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Structural insight into cap-snatching and RNA synthesis by influenza polymerase

https://doi.org/10.1038/nature14009
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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UCSF Chimera—A visualization system for exploratory research and analysis
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Surprising Function of the Three Influenza Viral Polymerase Proteins: Selective Protection of Viral mRNAs against the Cap-Snatching Reaction Catalyzed by the Same Polymerase Proteins
inferredcites →https://doi.org/10.1007/978-1-62703-691-7_8openalex-snapshot
Multiprotein Complex Production in Insect Cells by Using Polyproteins
inferredcites →https://doi.org/10.1016/0092-8674(81)90449-9openalex-snapshot
A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription
inferredcites →https://doi.org/10.1016/0092-8674(83)90393-8openalex-snapshot
Molecular model of a eucaryotic transcription complex: Functions and movements of influenza P proteins during capped RNA-primed transcription
inferredcites →https://doi.org/10.1016/j.biocel.2014.05.022openalex-snapshot
Biophysical characterization of sites of host adaptive mutation in the influenza A virus RNA polymerase PB2 RNA-binding domain
inferredcites →https://doi.org/10.1016/j.sbi.2009.10.011openalex-snapshot
RNA-dependent RNA polymerases from flaviviruses and Picornaviridae
inferredcites →https://doi.org/10.1016/j.virol.2010.09.003openalex-snapshot
Base-pairing promotes leader selection to prime in vitro influenza genome transcription
inferredcites →https://doi.org/10.1016/j.virol.2010.09.006openalex-snapshot
Preferential use of RNA leader sequences during influenza A transcription initiation in vivo
inferredcites →https://doi.org/10.1016/s1097-2765(00)80099-4openalex-snapshot
Influenza Virus NS1 Protein Interacts with the Cellular 30 kDa Subunit of CPSF and Inhibits 3′ End Formation of Cellular Pre-mRNAs
inferredcites →https://doi.org/10.1038/35065653openalex-snapshot
A mechanism for initiating RNA-dependent RNA polymerization
inferredcites →https://doi.org/10.1038/nature05379openalex-snapshot
The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA
inferredcites →https://doi.org/10.1038/nature07720openalex-snapshot
Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site
inferredcites →https://doi.org/10.1038/nature07745openalex-snapshot
The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit
inferredcites →https://doi.org/10.1038/nature14008openalex-snapshot
Structure of influenza A polymerase bound to the viral RNA promoter
inferredcites →https://doi.org/10.1038/nsmb.1421openalex-snapshot
The structural basis for cap binding by influenza virus polymerase subunit PB2
inferredcites →https://doi.org/10.1038/sj.emboj.7601912openalex-snapshot
Structural insights into the mechanism and evolution of the vaccinia virus mRNA cap N7 methyl‐transferase
inferredcites →https://doi.org/10.1038/srep06181openalex-snapshot
Deep sequencing reveals the eight facets of the influenza A/HongKong/1/1968 (H3N2) virus cap-snatching process
inferredcites →https://doi.org/10.1046/j.1365-2443.1999.00275.xopenalex-snapshot
Two separate sequences of PB2 subunit constitute the RNA cap‐binding site of influenza virus RNA polymerase
inferredcites →https://doi.org/10.1073/pnas.0307127101openalex-snapshot
3D structure of the influenza virus polymerase complex: Localization of subunit domains
inferredcites →https://doi.org/10.1073/pnas.1007626107openalex-snapshot
Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase
inferredcites →https://doi.org/10.1073/pnas.1315068110openalex-snapshot
Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus
inferredcites →https://doi.org/10.1073/pnas.78.12.7355openalex-snapshot
Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m 7 GpppNm) on RNAs and in initiating viral RNA transcription
inferredcites →https://doi.org/10.1093/emboj/20.8.2078openalex-snapshot
The active sites of the influenza cap‐dependent endonuclease are on different polymerase subunits
inferredcites →https://doi.org/10.1093/emboj/cdg109openalex-snapshot
Crucial role of CA cleavage sites in the cap‐snatching mechanism for initiating viral mRNA synthesis
inferredcites →https://doi.org/10.1093/nar/10.15.4803openalex-snapshot
Identification of the cap binding protein of influenza virus
inferredcites →https://doi.org/10.1093/nar/gkt603openalex-snapshot
Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage
inferredcites →https://doi.org/10.1099/0022-1317-76-3-603openalex-snapshot
The role of template-primer interactions in cleavage and initiation by the influenza virus polymerase
inferredcites →https://doi.org/10.1099/0022-1317-79-4-673openalex-snapshot
Nucleotides in the panhandle structure of the influenza B virus virion RNA are involved in the specificity between influenza A and B viruses.
