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Jatrophane Diterpenes as P-Glycoprotein Inhibitors. First Insights of Structure−Activity Relationships and Discovery of a New, Powerful Lead

https://doi.org/10.1021/jm030787e
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00234655openalex-snapshot
The biology of the P-glycoproteins
inferredcites →https://doi.org/10.1007/s002329900305openalex-snapshot
The P-Glycoprotein Efflux Pump: How Does it Transport Drugs?
inferredcites →https://doi.org/10.1016/s0031-9422(97)00744-9openalex-snapshot
Germacranolides and a monoterpene cyclic peroxide from Artemisia fragrans
inferredcites →https://doi.org/10.1016/s0031-9422(99)00166-1openalex-snapshot
Jatrophane and tigliane diterpenes from the latex of Euphorbia obtusifolia
inferredcites →https://doi.org/10.1016/s0168-6445(97)00051-xopenalex-snapshot
Mechanisms of multidrug transporters
inferredcites →https://doi.org/10.1016/s0960-9822(00)00059-2openalex-snapshot
P-Glycoprotein: To flip or not to flip?
inferredcites →https://doi.org/10.1021/jm0111301openalex-snapshot
Discovery and Biological Evaluation of a New Family of Potent Modulators of Multidrug Resistance: Reversal of Multidrug Resistance of Mouse Lymphoma Cells by New Natural Jatrophane Diterpenoids Isolated from Euphorbia Species
inferredcites →https://doi.org/10.1021/jm991128yopenalex-snapshot
C-Isoprenylation of Flavonoids Enhances Binding Affinity toward P-Glycoprotein and Modulation of Cancer Cell Chemoresistance
inferredcites →https://doi.org/10.1021/np960669copenalex-snapshot
Macrocyclic Diterpene Polyesters of the Jatrophane Type from Euphorbia esula
inferredcites →https://doi.org/10.1021/np970507wopenalex-snapshot
Macrocyclic Diterpenoids from Euphorbia semiperfoliata
inferredcites →https://doi.org/10.1124/mol.51.6.1024openalex-snapshot
P-Glycoprotein Substrates and Antagonists Cluster into Two Distinct Groups

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone
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Jatrophane Diterpenoids from the Seeds of Euphorbia peplus with Potential Bioactivities in Lysosomal-Autophagy Pathway
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Jatrophane diterpenes from Euphorbiaceae family
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Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells
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Discovery of a novel highly potent and low-toxic jatrophane derivative enhancing the P-glycoprotein-mediated doxorubicin sensitivity of MCF-7/ADR cells
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New anti-cancer characteristics of jatrophane diterpenes from Euphorbia dendroides
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A new cytotoxic casbane diterpene from Euphorbia pekinensis
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Macrocyclic diterpenoids from the Iranian plant Euphorbia bungei Boiss.
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Cyparissins A and B, jatrophane diterpenes from Euphorbia cyparissias as Pgp inhibitors and cytotoxic agents against ovarian cancer cell lines
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Jatrophanes as promising multidrug resistance modulators: Advances of structure–activity relationships
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The use of Euphorbia falcata extract as eco-friendly corrosion inhibitor of carbon steel in hydrochloric acid solution
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New malonate macrocycle bearing two isosteviol moieties and its adduct with fullerene C60
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Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris
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Bioactive jatrophane diterpenes from Euphorbia guyoniana
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Jatrophane diterpenoids from the latex of Euphorbia dendroides and their anti-P-glycoprotein activity in human multi-drug resistant cancer cell lines
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Diterpenoid constituents of Euphorbia macrorrhiza
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Jatrophane diterpenoids with multidrug-resistance modulating activity from the latex of Euphorbia nicaeensis
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Jatrophane diterpenoids from Fructus Euphorbia sororia
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Amygdaloidins A–L, twelve new 13 α-OH jatrophane diterpenes from Euphorbia amygdaloides L.
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New premyrsinane-type diterpene polyesters from Euphorbia falcata
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Cyclomyrsinane and premyrsinane diterpenes from Euphorbia falcata modulate resistance of cancer cells to doxorubicin
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Cyclomyrsinane and premyrsinane diterpenes from Euphorbia sogdiana Popov
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Synthesis of the cyclopentane core of pepluanin A
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Enantioselective synthesis of the C-14 to C-5 cyclopentane segment of jatrophane diterpenes
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Chapter 3 Natural substrates and inhibitors of multidrug resistant pumps (MDRs) redefine the plant antimicrobials
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Lathyrol Diterpenes as Modulators of P-Glycoprotein Dependent Multidrug Resistance: Structure–Activity Relationship Studies on Euphorbia Factor L 3 Derivatives
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Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects
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Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity
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One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels–Alder Reaction
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Discovery and Biological Evaluation of the Novel Naturally Occurring Diterpene Pepluanone as Antiinflammatory Agent
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Nonprenylated Rotenoids, a New Class of Potent Breast Cancer Resistance Protein Inhibitors
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Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters
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Synthesis of the Norjatrophane Diterpene (−)-15-Acetyl-3-propionyl- 17-norcharaciol
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Biogenetical Related Highly Oxygenated Macrocyclic Diterpenes from Sea Spurge Euphorbia paralias
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Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators
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Oxidation and cyclization of casbene in the biosynthesis of Euphorbia factors from mature seeds of Euphorbia lathyris L.
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Guyonianin A and B, Two Polyester Diterpenes from Algerian Euphorbia guyoniana
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Jatrophane Diterpenoids With Protective Effect on Human Lymphocytes DNA
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Plant Compounds and Derivatives as Inhibitors of Cancer Cell Multidrug Resistance
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The establishing of resistant cancer cell lines as a model for testing of new chemotherapeutics: molecular characterization of resistance developed after continuous treatment with paclitaxel
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Macrocyclic Diterpenoids from Euphorbia peplus Possessing Activity Towards Autophagic Flux
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Euphocactoside, a New Megastigmane Glycoside from Euphorbia cactus Growing in Saudi Arabia
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Triterpenes from Euphorbia rigida
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