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4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/hep.510290510openalex-snapshot
Regulation of Rat Hepatocyte Protein Kinase C β Isoenzymes by the Lipid Peroxidation Product 4–Hydroxy–2,3–Nonenal: A Signaling Pathway to Modulate Vesicular Transport of Glycoproteins
inferredcites →https://doi.org/10.1006/abbi.1995.1028openalex-snapshot
The Hepatocellular Metabolism of 4-Hydroxynonenal by Alcohol Dehydrogenase, Aldehyde Dehydrogenase, and Glutathione S-Transferase
inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
inferredcites →https://doi.org/10.1006/bbrc.1999.0389openalex-snapshot
The Influence of SV40 Immortalization of Human Fibroblasts on p53-Dependent Radiation Responses
inferredcites →https://doi.org/10.1006/bbrc.2001.4707openalex-snapshot
Two Distinct 4-Hydroxynonenal Metabolizing Glutathione S-Transferase Isozymes Are Differentially Expressed in Human Tissues
inferredcites →https://doi.org/10.1006/scbi.1998.0098openalex-snapshot
p53 and apoptosis
inferredcites →https://doi.org/10.1006/taap.1996.0152openalex-snapshot
4-Hydroxynonenal-Induced Cell Death in Murine Alveolar Macrophages
inferredcites →https://doi.org/10.1006/taap.1996.8070openalex-snapshot
Increased Resistance to Oxidative Stress in Transfected Cultured Cells Overexpressing GlutathioneS-Transferase mGSTA4-4
inferredcites →https://doi.org/10.1007/978-3-642-65340-7_19openalex-snapshot
Retinal Metabolism in Dark and Light
inferredcites →https://doi.org/10.1007/s10384-003-0043-xopenalex-snapshot
Ionizing Radiation Induces a p53-dependent Apoptotic Mechanism in ARPE-19 Cells
inferredcites →https://doi.org/10.1016/0022-1759(83)90303-4openalex-snapshot
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
inferredcites →https://doi.org/10.1016/0092-8674(92)90593-2openalex-snapshot
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
inferredcites →https://doi.org/10.1016/0092-8674(93)90500-popenalex-snapshot
WAF1, a potential mediator of p53 tumor suppression
inferredcites →https://doi.org/10.1016/0092-8674(94)90543-6openalex-snapshot
Cyclins and cancer II: Cyclin D and CDK inhibitors come of age
inferredcites →https://doi.org/10.1016/0092-8674(95)90412-3openalex-snapshot
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
inferredcites →https://doi.org/10.1016/0092-8674(95)90513-8openalex-snapshot
A novel form of Epstein-Barr virus latency in normal B cells in vivo
inferredcites →https://doi.org/10.1016/0891-5849(91)90192-6openalex-snapshot
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
inferredcites →https://doi.org/10.1016/j.bbrc.2005.06.099openalex-snapshot
Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.05.033openalex-snapshot
Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.08.027openalex-snapshot
Signaling kinases modulated by 4-hydroxynonenal
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2004.10.014openalex-snapshot
4-Hydroxynonenal modulation of p53 family gene expression in the SK-N-BE neuroblastoma cell line
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2006.04.005openalex-snapshot
c-Jun N-terminal kinase upregulation as a key event in the proapoptotic interaction between transforming growth factor-β1 and 4-hydroxynonenal in colon mucosa
inferredcites →https://doi.org/10.1016/j.taap.2003.10.001openalex-snapshot
Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse
inferredcites →https://doi.org/10.1016/s0014-4835(03)00023-xopenalex-snapshot
Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
inferredcites →https://doi.org/10.1016/s0021-9258(18)47344-9openalex-snapshot
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
inferredcites →https://doi.org/10.1016/s0092-8674(00)80416-xopenalex-snapshot