inferredcites →https://doi.org/10.1099/vir.0.029231-0openalex-snapshot
Cellular cap-binding proteins associate with influenza virus mRNAs
inferredcites →https://doi.org/10.1107/s0907444901012471openalex-snapshot
Pushing the boundaries of molecular replacement with maximum likelihood
inferredcites →https://doi.org/10.1107/s0907444903017694openalex-snapshot
Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0
inferredcites →https://doi.org/10.1107/s0907444909008671openalex-snapshot
UROX2.0: an interactive tool for fitting atomic models into electron-microscopy reconstructions
inferredcites →https://doi.org/10.1107/s0907444909042073openalex-snapshot
MolProbity : all-atom structure validation for macromolecular crystallography
inferredcites →https://doi.org/10.1107/s0907444909047374openalex-snapshot
Integration, scaling, space-group assignment and post-refinement
inferredcites →https://doi.org/10.1107/s0907444995008754openalex-snapshot
Methods used in the structure determination of bovine mitochondrial F1 ATPase
inferredcites →https://doi.org/10.1107/s0907444996012255openalex-snapshot
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
inferredcites →https://doi.org/10.1107/s0907444998017363openalex-snapshot
Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
inferredcites →https://doi.org/10.1107/s1399004714016241openalex-snapshot
Conformation-independent structural comparison of macromolecules withProSMART
inferredcites →https://doi.org/10.1126/science.1227270openalex-snapshot
Organization of the Influenza Virus Replication Machinery
inferredcites →https://doi.org/10.1128/jvi.00386-12openalex-snapshot
Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA
inferredcites →https://doi.org/10.1128/jvi.02293-07openalex-snapshot
Interaction of the Influenza A Virus Nucleocapsid Protein with the Viral RNA Polymerase Potentiates Unprimed Viral RNA Replication
inferredcites →https://doi.org/10.1128/jvi.02375-10openalex-snapshot
Recognition of Cap Structure by Influenza B Virus RNA Polymerase Is Less Dependent on the Methyl Residue than Recognition by Influenza A Virus Polymerase
inferredcites →https://doi.org/10.1128/jvi.72.2.1280-1286.1998openalex-snapshot
Polyadenylation of Influenza Virus mRNA Transcribed In Vitro from Model Virion RNA Templates: Requirement for 5′ Conserved Sequences
inferredcites →https://doi.org/10.1128/jvi.73.3.2109-2114.1999openalex-snapshot
A Hairpin Loop at the 5′ End of Influenza A Virus Virion RNA Is Required for Synthesis of Poly(A) + mRNA In Vitro
inferredcites →https://doi.org/10.1128/jvi.80.5.2337-2348.2006openalex-snapshot
Different De Novo Initiation Strategies Are Used by Influenza Virus RNA Polymerase on Its cRNA and Viral RNA Promoters during Viral RNA Replication
inferredcites →https://doi.org/10.1371/journal.pone.0036415openalex-snapshot
Influenza Polymerase Activity Correlates with the Strength of Interaction between Nucleoprotein and PB2 through the Host-Specific Residue K/E627
inferredcites →https://doi.org/10.1371/journal.ppat.1000462openalex-snapshot
Genetic trans-Complementation Establishes a New Model for Influenza Virus RNA Transcription and Replication
inferredcites →https://doi.org/10.1371/journal.ppat.1000491openalex-snapshot
The Structure of a Biologically Active Influenza Virus Ribonucleoprotein Complex
inferredcites →https://doi.org/10.1371/journal.ppat.1001101openalex-snapshot
Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral Cap-Dependent Transcription
inferredcites →https://doi.org/10.4149/av_2013_02_113openalex-snapshot
The RNA polymerase of influenza A virus: mechanisms of viral transcription and replication
inferredcites →https://doi.org/10.4161/rna.8.2.14513openalex-snapshot
The influenza virus RNA synthesis machine

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Putative bundling signals incompatible between influenza C and D viruses
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The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor
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Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 Å Resolution
inferred← citeshttps://doi.org/10.1016/j.molcel.2015.11.016openalex-snapshot
Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
inferred← citeshttps://doi.org/10.1016/j.molcel.2018.05.011openalex-snapshot
A Mechanism for the Activation of the Influenza Virus Transcriptase
inferred← citeshttps://doi.org/10.1016/j.molcel.2026.04.014openalex-snapshot
5′-Triphosphate guanosine RNAs recruit GTP-binding proteins to suppress RIG-I/IFN type I signaling
inferred← citeshttps://doi.org/10.1016/j.molliq.2020.114784openalex-snapshot
Prediction and characterization of influenza virus polymerase inhibitors through blind docking and ligand based virtual screening
inferred← citeshttps://doi.org/10.1016/j.pscia.2025.100095openalex-snapshot
Physiologically based pharmacokinetic (PBPK) modeling of drug-drug interactions between suraxavir marboxil and CYP3A4 inhibitors: Quantitative prediction of pharmacokinetic effects on active metabolite GP1707D07
inferred← citeshttps://doi.org/10.1016/j.sbi.2015.04.007openalex-snapshot
Polyproteins in structural biology
inferred← citeshttps://doi.org/10.1016/j.sbi.2016.01.002openalex-snapshot
Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases
inferred← citeshttps://doi.org/10.1016/j.tim.2018.12.013openalex-snapshot
Interplay between Influenza Virus and the Host RNA Polymerase II Transcriptional Machinery
inferred← citeshttps://doi.org/10.1016/j.tim.2022.09.015openalex-snapshot
A structural understanding of influenza virus genome replication
inferred← citeshttps://doi.org/10.1016/j.virol.2015.03.009openalex-snapshot
Transmission of influenza A viruses
inferred← citeshttps://doi.org/10.1016/j.virol.2015.03.018openalex-snapshot
The RNA synthesis machinery of negative-stranded RNA viruses
inferred← citeshttps://doi.org/10.1016/j.virol.2015.12.016openalex-snapshot
dsRNA-ended genomes in orthobunyavirus particles and infected cells
inferred← citeshttps://doi.org/10.1016/j.virol.2016.06.018openalex-snapshot
Inherent properties not conserved in other tenuiviruses increase priming and realignment cycles during transcription of Rice stripe virus
inferred← citeshttps://doi.org/10.1016/j.virol.2016.11.008openalex-snapshot
PB2 substitutions V598T/I increase the virulence of H7N9 influenza A virus in mammals
inferred← citeshttps://doi.org/10.1016/j.virol.2017.06.009openalex-snapshot
Evolutionary conservation of influenza A PB2 sequences reveals potential target sites for small molecule inhibitors
inferred← citeshttps://doi.org/10.1016/j.virol.2019.08.002openalex-snapshot
Priming and realignment by the influenza a virus RdRp is dependent on the length of the host primers and the extent of base pairing to viral RNA
inferred← citeshttps://doi.org/10.1016/j.virol.2019.10.017openalex-snapshot
A convenient in vivo cap donor delivery system to investigate the cap snatching of plant bunyaviruses
inferred← citeshttps://doi.org/10.1016/j.virol.2021.04.001openalex-snapshot
Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus
inferred← citeshttps://doi.org/10.1016/j.virol.2025.110414openalex-snapshot
Harnessing viral internal proteins to combat flu and beyond
inferred← citeshttps://doi.org/10.1016/j.virs.2022.10.005openalex-snapshot
Revisiting influenza A virus life cycle from a perspective of genome balance
inferred← citeshttps://doi.org/10.1016/j.virs.2023.06.002openalex-snapshot
PA-E18G substitution in influenza A virus confers resistance to ZX-7101, a cap-dependent endonuclease inhibitor
inferred← citeshttps://doi.org/10.1016/j.virusres.2015.03.017openalex-snapshot
Influenza virus polymerase: Functions on host range, inhibition of cellular response to infection and pathogenicity
inferred← citeshttps://doi.org/10.1016/j.virusres.2017.01.013openalex-snapshot
Structural insights into RNA synthesis by the influenza virus transcription-replication machine
inferred← citeshttps://doi.org/10.1016/j.virusres.2017.01.018openalex-snapshot
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
inferred← citeshttps://doi.org/10.1016/j.virusres.2018.06.013openalex-snapshot
Development of an ELISA assay for screening inhibitors against divalent metal ion dependent alphavirus capping enzyme
inferred← citeshttps://doi.org/10.1016/j.virusres.2021.198573openalex-snapshot
