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Drug repurposing screens and synergistic drug‐combinations for infectious diseases

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Innovation and marketing in the pharmaceutical industry : emerging practices, research, and policies
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Innovation in the Pharmaceutical Industry: The Process of Drug Discovery and Development
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Omics for Personalized Medicine
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Synergistic drug combination effectively blocks Ebola virus infection
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Pharmacogenomics for infectious diseases in sub-Saharan Africa: Successes and opportunities
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Phenotypic Landscape of a Bacterial Cell
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Phenotypic screens as a renewed approach for drug discovery
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Drug combination therapy increases successful drug repositioning
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Impact of infection control interventions and antibiotic use on hospital MRSA: a multivariate interrupted time-series analysis
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A randomised, double-blind, phase 3 study comparing the efficacy and safety of ceftazidime/avibactam plus metronidazole versus meropenem for complicated intra-abdominal infections in hospitalised adults in Asia
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Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst
inferredcites →https://doi.org/10.1016/j.lfs.2013.04.005openalex-snapshot
Novel protective properties of auranofin: Inhibition of human astrocyte cytotoxic secretions and direct neuroprotection
inferredcites →https://doi.org/10.1016/s0140-6736(12)61728-0openalex-snapshot
Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010
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Zika virus and microcephaly: why is this situation a PHEIC?
inferredcites →https://doi.org/10.1021/jm025502xopenalex-snapshot
Nanomolar Inhibitors of Staphylococcus aureus Methionyl tRNA Synthetase with Potent Antibacterial Activity against Gram-Positive Pathogens
inferredcites →https://doi.org/10.1038/36786openalex-snapshot
The complete genome sequence of the Gram-positive bacterium Bacillus subtilis
inferredcites →https://doi.org/10.1038/cddis.2013.473openalex-snapshot
A candidate anti-HIV reservoir compound, auranofin, exerts a selective ‘anti-memory’ effect by exploiting the baseline oxidative status of lymphocytes
inferredcites →https://doi.org/10.1038/emi.2014.88openalex-snapshot
Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs
inferredcites →https://doi.org/10.1038/emi.2016.123openalex-snapshot
Rapid antimicrobial susceptibility test for identification of new therapeutics and drug combinations against multidrug-resistant bacteria
inferredcites →https://doi.org/10.1038/nature12876openalex-snapshot
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
inferredcites →https://doi.org/10.1038/nature14594openalex-snapshot
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa
inferredcites →https://doi.org/10.1038/nchembio.1911openalex-snapshot
Synergistic, collaterally sensitive β-lactam combinations suppress resistance in MRSA
inferredcites →https://doi.org/10.1038/nchembio.559openalex-snapshot
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
inferredcites →https://doi.org/10.1038/nm.2758openalex-snapshot
A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target
inferredcites →https://doi.org/10.1038/nm.4184openalex-snapshot
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
inferredcites →https://doi.org/10.1038/nrd.2016.230openalex-snapshot
A comprehensive map of molecular drug targets
inferredcites →https://doi.org/10.1038/nrd3975openalex-snapshot
Platforms for antibiotic discovery
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Pioneering government-sponsored drug repositioning collaborations: progress and learning
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The future challenges facing the development of new antimicrobial drugs
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Evolution of multi-drug resistant HCV clones from pre-existing resistant-associated variants during direct-acting antiviral therapy determined by third-generation sequencing
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Fungal Infections Associated with Contaminated Methylprednisolone in Tennessee
inferredcites →https://doi.org/10.1056/nejmoa1314981openalex-snapshot
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
inferredcites →https://doi.org/10.1056/nejmoa1411677openalex-snapshot
A Case of Severe Ebola Virus Infection Complicated by Gram-Negative Septicemia
inferredcites →https://doi.org/10.1073/pnas.1504022112openalex-snapshot
Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis
inferredcites →https://doi.org/10.1086/647952openalex-snapshot
Antimicrobial Susceptibility Testing: A Review of General Principles and Contemporary Practices
inferredcites →https://doi.org/10.1089/adt.2016.701openalex-snapshot
Validation of a High-Throughput Screening Assay for Identification of Adjunctive and Directly Acting Antimicrobials Targeting Carbapenem-Resistant Enterobacteriaceae
inferredcites →https://doi.org/10.1093/jac/14.5.529openalex-snapshot
Ampicillin combined with sulbactam or metronidazole for single-dose chemoprophylaxis in major gynaecological surgery
inferredcites →https://doi.org/10.1093/jac/46.5.767openalex-snapshot
Streptococcus pneumoniae resistance to erythromycin and penicillin in relation to macrolide and beta-lactam consumption in Spain (1979-1997)
inferredcites →https://doi.org/10.1093/jac/dkn198openalex-snapshot
Modelling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant Staphylococcus aureus: a time-series analysis
inferredcites →https://doi.org/10.1093/jac/dkp197openalex-snapshot
In vitro activity of the -lactamase inhibitor NXL104 against KPC-2 carbapenemase and Enterobacteriaceae expressing KPC carbapenemases
inferredcites →https://doi.org/10.1093/jac/dkt392openalex-snapshot
Carbapenemase-producing Enterobacteriaceae and non-Enterobacteriaceae from animals and the environment: an emerging public health risk of our own making?
