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Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.cell.2007.11.019openalex-snapshot
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
inferredcites →https://doi.org/10.1016/j.celrep.2015.12.018openalex-snapshot
Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients
inferredcites →https://doi.org/10.1016/j.celrep.2016.09.062openalex-snapshot
Generating Late-Onset Human iPSC-Based Disease Models by Inducing Neuronal Age-Related Phenotypes through Telomerase Manipulation
inferredcites →https://doi.org/10.1016/j.celrep.2016.11.071openalex-snapshot
Peroxiredoxin 1 Protects Telomeres from Oxidative Damage and Preserves Telomeric DNA for Extension by Telomerase
inferredcites →https://doi.org/10.1016/j.neuron.2006.09.018openalex-snapshot
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
inferredcites →https://doi.org/10.1016/j.neuron.2014.10.016openalex-snapshot
Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts
inferredcites →https://doi.org/10.1016/j.stem.2011.01.013openalex-snapshot
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
inferredcites →https://doi.org/10.1016/j.stem.2013.04.003openalex-snapshot
A Small Molecule Screen in Stem-Cell-Derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS
inferredcites →https://doi.org/10.1016/j.stem.2013.11.006openalex-snapshot
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
inferredcites →https://doi.org/10.1016/j.stem.2014.02.004openalex-snapshot
Modeling ALS with iPSCs Reveals that Mutant SOD1 Misregulates Neurofilament Balance in Motor Neurons
inferredcites →https://doi.org/10.1016/j.stem.2014.03.004openalex-snapshot
Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1
inferredcites →https://doi.org/10.1016/j.stem.2015.09.001openalex-snapshot
Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects
inferredcites →https://doi.org/10.1038/cdd.2013.159openalex-snapshot
Jmjd3 is essential for the epigenetic modulation of microglia phenotypes in the immune pathogenesis of Parkinson’s disease
inferredcites →https://doi.org/10.1038/cr.2011.133openalex-snapshot
Defining the nature of human pluripotent stem cell progeny
inferredcites →https://doi.org/10.1038/mt.2011.135openalex-snapshot
Rapid and Efficient Generation of Functional Motor Neurons From Human Pluripotent Stem Cells Using Gene Delivered Transcription Factor Codes
inferredcites →https://doi.org/10.1038/nature08797openalex-snapshot
Direct conversion of fibroblasts to functional neurons by defined factors
inferredcites →https://doi.org/10.1038/nature09879openalex-snapshot
Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome
inferredcites →https://doi.org/10.1038/nature10202openalex-snapshot
Induction of human neuronal cells by defined transcription factors
inferredcites →https://doi.org/10.1038/nature10284openalex-snapshot
Direct generation of functional dopaminergic neurons from mouse and human fibroblasts
inferredcites →https://doi.org/10.1038/nature10648openalex-snapshot
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
inferredcites →https://doi.org/10.1038/ncomms10100openalex-snapshot
Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons
inferredcites →https://doi.org/10.1038/ncomms3183openalex-snapshot
Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons
inferredcites →https://doi.org/10.1038/nm1204openalex-snapshot
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
inferredcites →https://doi.org/10.1038/nmeth.1972openalex-snapshot
Small molecules enable highly efficient neuronal conversion of human fibroblasts
inferredcites →https://doi.org/10.1038/nn.4085openalex-snapshot
Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS
inferredcites →https://doi.org/10.1038/nn.4273openalex-snapshot
Modeling ALS with motor neurons derived from human induced pluripotent stem cells
inferredcites →https://doi.org/10.1038/nprot.2015.102openalex-snapshot
MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons
inferredcites →https://doi.org/10.1038/nrg3764openalex-snapshot
Investigating human disease using stem cell models
inferredcites →https://doi.org/10.1038/nrm2238openalex-snapshot
The role of nuclear architecture in genomic instability and ageing
inferredcites →https://doi.org/10.1038/nrn1809openalex-snapshot
Neural plasticity in the ageing brain
inferredcites →https://doi.org/10.1038/nrn3430openalex-snapshot
The changing scene of amyotrophic lateral sclerosis
inferredcites →https://doi.org/10.1073/pnas.1105135108openalex-snapshot
Direct conversion of human fibroblasts to dopaminergic neurons
inferredcites →https://doi.org/10.1093/hmg/ddu205openalex-snapshot
