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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

https://doi.org/10.7554/elife.63326
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1 of the 85 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1084/jem.20190251 (notice 2026-06-12).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/s00726-011-0867-5openalex-snapshot
The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
inferredcites →https://doi.org/10.1016/0026-0495(87)90207-1openalex-snapshot
Cystine and lysine transport in cultured human renal epithelial cells
inferredcites →https://doi.org/10.1016/j.ccell.2017.09.013openalex-snapshot
mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
inferredcites →https://doi.org/10.1016/j.cell.2005.10.024openalex-snapshot
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
inferredcites →https://doi.org/10.1016/j.cell.2011.06.034openalex-snapshot
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
inferredcites →https://doi.org/10.1016/j.celrep.2017.04.042openalex-snapshot
mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4
inferredcites →https://doi.org/10.1016/j.chembiol.2008.02.010openalex-snapshot
Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells
inferredcites →https://doi.org/10.1016/j.chest.2019.05.038openalex-snapshot
Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells
inferredcites →https://doi.org/10.1016/j.cmet.2008.07.007openalex-snapshot
SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
inferredcites →https://doi.org/10.1016/j.cub.2014.08.007openalex-snapshot
RETRACTED: The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
inferredcites →https://doi.org/10.1016/j.molcel.2007.12.023openalex-snapshot
Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis
inferredcites →https://doi.org/10.1016/j.molcel.2010.06.022openalex-snapshot
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
inferredcites →https://doi.org/10.1016/j.molcel.2017.05.030openalex-snapshot
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT
inferredcites →https://doi.org/10.1016/j.redox.2015.03.003openalex-snapshot
Expression of xCT and activity of system xc− are regulated by NRF2 in human breast cancer cells in response to oxidative stress
inferredcites →https://doi.org/10.1016/j.tem.2009.05.008openalex-snapshot
ATF4-dependent transcription mediates signaling of amino acid limitation
inferredcites →https://doi.org/10.1016/j.tem.2017.07.003openalex-snapshot
Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells
inferredcites →https://doi.org/10.1016/s0021-9258(18)35980-5openalex-snapshot
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).
inferredcites →https://doi.org/10.1016/s0021-9258(19)85901-xopenalex-snapshot
Transport interaction of L-cystine and L-glutamate in human diploid fibroblasts in culture.
inferredcites →https://doi.org/10.1016/s0303-7207(02)00230-7openalex-snapshot
Transdominant suppression of estrogen receptor signaling by progesterone receptor ligands in uterine leiomyoma cells
inferredcites →https://doi.org/10.1016/s1097-2765(00)00108-8openalex-snapshot
Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells
inferredcites →https://doi.org/10.1016/s1097-2765(00)80036-2openalex-snapshot
Identification of a tRNA-Specific Nuclear Export Receptor
inferredcites →https://doi.org/10.1016/s1097-2765(01)00265-9openalex-snapshot
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
inferredcites →https://doi.org/10.1016/s1097-2765(03)00105-9openalex-snapshot
An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress
inferredcites →https://doi.org/10.1016/s1535-6108(03)00187-9openalex-snapshot
TSC2 regulates VEGF through mTOR-dependent and -independent pathways
inferredcites →https://doi.org/10.1038/nature11083openalex-snapshot
A unifying model for mTORC1-mediated regulation of mRNA translation
inferredcites →https://doi.org/10.1038/nature13473openalex-snapshot
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
inferredcites →https://doi.org/10.1038/nature13492openalex-snapshot
Coordinated regulation of protein synthesis and degradation by mTORC1
inferredcites →https://doi.org/10.1038/nature13537openalex-snapshot
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis
inferredcites →https://doi.org/10.1038/ncb2738openalex-snapshot
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
inferredcites →https://doi.org/10.1038/ncomms7239openalex-snapshot
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
inferredcites →https://doi.org/10.1038/nm1337openalex-snapshot
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
inferredcites →https://doi.org/10.1038/nmeth.2812openalex-snapshot
E-CRISP: fast CRISPR target site identification
inferredcites →https://doi.org/10.1038/nprot.2013.143openalex-snapshot
Genome engineering using the CRISPR-Cas9 system
inferredcites →https://doi.org/10.1038/nrc.2016.84openalex-snapshot
Oxygen availability and metabolic adaptations
inferredcites →https://doi.org/10.1038/nrm2672openalex-snapshot
Molecular mechanisms of mTOR-mediated translational control
inferredcites →https://doi.org/10.1038/s41418-019-0274-0openalex-snapshot
mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis
inferredcites →https://doi.org/10.1038/s42255-019-0038-7openalex-snapshot
Molecular logic of mTORC1 signalling as a metabolic rheostat
inferredcites →https://doi.org/10.1038/sj.emboj.7600193openalex-snapshot
Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases
inferredcites →https://doi.org/10.1038/srep28973openalex-snapshot
CRISP-ID: decoding CRISPR mediated indels by Sanger sequencing
inferredcites →https://doi.org/10.1073/pnas.0400541101openalex-snapshot
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells
inferredcites →https://doi.org/10.1073/pnas.0506580102openalex-snapshot
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
inferredcites →https://doi.org/10.1073/pnas.1213343109openalex-snapshot
Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
inferredcites →https://doi.org/10.1073/pnas.1821863116openalex-snapshot
Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells
inferredcites →https://doi.org/10.1073/pnas.2022120118openalex-snapshot
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction
inferredcites →https://doi.org/10.1073/pnas.91.10.4441openalex-snapshot
Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.