inferredcites →https://doi.org/10.1093/jac/dkx113openalex-snapshot
A new rapid resazurin-based microdilution assay for antimicrobial susceptibility testing of Neisseria gonorrhoeae
inferredcites →https://doi.org/10.1093/nar/gkv1037openalex-snapshot
The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
inferredcites →https://doi.org/10.1097/mjt.0000000000000433openalex-snapshot
New and Emerging Antibiotics for Complicated Intra-Abdominal Infections
inferredcites →https://doi.org/10.1111/bph.13354openalex-snapshot
The Concise Guide to PHARMACOLOGY 2015/16: Enzymes
inferredcites →https://doi.org/10.1111/bph.13895openalex-snapshot
Drug repurposing screens and synergistic drug‐combinations for infectious diseases
inferredcites →https://doi.org/10.1111/j.1365-2958.1995.tb02309.xopenalex-snapshot
Open complex formation by Escherichia coli RNA polymerase: the mechanism of polymerase‐induced strand separation of double helical DNA
inferredcites →https://doi.org/10.1111/j.1469-0691.2006.01528.xopenalex-snapshot
Impact of antibiotic restrictions: the pharmaceutical perspective
inferredcites →https://doi.org/10.1126/science.135.3508.1067openalex-snapshot
Synergism between Streptomycin and Penicillin: A Proposed Mechanism
inferredcites →https://doi.org/10.1126/scitranslmed.3001862openalex-snapshot
The NCGC Pharmaceutical Collection: A Comprehensive Resource of Clinically Approved Drugs Enabling Repurposing and Chemical Genomics
inferredcites →https://doi.org/10.1126/scitranslmed.3004129openalex-snapshot
Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing
inferredcites →https://doi.org/10.1126/scitranslmed.3009845openalex-snapshot
Single-molecule sequencing to track plasmid diversity of hospital-associated carbapenemase-producing Enterobacteriaceae
inferredcites →https://doi.org/10.1126/scitranslmed.3009940openalex-snapshot
Prediction of resistance development against drug combinations by collateral responses to component drugs
inferredcites →https://doi.org/10.1126/scitranslmed.3010286openalex-snapshot
Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection
inferredcites →https://doi.org/10.1128/aac.13.3.389openalex-snapshot
In vitro study of clavulanic acid in combination with penicillin, amoxycillin, and carbenicillin
inferredcites →https://doi.org/10.1128/aac.17.4.615openalex-snapshot
CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and Bacteroides
inferredcites →https://doi.org/10.1128/aac.24.5.679openalex-snapshot
Amoxicillin combined with clavulanic acid for the treatment of soft tissue infections in children
inferredcites →https://doi.org/10.1128/aac.29.6.980openalex-snapshot
Comparative activities of the beta-lactamase inhibitors YTR 830, clavulanate, and sulbactam combined with ampicillin and broad-spectrum penicillins against defined beta-lactamase-producing aerobic gram-negative bacilli
inferredcites →https://doi.org/10.1128/aac.35.7.1348openalex-snapshot
Pneumocystis carinii dihydrofolate reductase used to screen potential antipneumocystis drugs
inferredcites →https://doi.org/10.1128/aac.46.10.3118-3124.2002openalex-snapshot
Discovery of a Novel and Potent Class of FabI-Directed Antibacterial Agents
inferredcites →https://doi.org/10.1128/aac.46.11.3343-3347.2002openalex-snapshot
Defining and Combating the Mechanisms of Triclosan Resistance in Clinical Isolates ofStaphylococcus aureus
inferredcites →https://doi.org/10.1128/jcm.00313-13openalex-snapshot
Next-Generation Antimicrobial Susceptibility Testing
inferredcites →https://doi.org/10.1128/jcm.00932-16openalex-snapshot
Verification of an Automated, Digital Dispensing Platform for At-Will Broth Microdilution-Based Antimicrobial Susceptibility Testing
inferredcites →https://doi.org/10.1128/jcm.01643-15openalex-snapshot
Clinical Performance of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Method for Detection of Certain bla KPC -Containing Plasmids
inferredcites →https://doi.org/10.1128/jcm.01714-16openalex-snapshot
Commentary: Next-Generation Epidemiology: Using Real-Time Core Genome Multilocus Sequence Typing To Support Infection Control Policy
inferredcites →https://doi.org/10.1128/mbio.00765-13openalex-snapshot
Estrogen Receptor Antagonists Are Anti-Cryptococcal Agents That Directly Bind EF Hand Proteins and Synergize with FluconazoleIn Vivo
inferredcites →https://doi.org/10.1136/bmj.i5978openalex-snapshot
Hospital transmittedCandida aurisinfections confirmed in the US
inferredcites →https://doi.org/10.1158/0008-5472.can-13-2033openalex-snapshot
Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
inferredcites →https://doi.org/10.1186/cc9997openalex-snapshot
New treatment options against gram-negative organisms
inferredcites →https://doi.org/10.1186/gm394openalex-snapshot
Pharmacogenomics: a key component of personalized therapy
inferredcites →https://doi.org/10.1186/preaccept-6556009101270526openalex-snapshot
Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study
inferredcites →https://doi.org/10.1371/journal.ppat.0030018openalex-snapshot
