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Crystal Structure Determination of Aristolochene Synthase from the Blue Cheese Mold, Penicillium roqueforti*
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics
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Overexpression in Escherichia coli of Soluble Aristolochene Synthase from Penicillium roqueforti
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Expression of a Plant Sesquiterpene Cyclase Gene in Escherichia coli
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Purification and characterization of the sesquiterpene cyclase aristolochene synthase from Penicillium roqueforti
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Ishwarane in Bixa orellana leaf oil
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5-epi-aristolochene is a common precursor of the sesquiterpenoid phytoalexins capsidiol and debneyol
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Synthesis of (+)-5-epi-aristolochene and (+)-1-deoxycapsidiol from capsidiol
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Monoterpene Biosynthesis
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Sesquiterpene Biosynthesis: Cyclization Mechanisms
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Aristolochene synthase. Isolation, characterization, and bacterial expression of a sesquiterpenoid biosynthetic gene (Ari1) from Penicillium roqueforti.
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Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
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Ishwarane and aristolochene, two new sesquiterpene hydrocarbons from Aristolochia indica
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[44] Monoterpene and sesquiterpene cyclases
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[31] PHASES-95: A program package for processing and analyzing diffraction data from macromolecules
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A fast algorithm for rendering space-filling molecule pictures
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Managing and manipulating carbocations in biology: terpenoid cyclase structure and mechanism
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Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes
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Isoprenoid biosynthesis. Stereochemistry of the cyclization of allylic pyrophosphates
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Novel ion specificity of a carboxylate cluster magnesium(II) binding site: Strong charge selectivity and weak size selectivity
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Crystal Structure of Recombinant Farnesyl Diphosphate Synthase at 2.6-.ANG. Resolution
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Trichodiene Synthase. Probing the Role of the Highly Conserved Aspartate-Rich Region by Site-Directed Mutagenesis
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Enzymic formation of sesquiterpenes
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Aristolochene Synthase. Mechanism-Based Inhibition of a Terpenoid Cyclase
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Aristolochene biosynthesis. Stereochemistry of the deprotonation steps in the enzymatic cyclization of farnesyl pyrophosphate
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Aristolochene biosynthesis and enzymatic cyclization of farnesyl pyrophosphate
inferredcites →https://doi.org/10.1021/ja961981bopenalex-snapshot
Aristolochene Synthase. Elucidation of the Cryptic Germacrene A Synthase Activity Using the Anomalous Substrate Dihydrofarnesyl Diphosphate
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Carbocation−π Interaction: Computational Study of Complexation of Methyl Cation with Benzene and Comparisons with Related Systems
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Demonstration of Germacrene A as an Intermediate in 5-Epi-aristolochene Synthase Catalysis
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Cloning and Bacterial Expression of a Sesquiterpene Cyclase from Hyoscyamus muticus and Its Molecular Comparison to Related Terpene Cyclases
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Crystallographic Computing 6
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The structure and evolution of a/β barrel proteins
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Induction of Sesquiterpene Cyclase and Suppression of Squalene Synthetase Activities in Plant Cell Cultures Treated with Fungal Elicitor
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MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures
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Improved methods for building protein models in electron density maps and the location of errors in these models
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The CCP4 suite: programs for protein crystallography
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Methods used in the structure determination of bovine mitochondrial F1 ATPase
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inferredcites →https://doi.org/10.1126/science.277.5333.1820openalex-snapshot
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Comprehensive natural products chemistry
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Isolation of (-)-.GAMMA.-cadinene and aristolochene from Aspergillus terreus.