inferredcites →https://doi.org/10.1074/jbc.m101198200openalex-snapshot
Identification of Activating Transcription Factor 4 (ATF4) as an Nrf2-interacting Protein
inferredcites →https://doi.org/10.1074/jbc.m208704200openalex-snapshot
Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression
inferredcites →https://doi.org/10.1074/jbc.m610510200openalex-snapshot
Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids
inferredcites →https://doi.org/10.1074/jbc.ra119.012095openalex-snapshot
Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ
inferredcites →https://doi.org/10.1074/jbc.tm117.000257openalex-snapshot
Regulation of redox balance in cancer and T cells
inferredcites →https://doi.org/10.1084/jem.20071460openalex-snapshot
ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo
inferredcites →https://doi.org/10.1084/jem.20190251openalex-snapshot
RETRACTED: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion
inferredcites →https://doi.org/10.1089/omi.2011.0118openalex-snapshot
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
inferredcites →https://doi.org/10.1093/bioinformatics/btp616openalex-snapshot
edgeR : a Bioconductor package for differential expression analysis of digital gene expression data
inferredcites →https://doi.org/10.1093/emboj/17.24.7430openalex-snapshot
The role of exportin‐t in selective nuclear export of mature tRNAs
inferredcites →https://doi.org/10.1093/nar/gkv007openalex-snapshot
limma powers differential expression analyses for RNA-sequencing and microarray studies
inferredcites →https://doi.org/10.1093/nar/gkw983openalex-snapshot
Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse
inferredcites →https://doi.org/10.1093/nar/gky1094openalex-snapshot
Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis
inferredcites →https://doi.org/10.1093/nar/gkz114openalex-snapshot
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
inferredcites →https://doi.org/10.1101/087969458.30.139openalex-snapshot
5 Protein Kinases That Phosphorylate eIF2 and eIF2B, and Their Role in Eukaryotic Cell Translational Control
inferredcites →https://doi.org/10.1101/gad.1256804openalex-snapshot
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
inferredcites →https://doi.org/10.1101/gad.322704openalex-snapshot
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
inferredcites →https://doi.org/10.1101/gad.329763.119openalex-snapshot
Hippo pathway deletion in adult resting cardiac fibroblasts initiates a cell state transition with spontaneous and self-sustaining fibrosis
inferredcites →https://doi.org/10.1126/science.1084648openalex-snapshot
Comprehensive Identification of Human bZIP Interactions with Coiled-Coil Arrays
inferredcites →https://doi.org/10.1126/science.1182228openalex-snapshot
Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
inferredcites →https://doi.org/10.1126/science.1209038openalex-snapshot
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
inferredcites →https://doi.org/10.1126/science.6836290openalex-snapshot
Selective Modification of Glutathione Metabolism
inferredcites →https://doi.org/10.1126/science.aab2674openalex-snapshot
Sestrin2 is a leucine sensor for the mTORC1 pathway
inferredcites →https://doi.org/10.1126/science.aad0489openalex-snapshot
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle
inferredcites →https://doi.org/10.1126/scisignal.aao6604openalex-snapshot
Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT
inferredcites →https://doi.org/10.1128/mcb.00221-14openalex-snapshot
Nrf2- and ATF4-Dependent Upregulation of xCT Modulates the Sensitivity of T24 Bladder Carcinoma Cells to Proteasome Inhibition
inferredcites →https://doi.org/10.1128/mcb.00911-15openalex-snapshot
C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4
inferredcites →https://doi.org/10.1128/mcb.21.12.3995-4004.2001openalex-snapshot
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
inferredcites →https://doi.org/10.1128/mcb.22.20.7004-7014.2002openalex-snapshot
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
inferredcites →https://doi.org/10.1146/annurev-cancerbio-030617-050329openalex-snapshot
Nutrient Sensing in Cancer
inferredcites →https://doi.org/10.1158/0008-5472.can-16-2458openalex-snapshot
p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0507openalex-snapshot