Antifungal Chemical Compounds Identified Using a C. elegans Pathogenicity Assay
inferredcites →https://doi.org/10.2460/ajvr.1997.58.07.749openalex-snapshot
Growth of Pasteurella haemolytica and production of its leukotoxin in semi-defined media
inferredcites →https://doi.org/10.7554/elife.09744openalex-snapshot
The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Systematic Analysis of Traditional Chinese Medicine Prescriptions Provides New Insights into Drug Combination Therapy for Pox
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Experimental Models for Drug Repurposing in Viral Hepatitis
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Polymyxin B‐Triggered Assembly of Peptide Hydrogels for Localized and Sustained Release of Combined Antimicrobial Therapy
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Reprogramming of antibiotics to combat antimicrobial resistance
inferred← citeshttps://doi.org/10.1002/btpr.3110openalex-snapshot
Computational drug repurposing study of the RNA binding domain of SARS‐CoV ‐2 nucleocapsid protein with antiviral agents
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Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19
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Deep learning for predicting synergistic drug combinations: State‐of‐the‐arts and future directions
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Selected pharmacotherapy agents as antiproliferative and anti‐inflammatory compounds
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Phytochemical conjugation as a potential semisynthetic approach toward reactive and reuse of obsolete sulfonamides against pathogenic bacteria
inferred← citeshttps://doi.org/10.1002/mbo3.70317openalex-snapshot
Host–Pathogen Dual Targeting With Repurposed Drugs Identifies a Synergistic Therapy for Intracellular Staphylococcus aureus
inferred← citeshttps://doi.org/10.1002/mbo3.824openalex-snapshot
Identification of Asparagopsis armata‐associated bacteria and characterization of their bioactive potential
inferred← citeshttps://doi.org/10.1002/minf.202000012openalex-snapshot
Drug Re‐positioning Studies for Novel HIV‐1 Inhibitors Using Binary QSAR Models and Multi‐target‐driven In Silico Studies
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Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach**
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Computational Modeling in Virus Infections and Virtual Screening, Docking, and Molecular Dynamics in Drug Design
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Siddha Medicine and Computer Modeling: A Treasure for SARS-CoV-2 Treatment
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Computational Modeling in the Development of Antiviral Agents
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Deciphering Microbial Regulation of Heterogeneity and Drug Adaptation with Meta-transcriptomics and Other System-Level Tools
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Genomic Approaches for Drug Repositioning
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Repurposing of Drugs for the Treatment of Microbial Diseases
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Recent Advances in the Treatment of Parasitic Diseases: Current Status and Future
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Dengue virus replication inhibition by dibenzothiepin derivatives
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Pentamidine sensitizes FDA-approved non-antibiotics for the inhibition of multidrug-resistant Gram-negative pathogens
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Antimicrobial Armageddon: The Professional Guide to Conquering Antibiotic Resistance
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Repurposed Molecules: A New Hope in Tackling Neglected Infectious Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-816125-8.00015-8openalex-snapshot
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In Silico Drug Repurposing for MDR Bacteria: Opportunities and Challenges
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Therapeutic Efficacy of Antibiotics in the Treatment of Chronic Diseases
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Drug Combinations
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Application of synthetic products against pathogenic fungal biofilm development with special reference to combinational approaches
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Strategies for delivery of antiviral agents
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In silico approaches in drug discovery for SARS-CoV-2
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Novel strategies for drug repurposing
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Drug repurposing for parasitic protozoan diseases
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Multi-stage transcriptome profiling of the neglected food-borne echinostome Artyfechinostomum sufrartyfex reveal potential diagnostic and drug targets
