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Clustering of Type 2 Diabetes Genetic Loci by Multi-Trait Associations Identifies Disease Mechanisms and Subtypes

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/bies.201100015openalex-snapshot
β‐Cell evolution: How the pancreas borrowed from the brain
inferredcites →https://doi.org/10.1002/hep.27242openalex-snapshot
Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis
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Disentangling the Role of Melatonin and its Receptor MTNR1B in Type 2 Diabetes: Still a Long Way to Go?
inferredcites →https://doi.org/10.1016/j.ajhg.2017.01.011openalex-snapshot
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice
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Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
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Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
inferredcites →https://doi.org/10.1038/nature14132openalex-snapshot
New genetic loci link adipose and insulin biology to body fat distribution
inferredcites →https://doi.org/10.1038/nature14177openalex-snapshot
Genetic studies of body mass index yield new insights for obesity biology
inferredcites →https://doi.org/10.1038/nature14962openalex-snapshot
The UK10K project identifies rare variants in health and disease
inferredcites →https://doi.org/10.1038/nature15393openalex-snapshot
A global reference for human genetic variation
inferredcites →https://doi.org/10.1038/nature18642openalex-snapshot
The genetic architecture of type 2 diabetes
inferredcites →https://doi.org/10.1038/nature19806openalex-snapshot
Genome-wide associations for birth weight and correlations with adult disease
inferredcites →https://doi.org/10.1038/nchembio.1414openalex-snapshot
Seeing is believing
inferredcites →https://doi.org/10.1038/ncomms10023openalex-snapshot
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
inferredcites →https://doi.org/10.1038/ncomms10494openalex-snapshot
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
inferredcites →https://doi.org/10.1038/ncomms10495openalex-snapshot
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
inferredcites →https://doi.org/10.1038/ncomms9866openalex-snapshot
Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution
inferredcites →https://doi.org/10.1038/ng.2274openalex-snapshot
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
inferredcites →https://doi.org/10.1038/ng.2383openalex-snapshot
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
inferredcites →https://doi.org/10.1038/ng.2500openalex-snapshot
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
inferredcites →https://doi.org/10.1038/ng.2610openalex-snapshot
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease
inferredcites →https://doi.org/10.1038/ng.3097openalex-snapshot
Defining the role of common variation in the genomic and biological architecture of adult human height
inferredcites →https://doi.org/10.1038/ng.3300openalex-snapshot
The impact of low-frequency and rare variants on lipid levels
inferredcites →https://doi.org/10.1038/ng.3437openalex-snapshot
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
inferredcites →https://doi.org/10.1038/ng.3557openalex-snapshot
Somatic ERCC2 mutations are associated with a distinct genomic signature in urothelial tumors
inferredcites →https://doi.org/10.1038/ng.3643openalex-snapshot
A reference panel of 64,976 haplotypes for genotype imputation
inferredcites →https://doi.org/10.1038/ng.3656openalex-snapshot
Next-generation genotype imputation service and methods
inferredcites →https://doi.org/10.1038/ng.3738openalex-snapshot
Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation
inferredcites →https://doi.org/10.1038/ng.520openalex-snapshot
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
inferredcites →https://doi.org/10.1038/ng.521openalex-snapshot
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
inferredcites →https://doi.org/10.1038/ng.784openalex-snapshot
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
inferredcites →https://doi.org/10.1038/nmeth.1906openalex-snapshot
ChromHMM: automating chromatin-state discovery and characterization
inferredcites →https://doi.org/10.1038/nmeth.2307openalex-snapshot
Improved whole-chromosome phasing for disease and population genetic studies
inferredcites →https://doi.org/10.1038/s41467-017-02380-9openalex-snapshot
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
inferredcites →https://doi.org/10.1038/s41588-018-0084-1openalex-snapshot
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
inferredcites →https://doi.org/10.1073/pnas.1323785111openalex-snapshot
TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content