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inferred← citeshttps://doi.org/10.1021/jo902397vopenalex-snapshot
Intermediacy of Eudesmane Cation during Catalysis by Aristolochene Synthase
inferred← citeshttps://doi.org/10.1021/ol2000843openalex-snapshot
Inhibition of (+)-Aristolochene Synthase with Iminium Salts Resembling Eudesmane Cation
inferred← citeshttps://doi.org/10.1038/ja.2016.39openalex-snapshot
General base-general acid catalysis by terpenoid cyclases
inferred← citeshttps://doi.org/10.1038/nature04607openalex-snapshot
Designed divergent evolution of enzyme function
inferred← citeshttps://doi.org/10.1038/nrmicro1286openalex-snapshot
Fungal secondary metabolism — from biochemistry to genomics
inferred← citeshttps://doi.org/10.1038/s41467-019-10220-1openalex-snapshot
The UbiX flavin prenyltransferase reaction mechanism resembles class I terpene cyclase chemistry
inferred← citeshttps://doi.org/10.1039/b008338kopenalex-snapshot
Mutagenesis approaches to deduce structure–function relationships in terpene synthases
inferred← citeshttps://doi.org/10.1039/b206517gopenalex-snapshot
Tyrosine 92 of aristolochene synthase directs cyclisation of farnesyl pyrophosphateElectronic supplementary information (ESI) available: GC-profiles of co-injections of 4 from ASY92V and authentic material and mass spectra of 4 produced by ASY92V and an authentic sample. See…
inferred← citeshttps://doi.org/10.1039/b306867fopenalex-snapshot
Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysisElectronic Supplementary Information (ESI) available: GC profiles of co-injections of germacrene A from ASW334F and ASW334V with authentic germacrene A; mass spectra of germacrene A produced by ASW334V and…
inferred← citeshttps://doi.org/10.1039/b407932aopenalex-snapshot
Dual role for phenylalanine 178 during catalysis by aristolochene synthase
inferred← citeshttps://doi.org/10.1039/b507392hopenalex-snapshot
Bacterial volatiles: the smell of small organisms
inferred← citeshttps://doi.org/10.1039/b604147gopenalex-snapshot
Stabilisation of transition states prior to and following eudesmane cation in aristolochene synthase
inferred← citeshttps://doi.org/10.1039/b709562gopenalex-snapshot
Probing the reaction mechanism of aristolochene synthase with 12,13-difluorofarnesyl diphosphate
inferred← citeshttps://doi.org/10.1039/b713301bopenalex-snapshot
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity
inferred← citeshttps://doi.org/10.1039/b804198aopenalex-snapshot
Stereochemistry of eudesmane cation formation during catalysis by aristolochene synthase from Penicillium roqueforti
inferred← citeshttps://doi.org/10.1039/c0cc02960bopenalex-snapshot
Electrostatic effects on (di)terpene synthase product outcome
inferred← citeshttps://doi.org/10.1039/c1np00060hopenalex-snapshot
Sesquiterpene synthases: Passive catalysts or active players?
inferred← citeshttps://doi.org/10.1039/c1np00063bopenalex-snapshot
Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis
inferred← citeshttps://doi.org/10.1039/c1ob06184dopenalex-snapshot
Templating effects in aristolochene synthase catalysis: elimination versus cyclisation
inferred← citeshttps://doi.org/10.1039/c1ra00212kopenalex-snapshot
Biosynthesis of acorane sesquiterpenes by Trichoderma
inferred← citeshttps://doi.org/10.1039/c2cc17588fopenalex-snapshot
The role of aristolochene synthase in diphosphate activation
inferred← citeshttps://doi.org/10.1039/c2np20059gopenalex-snapshot
Terpenoid synthase structures: a so far incomplete view of complex catalysis
inferred← citeshttps://doi.org/10.1039/c4ob00479eopenalex-snapshot
Improved selectivity of an engineered multi-product terpene synthase
inferred← citeshttps://doi.org/10.1039/c6ob01761dopenalex-snapshot
Carbocation–π interaction: evaluation of the stabilization by phenylalanine of a biochemical carbocation intermediate
inferred← citeshttps://doi.org/10.1039/c8np00026copenalex-snapshot
Cyclopentane-forming di/sesterterpene synthases: widely distributed enzymes in bacteria, fungi, and plants
inferred← citeshttps://doi.org/10.1039/c8ob02744gopenalex-snapshot
Mechanistic characterization of three sesquiterpene synthases from the termite-associated fungus Termitomyces
inferred← citeshttps://doi.org/10.1039/d0ob01565bopenalex-snapshot
A simpler method affords evaluation of π stabilization by phenylalanine of several biochemical carbocations
inferred← citeshttps://doi.org/10.1055/a-1675-8208openalex-snapshot
Mechanistic Investigations on Microbial Type I Terpene Synthases through Site-Directed Mutagenesis
inferred← citeshttps://doi.org/10.1073/pnas.0337625100openalex-snapshot
Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis
inferred← citeshttps://doi.org/10.1073/pnas.0802312105openalex-snapshot
Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol
inferred← citeshttps://doi.org/10.1073/pnas.231313098openalex-snapshot
Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade
inferred← citeshttps://doi.org/10.1073/pnas.232591099openalex-snapshot
Bornyl diphosphate synthase: Structure and strategy for carbocation manipulation by a terpenoid cyclase
inferred← citeshttps://doi.org/10.1073/pnas.261562898openalex-snapshot
Molecular scaffolds for chemical wizardry: Learning nature's rules for terpene cyclases