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Predicting population dynamics of antimicrobial resistance using mechanistic modeling and machine learning
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Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms
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ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen
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Drug Repurposing Identifies New Promising Treatment Options for Invasive Fungal Diseases
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Autoencoder-based drug synergy framework for malignant diseases
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Molecular descriptor analysis of approved drugs using unsupervised learning for drug repurposing
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Comparative metabolomics revealed key pathways associated with the synergistic killing of multidrug-resistant Klebsiella pneumoniae by a bacteriophage-polymyxin combination
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Advancing precision medicine with personalized drug screening
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Repurposing of the gold drug auranofin and a review of its derivatives as antibacterial therapeutics
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Machine learning to design antimicrobial combination therapies: Promises and pitfalls
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Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis
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Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
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Drug repositioning is an alternative for the treatment of coronavirus COVID-19
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Repositioning of non-antibiotic drugs as an alternative to microbial resistance: a systematic review
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Isobavachalcone enhances sensitivity of colistin-resistant Klebsiella pneumoniae: In vitro and in vivo proof-of-concept studies
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A multi-functional oxidative konjac glucomannan/ε-poly-l-lysine hydrogel with antibacterial, haemostatic, and chronic diabetic wound-treating properties
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Discovery and development of safe-in-man broad-spectrum antiviral agents
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An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes
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A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning
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Systematic analysis of traditional Chinese medicine prescriptions provides new insights into drug combination therapy for pox
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Immunomodulatory effect of traditional Chinese medicine in infectious diseases
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Industry 4.0 technologies adoption for digital transition in drug discovery and development: A review
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Latent Class Analysis Reveals, in patient profiles, COVID-19–related better prognosis by calcifediol treatment than glucocorticoids
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Current status of antihistamine drugs repurposing for infectious diseases
inferred← citeshttps://doi.org/10.1016/j.molstruc.2020.129449openalex-snapshot
Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study
inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155421openalex-snapshot
Gramine sensitizes Klebsiella pneumoniae to tigecycline killing
inferred← citeshttps://doi.org/10.1016/j.talanta.2019.01.039openalex-snapshot
A simple and rapid colorimetric bacteria detection method based on bacterial inhibition of glucose oxidase-catalyzed reaction
inferred← citeshttps://doi.org/10.1016/j.tim.2018.04.004openalex-snapshot
Drug Repurposing for Viral Infectious Diseases: How Far Are We?
inferred← citeshttps://doi.org/10.1016/j.tranon.2018.06.002openalex-snapshot
Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
inferred← citeshttps://doi.org/10.1016/j.tube.2023.102363openalex-snapshot
Isoniazid-N-acylhydrazones as promising compounds for the anti-tuberculosis treatment
inferred← citeshttps://doi.org/10.1016/j.xcrp.2023.101520openalex-snapshot
Integrating multi-modal deep learning on knowledge graph for the discovery of synergistic drug combinations against infectious diseases
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.04.004openalex-snapshot
Review on 505(b)(2) Drug Products Approved by USFDA from 2010 to 2020 Emphasizing Intellectual Property and Regulatory Considerations for Reformulations and New Combinations
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b02690openalex-snapshot
Overcoming Multidrug-Resistance in Bacteria with a Two-Step Process to Repurpose and Recombine Established Drugs