Human-induced pluripotent stem cells pave the road for a better understanding of motor neuron disease
inferredcites →https://doi.org/10.1093/nar/30.10.e47openalex-snapshot
Telomere measurement by quantitative PCR
inferredcites →https://doi.org/10.1101/gad.173922.111openalex-snapshot
Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
inferredcites →https://doi.org/10.1182/blood-2013-02-484444openalex-snapshot
Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines
inferredcites →https://doi.org/10.1186/preaccept-4817442551293959openalex-snapshot
Suppression of histone deacetylation promotes the differentiation of human pluripotent stem cells towards neural progenitor cells
inferredcites →https://doi.org/10.1242/dev.092163openalex-snapshot
Direct neuronal reprogramming: learning from and for development
inferredcites →https://doi.org/10.1523/jneurosci.4441-10.2011openalex-snapshot
Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells
inferredcites →https://doi.org/10.18632/aging.101248openalex-snapshot
Aged induced pluripotent stem cell (iPSCs) as a new cellular model for studying premature aging
inferredcites →https://doi.org/10.7554/elife.18648openalex-snapshot
Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Roles of Ipsc in Advancing Treatments for Neurological Disorders
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Generation of Induced Dopaminergic Neurons from Human Fetal Fibroblasts
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Transcription Factor-Mediated Differentiation of Motor Neurons from Human Pluripotent Stem Cells
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Generation and Characterization of Human Induced Pluripotent Stem Cells via Retroviral Delivery of Yamanaka Factors
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Integrated Approach for the Differentiation of Neurons and Astrocytes from Human Pluripotent Stem Cells
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Direct Reprogramming Strategies for the Treatment of Nervous System Injuries and Neurodegenerative Disorders
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CAPRIN1P512L causes aberrant protein aggregation and associates with early-onset ataxia
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The complex web of membrane contact sites in brain aging and neurodegeneration
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Direct Reprogramming of Somatic Cells to Neurons: Pros and Cons of Chemical Approach
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Using Patient-Derived Induced Pluripotent Stem Cells to Identify Parkinson’s Disease-Relevant Phenotypes
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Patient-Specific Cells for Modeling and Decoding Amyotrophic Lateral Sclerosis: Advances and Challenges
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Progerin-Induced Transcriptional Changes in Huntington’s Disease Human Pluripotent Stem Cell-Derived Neurons
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Role of NCKAP1 in the Defective Phagocytic Function of Microglia-Like Cells Derived from Rapidly Progressing Sporadic ALS
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Deconstructing age reprogramming
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.11299-1openalex-snapshot
iPSCs-Induced Cellular Reprogramming
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Overview of Tissue Engineering Concepts and Applications
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Basic Concepts and Emergent Disease Mechanisms of Amyotrophic Lateral Sclerosis
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Induced pluripotent stem cells for modeling of spinal muscular atrophy
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Direct neuronal reprogramming by transdifferentiation and application of induced neurons
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Neurological diseases at the blood-brain barrier: Stemming new scientific paradigms using patient-derived induced pluripotent cells
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Comprehensive characterization of the human neural stem cell line HNSC.100 as a versatile model for neurobiological research
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.04.105openalex-snapshot
Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile
inferred← citeshttps://doi.org/10.1016/j.ddmod.2019.01.001openalex-snapshot
Human neurons to model aging: A dish best served old
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When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron
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Insights and applications of direct neuronal reprogramming
