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Production of Recombinant Adeno-associated Virus Vectors Using Suspension HEK293 Cells and Continuous Harvest of Vector From the Culture Media for GMP FIX and FLT1 Clinical Vector
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Efficient recombinant adeno-associated virus production by a stable rep-cap HeLa cell line correlates with adenovirus-induced amplification of the integrated rep-cap genome
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Scalable production of adeno‐associated virus type 2 vectors via suspension transfection
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Economized large‐scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system
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Large-Scale Production of Recombinant Adeno-Associated Viral Vectors
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High-titer, serum-free production of adeno-associated virus vectors by polyethyleneimine-mediated plasmid transfection in mammalian suspension cells
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Critical assessment of current adeno-associated viral vector production and quantification methods
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Purification of recombinant adeno-associated virus type 8 vectors by ion exchange chromatography generates clinical grade vector stock
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Scalable serum-free production of recombinant adeno-associated virus type 2 by transfection of 293 suspension cells
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Successful Production of Pseudotyped rAAV Vectors Using a Modified Baculovirus Expression System
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Production and purification of serotype 1, 2, and 5 recombinant adeno-associated viral vectors
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35. High Titer Recombinant Adeno-Associated Virus Production Using Replication Deficient Herpes Simplex Viruses Type I
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An efficient rHSV-based complementation system for the production of multiple rAAV vector serotypes
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Toward exascale production of recombinant adeno-associated virus for gene transfer applications
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Clinical gene therapy using recombinant adeno-associated virus vectors
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Production and characterization of adeno-associated viral vectors
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Adeno-associated virus vectors can be efficiently produced without helper virus
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High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap
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Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
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Self-complementary recombinant adeno-associated virus (scAAV) vectors promote efficient transduction independently of DNA synthesis
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An inducible system for highly efficient production of recombinant adeno-associated virus (rAAV) vectors in insect Sf9 cells
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A viral assembly factor promotes AAV2 capsid formation in the nucleolus
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Scalable Purification of Adeno-Associated Virus Type 2, 4, or 5 Using Ion-Exchange Chromatography
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Insect Cells as a Factory to Produce Adeno-Associated Virus Type 2 Vectors
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Novel Tools for Production and Purification of Recombinant Adenoassociated Virus Vectors
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Scalable Recombinant Adeno-Associated Virus Production Using Recombinant Herpes Simplex Virus Type 1 Coinfection of Suspension-Adapted Mammalian Cells
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Rapid, Simple, and Versatile Manufacturing of Recombinant Adeno-Associated Viral Vectors at Scale
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Efficient Serotype-Dependent Release of Functional Vector into the Culture Medium During Adeno-Associated Virus Manufacturing
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Adenovirus-Associated Defective Virus Particles
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Herpes Simplex Virus Types 1 and 2 Completely Help Adenovirus-Associated Virus Replication
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Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus
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Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity
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Scalable Generation of High-Titer Recombinant Adeno-Associated Virus Type 5 in Insect Cells