inferred← citeshttps://doi.org/10.1021/acs.chemmater.5c00958openalex-snapshot
Near-Infrared Light-Triggered Bacterial Eradication by Different Morphologies of NH2-MIL-101(Fe)@Ag
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c00038openalex-snapshot
Repurposing of Marine Raw Materials in the Formulation of Innovative Plant Protection Products
inferred← citeshttps://doi.org/10.1021/acs.jafc.2c06991openalex-snapshot
Gallic Acid Restores the Sulfonamide Sensitivity of Multidrug-Resistant Streptococcus suis via Polypharmaceology Mechanism
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c00709openalex-snapshot
AttenSyn: An Attention-Based Deep Graph Neural Network for Anticancer Synergistic Drug Combination Prediction
inferred← citeshttps://doi.org/10.1021/acs.jcim.4c00003openalex-snapshot
HANSynergy: Heterogeneous Graph Attention Network for Drug Synergy Prediction
inferred← citeshttps://doi.org/10.1021/acs.jcim.4c01101openalex-snapshot
DDSBC: A Stacking Ensemble Classifier-Based Approach for Breast Cancer Drug-Pair Cell Synergy Prediction
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00550openalex-snapshot
Synthesis and Structure–Activity Relationship Study of Antimicrobial Auranofin against ESKAPE Pathogens
inferred← citeshttps://doi.org/10.1021/acschembio.2c00613openalex-snapshot
Cooperative Membrane Damage as a Mechanism for Pentamidine–Antibiotic Mutual Sensitization
inferred← citeshttps://doi.org/10.1021/acscombsci.8b00088openalex-snapshot
Combating a Master Manipulator: Staphylococcus aureus Immunomodulatory Molecules as Targets for Combinatorial Drug Discovery
inferred← citeshttps://doi.org/10.1021/acsomega.5c00996openalex-snapshot
Amiodarone and Ravuconazole Combination Potentiates Chemotherapy against Drug-Resistant Trypanosoma cruzi Strains
inferred← citeshttps://doi.org/10.1021/acsomega.6c03899openalex-snapshot
Synergistic Ionic Liquid-Antibiotic Combination as a Strategy against Methicillin-Resistant Staphylococcus aureus (MRSA)
inferred← citeshttps://doi.org/10.1021/acsptsci.0c00112openalex-snapshot
Identifying SARS-CoV‑2 Entry Inhibitors through Drug Repurposing Screens of SARS‑S and MERS‑S Pseudotyped Particles
inferred← citeshttps://doi.org/10.1038/s41429-023-00594-2openalex-snapshot
Drug repurposing strategy II: from approved drugs to agri-fungicide leads
inferred← citeshttps://doi.org/10.1038/s41467-019-09186-xopenalex-snapshot
Network-based prediction of drug combinations
inferred← citeshttps://doi.org/10.1038/s41598-022-08272-3openalex-snapshot
Functionalization of an extended-gate field-effect transistor (EGFET) for bacteria detection
inferred← citeshttps://doi.org/10.1038/s41598-022-10393-8openalex-snapshot
Potential cannabidiol (CBD) repurposing as antibacterial and promising therapy of CBD plus polymyxin B (PB) against PB-resistant gram-negative bacilli
inferred← citeshttps://doi.org/10.1038/s41598-025-87146-wopenalex-snapshot
Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1
inferred← citeshttps://doi.org/10.1038/s41598-025-99741-yopenalex-snapshot
Synergistic mechanism of olaparib and cisplatin on breast cancer elucidated by network pharmacology
inferred← citeshttps://doi.org/10.1039/9781788016858-00232openalex-snapshot
Repurposing Approved Drugs to Block Highly Pathogenic Emerging Viruses
inferred← citeshttps://doi.org/10.1039/d4md00449copenalex-snapshot
Understanding the mechanisms of antimicrobial resistance and potential therapeutic approaches against the Gram-negative pathogen Acinetobacter baumannii
inferred← citeshttps://doi.org/10.1039/d5ra07169kopenalex-snapshot
Interleaving-twisted nanoarchitectured porous organic polymer synergizes photoactivity enhancement and nanozyme-powered microenvironment remodeling for advanced infected wound therapy
inferred← citeshttps://doi.org/10.1042/bcj20210198openalex-snapshot
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
inferred← citeshttps://doi.org/10.1042/bcj20210199openalex-snapshot
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease
inferred← citeshttps://doi.org/10.1042/bcj20210201openalex-snapshot
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp13 helicase
inferred← citeshttps://doi.org/10.1080/07391102.2022.2091658openalex-snapshot
A new approach used in docking study for predicting the combination drug efficacy in EML4-ALK target of NSCLC
inferred← citeshttps://doi.org/10.1080/08927014.2025.2486250openalex-snapshot
Effect of promethazine against Staphylococcus aureus and its preventive action in the formation of biofilms on silicone catheters
inferred← citeshttps://doi.org/10.1080/13543776.2018.1503252openalex-snapshot
Future perspectives for cryptococcosis treatment
inferred← citeshttps://doi.org/10.1080/17425247.2021.1886074openalex-snapshot
Inhaled fixed-dose combination powders for the treatment of respiratory infections
inferred← citeshttps://doi.org/10.1089/jamp.2022.0062openalex-snapshot
Safety, Tolerability, and Pharmacokinetics of Nebulized Hydroxychloroquine: A Pilot Study in Healthy Volunteers