inferredcites →https://doi.org/10.1073/pnas.1621192114openalex-snapshot
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes
inferredcites →https://doi.org/10.1074/jbc.m116.719955openalex-snapshot
Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins
inferredcites →https://doi.org/10.1086/519024openalex-snapshot
A Bayesian Measure of the Probability of False Discovery in Genetic Epidemiology Studies
inferredcites →https://doi.org/10.1093/hmg/ddu510openalex-snapshot
A novel common variant in DCST2 is associated with length in early life and height in adulthood
inferredcites →https://doi.org/10.1093/hmg/ddv264openalex-snapshot
Recent advances in understanding the genetic architecture of type 2 diabetes
inferredcites →https://doi.org/10.1093/jamia/ocv034openalex-snapshot
Toward high-throughput phenotyping: unbiased automated feature extraction and selection from knowledge sources
inferredcites →https://doi.org/10.1097/mol.0000000000000155openalex-snapshot
Glucokinase regulatory protein
inferredcites →https://doi.org/10.1101/166298openalex-snapshot
Genome-wide genetic data on ~500,000 UK Biobank participants
inferredcites →https://doi.org/10.1109/tpami.2012.240openalex-snapshot
Automatic Relevance Determination in Nonnegative Matrix Factorization with the /spl beta/-Divergence
inferredcites →https://doi.org/10.1126/scitranslmed.aaa9364openalex-snapshot
Identification of type 2 diabetes subgroups through topological analysis of patient similarity
inferredcites →https://doi.org/10.1161/circgenetics.112.964619openalex-snapshot
Genome-Wide Association Study Identifies Novel Loci Associated With Concentrations of Four Plasma Phospholipid Fatty Acids in the De Novo Lipogenesis Pathway
inferredcites →https://doi.org/10.1161/circgenetics.113.000208openalex-snapshot
Genome-Wide Association Study of Plasma N6 Polyunsaturated Fatty Acids Within the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
inferredcites →https://doi.org/10.1194/jlr.m052456openalex-snapshot
Genetic loci associated with circulating levels of very long-chain saturated fatty acids
inferredcites →https://doi.org/10.1212/wnl.0000000000002528openalex-snapshot
Low-frequency and common genetic variation in ischemic stroke
inferredcites →https://doi.org/10.1371/journal.pgen.1001324openalex-snapshot
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
inferredcites →https://doi.org/10.1371/journal.pgen.1002193openalex-snapshot
Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium
inferredcites →https://doi.org/10.1371/journal.pgen.1002607openalex-snapshot
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
inferredcites →https://doi.org/10.1371/journal.pgen.1004235openalex-snapshot
A Central Role for GRB10 in Regulation of Islet Function in Man
inferredcites →https://doi.org/10.1371/journal.pone.0018743openalex-snapshot
Predicting Diabetic Nephropathy Using a Multifactorial Genetic Model
inferredcites →https://doi.org/10.1371/journal.pone.0162388openalex-snapshot
Algorithms for the Capture and Adjudication of Prevalent and Incident Diabetes in UK Biobank
inferredcites →https://doi.org/10.2337/db08-1607openalex-snapshot
Changes in Insulin Sensitivity and Insulin Release in Relation to Glycemia and Glucose Tolerance in 6,414 Finnish Men
inferredcites →https://doi.org/10.2337/db10-0502openalex-snapshot
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
inferredcites →https://doi.org/10.2337/db11-0415openalex-snapshot
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db11-1516openalex-snapshot
Reduced Insulin Exocytosis in Human Pancreatic β-Cells With Gene Variants Linked to Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db13-0949openalex-snapshot
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
inferredcites →https://doi.org/10.2337/db14-0318openalex-snapshot
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
inferredcites →https://doi.org/10.2337/db15-1671openalex-snapshot
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
inferredcites →https://doi.org/10.2337/db16-0199openalex-snapshot
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
inferredcites →https://doi.org/10.2337/db16-0962openalex-snapshot
A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response
inferredcites →https://doi.org/10.2337/db16-1253openalex-snapshot
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
inferredcites →https://doi.org/10.2337/dc18-s002openalex-snapshot
2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2018
inferredcites →https://doi.org/10.2337/diabetes.50.3.681openalex-snapshot
A Genome Scan for Type 2 Diabetes Susceptibility Loci in a Genetically Isolated Population
inferredcites →https://doi.org/10.3390/jpm6010005openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Diabetes subtypes classification for personalized health care: A review