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
inferredcites →https://doi.org/10.1016/s0092-8674(00)81774-2openalex-snapshot
Signaling to p53
inferredcites →https://doi.org/10.1016/s0092-8674(00)81871-1openalex-snapshot
p53, the Cellular Gatekeeper for Growth and Division
inferredcites →https://doi.org/10.1016/s0098-2997(03)00017-7openalex-snapshot
Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
inferredcites →https://doi.org/10.1016/s0098-2997(03)00020-7openalex-snapshot
Oxidized LDL and 4-hydroxynonenal modulate tyrosine kinase receptor activity
inferredcites →https://doi.org/10.1016/s0098-2997(03)00021-9openalex-snapshot
4-Hydroxynonenal from pathology to physiology
inferredcites →https://doi.org/10.1016/s0169-328x(98)00339-8openalex-snapshot
Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin
inferredcites →https://doi.org/10.1021/bi701559fopenalex-snapshot
4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas
inferredcites →https://doi.org/10.1021/ja057358lopenalex-snapshot
Inhibition of Thioredoxin and Thioredoxin Reductase by 4-Hydroxy-2-nonenal in Vitro and in Vivo
inferredcites →https://doi.org/10.1038/nrm2395openalex-snapshot
Transcriptional control of human p53-regulated genes
inferredcites →https://doi.org/10.1038/sj.onc.1201404openalex-snapshot
DNA-damage-inducible p53 activity in SV40-transformed cells
inferredcites →https://doi.org/10.1038/sj.onc.1208615openalex-snapshot
The p53 pathway: positive and negative feedback loops
inferredcites →https://doi.org/10.1042/bj20020041openalex-snapshot
Cloning and expression of a novel Mu class murine glutathione transferase isoenzyme
inferredcites →https://doi.org/10.1074/jbc.274.4.2234openalex-snapshot
Activation of Stress Signaling Pathways by the End Product of Lipid Peroxidation
inferredcites →https://doi.org/10.1074/jbc.m106838200openalex-snapshot
Accelerated Metabolism and Exclusion of 4-Hydroxynonenal through Induction of RLIP76 and hGST5.8 Is an Early Adaptive Response of Cells to Heat and Oxidative Stress
inferredcites →https://doi.org/10.1074/jbc.m211134200openalex-snapshot
Electrophilic Prostaglandins and Lipid Aldehydes Repress Redox-sensitive Transcription Factors p53 and Hypoxia-inducible Factor by Impairing the Selenoprotein Thioredoxin Reductase
inferredcites →https://doi.org/10.1074/jbc.m305766200openalex-snapshot
Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis
inferredcites →https://doi.org/10.1074/jbc.m509065200openalex-snapshot
Identification of a Lipid Peroxidation Product as a Potential Trigger of the p53 Pathway
inferredcites →https://doi.org/10.1076/ceyr.22.3.165.5517openalex-snapshot
Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells
inferredcites →https://doi.org/10.1083/jcb.33.1.61openalex-snapshot
THE RENEWAL OF PHOTORECEPTOR CELL OUTER SEGMENTS
inferredcites →https://doi.org/10.1093/carcin/bgl111openalex-snapshot
Thioredoxin reductase is required for the inactivation of tumor suppressor p53 and for apoptosis induced by endogenous electrophiles
inferredcites →https://doi.org/10.1101/gad.11.24.3471openalex-snapshot
DNA damage induces phosphorylation of the amino terminus of p53
inferredcites →https://doi.org/10.1111/j.1432-1033.2004.04067.xopenalex-snapshot
Transfection with 4‐hydroxynonenal‐metabolizing glutathione S‐transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
inferredcites →https://doi.org/10.1126/science.281.5383.1677openalex-snapshot
Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53
inferredcites →https://doi.org/10.1126/science.290.5493.989openalex-snapshot
Role of BAX in the Apoptotic Response to Anticancer Agents
inferredcites →https://doi.org/10.1126/science.7878464openalex-snapshot
Apoptosis in the Pathogenesis and Treatment of Disease