inferred← citeshttps://doi.org/10.1093/bib/bbab390openalex-snapshot
DeepDDS: deep graph neural network with attention mechanism to predict synergistic drug combinations
inferred← citeshttps://doi.org/10.1093/bib/bbad285openalex-snapshot
A model-agnostic framework to enhance knowledge graph-based drug combination prediction with drug–drug interaction data and supervised contrastive learning
inferred← citeshttps://doi.org/10.1093/bib/bbag157openalex-snapshot
TensoGraph: a tensor–transformer framework for global–local drug synergy prediction on heterogeneous graphs
inferred← citeshttps://doi.org/10.1093/bioinformatics/btac538openalex-snapshot
Multidrug representation learning based on pretraining model and molecular graph for drug interaction and combination prediction
inferred← citeshttps://doi.org/10.1093/icc/dtac023openalex-snapshot
Functional diversification and exaptation: the emergence of new drug uses in the pharma industry
inferred← citeshttps://doi.org/10.1093/lambio/ovad119openalex-snapshot
Antibiofilm activity of promethazine, deferiprone, and Manuka honey in an ex vivo wound model
inferred← citeshttps://doi.org/10.1093/mmy/myac039openalex-snapshot
Biofilm and hyphal inhibitory synergistic effects of phytoactives piperine and cinnamaldehyde against Candida albicans
inferred← citeshttps://doi.org/10.1093/nar/gkaa1272openalex-snapshot
Network controllability-based algorithm to target personalized driver genes for discovering combinatorial drugs of individual patients
inferred← citeshttps://doi.org/10.1097/mjt.0000000000001022openalex-snapshot
Antimicrobial and Antineoplastic Properties of Sertraline
inferred← citeshttps://doi.org/10.1097/mjt.0000000000001122openalex-snapshot
Amlodipine Repositioning: Scientific Studies and Synergistic Effects
inferred← citeshttps://doi.org/10.1101/2020.05.12.091165openalex-snapshot
Potential antiviral options against SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1101/2021.04.07.438812openalex-snapshot
Identifying SARS-CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of Nsp14/nsp10 Exoribonuclease
inferred← citeshttps://doi.org/10.1101/2021.04.12.439341openalex-snapshot
Cannabidiol (CBD) repurposing as antibacterial: promising therapy of CBD plus polymyxin B against superbugs
inferred← citeshttps://doi.org/10.1101/2022.05.16.491802openalex-snapshot
Novel synergistic combinations of last-line antibiotics and FDA-approved drugs against Klebsiella pneumoniae revealed by in vitro synergy screenings
inferred← citeshttps://doi.org/10.1101/2025.06.02.657361openalex-snapshot
Integrating Multimodal Data for a Comprehensive Knowledge Graph to Advance Infectious Disease Research
inferred← citeshttps://doi.org/10.1101/571620openalex-snapshot
A novel network controllability algorithm to target personalized driver genes for discovering combinational drugs of individual cancer patient
inferred← citeshttps://doi.org/10.1109/bibm62325.2024.10822303openalex-snapshot
Drug Combination Side Effect Prediction Based on Polypharmacy Network and GraphSAGE Algorithm
inferred← citeshttps://doi.org/10.1109/embc58623.2025.11253169openalex-snapshot
PMDSynergy: Pre-training-based multi-dimensional fusion model for cancer drug synergy prediction
inferred← citeshttps://doi.org/10.1109/jbhi.2024.3421916openalex-snapshot
MDNNSyn: A Multi-Modal Deep Learning Framework for Drug Synergy Prediction
inferred← citeshttps://doi.org/10.1111/apm.13014openalex-snapshot
The first wide‐scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs
inferred← citeshttps://doi.org/10.1111/bph.14081openalex-snapshot
Inventing new therapies without reinventing the wheel: the power of drug repurposing
inferred← citeshttps://doi.org/10.1111/cbdd.13453openalex-snapshot
Improving inverse docking target identification with Z‐score selection
inferred← citeshttps://doi.org/10.1111/cbdd.14345openalex-snapshot
Arylidene and amino spacer‐linked rhodanine‐quinoline hybrids as upgraded antimicrobial agents
inferred← citeshttps://doi.org/10.1111/jam.14312openalex-snapshot
Repurposing auranofin to combat uropathogenic Escherichia coli biofilms
inferred← citeshttps://doi.org/10.1124/jpet.120.000123openalex-snapshot
Drug Discovery Strategies for SARS-CoV-2
inferred← citeshttps://doi.org/10.1124/pharmrev.124.000951openalex-snapshot
Drug-Drug Interactions and Synergy: From Pharmacological Models to Clinical Application
inferred← citeshttps://doi.org/10.1128/aac.00609-19openalex-snapshot
The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum
inferred← citeshttps://doi.org/10.1128/aac.00878-21openalex-snapshot
Adaptive Responses of Pseudomonas aeruginosa to Treatment with Antibiotics
inferred← citeshttps://doi.org/10.1128/aac.01015-23openalex-snapshot
Two-way pharmacodynamic modeling of drug combinations and its application to pairs of repurposed Ebola and SARS-CoV-2 agents
inferred← citeshttps://doi.org/10.1128/aac.01084-18openalex-snapshot
Screening a Repurposing Library for Inhibitors of Multidrug-Resistant Candida auris Identifies Ebselen as a Repositionable Candidate for Antifungal Drug Development
