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Separation of Full and Empty AAV Capsids by Anion-Exchange Chromatography Using Choline-Type Salts

https://doi.org/10.2139/ssrn.4592842
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AAV vectors applied to the treatment of CNS disorders: Clinical status and challenges
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Developing an Anion Exchange Chromatography Assay for Determining Empty and Full Capsid Contents in AAV6.2
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Development of a scalable and robust AEX method for enriched rAAV preparations in genome-containing VCs of serotypes 5, 6, 8, and 9
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Anion-exchange HPLC assay for separation and quantification of empty and full capsids in multiple adeno-associated virus serotypes
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Production and characterization of an AAV1-VP3-only capsid: An analytical benchmark standard
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Rationale and strategies for the development of safe and effective optimized AAV vectors for human gene therapy
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Adeno-associated virus (AAV) cell entry: structural insights
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AAV vectors: The Rubik’s cube of human gene therapy
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Quantification of adeno-associated virus particles and empty capsids by optical density measurement
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Development of a Two-Dimensional Liquid Chromatography-Mass Spectrometry Platform for Simultaneous Multi-Attribute Characterization of Adeno-Associated Viruses
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Resolving Adeno-Associated Viral Particle Diversity With Charge Detection Mass Spectrometry
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Empty virions in AAV8 vector preparations reduce transduction efficiency and may cause total viral particle dose-limiting side effects
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Comprehensive characterization and quantification of adeno associated vectors by size exclusion chromatography and multi angle light scattering
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An overview of health technology assessments of gene therapies with the focus on cost-effectiveness models
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Development and Validation of an Anion Exchange High-Performance Liquid Chromatography Method for Analysis of Empty Capsids and Capsids Encapsidating Genetic Material in a Purified Preparation of Recombinant Adeno-Associated Virus Serotype 5
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Application of Size Exclusion Chromatography with Multiangle Light Scattering in the Analytical Development of a Preclinical Stage Gene Therapy Program
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Structural Insights into Adeno-Associated Virus Serotype 5
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Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking
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The Role of Recombinant AAV in Precise Genome Editing
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A versatile toolkit for overcoming AAV immunity
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Beneficial Effects of Betaine: A Comprehensive Review
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Anion-Exchange Chromatography at the Service of Gene Therapy: Baseline Separation of Full/Empty Adeno-Associated Virus Capsids by Screening of Conditions and Step Gradient Elution Mode
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Biophysical Characterization of Adeno-Associated Virus Vectors Using Ion-Exchange Chromatography Coupled to Light Scattering Detectors
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l-Carnitine Supplementation in Recovery after Exercise
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Dietary Choline Intake: Current State of Knowledge Across the Life Cycle
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An Overview of 1,2,3-triazole-Containing Hybrids and Their Potential Anticholinesterase Activities
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