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Production, Processing, and Characterization of Synthetic AAV Gene Therapy Vectors

https://doi.org/10.1002/biot.202000025

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Molecular design for recombinant adeno-associated virus (rAAV) vector production

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Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/s40883-026-00561-xopenalex-snapshot

Revolutionizing Gene Therapy: An Explicative Review on Engineering Adeno-associated Virus Vectors

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2023.11.013openalex-snapshot

Technological advancements in viral vector designing and optimization for therapeutic applications

inferred← citeshttps://doi.org/10.1016/j.ab.2023.115421openalex-snapshot

Separation of full and empty adeno-associated virus capsids by anion-exchange chromatography using choline-type salts

inferred← citeshttps://doi.org/10.1016/j.addr.2021.113940openalex-snapshot

Scaled preparation of extracellular vesicles from conditioned media

inferred← citeshttps://doi.org/10.1016/j.bbadva.2025.100151openalex-snapshot

Quality assessment strategy development and analytical method selection of GMP grade biological drugs for gene and cell therapy

inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189485openalex-snapshot

Employing bacteriophages to combat cancer

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2024.122853openalex-snapshot

Pharmaceutical strategies for optimized mRNA expression

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2023.108179openalex-snapshot

Cell-culture process optimization via model-based predictions of metabolism and protein glycosylation

inferred← citeshttps://doi.org/10.1016/j.biotechadv.2024.108391openalex-snapshot

Advances and opportunities in process analytical technologies for viral vector manufacturing

inferred← citeshttps://doi.org/10.1016/j.cell.2021.02.030openalex-snapshot

Novel approaches for vaccine development

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.464632openalex-snapshot

Rational downstream development for adeno-associated virus full/empty capsid separation – A streamlined methodology based on high-throughput screening and mechanistic modeling

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.464684openalex-snapshot

Adeno-associated virus analysis by size exclusion chromatography within 3 minutes using short bio-inert columns made with 3 µm particles operated at high flowrates

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465396openalex-snapshot

Peptide Ligands for the Affinity Purification of Adenovirus from Hek293 and Vero Cell Lysates

inferred← citeshttps://doi.org/10.1016/j.chroma.2024.465586openalex-snapshot

Purification of AAV8 through a scalable two-step monolithic chromatography approach

inferred← citeshttps://doi.org/10.1016/j.chroma.2025.465672openalex-snapshot

Ion exchange chromatography of biotherapeutics: Fundamental principles and advanced approaches

inferred← citeshttps://doi.org/10.1016/j.chroma.2025.465674openalex-snapshot

Combining steric exclusion with anion exchange – development of a universal and scalable adeno-associated virus downstream process

inferred← citeshttps://doi.org/10.1016/j.chroma.2025.465786openalex-snapshot

Enhancing sanitization for AVB Sepharose resin in AAV vector purification

inferred← citeshttps://doi.org/10.1016/j.chroma.2025.466319openalex-snapshot

Preparative choline-based anion-exchange chromatography for enrichment of full adeno-associated virus capsids

inferred← citeshttps://doi.org/10.1016/j.cobme.2021.100339openalex-snapshot

Overview of analytics needed to support a robust gene therapy manufacturing process

inferred← citeshttps://doi.org/10.1016/j.coche.2021.100722openalex-snapshot

Bioprocess monitoring and control: challenges in cell and gene therapy

inferred← citeshttps://doi.org/10.1016/j.copbio.2021.06.025openalex-snapshot

Analytical methods to characterize recombinant adeno-associated virus vectors and the benefit of standardization and reference materials

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.117010openalex-snapshot

Adeno-associated viral vectors deliver gene vaccines

inferred← citeshttps://doi.org/10.1016/j.ejpb.2023.07.002openalex-snapshot

The ice age – A review on formulation of Adeno-associated virus therapeutics

inferred← citeshttps://doi.org/10.1016/j.gene.2024.148733openalex-snapshot

Delivery of CRISPR/Cas9 system by AAV as vectors for gene therapy

inferred← citeshttps://doi.org/10.1016/j.gene.2024.149122openalex-snapshot

The Unveiled Novel regulator of Adeno-associated virus production in HEK293 cells

inferred← citeshttps://doi.org/10.1016/j.isci.2024.109777openalex-snapshot

New AAV9 engineered variants with enhanced neurotropism and reduced liver off-targeting in mice and marmosets

inferred← citeshttps://doi.org/10.1016/j.jpain.2022.03.234openalex-snapshot

Anti-Nociceptive and Anti-Aversive Drugs Differentially Modulate Distinct Inputs to the Rat Lateral Parabrachial Nucleus