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inferred← citeshttps://doi.org/10.1016/j.jbiotec.2025.12.007openalex-snapshot
Multi-parameter process optimization for high yield AAV2 vector production using scale-down multi-parallel bioreactor systems and high-throughput analytical tools
inferred← citeshttps://doi.org/10.1016/j.jchromb.2019.06.011openalex-snapshot
Scalable method utilizing low pH for DNA removal in the harvest of recombinant adeno-associated virus vectors
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.113600openalex-snapshot
AAV9-delivery of interleukin-37b gene prevents recurrent herpetic stromal keratitis via the SIGIRR pathway in mice
inferred← citeshttps://doi.org/10.1016/j.memlet.2026.100120openalex-snapshot
IROP: Ionic regulation of permeation for high-yield AAV purification
inferred← citeshttps://doi.org/10.1016/j.nbt.2026.02.008openalex-snapshot
Automated plasmid purification system enables increased AAV production
inferred← citeshttps://doi.org/10.1016/j.neurot.2024.e00434openalex-snapshot
Neurosurgical gene therapy for central nervous system diseases
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201700openalex-snapshot
Manufacture of adeno-associated virus vectors by a novel human-derived cell line HAT and comprehensive evaluation of the vectors
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201777openalex-snapshot
CRISPR-Cas9 screening reveals TM9SF2 knockout as a solution to HEK293 cell aggregation for improved AAV production
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201787openalex-snapshot
AAV vector production in suspension cells using PEI transfection and sodium butyrate with orthogonal assessment of function and quality
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201815openalex-snapshot
Host determinants of exo-rAAV production revealed by extended gene expression analysis in HEK293 cells
inferred← citeshttps://doi.org/10.1016/j.omta.2026.201829openalex-snapshot
Development of the “EASY-HSV system” based on HSV-1 genome-maintaining 293 cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2017.11.002openalex-snapshot
A Robust System for Production of Superabundant VP1 Recombinant AAV Vectors
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.01.002openalex-snapshot
Pharmacology of Recombinant Adeno-associated Virus Production
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.05.001openalex-snapshot
Helper-free Production of Laboratory Grade AAV and Purification by Iodixanol Density Gradient Centrifugation
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.05.005openalex-snapshot
A Recombinant Baculovirus Efficiently Generates Recombinant Adeno-Associated Virus Vectors in Cultured Insect Cells and Larvae
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.07.011openalex-snapshot
An Observational Study from Long-Term AAV Re-administration in Two Hemophilia Dogs
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.09.005openalex-snapshot
Development of a Novel Recombinant Adeno-Associated Virus Production System Using Human Bocavirus 1 Helper Genes
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.10.015openalex-snapshot
Highly Efficient Ultracentrifugation-free Chromatographic Purification of Recombinant AAV Serotype 9
inferred← citeshttps://doi.org/10.1016/j.omtm.2018.11.004openalex-snapshot
Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.03.013openalex-snapshot
Development of an In Vitro Biopotency Assay for an AAV8 Hemophilia B Gene Therapy Vector Suitable for Clinical Product Release
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.05.018openalex-snapshot
Methods Matter: Standard Production Platforms for Recombinant AAV Produce Chemically and Functionally Distinct Vectors
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.06.004openalex-snapshot
Creation of a High-Yield AAV Vector Production Platform in Suspension Cells Using a Design-of-Experiment Approach
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.10.014openalex-snapshot
Targeting the Root Cause of Mucopolysaccharidosis IIIA with a New scAAV9 Gene Replacement Vector
inferred← citeshttps://doi.org/10.1016/j.omtm.2020.10.023openalex-snapshot
Modulation of the liver immune microenvironment by the adeno-associated virus serotype 8 gene therapy vector
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.02.010openalex-snapshot
Analytical methods for process and product characterization of recombinant adeno-associated virus-based gene therapies
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.04.006openalex-snapshot
Mechanistic model for production of recombinant adeno-associated virus via triple transfection of HEK293 cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.11.013openalex-snapshot
Assessment of genome packaging in AAVs using Orbitrap-based charge-detection mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.omtm.2021.12.006openalex-snapshot
