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Molecular Mechanism of 4-Hydroxynonenal Induced Cell Death

https://doi.org/10.2139/ssrn.4794612
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Deubiquitinase OTUD5 as a Novel Protector against 4‐HNE‐Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury
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Inactivation of Bcl‐2 through IκB kinase (IKK)‐dependent phosphorylation mediates apoptosis upon exposure to 4‐hydroxynonenal (HNE)
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Cell death mechanisms in eukaryotes
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4-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells
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Inhibition of NF-κB Activation by 4-Hydroxynonenal Contributes to Liver Injury in a Mouse Model of Alcoholic Liver Disease
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Oxidatively damaged proteins of heart mitochondrial electron transport complexes
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Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol
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Lipid peroxidation in cell death
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Mitophagy mechanisms and role in human diseases
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Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
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Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
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Reactions of 4-hydroxynonenal with proteins and cellular targets
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Oxidative stress, inflammation, and cancer: How are they linked?
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Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition
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Assessing bioenergetic function in response to oxidative stress by metabolic profiling
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Proatherogenic effects of 4-hydroxynonenal
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Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria
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Aldehyde dehydrogenase 2 regulates autophagy via the Akt-mTOR pathway to mitigate renal ischemia-reperfusion injury in hypothermic machine perfusion
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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement
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Deciphering the mechanism of HNE-induced apoptosis in cultured murine cortical neurons: Transcriptional responses and cellular pathways
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Long-chain polyunsaturated fatty acids (LCPUFA) from genesis to senescence: The influence of LCPUFA on neural development, aging, and neurodegeneration
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Autophagy as an essential cellular antioxidant pathway in neurodegenerative disease
inferredcites →https://doi.org/10.1016/j.redox.2014.04.003openalex-extracted
Formation of electrophilic oxidation products from mitochondrial cardiolipin in vitro and in vivo in the context of apoptosis and atherosclerosis
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4-Hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells
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Role of endoplasmic reticulum stress in acrolein-induced endothelial activation
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Reactive Carbonyl Species: Diabetic Complication in the Heart and Lungs
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Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: Roles of ROS and MAPK pathways
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Basic aspects of the biochemical reactivity of 4-hydroxynonenal
inferredcites →https://doi.org/10.1016/s0098-2997(03)00013-xopenalex-extracted
HNE––signaling pathways leading to its elimination
inferredcites →https://doi.org/10.1016/s0304-4165(98)00002-6openalex-extracted
Inhibition of cytochrome c oxidase activity by 4-hydroxynonenal (HNE)
inferredcites →https://doi.org/10.1021/bi060780+openalex-extracted
Regulation of CD95 (Fas) Expression and Fas-Mediated Apoptotic Signaling in HLE B-3 Cells by 4-Hydroxynonenal
inferredcites →https://doi.org/10.1021/bi100517xopenalex-extracted
Mechanisms of 4-Hydroxy-2-nonenal Induced Pro- and Anti-Apoptotic Signaling
inferredcites →https://doi.org/10.1021/bi701559fopenalex-extracted
4-Hydroxynonenal Self-Limits Fas-Mediated DISC-Independent Apoptosis by Promoting Export of Daxx from the Nucleus to the Cytosol and Its Binding to Fas
inferredcites →https://doi.org/10.1021/tx00044a014openalex-extracted
Structural Definition of Early Lysine and Histidine Adduction Chemistry of 4-Hydroxynonenal
