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Design and Synthesis of Acetylenyl Benzamide Derivatives as Novel Glucokinase Activators for the Treatment of T2DM

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/iub.411openalex-snapshot
Liver glucokinase: An overview on the regulatorymechanisms of its activity
inferredcites →https://doi.org/10.1016/j.bmc.2009.04.040openalex-snapshot
Structure–activity relationships of 3,5-disubstituted benzamides as glucokinase activators with potent in vivo efficacy
inferredcites →https://doi.org/10.1016/j.bmc.2014.02.009openalex-snapshot
Discovery of 3-(4-methanesulfonylphenoxy)-N-[1-(2-methoxy-ethoxymethyl)-1H-pyrazol-3-yl]-5-(3-methylpyridin-2-yl)-benzamide as a novel glucokinase activator (GKA) for the treatment of type 2 diabetes mellitus
inferredcites →https://doi.org/10.1016/j.bmcl.2009.03.137openalex-snapshot
Discovery of novel 3,6-disubstituted 2-pyridinecarboxamide derivatives as GK activators
inferredcites →https://doi.org/10.1016/j.bmcl.2011.03.093openalex-snapshot
Design of a potent, soluble glucokinase activator with increased pharmacokinetic half-life
inferredcites →https://doi.org/10.1016/j.bmcl.2012.11.018openalex-snapshot
Discovery of a novel phenylethyl benzamide glucokinase activator for the treatment of type 2 diabetes mellitus
inferredcites →https://doi.org/10.1016/j.tips.2012.11.007openalex-snapshot
GKAs for diabetes therapy: why no clinically useful drug after two decades of trying?
inferredcites →https://doi.org/10.1021/bi060253qopenalex-snapshot
Glucose-Induced Conformational Changes in Glucokinase Mediate Allosteric Regulation: Transient Kinetic Analysis
inferredcites →https://doi.org/10.1021/bi900374copenalex-snapshot
Binding Kinetics of Glucose and Allosteric Activators to Human Glucokinase Reveal Multiple Conformational States
inferredcites →https://doi.org/10.1021/jm020406hopenalex-snapshot
Surflex: Fully Automatic Flexible Molecular Docking Using a Molecular Similarity-Based Search Engine
inferredcites →https://doi.org/10.1021/jm2014887openalex-snapshot
Discovery of (S)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus
inferredcites →https://doi.org/10.1021/ml400027yopenalex-snapshot
Identification of RO4597014, a Glucokinase Activator Studied in the Clinic for the Treatment of Type 2 Diabetes
inferredcites →https://doi.org/10.1021/op400354gopenalex-snapshot
Scalable Synthesis of a Nonracemic α-Arylpropionic Acid via Ketene Desymmetrization for a Glucokinase Activator
inferredcites →https://doi.org/10.1039/c1md00090jopenalex-snapshot
Overcoming retinoic acid receptor-α based testicular toxicity in the optimisation of glucokinase activators
inferredcites →https://doi.org/10.1126/science.1084073openalex-snapshot
Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy
inferredcites →https://doi.org/10.1517/13543776.2014.918957openalex-snapshot
A patent review of glucokinase activators and disruptors of the glucokinase – glucokinase regulatory protein interaction: 2011 – 2014
inferredcites →https://doi.org/10.2337/db07-0026openalex-snapshot
Glucose-Dependent Modulation of Insulin Secretion and Intracellular Calcium Ions by GKA50, a Glucokinase Activator
inferredcites →https://doi.org/10.2337/dc11-1200openalex-snapshot
Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes
inferredcites →https://doi.org/10.2337/diab.45.2.223openalex-snapshot
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4635544openalex-extracted
inferred← citeshttps://doi.org/10.1002/bab.2541openalex-snapshot
Tetrahydropalmatine from medicinal plants activates human glucokinase to regulate glucose homeostasis
inferred← citeshttps://doi.org/10.1002/cbdv.202402738openalex-snapshot
ADME, Toxicity, Molecular Docking, Molecular Dynamics, Glucokinase activation, DPP‐IV, α‐amylase, and α‐glucosidase Inhibition Assays of Mangiferin and Friedelin for Antidiabetic Potential
inferred← citeshttps://doi.org/10.1007/s11224-019-01468-wopenalex-snapshot
The index of ideality of correlation: A statistical yardstick for better QSAR modeling of glucokinase activators
inferred← citeshttps://doi.org/10.1007/s40200-022-01019-xopenalex-snapshot
Targeting human Glucokinase for the treatment of type 2 diabetes: an overview of allosteric Glucokinase activators
inferred← citeshttps://doi.org/10.1007/s40203-021-00116-8openalex-snapshot
Investigation of phytoconstituents of Enicostemma littorale as potential glucokinase activators through molecular docking for the treatment of type 2 diabetes mellitus
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Notable synthesis, properties and chemical gas sensing trends on molybdenum disulphides and diselenides two-dimensional nanostructures: A critical review
inferred← citeshttps://doi.org/10.1016/j.comptc.2023.114079openalex-snapshot
Chemical sensing ability of aminated graphdiyne (GDY-NH2) toward highly toxic organic volatile pollutants
inferred← citeshttps://doi.org/10.1016/j.ejmech.2017.07.051openalex-snapshot
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.molliq.2017.12.011openalex-snapshot