Cellular hnRNPAB interacts with avian influenza viral protein PB2 and inhibits virus replication potentially by restricting PB2 mRNA nuclear export and PB2 protein level
inferred← citeshttps://doi.org/10.1016/j.xinn.2021.100080openalex-snapshot
Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
inferred← citeshttps://doi.org/10.1016/j.ymeth.2019.11.010openalex-snapshot
Molecular characterization and RSV Co-infection of Nicotiana benthamiana with three distinct begomoviruses
inferred← citeshttps://doi.org/10.1017/s0033583523000021openalex-snapshot
Single-molecule FRET for virology: 20 years of insight into protein structure and dynamics
inferred← citeshttps://doi.org/10.1021/acs.biochem.5b01087openalex-snapshot
Two Distinctive Binding Modes of Endonuclease Inhibitors to the N-Terminal Region of Influenza Virus Polymerase Acidic Subunit
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b00514openalex-snapshot
Identification of a Novel Complex between the Nucleoprotein and PA(1–27) of Influenza A Virus Polymerase
inferred← citeshttps://doi.org/10.1021/acs.jafc.7b00276openalex-snapshot
Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01257openalex-snapshot
Discovery of Aryl Benzoyl Hydrazide Derivatives as Novel Potent Broad-Spectrum Inhibitors of Influenza A Virus RNA-Dependent RNA Polymerase (RdRp)
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00857openalex-snapshot
Identification of N- and C-3-Modified Laudanosoline Derivatives as Novel Influenza PAN Endonuclease Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00012openalex-snapshot
A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01474openalex-snapshot
Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c03492openalex-snapshot
Application of Bioisosteres in the Design and Discovery of FDA-Approved Drugs and Advanced Clinical Candidates
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b01227openalex-snapshot
Inhibitors of Influenza Virus Polymerase Acidic (PA) Endonuclease: Contemporary Developments and Perspectives
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00531openalex-snapshot
A Small-Molecule Compound Has Anti-influenza A Virus Activity by Acting as a ‘‘PB2 Inhibitor”
inferred← citeshttps://doi.org/10.1021/acschembio.9b00552openalex-snapshot
Discovery of Influenza Polymerase PA–PB1 Interaction Inhibitors Using an In Vitro Split-Luciferase Complementation-Based Assay
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00552openalex-snapshot
Inhibition of Influenza Virus Polymerase by Interfering with Its Protein–Protein Interactions
inferred← citeshttps://doi.org/10.1021/acsinfecdis.7b00265openalex-snapshot
Inhibitors of Influenza A Virus Polymerase
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.1c00584openalex-snapshot
Computational Prediction of the Binding Pose of Metal-Binding Pharmacophores
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00109openalex-snapshot
Virtual Screening and Biological Validation of Novel Influenza Virus PA Endonuclease Inhibitors
inferred← citeshttps://doi.org/10.1021/acsnano.4c01362openalex-snapshot
Conformational Dynamics of Influenza A Virus Ribonucleoprotein Complexes during RNA Synthesis
inferred← citeshttps://doi.org/10.1038/516338aopenalex-snapshot
An RNA-synthesizing machine
inferred← citeshttps://doi.org/10.1038/nature14008openalex-snapshot
Structure of influenza A polymerase bound to the viral RNA promoter
inferred← citeshttps://doi.org/10.1038/nature15525openalex-snapshot
Crystal structure of the RNA-dependent RNA polymerase from influenza C virus
inferred← citeshttps://doi.org/10.1038/nature20594openalex-snapshot
Structural basis of an essential interaction between influenza polymerase and Pol II CTD
inferred← citeshttps://doi.org/10.1038/ncomms12754openalex-snapshot
Influenza B virus non-structural protein 1 counteracts ISG15 antiviral activity by sequestering ISGylated viral proteins
inferred← citeshttps://doi.org/10.1038/ncomms13876openalex-snapshot
Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction
inferred← citeshttps://doi.org/10.1038/ncomms9749openalex-snapshot
X-ray structure and activities of an essential Mononegavirales L-protein domain
inferred← citeshttps://doi.org/10.1038/nmicrobiol.2016.29openalex-snapshot