inferred← citeshttps://doi.org/10.1128/aac.01208-19openalex-snapshot
Promethazine Exhibits Antiparasitic Properties In Vitro and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal Model
inferred← citeshttps://doi.org/10.1128/aac.01307-22openalex-snapshot
High-Resolution Bacterial Cytological Profiling Reveals Intrapopulation Morphological Variations upon Antibiotic Exposure
inferred← citeshttps://doi.org/10.1128/mbio.02726-21openalex-snapshot
Ceragenins and Antimicrobial Peptides Kill Bacteria through Distinct Mechanisms
inferred← citeshttps://doi.org/10.1128/msystems.00233-21openalex-snapshot
Identification and Development of Therapeutics for COVID-19
inferred← citeshttps://doi.org/10.1128/msystems.01026-23openalex-snapshot
Repurposing of the antimalarial agent tafenoquine to combat MRSA
inferred← citeshttps://doi.org/10.1128/spectrum.03469-22openalex-snapshot
Mechanism of Action of Isopropoxy Benzene Guanidine against Multidrug-Resistant Pathogens
inferred← citeshttps://doi.org/10.1128/spectrum.04052-22openalex-snapshot
Flufenamic Acid, a Promising Agent for the Sensitization of Colistin-Resistant Gram-Negative Bacteria to Colistin
inferred← citeshttps://doi.org/10.1155/2024/6635476openalex-snapshot
Identification of the Plausible Drug Target via Network/Genome Analysis and Its Molecular Interaction Studies Against Multidrug Resistance Bacterial Pathogens
inferred← citeshttps://doi.org/10.11606/d.60.2022.tde-21032022-082714openalex-snapshot
Atividade antibacteriana do canabidiol: potencial reposicionamento e combinação com polimixina B contra bactérias multidroga-resistentes
inferred← citeshttps://doi.org/10.1177/1535370218755659openalex-snapshot
Better living through chemistry: Addressing emerging antibiotic resistance
inferred← citeshttps://doi.org/10.1186/s12951-024-02706-yopenalex-snapshot
Infection microenvironment-triggered nanoparticles eradicate MRSA by thermally amplified chemodynamic therapy and M1 macrophage
inferred← citeshttps://doi.org/10.1186/s13321-024-00859-4openalex-snapshot
piscesCSM: prediction of anticancer synergistic drug combinations
inferred← citeshttps://doi.org/10.1186/s13568-021-01272-yopenalex-snapshot
Antimicrobial compounds were isolated from the secondary metabolites of Gordonia, a resident of intestinal tract of Periplaneta americana
inferred← citeshttps://doi.org/10.1186/s13568-024-01660-0openalex-snapshot
Drug repurposing: insights into the antimicrobial effects of AKBA against MRSA
inferred← citeshttps://doi.org/10.1186/s41231-019-0050-7openalex-snapshot
Lost in translation: the valley of death across preclinical and clinical divide – identification of problems and overcoming obstacles
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1010951openalex-snapshot
MGAE-DC: Predicting the synergistic effects of drug combinations through multi-channel graph autoencoders
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1013619openalex-snapshot
Robust prediction of drug combination side effects in realistic settings
inferred← citeshttps://doi.org/10.1371/journal.pone.0257784openalex-snapshot
Drug repurposing for COVID-19 based on an integrative meta-analysis of SARS-CoV-2 induced gene signature in human airway epithelium
inferred← citeshttps://doi.org/10.1371/journal.pone.0326632openalex-snapshot
Genome-wide identification and in-silico characterization of phytopathogenic Taf14 gene in Fusarium oxysporum fungus, and fungicide repurposing
inferred← citeshttps://doi.org/10.14293/s2199-1006.1.sor-.pppt99i.v1openalex-snapshot
Investigation of N Terminal Domain of SARS CoV 2 Nucleocapsid Protein with Antiviral Compounds Based on Molecular Modeling Approach
inferred← citeshttps://doi.org/10.14719/pst.2855openalex-snapshot
Evaluation of antibacterial and antifungal activities of Pistacia atlantica and Pistacia khinjuk
inferred← citeshttps://doi.org/10.1590/s2175-97902019000418089openalex-snapshot
Synergistic effect of sertraline and disulfiram against multidrug resistant bacteria as a new alternative to drug repositioning
inferred← citeshttps://doi.org/10.16891/2317-434x.v8.e3.a2020.pp636-648openalex-snapshot
ESTUDO IN SILICO DO POTENCIAL DE FÁRMACOS AZÓLICOS SOBRE SARS-CoV-2: UMA ABORDAGEM QUÍMICA-MEDICINAL
inferred← citeshttps://doi.org/10.17760/d20317952openalex-snapshot
Preparation of nanoparticles by green synthesis and a study on their antibacterial and anticancer properties
inferred← citeshttps://doi.org/10.21203/rs.3.rs-313547/v1openalex-snapshot
Antimicrobial compounds were isolated from the secondary metabolites of endophytic Gordonia in the intestinal tract of Periplaneta americana
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5344759/v1openalex-snapshot
Clinical outcomes of early neonatal sepsis and associated factors in Debre- Tabor comprehensive specialized hospital in Amhara region, Ethiopia
inferred← citeshttps://doi.org/10.2147/dddt.s366423openalex-snapshot
Identification of Drug Combination Therapies for SARS-CoV-2: A Molecular Dynamics Simulations Approach