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Engrafted stem cell therapy for Alzheimer's disease: A promising treatment strategy with clinical outcome
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Dysfunction of the blood-brain barrier and neurovascular unit in amyotrophic lateral sclerosis – From advanced human models to treatments
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Dissecting Alzheimer's disease pathogenesis in human 2D and 3D models
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Epigenetic regulation of neural lineage elaboration: Implications for therapeutic reprogramming
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Generation of patient-specific induced pluripotent stem cell line (CSUi002-A) from a patient with isolated dystonia carrying TOR1A mutation
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Establishment of an induced pluripotent stem cell line (CSUi003-A) from fibroblasts of a healthy elderly individual
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An induced pluripotent stem cell line (CSUi004-A) from skin fibroblasts of a healthy individual
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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients
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Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease
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Investigating the Structure of Neurotoxic Protein Aggregates Inside Cells
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Modeling hypothalamic pathophysiology in vitro for metabolic, circadian, and sleep disorders
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Direct conversion of fibroblasts to osteoblasts as a novel strategy for bone regeneration in elderly individuals
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TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons
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Three-dimensional modeling of human neurodegeneration: brain organoids coming of age
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Screens in aging-relevant human ALS-motor neurons identify MAP4Ks as therapeutic targets for the disease
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Investigation of mitochondrial phenotypes in motor neurons derived by direct conversion of fibroblasts from familial ALS subjects
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Strategies for modeling aging and age-related diseases
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Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence
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Human neuronal maturation comes of age: cellular mechanisms and species differences
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Neuronal aging causes mislocalization of splicing proteins and unchecked cellular stress
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Depletion of senescent-like neuronal cells alleviates cisplatin-induced peripheral neuropathy in mice
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A quantitative model of cellular decision making in direct neuronal reprogramming
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Direct conversion of urine-derived cells into functional motor neuron-like cells by defined transcription factors
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Tracing mitochondrial marks of neuronal aging in iPSCs-derived neurons and directly converted neurons
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The aging factor EPS8 induces disease-related protein aggregation through RAC signaling hyperactivation
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Electrophysiological characterization of sourced human iPSC-derived motor neurons
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Disease Modeling of Neurodegenerative Disorders Using Direct Neural Reprogramming
inferred← citeshttps://doi.org/10.1089/cell.2022.0127openalex-snapshot
Direct Reprogramming Retains Aging Signatures That Are Critical to Reveal Parkinson's Disease-Associated Autophagy Phenotypes
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Recent progress in translational engineered in vitro models of the central nervous system
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Distinct subcellular autophagy impairments in induced neurons from patients with Huntington's disease
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Identifying key regulators in neuronal transdifferentiation by gene regulatory network analysis