The role of the priming loop in influenza A virus RNA synthesis
inferred← citeshttps://doi.org/10.1038/nrmicro.2016.87openalex-snapshot
Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis
inferred← citeshttps://doi.org/10.1038/s41467-017-01057-7openalex-snapshot
Three-dimensional context rather than NLS amino acid sequence determines importin α subtype specificity for RCC1
inferred← citeshttps://doi.org/10.1038/s41467-019-10236-7openalex-snapshot
In situ structures of rotavirus polymerase in action and mechanism of mRNA transcription and release
inferred← citeshttps://doi.org/10.1038/s41467-019-14246-3openalex-snapshot
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
inferred← citeshttps://doi.org/10.1038/s41467-020-16585-yopenalex-snapshot
Modeling mitigation of influenza epidemics by baloxavir
inferred← citeshttps://doi.org/10.1038/s41467-020-17349-4openalex-snapshot
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
inferred← citeshttps://doi.org/10.1038/s41467-020-17407-xopenalex-snapshot
Molecular basis of host-adaptation interactions between influenza virus polymerase PB2 subunit and ANP32A
inferred← citeshttps://doi.org/10.1038/s41467-020-19364-xopenalex-snapshot
Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
inferred← citeshttps://doi.org/10.1038/s41467-021-24458-1openalex-snapshot
Structural basis for recognition and regulation of arenavirus polymerase L by Z protein
inferred← citeshttps://doi.org/10.1038/s41467-021-27305-5openalex-snapshot
Conformational changes in Lassa virus L protein associated with promoter binding and RNA synthesis activity
inferred← citeshttps://doi.org/10.1038/s41467-021-27950-wopenalex-snapshot
Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies
inferred← citeshttps://doi.org/10.1038/s41467-022-28428-zopenalex-snapshot
Structural snapshots of La Crosse virus polymerase reveal the mechanisms underlying Peribunyaviridae replication and transcription
inferred← citeshttps://doi.org/10.1038/s41467-023-36389-0openalex-snapshot
The ubiquitination landscape of the influenza A virus polymerase
inferred← citeshttps://doi.org/10.1038/s41467-023-44044-xopenalex-snapshot
Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family
inferred← citeshttps://doi.org/10.1038/s41467-024-46601-4openalex-snapshot
Structural characterization of the oligomerization of full-length Hantaan virus polymerase into symmetric dimers and hexamers
inferred← citeshttps://doi.org/10.1038/s41467-024-48848-3openalex-snapshot
Cryo-EM structures of Thogoto virus polymerase reveal unique RNA transcription and replication mechanisms among orthomyxoviruses
inferred← citeshttps://doi.org/10.1038/s41467-024-51007-3openalex-snapshot
Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase
inferred← citeshttps://doi.org/10.1038/s41467-025-57092-2openalex-snapshot
Analysis of NS2-dependent effects on influenza PB1 segment extends replication requirements beyond the canonical promoter
inferred← citeshttps://doi.org/10.1038/s41477-025-01940-yopenalex-snapshot
Structural basis for the activation of plant bunyavirus replication machinery and its dual-targeted inhibition by ribavirin
inferred← citeshttps://doi.org/10.1038/s41564-019-0487-5openalex-snapshot
Structural insight into RNA synthesis by influenza D polymerase
inferred← citeshttps://doi.org/10.1038/s41564-020-0675-3openalex-snapshot
Structural insights into influenza A virus ribonucleoproteins reveal a processive helical track as transcription mechanism
inferred← citeshttps://doi.org/10.1038/s41564-020-0712-2openalex-snapshot
Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation
inferred← citeshttps://doi.org/10.1038/s41564-026-02319-1openalex-snapshot
Structure of Crimean–Congo haemorrhagic fever virus RNA polymerase
inferred← citeshttps://doi.org/10.1038/s41579-020-00501-8openalex-snapshot
Structural insights into RNA polymerases of negative-sense RNA viruses
inferred← citeshttps://doi.org/10.1038/s41586-019-1530-7openalex-snapshot
Structures of influenza A virus RNA polymerase offer insight into viral genome replication
inferred← citeshttps://doi.org/10.1038/s41586-020-2114-2openalex-snapshot
Structural insight into arenavirus replication machinery