inferredcites →https://doi.org/10.1038/cdd.2008.110openalex-extracted
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies
inferredcites →https://doi.org/10.1038/cdd.2013.138openalex-extracted
Cell death and diseases related to oxidative stress:4-hydroxynonenal (HNE) in the balance
inferredcites →https://doi.org/10.1038/nature13683openalex-extracted
Inflammatory caspases are innate immune receptors for intracellular LPS
inferredcites →https://doi.org/10.1038/nature15514openalex-extracted
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
inferredcites →https://doi.org/10.1038/nature15541openalex-extracted
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
inferredcites →https://doi.org/10.1038/nature18590openalex-extracted
Pore-forming activity and structural autoinhibition of the gasdermin family
inferredcites →https://doi.org/10.1038/nature18629openalex-extracted
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
inferredcites →https://doi.org/10.1038/ncb0311-184openalex-extracted
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
inferredcites →https://doi.org/10.1038/s41392-020-00428-9openalex-extracted
Ferroptosis: mechanisms and links with diseases
inferredcites →https://doi.org/10.1038/s41418-019-0470-yopenalex-extracted
Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling
inferredcites →https://doi.org/10.1038/s41418-020-00691-xopenalex-extracted
Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics
inferredcites →https://doi.org/10.1038/s41419-019-1719-6openalex-extracted
Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis
inferredcites →https://doi.org/10.1038/s41419-019-2064-5openalex-extracted
ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation
inferredcites →https://doi.org/10.1038/s41422-018-0090-yopenalex-extracted
Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis
inferredcites →https://doi.org/10.1038/s41422-019-0164-5openalex-extracted
The molecular machinery of regulated cell death
inferredcites →https://doi.org/10.1038/s41577-019-0165-0openalex-extracted
The NLRP3 inflammasome: molecular activation and regulation to therapeutics
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Ferroptosis: mechanisms, biology and role in disease
inferredcites →https://doi.org/10.1038/s41590-020-0669-6openalex-extracted
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
inferredcites →https://doi.org/10.1038/s41598-018-19213-4openalex-extracted
The ferroptosis inducer erastin irreversibly inhibits system xc− and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
inferredcites →https://doi.org/10.1038/srep27849openalex-extracted
Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease
inferredcites →https://doi.org/10.1046/j.1471-4159.1999.0720529.xopenalex-extracted
Pivotal Role of Mitochondrial Calcium Uptake in Neural Cell Apoptosis and Necrosis
inferredcites →https://doi.org/10.1053/bega.2002.0333openalex-extracted
Pathogenesis of steatohepatitis
inferredcites →https://doi.org/10.1073/pnas.0712245105openalex-extracted
Discovery of a lysophospholipid acyltransferase family essential for membrane asymmetry and diversity
inferredcites →https://doi.org/10.1073/pnas.1603244113openalex-extracted
Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis
inferredcites →https://doi.org/10.1074/jbc.274.17.11611openalex-extracted
4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis
inferredcites →https://doi.org/10.1074/jbc.m010677200openalex-extracted
Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress
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Apoptosis: A Review of Programmed Cell Death
inferredcites →https://doi.org/10.1080/15548627.2017.1356948openalex-extracted
Regulation of autophagy, mitochondrial dynamics, and cellular bioenergetics by 4-hydroxynonenal in primary neurons
inferredcites →https://doi.org/10.1080/21655979.2021.2001913openalex-extracted
Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction
inferredcites →https://doi.org/10.1080/21655979.2022.2033381openalex-extracted
Crosstalk of pyroptosis, ferroptosis, and mitochondrial aldehyde dehydrogenase 2-related mechanisms in sepsis-induced lung injury in a mouse model
inferredcites →https://doi.org/10.1093/eurheartj/ehq253openalex-extracted
Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde
inferredcites →https://doi.org/10.1097/01.asn.0000034911.03334.c3openalex-extracted
Novel Effects of Neutrophil-Derived Proteinase 3 and Elastase on the Vascular Endothelium Involve In Vivo Cleavage of NF-κB and Proapoptotic Changes in JNK, ERK, and p38 MAPK Signaling Pathways
inferredcites →https://doi.org/10.1097/shk.0000000000001104openalex-extracted
Ulinastatin Protects Against LPS-Induced Acute Lung Injury By Attenuating TLR4/NF-κB Pathway Activation and Reducing Inflammatory Mediators
inferredcites →https://doi.org/10.1111/cpr.12761openalex-extracted
Ferroptosis: Final destination for cancer?