Comparison of highly pure rAAV9 vector stocks produced in suspension by PEI transfection or HSV infection reveals striking quantitative and qualitative differences
inferred← citeshttps://doi.org/10.1016/j.omtm.2022.02.002openalex-snapshot
In vivo overexpression of frataxin causes toxicity mediated by iron-sulfur cluster deficiency
inferred← citeshttps://doi.org/10.1016/j.omtm.2023.01.002openalex-snapshot
Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2023.07.007openalex-snapshot
Partial genome content within rAAVs impacts performance in a cell assay-dependent manner
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101188openalex-snapshot
Recombinant AAV genome size effect on viral vector production, purification, and thermostability
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101194openalex-snapshot
Liter-scale manufacturing of shelf-stable plasmid DNA/PEI transfection particles for viral vector production
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101278openalex-snapshot
Temporal insights into molecular and cellular responses during rAAV production in HEK293T cells
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101317openalex-snapshot
An autonucleolytic suspension HEK293F host cell line for high-titer serum-free AAV5 and AAV9 production with reduced levels of DNA impurity
inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101329openalex-snapshot
Unlocking DOE potential by selecting the most appropriate design for rAAV optimization
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101424openalex-snapshot
Preclinical development of TAK-754, a high-performance AAV8-based vector expressing coagulation factor VIII
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101441openalex-snapshot
A two-pass anion-exchange chromatography strategy for enrichment of full capsids in manufacturing of adeno-associated viral vectors
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101530openalex-snapshot
Orthogonal approaches to AAV vector characterization: Validating quantitative TEM for partially filled particles
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101594openalex-snapshot
Establishment of a novel human amniotic epithelial-derived cell line, HAT, for high-yield AAV vector production
inferred← citeshttps://doi.org/10.1016/j.omtm.2025.101615openalex-snapshot
Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells
inferred← citeshttps://doi.org/10.1016/j.omtn.2022.03.017openalex-snapshot
Directed evolution of adeno-associated virus 5 capsid enables specific liver tropism
inferred← citeshttps://doi.org/10.1016/j.omtn.2025.102563openalex-snapshot
AAVone: A cost-effective, single-plasmid solution for efficient AAV production with reduced DNA impurities
inferred← citeshttps://doi.org/10.1016/j.pep.2025.106867openalex-snapshot
Optimized production and coagulation activity of rhFVII in HEK293 cells for bleeding disorders
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108104openalex-snapshot
Gene modification: Exploring the potential in treating kidney diseases
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2020.100915openalex-snapshot
Immune responses to retinal gene therapy using adeno-associated viral vectors – Implications for treatment success and safety
inferred← citeshttps://doi.org/10.1016/j.redox.2021.102198openalex-snapshot
The metabolic signaling of the nucleoredoxin-like 2 gene supports brain function
inferred← citeshttps://doi.org/10.1016/j.seppur.2024.128557openalex-snapshot
Single-use chromatographic clarification to eliminate endonuclease treatment in production of recombinant adeno-associated viral vectors
inferred← citeshttps://doi.org/10.1016/j.slast.2026.100404openalex-snapshot
Viral vector research in human gene therapy: Basic principles, alternative evaluation models, and clinical applications
inferred← citeshttps://doi.org/10.1016/j.synbio.2025.12.018openalex-snapshot
Enhanced AAV production via rational design of a novel pHelper vector integrated with HSV-1 helper genes
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.03.026openalex-snapshot
Combined 100 keV Cryo-Electron Microscopy and Image Analysis Methods to Characterize the Wider Adeno-Associated Viral Products
inferred← citeshttps://doi.org/10.1016/j.ymthe.2017.03.033openalex-snapshot
Gene Therapy for Hemophilia
inferred← citeshttps://doi.org/10.1016/j.ymthe.2018.01.009openalex-snapshot
Long-Term Improvement of Neurological Signs and Metabolic Dysfunction in a Mouse Model of Krabbe’s Disease after Global Gene Therapy
inferred← citeshttps://doi.org/10.1016/j.ymthe.2018.07.011openalex-snapshot
Systemic AAV Micro-dystrophin Gene Therapy for Duchenne Muscular Dystrophy
inferred← citeshttps://doi.org/10.1016/j.ymthe.2018.07.015openalex-snapshot
Longitudinal In Vivo Monitoring of the CNS Demonstrates the Efficacy of Gene Therapy in a Sheep Model of CLN5 Batten Disease
inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.01.026openalex-snapshot
Waning efficacy in a long-term AAV-mediated gene therapy study in the murine model of Krabbe disease
inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.04.005openalex-snapshot
Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses
inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.05.002openalex-snapshot
“D” matters in recombinant AAV DNA packaging
inferred← citeshttps://doi.org/10.1016/j.ymthe.2022.09.015openalex-snapshot
AAV vectors: The Rubik’s cube of human gene therapy
inferred← citeshttps://doi.org/10.1016/j.ymthe.2023.11.022openalex-snapshot
Systematic comparison of rAAV vectors manufactured using large-scale suspension cultures of Sf9 and HEK293 cells
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.04.030openalex-snapshot
Age-sensitive response of systemic AAV-mediated gene therapy in a newly characterized feline model of mucolipidosis II
inferred← citeshttps://doi.org/10.1016/j.ymthe.2025.12.039openalex-snapshot
Intravenous administration of EXG110 resulted in substrate correction in Fabry mice and sustained enzyme activity in non-human primates
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00790openalex-snapshot
Programmable Assembly of Adeno-Associated Virus–Antibody Composites for Receptor-Mediated Gene Delivery
inferred← citeshttps://doi.org/10.1021/acs.langmuir.2c02643openalex-snapshot
Empty and Full AAV Capsid Charge and Hydrophobicity Differences Measured with Single-Particle AFM
inferred← citeshttps://doi.org/10.1021/acs.langmuir.3c00241openalex-snapshot
Distinguishing between DNA-Loaded Full and Empty Capsids of Adeno-Associated Virus with Atomic Force Microscopy Imaging
inferred← citeshttps://doi.org/10.1021/acssynbio.2c00207openalex-snapshot
Construction of an rAAV Producer Cell Line through Synthetic Biology
inferred← citeshttps://doi.org/10.1021/cbmi.5c00070openalex-snapshot
An Automated Workflow Leveraging Machine Learning for Physical Titer Determination from Cryo-TEM Images of Adeno-Associated Virus Capsids
inferred← citeshttps://doi.org/10.1038/mtm.2015.49openalex-snapshot
Manufacturing of recombinant adeno-associated viral vectors: new technologies are welcome
inferred← citeshttps://doi.org/10.1038/mtm.2016.15openalex-snapshot
Distribution of AAV8 particles in cell lysates and culture media changes with time and is dependent on the recombinant vector
inferred← citeshttps://doi.org/10.1038/mtm.2016.2openalex-snapshot
Manufacturing of recombinant adeno-associated viral vectors for clinical trials
inferred← citeshttps://doi.org/10.1038/mtm.2016.31openalex-snapshot
A scalable method for the production of high-titer and high-quality adeno-associated type 9 vectors using the HSV platform
inferred← citeshttps://doi.org/10.1038/nrd.2018.110openalex-snapshot
Gene therapy for neurological disorders: progress and prospects
inferred← citeshttps://doi.org/10.1038/nrd.2018.158openalex-snapshot
Erratum: Gene therapy for neurological disorders: progress and prospects
inferred← citeshttps://doi.org/10.1038/s41434-020-0159-3openalex-snapshot
Treating Bietti crystalline dystrophy in a high-fat diet-exacerbated murine model using gene therapy
inferred← citeshttps://doi.org/10.1038/s41434-022-00368-9openalex-snapshot
IgG-cleavage protein allows therapeutic AAV gene delivery in passively immunized MPS IIIA mice
inferred← citeshttps://doi.org/10.1038/s41434-022-00380-zopenalex-snapshot
Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters
inferred← citeshttps://doi.org/10.1038/s41434-024-00477-7openalex-snapshot
The AAV2.7m8 capsid packages a higher degree of heterogeneous vector genomes than AAV2
inferred← citeshttps://doi.org/10.1038/s41467-021-26485-4openalex-snapshot
The membrane associated accessory protein is an adeno-associated viral egress factor
inferred← citeshttps://doi.org/10.1038/s41467-022-28738-2openalex-snapshot
Self-attenuating adenovirus enables production of recombinant adeno-associated virus for high manufacturing yield without contamination
inferred← citeshttps://doi.org/10.1038/s41467-026-71796-zopenalex-snapshot
A synthetic angiotensin II/ACE2-based hormone shunt controlling experimental hypertension
inferred← citeshttps://doi.org/10.1038/s41467-026-73921-4openalex-snapshot
Trivalent ions kinetic-gating for producing high-concentration and shelf-stable plasmid DNA/PEI particles
inferred← citeshttps://doi.org/10.1038/s41573-019-0012-9openalex-snapshot
Adeno-associated virus vector as a platform for gene therapy delivery
inferred← citeshttps://doi.org/10.1038/s41575-022-00729-0openalex-snapshot
Gene therapy for liver diseases — progress and challenges
inferred← citeshttps://doi.org/10.1038/s41576-019-0205-4openalex-snapshot
Engineering adeno-associated virus vectors for gene therapy
inferred← citeshttps://doi.org/10.1038/s41598-020-67136-wopenalex-snapshot
AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects
inferred← citeshttps://doi.org/10.1038/s41598-023-46298-3openalex-snapshot
Engineered CHO cells as a novel AAV production platform for gene therapy delivery
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