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Distinct sub-cellular autophagy impairments occur independently of protein aggregation in induced neurons from patients with Huntington’s disease
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Age-related pathological impairments in induced neurons derived from patients with idiopathic Parkinson’s disease
inferred← citeshttps://doi.org/10.1101/2023.04.24.538014openalex-snapshot
Chemical screens in aging-relevant human motor neurons identify MAP4Ks as therapeutic targets for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1101/2023.05.23.541995openalex-snapshot
Age-maintained human neurons demonstrate a developmental loss of intrinsic neurite growth ability
inferred← citeshttps://doi.org/10.1101/2023.11.21.568079openalex-snapshot
A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis
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Altered nuclear envelope homeostasis is a key pathogenic event in C9ORF72-linked ALS/FTD
inferred← citeshttps://doi.org/10.1101/2024.03.28.587193openalex-snapshot
Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models
inferred← citeshttps://doi.org/10.1101/2025.04.13.648609openalex-snapshot
Human induced pluripotent stem cell-derived astrocyte and neuron co-culture model for neuroinflammation modeling
inferred← citeshttps://doi.org/10.1101/393934openalex-snapshot
Balancing dynamic tradeoffs drives cellular reprogramming
inferred← citeshttps://doi.org/10.1111/acel.12862openalex-snapshot
Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1111/acel.13281openalex-snapshot
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease
inferred← citeshttps://doi.org/10.1111/acel.70232openalex-snapshot
Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS
inferred← citeshttps://doi.org/10.1111/acel.70751openalex-snapshot
Protracted Fate Acquisition and Epigenetic De‐Aging During Induced Neural Stem Cell Conversion of Human Blood Cells
inferred← citeshttps://doi.org/10.1111/bpa.13206openalex-snapshot
IFNγ protects motor neurons from oxidative stress via enhanced global protein synthesis in FUS ‐associated amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.1111/ejn.15466openalex-snapshot
Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function
inferred← citeshttps://doi.org/10.1111/febs.16162openalex-snapshot
Current status and future directions of clinical applications using iPS cells—focus on Japan
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Human pluripotent stem cell–derived models and drug screening in CNS precision medicine
inferred← citeshttps://doi.org/10.1134/s0012496623700849openalex-snapshot
Direct Reprogramming of Somatic Skin Cells from a Patient with Huntington’s Disease into Striatal Neurons to Create Models of Pathology
inferred← citeshttps://doi.org/10.1134/s0026893321040087openalex-snapshot
Transcription Factors of Direct Neuronal Reprogramming in Ontogenesis and Ex Vivo
inferred← citeshttps://doi.org/10.1146/annurev-biodatasci-092820-025214openalex-snapshot
Phenotyping Neurodegeneration in Human iPSCs
inferred← citeshttps://doi.org/10.1146/annurev-genet-120417-031534openalex-snapshot
Aging in a Dish: iPSC-Derived and Directly Induced Neurons for Studying Brain Aging and Age-Related Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.1152/ajpcell.00279.2020openalex-snapshot
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors
inferred← citeshttps://doi.org/10.1155/2019/1039623openalex-snapshot
Targeting N-Terminal Huntingtin with a Dual-sgRNA Strategy by CRISPR/Cas9
inferred← citeshttps://doi.org/10.1155/2021/5586052openalex-snapshot
Directly Reprogrammed Human Neurons to Understand Age‐Related Energy Metabolism Impairment and Mitochondrial Dysfunction in Healthy Aging and Neurodegeneration
inferred← citeshttps://doi.org/10.1155/2022/5969536openalex-snapshot
Role of Senescence in Tumorigenesis and Anticancer Therapy
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From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease
inferred← citeshttps://doi.org/10.1177/2472630318803277openalex-snapshot
Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization
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TERC haploid cell reprogramming: a novel therapeutic strategy for aplastic anemia
inferred← citeshttps://doi.org/10.1186/s13024-020-00411-6openalex-snapshot
Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.1186/s13072-018-0244-7openalex-snapshot
Age reprogramming and epigenetic rejuvenation
inferred← citeshttps://doi.org/10.1186/s40779-020-00271-7openalex-snapshot
Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules
inferred← citeshttps://doi.org/10.1186/s41232-024-00320-xopenalex-snapshot
Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease
inferred← citeshttps://doi.org/10.12688/f1000research.18926.1openalex-snapshot
Evolving principles underlying neural lineage conversion and their relevance for biomedical translation
inferred← citeshttps://doi.org/10.14670/hh-18-458openalex-snapshot
Limitations and challenges of direct cell reprogramming in vitro and in vivo.
inferred← citeshttps://doi.org/10.1515/jpm-2022-0575openalex-snapshot
Stem cell programming – prospects for perinatal medicine
inferred← citeshttps://doi.org/10.1515/medgen-2021-2085openalex-snapshot
Organ-on-a-chip technologies to study neuromuscular disorders: possibilities, limitations, and future hopes
inferred← citeshttps://doi.org/10.1523/jneurosci.2507-20.2020openalex-snapshot
Disease Modeling with Human Neurons Reveals LMNB1 Dysregulation Underlying DYT1 Dystonia
inferred← citeshttps://doi.org/10.20517/and.2023.01openalex-snapshot
The versatile applications of human pluripotent stem cell-derived microglia and microglia-containing brain organoids
inferred← citeshttps://doi.org/10.2174/0113894501279977231210170231openalex-snapshot
Transcription Factors in Brain Regeneration: A Potential Novel Therapeutic Target
inferred← citeshttps://doi.org/10.31857/s0026898421050086openalex-snapshot
Транскрипционные факторы прямого пронейронального репрограммирования в онтогенезе и ex vivo
inferred← citeshttps://doi.org/10.31857/s2686738924010131openalex-snapshot
Direct reprogramming of somatic skin cells from a patient with Huntington's disease into striatal neurons to create models of pathology
inferred← citeshttps://doi.org/10.3233/jad-200308openalex-snapshot
Dendrobium nobile Lindl. Alkaloids Ameliorate Cognitive Dysfunction in Senescence Accelerated SAMP8 Mice by Decreasing Amyloid-β Aggregation and Enhancing Autophagy Activity
inferred← citeshttps://doi.org/10.3389/fcell.2020.00443openalex-snapshot
Toward Generating Subtype-Specific Mesencephalic Dopaminergic Neurons in vitro
inferred← citeshttps://doi.org/10.3389/fcell.2022.962881openalex-snapshot
Motor neuron-derived induced pluripotent stem cells as a drug screening platform for amyotrophic lateral sclerosis
inferred← citeshttps://doi.org/10.3389/fcell.2026.1762891openalex-snapshot
Decoding the brain’s ATG8 paralog code: LC3–GABARAP specialization at synapses and the astrocyte–neuron interface
inferred← citeshttps://doi.org/10.3389/fgeed.2020.00007openalex-snapshot
The iNs and Outs of Direct Reprogramming to Induced Neurons
inferred← citeshttps://doi.org/10.3389/fmolb.2024.1383453openalex-snapshot
Protein aggregation and therapeutic strategies in SOD1- and TDP-43- linked ALS
inferred← citeshttps://doi.org/10.3389/fnagi.2020.00247openalex-snapshot
Stem Cells of the Aging Brain
inferred← citeshttps://doi.org/10.3389/fnagi.2022.1069482openalex-snapshot
Induced pluripotent stem cell-derived and directly reprogrammed neurons to study neurodegenerative diseases: The impact of aging signatures
inferred← citeshttps://doi.org/10.3389/fnagi.2022.750629openalex-snapshot
Genetic and Epigenetic Interplay Define Disease Onset and Severity in Repeat Diseases
inferred← citeshttps://doi.org/10.3389/fnagi.2023.1125739openalex-snapshot
Fountain of youth—Targeting autophagy in aging
inferred← citeshttps://doi.org/10.3389/fncel.2020.00121openalex-snapshot
Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration
inferred← citeshttps://doi.org/10.3389/fncel.2022.858432openalex-snapshot
Transgene and Chemical Transdifferentiation of Somatic Cells for Rapid and Efficient Neurological Disease Cell Models
inferred← citeshttps://doi.org/10.3389/fncel.2023.1003188openalex-snapshot
Reprogramming of adult human dermal fibroblasts to induced dorsal forebrain precursor cells maintains aging signatures
inferred← citeshttps://doi.org/10.3389/fncel.2023.1237641openalex-snapshot
A cutting-edge strategy for spinal cord injury treatment: resident cellular transdifferentiation
inferred← citeshttps://doi.org/10.3389/fneur.2026.1810863openalex-snapshot
Novel advanced patient-derived in vitro models of pediatric movement disorders to develop personalized therapeutic strategies
inferred← citeshttps://doi.org/10.3389/fnins.2018.00522openalex-snapshot
Mechanistic Insights Into MicroRNA-Induced Neuronal Reprogramming of Human Adult Fibroblasts
inferred← citeshttps://doi.org/10.3389/fnins.2019.00659openalex-snapshot
Alzheimer Disease Pathogenesis: Insights From Molecular and Cellular Biology Studies of Oligomeric Aβ and Tau Species
inferred← citeshttps://doi.org/10.3389/fnins.2019.01310openalex-snapshot
ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?
