs.6b04317openalex-snapshot

Structure of the ent -Copalyl Diphosphate Synthase PtmT2 from Streptomyces platensis CB00739, a Bacterial Type II Diterpene Synthase

inferred← citeshttps://doi.org/10.1021/jacs.6b05799openalex-snapshot

Genome-Based Discovery of an Unprecedented Cyclization Mode in Fungal Sesterterpenoid Biosynthesis

inferred← citeshttps://doi.org/10.1021/jacs.6c04151openalex-snapshot

Dimerization-Dependent Trans-Domain Coupling Enables Intermediate Transfer in Fungal Haloacid Dehalogenase-Like Terpene Cyclases

inferred← citeshttps://doi.org/10.1021/jacs.6c10016openalex-snapshot

Biosynthesis of Crinipellin Diterpenes in Mushroom Marasmius fiardii PR-910

inferred← citeshttps://doi.org/10.1021/jacs.7b09452openalex-snapshot

A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-Scale NMR-Coupled Crystalline Sponge X-ray Diffraction Analysis

inferred← citeshttps://doi.org/10.1021/jacs.8b10522openalex-snapshot

Enantioselective Conversion of Oligoprenol Derivatives to Macrocycles in the Germacrene, Cembrene, and 18-Membered Cyclic Sesterterpene Series

inferred← citeshttps://doi.org/10.1021/jacs.9b00131openalex-snapshot

Site-Selective Functionalization of Linear Diterpenoids through U-Shaped Folding in a Confined Artificial Cavity

inferred← citeshttps://doi.org/10.1038/nature14559openalex-snapshot

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

inferred← citeshttps://doi.org/10.1038/nchembio.1719openalex-snapshot

Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis

inferred← citeshttps://doi.org/10.1038/nrmicro3496openalex-snapshot

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

inferred← citeshttps://doi.org/10.1038/s41437-018-0058-1openalex-snapshot

Annotation of the Corymbia terpene synthase gene family shows broad conservation but dynamic evolution of physical clusters relative to Eucalyptus

inferred← citeshttps://doi.org/10.1038/s41467-023-39706-9openalex-snapshot

Molecular insights into the catalytic promiscuity of a bacterial diterpene synthase

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