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Mechanism of Assembly of the Dimanganese-Tyrosyl Radical Cofactor of Class Ib Ribonucleotide Reductase: Enzymatic Generation of Superoxide Is Required for Tyrosine Oxidation via a Mn(III)Mn(IV) Intermediate
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The Three-dimensional Structure of Mammalian Ribonucleotide Reductase Protein R2 Reveals a More-accessible Iron-radical Site than R2
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Comparisons of wild-type and mutant flavodoxins from Anacystis nidulans . Structural determinants of the redox potentials 1 1Edited by R. Huber
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Multifrequency EPR analysis of the dimanganese cluster of the putative sulfate thiohydrolase SoxB of Paracoccus pantotrophus
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Oxygen cleavage with manganese and iron in ribonucleotide reductase from Chlamydia trachomatis
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The state of copper in stellacyanin and laccase from the lacquer tree Rhus vernicifera
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Manganese-containing catalase from Thermus thermophilus peroxide-induced redox transformation of manganese ions in presence of specific inhibitors of catalase activity
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[27] Rapid colorimetric micromethod for the quantitation of complexed iron in biological samples
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[20] Use of rapid kinetics methods to study the assembly of the diferric-tyrosyl radical cofactor of E. coli ribonucleotide reductase
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Mechanistic Investigations of Ribonucleotide Reductases
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Global Kinetic Explorer: A new computer program for dynamic simulation and fitting of kinetic data
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Ribonucleotide reductase class I with different radical generating clusters
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Quantitative analysis of dinuclear manganese(II) EPR spectra
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EasySpin, a comprehensive software package for spectral simulation and analysis in EPR
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Activation of molecular oxygen by flavins and flavoproteins.
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Purification and Characterization of Flavodoxin from Peptostreptococcus elsdenii
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Iron and Free Radical in Ribonucleotide Reductase
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Electron Spin Resonance of the Iron-containing Protein B2 from Ribonucleotide Reductase
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[7] Freeze-quench and chemical-quench techniques
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[11] Fluorescence methods for studying equilibrium macromolecule-ligand interactions
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Harnessing free radicals: formation and function of the tyrosyl radical in ribonucleotide reductase
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Practical rapid quenching instrument for the study of reaction mechanisms by electron paramagnetic resonance spectroscopy
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Fluorescence and optical characteristics of reduced flavines and flavoproteins
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Facile Electron Transfer during Formation of Cluster X and Kinetic Competence of X for Tyrosyl Radical Production in Protein R2 of Ribonucleotide Reductase from Mouse
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(μ-1,2-Peroxo)diiron(III/III) Complex as a Precursor to the Diiron(III/IV) Intermediate X in the Assembly of the Iron-Radical Cofactor of Ribonucleotide Reductase from Mouse
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Escherichia coli Class Ib Ribonucleotide Reductase Contains a Dimanganese(III)-Tyrosyl Radical Cofactor in Vivo
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Bacillus subtilis Class Ib Ribonucleotide Reductase Is a Dimanganese(III)-Tyrosyl Radical Enzyme