inferred← citeshttps://doi.org/10.3389/fnins.2020.546484openalex-snapshot
Prospects of Directly Reprogrammed Adult Human Neurons for Neurodegenerative Disease Modeling and Drug Discovery: iN vs. iPSCs Models
inferred← citeshttps://doi.org/10.3389/fnins.2023.1198041openalex-snapshot
Moving CNS axon growth and regeneration research into human model systems
inferred← citeshttps://doi.org/10.3389/fnmol.2019.00297openalex-snapshot
Application of Urine-Derived Stem Cells to Cellular Modeling in Neuromuscular and Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3389/fnmol.2020.00046openalex-snapshot
Differential Influence of Sample Sex and Neuronal Maturation on mRNA and Protein Transport in Induced Human Neurons
inferred← citeshttps://doi.org/10.3389/fphys.2022.848220openalex-snapshot
Editorial: Challenges and Opportunities for Neuromuscular Disease Modelling Using Urine-derived Stem Cells
inferred← citeshttps://doi.org/10.3389/fpsyt.2023.1291115openalex-snapshot
Leveraging iPSC technology to assess neuro-immune interactions in neurological and psychiatric disorders
inferred← citeshttps://doi.org/10.3390/antiox15060689openalex-snapshot
Ginkgo Biloba Extract Ameliorates Age-Related Mitochondrial Deficits in Human iPSCs and Their Derived Neurons and Astrocytes
inferred← citeshttps://doi.org/10.3390/bioengineering10010093openalex-snapshot
In Vitro 3D Modeling of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/biology12060867openalex-snapshot
In Vitro Modeling as a Tool for Testing Therapeutics for Spinal Muscular Atrophy and IGHMBP2-Related Disorders
inferred← citeshttps://doi.org/10.3390/biomedicines9111635openalex-snapshot
Human iPSC-Derived Neurons as A Platform for Deciphering the Mechanisms behind Brain Aging
inferred← citeshttps://doi.org/10.3390/brainsci13030524openalex-snapshot
Somatic Cell Reprogramming for Nervous System Diseases: Techniques, Mechanisms, Potential Applications, and Challenges
inferred← citeshttps://doi.org/10.3390/cells10113087openalex-snapshot
A Step-by-Step Refined Strategy for Highly Efficient Generation of Neural Progenitors and Motor Neurons from Human Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.3390/cells13110903openalex-snapshot
hPSC-Derived Astrocytes at the Forefront of Translational Applications in Neurological Disorders
inferred← citeshttps://doi.org/10.3390/cells7050038openalex-snapshot
Patient-Derived iPSCs and iNs—Shedding New Light on the Cellular Etiology of Neurodegenerative Diseases
inferred← citeshttps://doi.org/10.3390/ijms25042392openalex-snapshot
Induced Pluripotent Stem Cells in Drug Discovery and Neurodegenerative Disease Modelling
inferred← citeshttps://doi.org/10.3390/ijms252111363openalex-snapshot
Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes
inferred← citeshttps://doi.org/10.3390/life13061254openalex-snapshot
Spinal Cord Organoids to Study Motor Neuron Development and Disease
inferred← citeshttps://doi.org/10.4103/1673-5374.306083openalex-snapshot
Generation of patient-specific motor neurons in modeling movement diseases
inferred← citeshttps://doi.org/10.4172/neuropsychiatry.1000511openalex-snapshot
Pluripotent Stem Cell Based Cultures to Study Key Aspects of Human Cerebral Cortex Development
inferred← citeshttps://doi.org/10.4252/wjsc.v11.i9.650openalex-snapshot
Impelling force and current challenges by chemicals in somatic cell reprogramming and expansion beyond hepatocytes
inferred← citeshttps://doi.org/10.59368/agingbio.20230010openalex-snapshot
Aging, Parkinson’s Disease, and Models: What Are the Challenges?
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126602openalex-snapshot
Additional file 1 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126605openalex-snapshot
Additional file 2 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126608openalex-snapshot
Additional file 3 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126611openalex-snapshot
Additional file 4 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126614openalex-snapshot
Additional file 5 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.13126617openalex-snapshot
Additional file 6 of Aging-relevant human basal forebrain cholinergic neurons as a cell model for Alzheimer’s disease
inferred← citeshttps://doi.org/10.6084/m9.figshare.25231192openalex-snapshot
Additional file 1 of Rapid and high-purity differentiation of human medium spiny neurons reveals LMNB1 hypofunction and subtype necessity in modeling Huntington’s disease
inferred← citeshttps://doi.org/10.64898/2026.01.21.700829openalex-snapshot
Comprehensive Characterization of the Human Neural Stem Cell Line HNSC.100 as a Versatile Model for Neurobiological Research
inferred← citeshttps://doi.org/10.70675/1968f5c5z6e83z4873z819ez491a01da8da7openalex-snapshot
Efficient neuronal reprogramming into corticofugal projection neurons at embryonic and postnatal stages in the mouse
inferred← citeshttps://doi.org/10.7554/elife.41356openalex-snapshot
Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons
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