inferredcites →https://doi.org/10.1128/jvi.65.12.6447-6453.1991openalex-snapshot
The ability of large T antigen to complex with p53 is necessary for the increased life span and partial transformation of human cells by simian virus 40
inferredcites →https://doi.org/10.1136/bjo.59.2.111-copenalex-snapshot
Handbook of Sensory Physiology
inferredcites →https://doi.org/10.1146/annurev.biochem.69.1.217openalex-snapshot
Apoptosis Signaling
inferredcites →https://doi.org/10.1159/000479441openalex-snapshot
Anti-Vascular Endothelial Growth Factors Protect Retinal Pigment Epithelium Cells Against Oxidation by Modulating Nitric Oxide Release and Autophagy
inferredcites →https://doi.org/10.1242/jcs.113.4.635openalex-snapshot
4-hydroxynonenal induces a cellular redox status-related activation of the caspase cascade for apoptotic cell death
inferredcites →https://doi.org/10.1523/jneurosci.17-13-05089.1997openalex-snapshot
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
inferredcites →https://doi.org/10.4161/cc.4.5.1672openalex-snapshot
Inhibition of p53 by Lentiviral Mediated sh RNA Abrogates G1 Arrest and Apoptosis in Retinal Pigmented Epithelial Cell Line

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4794612openalex-extracted
Molecular Mechanism of 4-Hydroxynonenal Induced Cell Death
inferred← citeshttps://doi.org/10.1002/9781119374947.ch12openalex-snapshot
Adipose Carbonylation and Mitochondrial Dysfunction
inferred← citeshttps://doi.org/10.1002/iub.2544openalex-snapshot
Identification of novel key molecular signatures in the pathogenesis of experimental diabetic retinopathy
inferred← citeshttps://doi.org/10.1002/jcp.28246openalex-snapshot
Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells
inferred← citeshttps://doi.org/10.1002/ptr.3297openalex-snapshot
Role of alpha class glutathione transferases (GSTs) in chemoprevention: GSTA1 and A4 overexpressing human leukemia (HL60) cells resist sulforaphane and curcumin induced toxicity
inferred← citeshttps://doi.org/10.1007/978-81-322-1533-2_8openalex-snapshot
Mechanisms of Chemopreventive Activity of Sulforaphane
inferred← citeshttps://doi.org/10.1007/978-981-13-6260-6_5openalex-snapshot
Aldehyde Dehydrogenase 2 and Heart Failure
inferred← citeshttps://doi.org/10.1007/s12015-026-11113-9openalex-snapshot
Differential Effects of Retinal Fatty Acids Under Oxidative Stress Reveal DHA’s Susceptibility to Ferroptosis and Polarity Disruption in iPSC Derived RPE Cells
inferred← citeshttps://doi.org/10.1007/s12017-011-8164-8openalex-snapshot
Naturally Occurring Genetic Variability in Expression of Gsta4 is Associated with Differential Survival of Axotomized Rat Motoneurons
inferred← citeshttps://doi.org/10.1016/b978-0-12-819672-4.00008-8openalex-snapshot
Microbiota, mucosal immunity, and Colon cancer
inferred← citeshttps://doi.org/10.1016/j.abb.2014.07.021openalex-snapshot
High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: Role in diabetic retinopathy
inferred← citeshttps://doi.org/10.1016/j.aninu.2021.08.003openalex-snapshot
Hydroxyproline alleviates 4-hydroxy-2-nonenal-induced DNA damage and apoptosis in porcine intestinal epithelial cells
inferred← citeshttps://doi.org/10.1016/j.arr.2015.09.002openalex-snapshot
RPE necroptosis in response to oxidative stress and in AMD
inferred← citeshttps://doi.org/10.1016/j.bbrc.2011.11.113openalex-snapshot
The expression and function of vascular endothelial growth factor in retinal pigment epithelial (RPE) cells is regulated by 4-hydroxynonenal (HNE) and glutathione S-transferaseA4-4
inferred← citeshttps://doi.org/10.1016/j.cbi.2010.12.018openalex-snapshot
Protective effect of rat aldo-keto reductase (AKR1C15) on endothelial cell damage elicited by 4-hydroxy-2-nonenal