inferred← citeshttps://doi.org/10.1016/j.lfs.2022.120375openalex-snapshot

Gene therapy: Comprehensive overview and therapeutic applications

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.123344openalex-snapshot

AAV2-mediated ABD-FGF21 gene delivery produces a sustained anti-hyperglycemic effect in type 2 diabetic mouse

inferred← citeshttps://doi.org/10.1016/j.omtm.2024.101309openalex-snapshot

Characterization of AAV vectors: A review of analytical techniques and critical quality attributes

inferred← citeshttps://doi.org/10.1016/j.pep.2024.106638openalex-snapshot

Efficient development of nanobody-based affinity chromatography for AAV8 purification

inferred← citeshttps://doi.org/10.1016/j.pmatsci.2022.100961openalex-snapshot

Essential cues of engineered polymeric materials regulating gene transfer pathways

inferred← citeshttps://doi.org/10.1016/j.trac.2023.117088openalex-snapshot

Chromatographic strategies for the analytical characterization of adeno-associated virus vector-based gene therapy products

inferred← citeshttps://doi.org/10.1016/j.trsl.2022.05.002openalex-snapshot

Intranasal application of adeno-associated viruses: a systematic review

inferred← citeshttps://doi.org/10.1016/j.xphs.2021.03.024openalex-snapshot

Manufacturing Challenges and Rational Formulation Development for AAV Viral Vectors

inferred← citeshttps://doi.org/10.1016/j.xphs.2022.03.004openalex-snapshot

Systematic Studies on Stabilization of AAV Vector Formulations by Lyophilization

inferred← citeshttps://doi.org/10.1016/j.xphs.2024.03.024openalex-snapshot

Drug product Formulation and Fill/Finish Manufacturing Process Considerations for AAV-Based Genomic Medicines

inferred← citeshttps://doi.org/10.1016/j.xphs.2025.104017openalex-snapshot

Impact of hydrodynamic, mechanical, and interfacial stress during downstream processing on adeno-associated virus serotype 8 and 9

inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.04.005openalex-snapshot

Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses

inferred← citeshttps://doi.org/10.1021/acs.analchem.5c03104openalex-snapshot

Insights into Adeno-Associated Virus Capsid Charge Heterogeneity

inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00260openalex-snapshot

Directed Evolution: Methodologies and Applications

inferred← citeshttps://doi.org/10.1021/acsnano.4c01888openalex-snapshot

Identifying Viral Vector Characteristics by Nanopore Sensing

inferred← citeshttps://doi.org/10.1021/acsomega.4c10900openalex-snapshot

Improving AAV Production Yield and Quality for Different Serotypes Using Distinct Processing Methods

inferred← citeshttps://doi.org/10.1021/acssynbio.2c00207openalex-snapshot

Construction of an rAAV Producer Cell Line through Synthetic Biology

inferred← citeshttps://doi.org/10.1038/s41392-024-01780-wopenalex-snapshot

Adeno-associated virus as a delivery vector for gene therapy of human diseases

inferred← citeshttps://doi.org/10.1038/s41434-022-00363-0openalex-snapshot

Changing trends in the development of AAV-based gene therapies: a meta-analysis of past and present therapies

inferred← citeshttps://doi.org/10.1038/s41587-025-02945-wopenalex-snapshot

Targeted delivery of genome editors in vivo

inferred← citeshttps://doi.org/10.1080/10826068.2025.2470220openalex-snapshot

Polyethylene glycol precipitation: fundamentals and recent advances

inferred← citeshttps://doi.org/10.1089/genbio.2021.0013openalex-snapshot

Advancing the Research and Development of Enzyme Replacement Therapies for Lysosomal Storage Diseases

inferred← citeshttps://doi.org/10.1089/hum.2019.284openalex-snapshot

Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography

inferred← citeshttps://doi.org/10.1089/hum.2021.080openalex-snapshot

rAAV Production and Titration at the Microscale for High-Throughput Screening

inferred← citeshttps://doi.org/10.1089/hum.2022.001openalex-snapshot

Development of an Inducible, Replication-Competent Assay Cell Line for Titration of Infectious Recombinant Adeno-Associated Virus Vectors

inferred← citeshttps://doi.org/10.1101/2023.11.06.565870openalex-snapshot

Hidden rAAV Breakpoints Detected Using Single-Molecule, Modified Base Sequencing

inferred← citeshttps://doi.org/10.1126/sciadv.abn4704openalex-snapshot

Semirational bioengineering of AAV vectors with increased potency and specificity for systemic gene therapy of muscle disorders

inferred← citeshttps://doi.org/10.1134/s0006297923120179openalex-snapshot

Viral Vectors in Gene Replacement Therapy

inferred← citeshttps://doi.org/10.1155/2023/2339702openalex-snapshot

Comprehensive Comparison of AAV Purification Methods: Iodixanol Gradient Centrifugation vs. Immuno-Affinity Chromatography