Synthesis, characterization and corrosion inhibition studies of N-phenyl-benzamides on the acidic corrosion of mild steel: Experimental and computational studies
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.128916openalex-snapshot
Hetero-substituted sulfonamido-benzamide hybrids as glucokinase activators: Design, synthesis, molecular docking and in-silico ADME evaluation
inferred← citeshttps://doi.org/10.1016/j.molstruc.2022.133803openalex-snapshot
Glucokinase activity enhancement by cellulose nanocrystals isolated from jujube seed: A novel perspective for type II diabetes mellitus treatment (In vitro)
inferred← citeshttps://doi.org/10.1016/j.obmed.2021.100329openalex-snapshot
Novel and emerging therapeutic drug targets for management of type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1016/j.rechem.2023.101105openalex-snapshot
Molecular docking, 2D-QSAR and ADMET studies of 4-sulfonyl-2-pyridone heterocycle as a potential glucokinase activator
inferred← citeshttps://doi.org/10.1016/j.sciaf.2024.e02226openalex-snapshot
Potential dual inhibitors of Hexokinases and mitochondrial complex I discovered through machine learning approach
inferred← citeshttps://doi.org/10.1016/j.sjbs.2022.01.058openalex-snapshot
Development of antidiabetic drugs from benzamide derivatives as glucokinase activator: A computational approach
inferred← citeshttps://doi.org/10.1021/acsomega.4c11555openalex-snapshot
Corrosion Inhibition and Adsorption Properties of N -{2-[2-(5-Methyl-1 H -pyrazol-3-yl)acetamido]phenyl}benzamide Monohydrate on C38 Steel in 1 M HCl: Insights from Electrochemical Analysis, DFT, and MD Simulations
inferred← citeshttps://doi.org/10.1021/acsomega.8b00039openalex-snapshot
Greener Biogenic Approach for the Synthesis of Palladium Nanoparticles Using Papaya Peel: An Eco-Friendly Catalyst for C–C Coupling Reaction
inferred← citeshttps://doi.org/10.1038/srep44681openalex-snapshot
Identification of mangiferin as a potential Glucokinase activator by structure-based virtual ligand screening
inferred← citeshttps://doi.org/10.1039/d3nj02388eopenalex-snapshot
Fabrication of versatile and sustainable cellulose nanocrystals from lettuce stalks as potential tamoxifen delivery vehicles for breast cancer treatment: biophysical, cellular and theoretical studies
inferred← citeshttps://doi.org/10.1080/07391102.2020.1854116openalex-snapshot
In vitroandin silicoevaluation ofN-(alkyl/aryl)-2-chloro-4-nitro-5- [(4-nitrophenyl)sulfamoyl]benzamide derivatives for antidiabetic potential using docking and molecular dynamic simulations
inferred← citeshttps://doi.org/10.1080/10406638.2022.2039229openalex-snapshot
Conformational, Reactivity Analysis, Wavefunction-Based Properties, Molecular Docking and Simulations of a Benzamide Derivative with Potential Antitumor Activity-DFT and MD Simulations
inferred← citeshttps://doi.org/10.1080/20468954.2024.2389762openalex-snapshot
Insights to the emerging potential of glucokinase activators as antidiabetic agent
inferred← citeshttps://doi.org/10.1111/cbdd.13979openalex-snapshot
A comprehensive review on glucokinase activators: Promising agents for the treatment of Type 2 diabetes
inferred← citeshttps://doi.org/10.1186/s13065-019-0532-8openalex-snapshot
Design, synthesis and evaluation of novel 3,5-disubstituted benzamide derivatives as allosteric glucokinase activators
inferred← citeshttps://doi.org/10.12677/cc.2018.24017openalex-snapshot
Progress in Hypoglycemic and Lipid-Lowering Drugs
inferred← citeshttps://doi.org/10.1517/13543784.2016.1152260openalex-snapshot
Investigational insulin secretagogues for type 2 diabetes
inferred← citeshttps://doi.org/10.2174/1381612826666200414163148openalex-snapshot
Recent Developments in Medicinal Chemistry of Allosteric Activators of Human Glucokinase for Type 2 Diabetes Mellitus Therapeutics
inferred← citeshttps://doi.org/10.2174/1573399814666180724100749openalex-snapshot
Recent Updates on Glucokinase Activators and Glucokinase Regulatory Protein Disrupters for the Treatment of Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.2174/1573408017666211029160203openalex-snapshot
In-silico Exploration of Phytoconstituents of Gymnema sylvestre as Potential Glucokinase Activators and DPP-IV Inhibitors for the Future Synthesis of Silver Nanoparticles for the Treatment of Type 2 Diabetes Mellitus
inferred← citeshttps://doi.org/10.2174/1573408018666220218093451openalex-snapshot
Design, Synthesis, Molecular Docking and In vitro Biological Evaluation of Benzamide Derivatives as Novel Glucokinase Activators
inferred← citeshttps://doi.org/10.31024/ajpp.2019.5.1.18openalex-snapshot
Molecular docking assessment of N-heteroaryl substituted benzamide derivatives as glucokinase activators
inferred← citeshttps://doi.org/10.31032/ijbpas/2021/10.8.5574openalex-snapshot
IN SILICO DESIGN, SYNTHESIS AND EVALUATION OF NOVEL BENZAMIDE DERIVATIVES AS NEWER GLUCOKINASE ACTIVATORS
inferred← citeshttps://doi.org/10.3389/fphar.2017.00169openalex-snapshot
Compound 19e, a Novel Glucokinase Activator, Protects against Cytokine-Induced Beta-Cell Apoptosis in INS-1 Cells
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