inferred← citeshttps://doi.org/10.1016/j.exer.2010.10.007openalex-snapshot
Differential roles of AMPKα1 and AMPKα2 in regulating 4-HNE-induced RPE cell death and permeability
inferred← citeshttps://doi.org/10.1016/j.exer.2010.11.010openalex-snapshot
Role of 4-hydroxynonenal in epidermal growth factor receptor-mediated signaling in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1016/j.exer.2013.10.018openalex-snapshot
Lens specific RLIP76 transgenic mice show a phenotype similar to microphthalmia
inferred← citeshttps://doi.org/10.1016/j.exer.2014.04.014openalex-snapshot
Protective effect of a laser-induced sub-lethal temperature rise on RPE cells from oxidative stress
inferred← citeshttps://doi.org/10.1016/j.exer.2015.02.001openalex-snapshot
Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells
inferred← citeshttps://doi.org/10.1016/j.exer.2018.08.019openalex-snapshot
Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1016/j.exer.2018.12.011openalex-snapshot
A derivative of betulinic acid protects human Retinal Pigment Epithelial (RPE) cells from cobalt chloride-induced acute hypoxic stress
inferred← citeshttps://doi.org/10.1016/j.exer.2021.108902openalex-snapshot
Altered transsulfuration pathway enzymes and redox homeostasis in inherited retinal degenerative diseases
inferred← citeshttps://doi.org/10.1016/j.fct.2024.115095openalex-snapshot
The interplay of oxidative stress, apoptotic signaling, and impaired mitochondrial function in the pyrethroid-induced cardiac injury: Alleviative role of curcumin-loaded chitosan nanoparticle
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.04.012openalex-snapshot
Role of 4-hydroxynonenal in chemopreventive activities of sulforaphane
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2012.04.021openalex-snapshot
Inhibition of Hydrogen peroxide signaling by 4-hydroxynonenal due to differential regulation of Akt1 and Akt2 contributes to decreases in cell survival and proliferation in hepatocellular carcinoma cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.10.493openalex-snapshot
Regulatory roles of glutathione-S-transferases and 4-hydroxynonenal in stress-mediated signaling and toxicity
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.11.027openalex-snapshot
Ptgr1 expression is regulated by NRF2 in rat hepatocarcinogenesis and promotes cell proliferation and resistance to oxidative stress
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.11.032openalex-snapshot
4-hydroxynonenal-mediated signaling and aging
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.03.017openalex-snapshot
4-Hydroxy-7-oxo-5-heptenoic acid (HOHA) lactone induces apoptosis in retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2020.09.009openalex-snapshot
4-Hydroxy-7-oxo-5-heptenoic acid lactone can induce mitochondrial dysfunction in retinal pigmented epithelial cells
inferred← citeshttps://doi.org/10.1016/j.gendis.2026.102454openalex-snapshot
Molecular mechanisms of autologous ozonized blood transfusion: Antioxidant and anti-inflammatory effects
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.145082openalex-snapshot
Extracellular GMFB activates the non-canonical FAS-FAF1 pathway to induce lysosomal dysfunction in early diabetic retinopathy
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.150272openalex-snapshot
Oxidative stress in diabetic retinopathy: Metabolic triggers, molecular pathways and emerging antioxidant therapies
inferred← citeshttps://doi.org/10.1016/j.jgo.2014.04.005openalex-snapshot
Determinants of short- and long-term survival from colorectal cancer in very elderly patients
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2014.07.016openalex-snapshot
Docosahexaenoic acid aggravates photooxidative damage in retinal pigment epithelial cells via lipid peroxidation