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Combined unsupervised-supervised machine learning for phenotyping complex diseases with its application to obstructive sleep apnea
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The value of genetic risk scores in precision medicine for diabetes
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PRSice-2: Polygenic Risk Score software for biobank-scale data
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Application of K-Means Algorithm on Normalized and Standardized Data for Type 2 Diabetes Subclusters
inferred← citeshttps://doi.org/10.1111/eci.13890openalex-snapshot
Big data and machine learning to tackle diabetes management
inferred← citeshttps://doi.org/10.17157/mat.6.4.730openalex-snapshot
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Genetic Determinants of Glycemic Traits and the Risk of Gestational Diabetes Mellitus
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Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study
inferred← citeshttps://doi.org/10.2337/figshare.15113193.v1openalex-snapshot
Distinct Molecular Signatures of Clinical Clusters in People with Type 2 Diabetes: an IMI-RHAPSODY Study
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From GWAS Signals to Molecular Mechanisms: Explainable AI for Causal Gene Prioritization and Biomolecular Target Interpretation
inferred← citeshttps://doi.org/10.3390/biomedicines10030643openalex-snapshot
Effects of a 13-Week Personalized Lifestyle Intervention Based on the Diabetes Subtype for People with Newly Diagnosed Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/biomedicines10123093openalex-snapshot
Identification of Novel Metabolic Subtypes Using Multi-Trait Limited Mixed Regression in the Chinese Population
inferred← citeshttps://doi.org/10.3390/biomedicines12030473openalex-snapshot
Animal Models for Understanding the Mechanisms of Beta Cell Death during Type 2 Diabetes Pathogenesis
inferred← citeshttps://doi.org/10.3390/cells12010169openalex-snapshot
Exosomes from Short-Term High-Fat or High-Sucrose Fed Mice Induce Hepatic Steatosis through Different Pathways
inferred← citeshttps://doi.org/10.3390/chemosensors11070391openalex-snapshot
Current Status and Prospect of Diabetes Diagnosis and Treatment Based on Biosensing Technology
inferred← citeshttps://doi.org/10.3390/diabetology6020011openalex-snapshot
Genetic Susceptibility of Type 2 Diabetes and Metabolic Syndrome
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The Identification of Diabetes Mellitus Subtypes Applying Cluster Analysis Techniques: A Systematic Review
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Deep Resequencing of 9 Candidate Genes Identifies a Role for ARAP1 and IGF2BP2 in Modulating Insulin Secretion Adjusted for Insulin Resistance in Obese Southern Europeans
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Lp(a) and the Risk for Cardiovascular Disease: Focus on the Lp(a) Paradox in Diabetes Mellitus
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An Overview of Inter-Tissue and Inter-Kingdom Communication Mediated by Extracellular Vesicles in the Regulation of Mammalian Metabolism
inferred← citeshttps://doi.org/10.3390/ijms26020637openalex-snapshot
Characterizing Circulating microRNA Signatures of Type 2 Diabetes Subtypes
inferred← citeshttps://doi.org/10.3390/ijms26083572openalex-snapshot
Advances in Metabolomics: A Comprehensive Review of Type 2 Diabetes and Cardiovascular Disease Interactions
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Polycystic Ovary Syndrome Susceptibility Loci Inform Disease Etiological Heterogeneity
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Diabetes Management Based on the Phenotype and Stage of the Disease: An Expert Proposal from the AGORA Diabetes Collaborative Group
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Blood–Brain Network-Based Polygenic Risk Scores Reveal Biomarker Signatures and the Progression of Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/jpm11121322openalex-snapshot
Development and Validation of Decision Rules Models to Stratify Coronary Artery Disease, Diabetes, and Hypertension Risk in Preventive Care: Cohort Study of Returning UK Biobank Participants
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Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
inferred← citeshttps://doi.org/10.3390/metabo11100691openalex-snapshot
The “Common Soil Hypothesis” Revisited—Risk Factors for Type 2 Diabetes and Cardiovascular Disease
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Genetics of Type 2 Diabetes: Past, Present, and Future
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