inferred← citeshttps://doi.org/10.1177/10430342251408498openalex-snapshot

Exploring Development Options of a Polishing Chromatography Step for AAV7 and AAV8

inferred← citeshttps://doi.org/10.1186/s12951-025-03595-5openalex-snapshot

An adeno-associated virus gene therapy strategy for anti-obesity treatment by nanocarrier-based delivery systems

inferred← citeshttps://doi.org/10.1186/s40364-024-00618-5openalex-snapshot

Gene therapy for polygenic or complex diseases

inferred← citeshttps://doi.org/10.1208/s12248-022-00768-0openalex-snapshot

ACUVRA: Anion-Exchange Chromatography UV-Ratio Analysis—A QC-Friendly Method for Monitoring Adeno-Associated Virus Empty Capsid Content To Support Process Development and GMP Release Testing

inferred← citeshttps://doi.org/10.13005/bpj/3040openalex-snapshot

Optimizing AAV Filtration: Comparative Analysis of Membrane Performance and Recovery Rates

inferred← citeshttps://doi.org/10.2147/idr.s544665openalex-snapshot

Vaccines as Potential Frontliners Against Antimicrobial Resistance (AMR): A Focused Review

inferred← citeshttps://doi.org/10.2174/0115665232369708250327081305openalex-snapshot

Imaged Capillary Isoelectric Focusing (icIEF) Platform for Characterization of Charge Variants of Adeno-Associated Virus (AAV) Capsids and Impact on their Transduction Efficiency

inferred← citeshttps://doi.org/10.21769/bioprotoc.4931openalex-snapshot

Streamlined Adeno-Associated Virus Production Using Suspension HEK293T Cells

inferred← citeshttps://doi.org/10.3389/fceng.2022.830421openalex-snapshot

Process Improvement of Adeno-Associated Virus Production

inferred← citeshttps://doi.org/10.3389/fcvm.2022.952755openalex-snapshot

AAV-mediated gene therapy: Advancing cardiovascular disease treatment

inferred← citeshttps://doi.org/10.3389/fmed.2021.809118openalex-snapshot

Gene Therapy Advances: A Meta-Analysis of AAV Usage in Clinical Settings

inferred← citeshttps://doi.org/10.3389/fnins.2022.966772openalex-snapshot

Applications and challenges of rhodopsin-based optogenetics in biomedicine

inferred← citeshttps://doi.org/10.3390/biomedicines13020361openalex-snapshot

Consecutive Affinity and Ion-Exchange Chromatography for AAV9 Vectors Purification

inferred← citeshttps://doi.org/10.3390/ijms26178282openalex-snapshot

AAV-Based Gene Therapy: Opportunities, Risks, and Scale-Up Strategies

inferred← citeshttps://doi.org/10.3390/ijms27156846openalex-snapshot

AAV Vectors in Regenerative Medicine and Cellular Reprogramming: Potential, Pitfalls, and Specificity Constraints

inferred← citeshttps://doi.org/10.3390/membranes12100944openalex-snapshot

Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes

inferred← citeshttps://doi.org/10.3390/membranes13090770openalex-snapshot

Affinity and Pseudo-Affinity Membrane Chromatography for Viral Vector and Vaccine Purifications: A Review

inferred← citeshttps://doi.org/10.3390/pharmaceutics15071931openalex-snapshot

Virus-Based Biological Systems as Next-Generation Carriers for the Therapy of Central Nervous System Diseases

inferred← citeshttps://doi.org/10.3390/separations11030073openalex-snapshot

Accelerated Development of AAV Purification Process Using a High-Throughput and Automated Crossflow System

inferred← citeshttps://doi.org/10.3390/therapeutics1020011openalex-snapshot

Application of Invasive Bacteria for the Delivery of Anti-Cancer Therapeutics

inferred← citeshttps://doi.org/10.3390/v14020266openalex-snapshot

Induction of Hepatitis E Virus Anti-ORF3 Antibodies from Systemic Administration of a Muscle-Specific Adeno-Associated Virus (AAV) Vector

inferred← citeshttps://doi.org/10.3390/v16081235openalex-snapshot

In-Depth Comparison of Adeno-Associated Virus Containing Fractions after CsCl Ultracentrifugation Gradient Separation

inferred← citeshttps://doi.org/10.3390/v17020239openalex-snapshot

Adeno-Associated Virus Vectors: Principles, Practices, and Prospects in Gene Therapy

inferred← citeshttps://doi.org/10.52243/bptjm.v1i2.28openalex-snapshot

Gene Therapy for Hemophilia

inferred← citeshttps://doi.org/10.56530/lcgc.na.st3379l8openalex-snapshot

Characterization of Adeno-Associated Virus (AAV) Gene Therapy Products

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