inferred← citeshttps://doi.org/10.1016/j.kjms.2013.06.002openalex-snapshot
Pharmacological implications from the adhesion‐induced signaling profiles in cultured human retinal pigment epithelial cells
inferred← citeshttps://doi.org/10.1016/j.labinv.2022.100058openalex-snapshot
p53 Activates the Lipoxygenase Activity of ALOX15B via Inhibiting SLC7A11 to Induce Ferroptosis in Bladder Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.labinv.2024.102027openalex-snapshot
Mediation of Ferroptosis Suppressor Protein 1 Expression via 4-Hydroxy-2-Nonenal Accumulation Contributes to Acquisition of Resistance to Apoptosis and Ferroptosis in Diffuse Large B-Cell Lymphoma
inferred← citeshttps://doi.org/10.1016/j.molcel.2019.12.027openalex-snapshot
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks
inferred← citeshttps://doi.org/10.1016/j.neuint.2021.105118openalex-snapshot
Lipid peroxidation in brain tumors
inferred← citeshttps://doi.org/10.1016/j.redox.2020.101799openalex-snapshot
Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.redox.2022.102292openalex-snapshot
Glia maturation factor-β induces ferroptosis by impairing chaperone-mediated autophagic degradation of ACSL4 in early diabetic retinopathy
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102840openalex-snapshot
Comparative mechanistic study of RPE cell death induced by different oxidative stresses
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102967openalex-snapshot
Oxidative stress in the eye and its role in the pathophysiology of ocular diseases
inferred← citeshttps://doi.org/10.1016/j.taap.2015.10.006openalex-snapshot
Antioxidant role of glutathione S-transferases: 4-Hydroxynonenal, a key molecule in stress-mediated signaling
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.03.004openalex-snapshot
Nrf-2/Gst-α mediated imatinib resistance through rapid 4-HNE clearance
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.5b00485openalex-snapshot
Covalent Modification of CDK2 by 4-Hydroxynonenal as a Mechanism of Inhibition of Cell Cycle Progression
inferred← citeshttps://doi.org/10.1021/acs.jafc.5b04341openalex-snapshot
Visible Light-Induced Lipid Peroxidation of Unsaturated Fatty Acids in the Retina and the Inhibitory Effects of Blueberry Polyphenols
inferred← citeshttps://doi.org/10.1021/bi100517xopenalex-snapshot
Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling
inferred← citeshttps://doi.org/10.1038/cdd.2013.138openalex-snapshot
Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
inferred← citeshttps://doi.org/10.1038/nri3459openalex-snapshot
Immunology of age-related macular degeneration
inferred← citeshttps://doi.org/10.1038/onc.2016.113openalex-snapshot
Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer
inferred← citeshttps://doi.org/10.1038/srep10630openalex-snapshot
The Oxidant Role of 4-Hydroxynonenal in Corneal Epithelium
inferred← citeshttps://doi.org/10.1038/srep17645openalex-snapshot
Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation
inferred← citeshttps://doi.org/10.1038/srep32929openalex-snapshot
4-Hydroxy-2-nonenal induces apoptosis by activating ERK1/2 signaling and depleting intracellular glutathione in intestinal epithelial cells
inferred← citeshttps://doi.org/10.1039/c3mb70114jopenalex-snapshot
RNA-seq data analysis at the gene and CDS levels provides a comprehensive view of transcriptome responses induced by 4-hydroxynonenal
inferred← citeshttps://doi.org/10.1039/c7cc03387gopenalex-snapshot
Lipid radicals cause light-induced retinal degeneration
inferred← citeshttps://doi.org/10.1053/j.gastro.2011.11.020openalex-snapshot
4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis–Infected Macrophages