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The Dimanganese(II) Site of Bacillus subtilis Class Ib Ribonucleotide Reductase
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Oxygen Activation in Flavoprotein Oxidases: The Importance of Being Positive
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A Manganese(IV)/Iron(IV) Intermediate in Assembly of the Manganese(IV)/Iron(III) Cofactor of Chlamydia trachomatis Ribonucleotide Reductase
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YfaE, a Ferredoxin Involved in Diferric-Tyrosyl Radical Maintenance in Escherichia coli Ribonucleotide Reductase
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An Active Dimanganese(III)−Tyrosyl Radical Cofactor in Escherichia coli Class Ib Ribonucleotide Reductase
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Electron Injection through a Specific Pathway Determines the Outcome of Oxygen Activation at the Diiron Cluster in the F208Y Mutant of Escherichia coli Ribonucleotide Reductase Protein R2
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Characterization of the Interaction between Manganese and Tyrosine Z in Acetate-Inhibited Photosystem II
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Low-pressure solubility of gases in liquid water
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The [Mn 2 (2-OHsalpn) 2 ] 2-,-,0,+ System: Synthesis, Structure, Spectroscopy, and Magnetism of the First Structurally Characterized Dinuclear Manganese Series Containing Four Distinct Oxidation States
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Active site spectral studies on manganese superoxide dismutase
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Metal-nitroxyl interactions. 51. Collapse of iron-nitroxyl electron-electron spin-spin splitting due to the increase in the electron spin relaxation rate for high-spin iron(III) when temperature is increased
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Catalytic mechanism of the manganese-containing superoxide dismutase of Escherichia coli studied by pulse radiolysis
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A Tyrosyl−Dimanganese Coupled Spin System is the Native Metalloradical Cofactor of the R2F Subunit of the Ribonucleotide Reductase of Corynebacterium ammoniagenes
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The Manganese Ion of the Heterodinuclear Mn/Fe Cofactor in Chlamydia trachomatis Ribonucleotide Reductase R2c Is Located at Metal Position 1
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Electron Paramagnetic Resonance Detection of Intermediates in the Enzymatic Cycle of an Extradiol Dioxygenase
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Identification of Protonated Oxygenic Ligands of Ribonucleotide Reductase Intermediate X
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Mechanism of Assembly of the Diferric Cluster−Tyrosyl Radical Cofactor of Escherichia coli Ribonucleotide Reductase from the Diferrous Form of the R2 Subunit
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Reconsideration of X, the Diiron Intermediate Formed during Cofactor Assembly in E. coli Ribonucleotide Reductase
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Differential Iron(II) Affinity of the Sites of the Diiron Cluster in Protein R2 of Escherichia coli Ribonucleotide Reductase: Tracking the Individual Sites through the O2 Activation Sequence
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Outer sphere mutagenesis of Lactobacillus plantarum manganese catalase disrupts the cluster core
inferredcites →https://doi.org/10.1073/pnas.0807348105openalex-snapshot
NrdI, a flavodoxin involved in maintenance of the diferric-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase
inferredcites →https://doi.org/10.1074/jbc.m002751200openalex-snapshot
The Active Form of the R2F Protein of Class Ib Ribonucleotide Reductase from Corynebacterium ammoniagenesIs a Diferric Protein
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Impact of the N5-proximal Asn on the Thermodynamic and Kinetic Stability of the Semiquinone Radical in Photolyase
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NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