inferred← citeshttps://doi.org/10.1074/jbc.m109.064683openalex-snapshot
Crystal Structure of Albaflavenone Monooxygenase Containing a Moonlighting Terpene Synthase Active Site
inferred← citeshttps://doi.org/10.1074/jbc.m110.165845openalex-snapshot
Cloning and Characterization of an Armillaria gallica cDNA Encoding Protoilludene Synthase, Which Catalyzes the First Committed Step in the Synthesis of Antimicrobial Melleolides
inferred← citeshttps://doi.org/10.1074/jbc.m111.337592openalex-snapshot
Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis
inferred← citeshttps://doi.org/10.1074/jbc.m114.571703openalex-snapshot
Plasticity and Evolution of (+)-3-Carene Synthase and (−)-Sabinene Synthase Functions of a Sitka Spruce Monoterpene Synthase Gene Family Associated with Weevil Resistance
inferred← citeshttps://doi.org/10.1074/jbc.m807140200openalex-snapshot
Defining the Potassium Binding Region in an Apple Terpene Synthase
inferred← citeshttps://doi.org/10.1093/bulcsj/uoag032openalex-snapshot
Structure-guided switching of carbocation quenching in sesquiterpene synthases for accessing aromadendrane and guaiane frameworks
inferred← citeshttps://doi.org/10.1101/cshperspect.a023903openalex-snapshot
The Need for Integrated Approaches in Metabolic Engineering
inferred← citeshttps://doi.org/10.1104/pp.110.161828openalex-snapshot
Characterization of δ-Guaiene Synthases from Cultured Cells of Aquilaria , Responsible for the Formation of the Sesquiterpenes in Agarwood
inferred← citeshttps://doi.org/10.1105/tpc.106.047779openalex-snapshot
Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function
inferred← citeshttps://doi.org/10.1107/s2053230x14003100openalex-snapshot
Crystallization and preliminary X-ray diffraction analysis of the diterpene cyclooctatin synthase (CYC) fromStreptomycessp. LZ35
inferred← citeshttps://doi.org/10.1111/1541-4337.12069openalex-snapshot
Filamentous Fungi and Mycotoxins in Cheese: A Review
inferred← citeshttps://doi.org/10.1111/j.1365-2958.2009.06717.xopenalex-snapshot
Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus
inferred← citeshttps://doi.org/10.1111/jam.12706openalex-snapshot
Penicillium roqueforti: a multifunctional cell factory of high value-added molecules
inferred← citeshttps://doi.org/10.1111/pce.12340openalex-snapshot
Biogenic volatile emissions from the soil
inferred← citeshttps://doi.org/10.1128/aem.00036-18openalex-snapshot
Sesquiterpene Synthase–3-Hydroxy-3-Methylglutaryl Coenzyme A Synthase Fusion Protein Responsible for Hirsutene Biosynthesis in Stereum hirsutum
inferred← citeshttps://doi.org/10.1128/jb.00759-08openalex-snapshot
Identification of Sesquiterpene Synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. Strain PCC 7120
inferred← citeshttps://doi.org/10.1186/s40643-021-00421-2openalex-snapshot
Mining methods and typical structural mechanisms of terpene cyclases
inferred← citeshttps://doi.org/10.1351/pac-con-09-09-37openalex-snapshot
Trinuclear metal clusters in catalysis by terpenoid synthases
inferred← citeshttps://doi.org/10.1351/pac200880081791openalex-snapshot
Chemical wizardry? The generation of diversity in terpenoid biosynthesis
inferred← citeshttps://doi.org/10.18002/10612/2678openalex-snapshot
Caracterización bioquímica y molecular de la biosíntesis del antitumoral andrastina y de la toxina PR en "Penicillium roqueforti" = Biochemical and Molecular Characterization of the Antitumoral Andratine and PR-toxin in "Penicillium roquefort"
inferred← citeshttps://doi.org/10.31274/etd-180810-3614openalex-snapshot
Structure and function of class I diterpene synthase
inferred← citeshttps://doi.org/10.3233/isb-00271openalex-snapshot
Prediction of 3-Dimensional Structure of Salivary Odorant-Binding Protein-2 of the Mosquito Culex Quinquefasciatus, the Vector of Human Lymphatic Filariasis
inferred← citeshttps://doi.org/10.32657/10356/68357openalex-snapshot
A genomics-guided study of the biosynthesis of microbial secondary metabolites
inferred← citeshttps://doi.org/10.3389/fgene.2020.00421openalex-snapshot
Comparative (Within Species) Genomics of the Vitis vinifera L. Terpene Synthase Family to Explore the Impact of Genotypic Variation Using Phased Diploid Genomes
inferred← citeshttps://doi.org/10.3389/fpls.2019.00177openalex-snapshot
Linking Terpene Synthases to Sesquiterpene Metabolism in Grapevine Flowers
inferred← citeshttps://doi.org/10.3390/bioengineering10050569openalex-snapshot
Transcriptome Analysis and Identification of Sesquiterpene Synthases in Liverwort Jungermannia exsertifolia
inferred← citeshttps://doi.org/10.3923/pjbs.2006.1088.1094openalex-snapshot
Measuring Technical Efficiency of Wheat Production in Southeastern Anatolia with Parametric and Nonparametric Methods
inferred← citeshttps://doi.org/10.3923/pjbs.2006.1095.1103openalex-snapshot
Watermelon Sudden Decay in Tunisia: Identification of Pathogenic Fungi and Determination of Primary Agents
inferred← citeshttps://doi.org/10.70675/53d60d87za0a6z43a9z820ez54a3f1e78a4eopenalex-snapshot
Biodiversité, bioactivité et biosynthèse des composés terpéniques volatils des lavandes ailées, Lavandula stoechas sensu lato, un complexe d'espèces méditerranéennes d'intérêt pharmacologique
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