inferred← citeshttps://doi.org/10.1074/jbc.m109.023572openalex-snapshot
Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton
inferred← citeshttps://doi.org/10.1074/jbc.m113.467662openalex-snapshot
4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway
inferred← citeshttps://doi.org/10.1080/10715762.2026.2667438openalex-snapshot
Proteomic insights into nepetin-mediated protection against oxidative stress in ARPE-19 cells
inferred← citeshttps://doi.org/10.1093/pnasnexus/pgac056openalex-snapshot
Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
inferred← citeshttps://doi.org/10.1096/fj.202402612rrropenalex-snapshot
Rhodopsin Induces Myopia via Lipid Peroxidation in Zebrafish Reared in a Dark Environment
inferred← citeshttps://doi.org/10.1111/ceo.13834openalex-snapshot
Retinal pigment epithelium and age‐related macular degeneration: A review of major disease mechanisms
inferred← citeshttps://doi.org/10.1111/opo.12198openalex-snapshot
Glutathione attenuates nitric oxide‐induced retinal lipid and protein changes
inferred← citeshttps://doi.org/10.1155/2014/360438openalex-snapshot
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
inferred← citeshttps://doi.org/10.1155/2014/427318openalex-snapshot
Oxidative Stress in Alzheimer’s Disease: Why Did Antioxidant Therapy Fail?
inferred← citeshttps://doi.org/10.1155/2015/402386openalex-snapshot
Cytotoxic and Antitumor Activity of Sulforaphane: The Role of Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1155/2015/617919openalex-snapshot
PRMT1 and PRMT4 Regulate Oxidative Stress-Induced Retinal Pigment Epithelial Cell Damage in SIRT1-Dependent and SIRT1-Independent Manners
inferred← citeshttps://doi.org/10.1155/2019/5937326openalex-snapshot
4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways
inferred← citeshttps://doi.org/10.1155/2023/5513507openalex-snapshot
Aldehyde Dehydrogenase 2 Ameliorates LPS-Induced Acute Kidney Injury through Detoxification of 4-HNE and Suppression of the MAPK Pathway
inferred← citeshttps://doi.org/10.1161/jaha.113.000779openalex-snapshot
Mitochondrial Aldehyde Dehydrogenase 2 Plays Protective Roles in Heart Failure After Myocardial Infarction via Suppression of the Cytosolic JNK/p53 Pathway in Mice
inferred← citeshttps://doi.org/10.1167/iovs.10-6991openalex-snapshot
Inhibition of Mdm2 Sensitizes Human Retinal Pigment Epithelial Cells to Apoptosis
inferred← citeshttps://doi.org/10.1167/iovs.12-10079openalex-snapshot
Elucidation of the Pathogenic Mechanism of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy by Proteomic Analysis
inferred← citeshttps://doi.org/10.1167/iovs.15-16401openalex-snapshot
4-Acetoxyphenol Prevents RPE Oxidative Stress–Induced Necrosis by Functioning as an NRF2 Stabilizer
inferred← citeshttps://doi.org/10.1167/iovs.61.10.1openalex-snapshot
Gradual Increase in Environmental Light Intensity Induces Oxidative Stress and Inflammation and Accelerates Retinal Neurodegeneration
inferred← citeshttps://doi.org/10.1371/journal.pone.0301239openalex-snapshot
Phenotypic high-throughput screening identifies aryl hydrocarbon receptor agonism as common inhibitor of toxin-induced retinal pigment epithelium cell death
inferred← citeshttps://doi.org/10.1515/bmc.2011.002openalex-snapshot
Aldose reductase: new insights for an old enzyme
inferred← citeshttps://doi.org/10.18632/oncotarget.6131openalex-snapshot
4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells
inferred← citeshttps://doi.org/10.2147/jir.s347231openalex-snapshot
Long-Chain Polyunsaturated Fatty Acids and Their Metabolites Regulate Inflammation in Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.29413/abs.2022-7.4.2openalex-snapshot
The role of some lipids and their metabolites in programmed cell death (lipoapoptosis).