inferred← citeshttps://doi.org/10.1038/s41586-021-03511-5openalex-snapshot
Unconventional viral gene expression mechanisms as therapeutic targets
inferred← citeshttps://doi.org/10.1038/s41586-023-06608-1openalex-snapshot
Molecular mechanism of de novo replication by the Ebola virus polymerase
inferred← citeshttps://doi.org/10.1038/s41586-026-10189-0openalex-snapshot
Mechanism of co-transcriptional cap snatching by influenza polymerase
inferred← citeshttps://doi.org/10.1038/s41586-026-10701-6openalex-snapshot
Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
inferred← citeshttps://doi.org/10.1038/s41586-026-10913-wopenalex-snapshot
RNA synthesis and substrate analogue inhibition in the CCHFV polymerase
inferred← citeshttps://doi.org/10.1038/s41591-024-03419-3openalex-snapshot
Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial
inferred← citeshttps://doi.org/10.1038/s41594-019-0232-zopenalex-snapshot
Structural snapshots of actively transcribing influenza polymerase
inferred← citeshttps://doi.org/10.1038/s41594-019-0243-9openalex-snapshot
Flu transcription captured in action
inferred← citeshttps://doi.org/10.1038/s41594-023-01043-2openalex-snapshot
An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles
inferred← citeshttps://doi.org/10.1038/s41598-017-09538-xopenalex-snapshot
Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit
inferred← citeshttps://doi.org/10.1038/s41598-017-18791-zopenalex-snapshot
Sweep Dynamics (SD) plots: Computational identification of selective sweeps to monitor the adaptation of influenza A viruses
inferred← citeshttps://doi.org/10.1038/s41598-018-20772-9openalex-snapshot
Identification of influenza polymerase inhibitors targeting C-terminal domain of PA through surface plasmon resonance screening
inferred← citeshttps://doi.org/10.1038/s41598-018-22328-3openalex-snapshot
Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus
inferred← citeshttps://doi.org/10.1038/s41598-018-22875-9openalex-snapshot
Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance
inferred← citeshttps://doi.org/10.1038/s41598-018-27890-4openalex-snapshot
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
inferred← citeshttps://doi.org/10.1038/s41598-018-31397-3openalex-snapshot
Multiple polymerase gene mutations for human adaptation occurring in Asian H5N1 influenza virus clinical isolates
inferred← citeshttps://doi.org/10.1038/s41598-019-53945-1openalex-snapshot
Molecular Dynamics Simulation reveals the mechanism by which the Influenza Cap-dependent Endonuclease acquires resistance against Baloxavir marboxil
inferred← citeshttps://doi.org/10.1038/s41598-020-58443-3openalex-snapshot
Antiviral activity of iridoid glycosides extracted from Fructus Gardeniae against influenza A virus by PACT-dependent suppression of viral RNA replication
inferred← citeshttps://doi.org/10.1038/s42003-021-02388-4openalex-snapshot
Ultrastructure of influenza virus ribonucleoprotein complexes during viral RNA synthesis
inferred← citeshttps://doi.org/10.1038/s42003-025-09384-yopenalex-snapshot
Cryo-EM structure of influenza polymerase bound to the cRNA promoter provides insights into the mechanism of viral replication
inferred← citeshttps://doi.org/10.1038/s44319-024-00208-4openalex-snapshot
NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switch
inferred← citeshttps://doi.org/10.1038/srep19474openalex-snapshot
PB2-588 V promotes the mammalian adaptation of H10N8, H7N9 and H9N2 avian influenza viruses
inferred← citeshttps://doi.org/10.1038/srep22880openalex-snapshot
A novel small-molecule inhibitor of influenza A virus acts by suppressing PA endonuclease activity of the viral polymerase
inferred← citeshttps://doi.org/10.1038/srep24727openalex-snapshot
Structural characterization of recombinant IAV polymerase reveals a stable complex between viral PA-PB1 heterodimer and host RanBP5
inferred← citeshttps://doi.org/10.1038/srep43691openalex-snapshot
NEDDylation of PB2 Reduces Its Stability and Blocks the Replication of Influenza A Virus
inferred← citeshttps://doi.org/10.1039/c6ob02144aopenalex-snapshot
Chemo-enzymatic modification of eukaryotic mRNA
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