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High‐resolution crystal structures of the flavoprotein NrdI in oxidized and reduced states – an unusual flavodoxin
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A Manganese(IV)/Iron(III) Cofactor in Chlamydia trachomatis Ribonucleotide Reductase
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Structural Basis for Activation of Class Ib Ribonucleotide Reductase
inferredcites →https://doi.org/10.1126/science.1650033openalex-snapshot
Mechanism of Assembly of the Tyrosyl Radical-Dinuclear Iron Cluster Cofactor of Ribonucleotide Reductase
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Thiyl Radicals in Ribonucleotide Reductases
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Class I Ribonucleotide Reductases: Metallocofactor Assembly and Repair In Vitro and In Vivo
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Ribonucleotide Reductases
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A New Method of Identifying the Site of Tyrosyl Radicals in Proteins
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Comprehensive natural products chemistry
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1021/cb400757hopenalex-snapshot
Crystal Structure of Bacillus cereus Class Ib Ribonucleotide Reductase Di-iron NrdF in Complex with NrdI
inferred← citeshttps://doi.org/10.1021/cr4006654openalex-snapshot
Biochemistry and Theory of Proton-Coupled Electron Transfer
inferred← citeshttps://doi.org/10.1021/ic4010906openalex-snapshot
Isolation and Characterization of a Dihydroxo-Bridged Iron(III,III)(μ-OH)2 Diamond Core Derived from Dioxygen
inferred← citeshttps://doi.org/10.1021/ja507435topenalex-snapshot
Electronic Structural Flexibility of Heterobimetallic Mn/Fe Cofactors: R2lox and R2c Proteins
inferred← citeshttps://doi.org/10.1021/jacs.0c00333openalex-snapshot
Key Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein
inferred← citeshttps://doi.org/10.1021/jacs.4c16271openalex-snapshot
O 2 Activation and Enzymatic C–H Bond Activation Mediated by a Dimanganese Cofactor
inferred← citeshttps://doi.org/10.1021/jacs.5b04331openalex-snapshot
Mn(II) Binding and Subsequent Oxidation by the Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy
inferred← citeshttps://doi.org/10.1021/jacs.5b04768openalex-snapshot
Ammonia Binds to the Dangler Manganese of the Photosystem II Oxygen-Evolving Complex
inferred← citeshttps://doi.org/10.1021/jacs.6b11563openalex-snapshot
Evidence for a Di-μ-oxo Diamond Core in the Mn(IV)/Fe(IV) Activation Intermediate of Ribonucleotide Reductase from Chlamydia trachomatis
inferred← citeshttps://doi.org/10.1021/jacs.9b04729openalex-snapshot
How Metal Ion Lewis Acidity and Steric Properties Influence the Barrier to Dioxygen Binding, Peroxo O–O Bond Cleavage, and Reactivity
inferred← citeshttps://doi.org/10.1038/s41586-018-0653-6openalex-snapshot
Metal-free ribonucleotide reduction powered by a DOPA radical in Mycoplasma pathogens
inferred← citeshttps://doi.org/10.1038/s42003-025-07565-3openalex-snapshot
Characterization of a second class Ie ribonucleotide reductase
inferred← citeshttps://doi.org/10.1039/c3dt51277kopenalex-snapshot
Reaction landscape of a pentadentate N5-ligated MnII complex with O2˙− and H2O2 includes conversion of a peroxomanganese(iii) adduct to a bis(μ-oxo)dimanganese(iii,iv) species
inferred← citeshttps://doi.org/10.1039/c8dt02300jopenalex-snapshot
Mn III -Peroxo adduct supported by a new tetradentate ligand shows acid-sensitive aldehyde deformylation reactivity
inferred← citeshttps://doi.org/10.1039/d0dt03706kopenalex-snapshot
A side-on Mn( iii )–peroxo supported by a non-heme pentadentate N 3 Py 2 ligand: synthesis, characterization and reactivity studies
inferred← citeshttps://doi.org/10.1039/d1cs00254fopenalex-snapshot
Cysteinyl radicals in chemical synthesis and in nature
inferred← citeshttps://doi.org/10.1039/d1dt00489aopenalex-snapshot
A combined experimental and theoretical study on a single, unsupported oxo-bridged Mn( iii , iii ) dimer coordinated to two iminobenzosemiquinone π-radical anions
inferred← citeshttps://doi.org/10.1039/d2cb00250gopenalex-snapshot
Study and design of amino acid-based radical enzymes using unnatural amino acids
inferred← citeshttps://doi.org/10.1039/d3dt02672hopenalex-snapshot