inferred← citeshttps://doi.org/10.3109/10715762.2010.498477openalex-snapshot
Chemistry and biochemistry of lipid peroxidation products
inferred← citeshttps://doi.org/10.3389/fcell.2020.591067openalex-snapshot
Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration
inferred← citeshttps://doi.org/10.3389/fcvm.2017.00038openalex-snapshot
Cardiac Cell Senescence and Redox Signaling
inferred← citeshttps://doi.org/10.3389/fimmu.2025.1571576openalex-snapshot
Targeting oxidative stress in diabetic retinopathy: mechanisms, pathology, and novel treatment approaches
inferred← citeshttps://doi.org/10.3389/fnut.2022.844757openalex-snapshot
Molecular Mechanisms of Iron Mediated Programmed Cell Death and Its Roles in Eye Diseases
inferred← citeshttps://doi.org/10.3389/fphar.2023.1122632openalex-snapshot
Acetaminophen-induced liver injury: Molecular mechanism and treatments from natural products
inferred← citeshttps://doi.org/10.3390/antiox10050653openalex-snapshot
Oxidative and Nitrosative Stress in Age-Related Macular Degeneration: A Review of Their Role in Different Stages of Disease
inferred← citeshttps://doi.org/10.3390/antiox9020150openalex-snapshot
In Vitro Aging of Human Skin Fibroblasts: Age-Dependent Changes in 4-Hydroxynonenal Metabolism
inferred← citeshttps://doi.org/10.3390/biom10030402openalex-snapshot
Involvement of Metabolic Lipid Mediators in the Regulation of Apoptosis
inferred← citeshttps://doi.org/10.3390/biom10050770openalex-snapshot
Proeryptotic Activity of 4-Hydroxynonenal: A New Potential Physiopathological Role for Lipid Peroxidation Products
inferred← citeshttps://doi.org/10.3390/cancers13246377openalex-snapshot
Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/cells10071763openalex-snapshot
Extracellular Vesicles under Oxidative Stress Conditions: Biological Properties and Physiological Roles
inferred← citeshttps://doi.org/10.3390/ijms22031361openalex-snapshot
Spermidine Attenuates Oxidative Stress-Induced Apoptosis via Blocking Ca2+ Overload in Retinal Pigment Epithelial Cells Independently of ROS
inferred← citeshttps://doi.org/10.3390/jdad2020017openalex-snapshot
Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease: Insights into Pathophysiology and Treatment
inferred← citeshttps://doi.org/10.3390/medsci13030087openalex-snapshot
Pathophysiological Mechanisms of Diabetes-Induced Macrovascular and Microvascular Complications: The Role of Oxidative Stress
inferred← citeshttps://doi.org/10.3390/nu15051255openalex-snapshot
Gamma-Muricholic Acid Inhibits Nonalcoholic Steatohepatitis: Abolishment of Steatosis-Dependent Peroxidative Impairment by FXR/SHP/LXRα/FASN Signaling
inferred← citeshttps://doi.org/10.3892/mmr.2021.11855openalex-snapshot
Potassium bromate-induced cell model of age-related macular degeneration in vitro
inferred← citeshttps://doi.org/10.4236/ojapo.2013.21001openalex-snapshot
Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity
inferred← citeshttps://doi.org/10.4239/wjd.v12.i9.1442openalex-snapshot
Cellular targets in diabetic retinopathy therapy
inferred← citeshttps://doi.org/10.5114/wo.2014.40456openalex-snapshot
Comparison of 4-hydroxynonenal induced p53-mediated apoptosis in prostate cancer cells LNCaP and DU145
inferred← citeshttps://doi.org/10.70675/3474a8e0zbde2z43f5za2aazac54d227d0d7openalex-snapshot
Dégénérescence maculaire liée à l'âge (DMLA) et voie du complément : rôle de la voie alterne du complément dans la pathologie
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