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Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
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The Fas Signaling Pathway: More Than a Paradigm
inferredcites →https://doi.org/10.1155/2014/360438openalex-extracted
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
inferredcites →https://doi.org/10.1155/2016/1245049openalex-extracted
Role of ROS and RNS Sources in Physiological and Pathological Conditions
inferredcites →https://doi.org/10.1155/2019/4857921openalex-extracted
ALDH2 Overexpression Alleviates High Glucose-Induced Cardiotoxicity by Inhibiting NLRP3 Inflammasome Activation
inferredcites →https://doi.org/10.1155/2022/2555476openalex-extracted
Aldehyde Dehydrogenase 2 (ALDH2) Elicits Protection against Pulmonary Hypertension via Inhibition of ERK1/2‐Mediated Autophagy
inferredcites →https://doi.org/10.1159/000213740openalex-extracted
STUDIES ON AGE PIGMENTS EVOLVING INTO A NEW THEORY OF BIOLOGICAL AGING
inferredcites →https://doi.org/10.1161/circresaha.108.183749openalex-extracted
Oxidized Low-Density Lipoproteins Trigger Endoplasmic Reticulum Stress in Vascular Cells
inferredcites →https://doi.org/10.1165/rcmb.2008-0302ocopenalex-extracted
IL-6 Protects against Hyperoxia-Induced Mitochondrial Damage via Bcl-2–Induced Bak Interactions with Mitofusions
inferredcites →https://doi.org/10.1186/1476-4598-12-86openalex-extracted
The complexity of NF-κB signaling in inflammation and cancer
inferredcites →https://doi.org/10.1186/s11658-020-00205-0openalex-extracted
Ferrostatin-1 alleviates lipopolysaccharide-induced acute lung injury via inhibiting ferroptosis
inferredcites →https://doi.org/10.1196/annals.1299.074openalex-extracted
Alveolar Cell Death in Hyperoxia‐Induced Lung Injury
inferredcites →https://doi.org/10.1201/9780203711309-16openalex-extracted
Carbonyl Toxification Hypothesis of Biological Aging
inferredcites →https://doi.org/10.1538/expanim.20-0123openalex-extracted
Effect of low-dose ethanol on NLRP3 inflammasome in diabetes-induced lung injury
inferredcites →https://doi.org/10.18632/oncotarget.6131openalex-extracted
4-Hydroxynonenal regulates mitochondrial function in human small airway epithelial cells
inferredcites →https://doi.org/10.3389/fendo.2020.628079openalex-extracted
Redox Epiphospholipidome in Programmed Cell Death Signaling: Catalytic Mechanisms and Regulation
inferredcites →https://doi.org/10.3389/fimmu.2018.01289openalex-extracted
IRE1α Implications in Endoplasmic Reticulum Stress-Mediated Development and Pathogenesis of Autoimmune Diseases
inferredcites →https://doi.org/10.3389/fphys.2017.00519openalex-extracted
NLRP3 Inflammasome as a Molecular Marker in Diabetic Cardiomyopathy
inferredcites →https://doi.org/10.3390/biom12111555openalex-extracted
Electrophilic Aldehyde 4-Hydroxy-2-Nonenal Mediated Signaling and Mitochondrial Dysfunction
inferredcites →https://doi.org/10.3892/etm.2017.4785openalex-extracted
Inhibition of ALDH2 expression aggravates renal injury in a rat sepsis syndrome model
inferredcites →https://doi.org/10.3892/mmr.2020.11114openalex-extracted
Dexmedetomidine alleviated sepsis‑induced myocardial ferroptosis and septic heart injury
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Gsta4 Null Mouse Embryonic Fibroblasts Exhibit Enhanced Sensitivity to Oxidants: Role of 4-Hydroxynonenal in Oxidant Toxicity
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