Reaction landscape of a mononuclear Mn III –hydroxo complex with hydrogen peroxide
inferred← citeshttps://doi.org/10.1073/pnas.1800356115openalex-snapshot
An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP
inferred← citeshttps://doi.org/10.1073/pnas.1811993115openalex-snapshot
Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical
inferred← citeshttps://doi.org/10.1073/pnas.2210908119openalex-snapshot
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis
inferred← citeshttps://doi.org/10.1074/jbc.m113.533554openalex-snapshot
Streptococcus sanguinis Class Ib Ribonucleotide Reductase
inferred← citeshttps://doi.org/10.1074/jbc.m113.533620openalex-snapshot
Genetic Characterization and Role in Virulence of the Ribonucleotide Reductases of Streptococcus sanguinis
inferred← citeshttps://doi.org/10.1074/jbc.m114.592535openalex-snapshot
Semiquinone-induced Maturation of Bacillus anthracis Ribonucleotide Reductase by a Superoxide Intermediate
inferred← citeshttps://doi.org/10.1074/jbc.m115.675223openalex-snapshot
Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor
inferred← citeshttps://doi.org/10.1074/jbc.ra118.004991openalex-snapshot
A glutaredoxin domain fused to the radical-generating subunit of ribonucleotide reductase (RNR) functions as an efficient RNR reductant
inferred← citeshttps://doi.org/10.1074/jbc.ra119.010570openalex-snapshot
Chemical flexibility of heterobimetallic Mn/Fe cofactors: R2lox and R2c proteins
inferred← citeshttps://doi.org/10.1093/mtomcs/mfab062openalex-snapshot
Mechanistic studies of the cofactor assembly in class Ib ribonucleotide reductases and protein affinity for MnII and FeII
inferred← citeshttps://doi.org/10.1101/190033openalex-snapshot
Unique ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
inferred← citeshttps://doi.org/10.1101/2022.08.01.502304openalex-snapshot
CADD from Chlamydia trachomatis is a manganese-dependent oxygenase that employs a self-sacrificing reaction for the synthesis of p -aminobenzoate
inferred← citeshttps://doi.org/10.1101/2023.06.06.543845openalex-snapshot
Structural insights into the initiation of free radical formation in the Class Ib ribonucleotide reductases
inferred← citeshttps://doi.org/10.1101/373563openalex-snapshot
Fusion of a functional glutaredoxin to the radical-generating subunit of ribonucleotide reductase
inferred← citeshttps://doi.org/10.1111/mmi.13034openalex-snapshot
Manganese homeostasis and utilization in pathogenic bacteria
inferred← citeshttps://doi.org/10.2478/artph-2013-0002openalex-snapshot
Transient absorption spectroscopy studies of proton-coupled electron transfers
inferred← citeshttps://doi.org/10.3389/fcimb.2023.943390openalex-snapshot
Why is manganese so valuable to bacterial pathogens?
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00134openalex-snapshot
Reannotation of the Ribonucleotide Reductase in a Cyanophage Reveals Life History Strategies Within the Virioplankton
inferred← citeshttps://doi.org/10.3390/ijms140713137openalex-snapshot
The Enzyme-Mediated Direct Reversal of a Dithymine Photoproduct in Germinating Endospores
inferred← citeshttps://doi.org/10.3390/inorganics13050137openalex-snapshot
The Bioinorganic Chemistry of the First Row d-Block Metal Ions—An Introduction
inferred← citeshttps://doi.org/10.3390/molecules24132462openalex-snapshot
Formation of Unstable and very Reactive Chemical Species Catalyzed by Metalloenzymes: A Mechanistic Overview
inferred← citeshttps://doi.org/10.3410/f.718000615.793476237openalex-snapshot
Faculty Opinions recommendation of A radical transfer pathway in spore photoproduct lyase.
inferred← citeshttps://doi.org/10.53846/goediss-5691openalex-snapshot
Hydrogen Bonds and Electrostatic Environment of Radical Intermediates in Ribonucleotide Reductase Ia
inferred← citeshttps://doi.org/10.64898/2026.02.11.705308openalex-snapshot
Ribonucleotide reductases recapitulate biogeographic patterns within virioplankton according to ocean biogeochemistry
inferred← citeshttps://doi.org/10.7554/elife.31529openalex-snapshot
Novel ATP-cone-driven allosteric regulation of ribonucleotide reductase via the radical-generating subunit
inferred← citeshttps://doi.org/10.7554/elife.79226openalex-snapshot
Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography
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