inferred← citeshttps://doi.org/10.2147/dddt.s405906openalex-snapshot
Knowledge Mapping of Drug Repositioning’s Theme and Development
inferred← citeshttps://doi.org/10.2174/0115748936325300241009051347openalex-snapshot
DSPE: An End-to-End Drug Synergy Combination Prediction Algorithm for Echinococcosis
inferred← citeshttps://doi.org/10.2174/0929867327666200812215852openalex-snapshot
Drug Repurposing: A Strategy for Discovering Inhibitors against Emerging Viral Infections
inferred← citeshttps://doi.org/10.2174/1871520621666211021143255openalex-snapshot
Repurposing Drugs as Novel Triple-negative Breast Cancer Therapeutics
inferred← citeshttps://doi.org/10.2174/18749445-v15-e2206200openalex-snapshot
Drug Development Strategies and Immunological Aspects of SARS-CoV-2
inferred← citeshttps://doi.org/10.2174/9789815123197123010010openalex-snapshot
Drug Repurposing for COVID-19 using Computational Methods
inferred← citeshttps://doi.org/10.22159/ajpcr.2019.v12i6.32706openalex-snapshot
ANTIMICROBIAL ACTIVITIES OF SUCCESSIVE SOLVENT EXTRACTS OF ALBIZIA LEBBECK AND SOLANUM SEAFORTHIANUM AGAINST SOME HUMAN PATHOGENIC MICROORGANISMS
inferred← citeshttps://doi.org/10.22214/ijraset.2024.58345openalex-snapshot
Artificial Intelligence in Antibiotic Discovery Against Superbugs
inferred← citeshttps://doi.org/10.22270/jddt.v15i2.6994openalex-snapshot
In vitro investigation of antifungal efficacy of diclofenac sodium salt against Aspergillus spp. strains causing food spoilage: a drug repurposing approach
inferred← citeshttps://doi.org/10.22377/ijpba.v14i1.2053openalex-snapshot
inferred← citeshttps://doi.org/10.23917/pharmacon.v22i2.13698openalex-snapshot
Drug Repurposing In Modern Drug Discovery: Role of In Silico Study
inferred← citeshttps://doi.org/10.26434/chemrxiv.12032712openalex-snapshot
Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study
inferred← citeshttps://doi.org/10.26434/chemrxiv.12032712.v1openalex-snapshot
Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of COVID-19 Main Protease: A Virtual Drug Repurposing Study
inferred← citeshttps://doi.org/10.26434/chemrxiv.12032712.v2openalex-snapshot
Screening of Clinically Approved and Investigation Drugs as Potential Inhibitors of SARS-CoV-2 Main Protease and Spike Receptor-Binding Domain Bound with ACE2 COVID19 Target Proteins: A Virtual Drug Repurposing Study
inferred← citeshttps://doi.org/10.26599/bdma.2024.9020054openalex-snapshot
MHCLSyn: Multi-View Hypergraph Contrastive Learning for Synergistic Drug Combination Prediction
inferred← citeshttps://doi.org/10.31925/farmacia.2020.6.17openalex-snapshot
SYNTHESIS AND EVALUATION OF THE ANTIMICROBIAL AND ANTIBIOFILM ACTIVITY OF NOVEL DIBENZOTHIEPINES
inferred← citeshttps://doi.org/10.3389/fchem.2026.1842082openalex-snapshot
AI-driven drug reposition for pathogens: a new paradigm in pandemic preparedness
inferred← citeshttps://doi.org/10.3389/fcimb.2018.00438openalex-snapshot
Repurposing Screen Identifies Unconventional Drugs With Activity Against Multidrug Resistant Acinetobacter baumannii
inferred← citeshttps://doi.org/10.3389/fcimb.2019.00067openalex-snapshot
Virtual Screen for Repurposing of Drugs for Candidate Influenza a M2 Ion-Channel Inhibitors
inferred← citeshttps://doi.org/10.3389/fcimb.2019.00193openalex-snapshot
Drug Repurposing to Fight Colistin and Carbapenem-Resistant Bacteria
inferred← citeshttps://doi.org/10.3389/fcimb.2022.926699openalex-snapshot
The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance
inferred← citeshttps://doi.org/10.3389/fmed.2023.1224922openalex-snapshot
Case report: Continuous infusions of ceftazidime-avibactam and aztreonam in combination through elastomeric infusors for 12 weeks for the treatment of bone and joint infections due to metallo-β-lactamase producing Enterobacterales
inferred← citeshttps://doi.org/10.3389/fmicb.2021.652863openalex-snapshot
Emerging Concern for Silver Nanoparticle Resistance in Acinetobacter baumannii and Other Bacteria
inferred← citeshttps://doi.org/10.3389/fmicb.2021.700605openalex-snapshot
Antimicrobial Activities of Alginate and Chitosan Oligosaccharides Against Staphylococcus aureus and Group B Streptococcus
inferred← citeshttps://doi.org/10.3389/fmicb.2024.1396663openalex-snapshot
Fingolimod synergizes and reverses K. pneumoniae resistance to colistin
inferred← citeshttps://doi.org/10.3389/fphar.2020.00248openalex-snapshot
Repurposing Clinical Drugs as AdoMetDC Inhibitors Using the SCAR Strategy
inferred← citeshttps://doi.org/10.3389/fphar.2026.1799614openalex-snapshot
Sodium New Houttuyfonate: a comprehensive review of pharmacological advances in antimicrobial, antitumor, and adjuvanticity effects
inferred← citeshttps://doi.org/10.3390/antibiotics12030499openalex-snapshot
Spiramycin Disarms Pseudomonas aeruginosa without Inhibiting Growth
inferred← citeshttps://doi.org/10.3390/antibiotics8040241openalex-snapshot
Host-Targeted Therapeutics against Multidrug Resistant Intracellular Staphylococcus aureus
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