MYC, Metabolism, and Cancer
inferredcites →https://doi.org/10.1172/jci0215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci15593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1172/jci200215593openalex-snapshot
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
inferredcites →https://doi.org/10.1182/blood-2007-09-111856openalex-snapshot
Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation
inferredcites →https://doi.org/10.1371/journal.pone.0215495openalex-snapshot
CiiiDER: A tool for predicting and analysing transcription factor binding sites
inferredcites →https://doi.org/10.4161/trns.25907openalex-snapshot
Dose-dependent regulation of target gene expression and cell proliferation by c-Myc levels
inferredcites →https://doi.org/10.7554/elife.06821openalex-snapshot
ATF4 licenses C/EBPβ activity in human mesenchymal stem cells primed for adipogenesis
inferredcites →https://doi.org/10.7554/elife.63326openalex-snapshot
The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4648361openalex-extracted
eIF2α Phosphorylation-Mediated Transcriptional Reprogramming Suppresses Impairment of Mitochondrial and GSH Homeostasis and Thereby Ferroptosis During ER Stress
inferred← citeshttps://doi.org/10.1002/advs.202507718openalex-snapshot
Tumor Intrinsic METTL5 Modulates ATF4 Translation to Prevent T Cell‐Induced Ferroptosis in Ovarian Cancer
inferred← citeshttps://doi.org/10.1002/bit.27748openalex-snapshot
Constitutively active Rheb mutants [T23M] and [E40K] drive increased production and secretion of recombinant protein in Chinese hamster ovary cells
inferred← citeshttps://doi.org/10.1002/bit.28050openalex-snapshot
Significant impact of mTORC1 and ATF4 pathways in CHO cell recombinant protein production induced by CDK4/6 inhibitor
inferred← citeshttps://doi.org/10.1002/cph4.70105openalex-snapshot
The Integrated Stress Response in Cancer: Paradox and Therapeutic Promise
inferred← citeshttps://doi.org/10.1002/jev2.12449openalex-snapshot
Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKα activation
inferred← citeshttps://doi.org/10.1002/mc.23437openalex-snapshot
Transcriptional and metabolic remodeling in clear cell renal cell carcinoma caused by ATF4 activation and the integrated stress response (ISR)
inferred← citeshttps://doi.org/10.1002/mc.70122openalex-snapshot
CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer
inferred← citeshttps://doi.org/10.1007/s00011-023-01815-yopenalex-snapshot
Serine metabolism in macrophage polarization
inferred← citeshttps://doi.org/10.1007/s00109-025-02559-4openalex-snapshot
ATF4 in proximal tubules modulates kidney function and modifies the metabolome
inferred← citeshttps://doi.org/10.1007/s00216-025-06275-3openalex-snapshot
Untargeted metabolomics and lipidomics to study autophagy induction in mouse embryonic fibroblasts
inferred← citeshttps://doi.org/10.1007/s00726-026-03517-1openalex-snapshot
Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1007/s10142-025-01757-0openalex-snapshot
Non-coding RNAs-regulated SLC7A11 modulates ferroptosis: a new strategy for cancer therapy
inferred← citeshttps://doi.org/10.1007/s10565-023-09816-7openalex-snapshot
Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells
inferred← citeshttps://doi.org/10.1007/s11010-026-05680-1openalex-snapshot
Endothelial ATF4 attenuates hypertensive vascular damage via preserving mitochondrial redox homeostasis
inferred← citeshttps://doi.org/10.1007/s11064-024-04213-wopenalex-snapshot
LINC00894 Regulates Cerebral Ischemia/Reperfusion Injury by Stabilizing EIF5 and Facilitating ATF4-Mediated Induction of FGF21 and ACOD1 Expression
inferred← citeshttps://doi.org/10.1007/s11357-023-00772-yopenalex-snapshot
The transcription regulator ATF4 is a mediator of skeletal muscle aging
inferred← citeshttps://doi.org/10.1007/s11357-023-00938-8openalex-snapshot
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
inferred← citeshttps://doi.org/10.1016/b978-0-12-821618-7.00182-6openalex-snapshot
mTORC1: Upstream and Downstream
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2024.119830openalex-snapshot
BBOX1 mediates metabolic reprogramming driven by hypoxia and participates in the malignant progress of high-grade serous ovarian cancer
inferred← citeshttps://doi.org/10.1016/j.bbcan.2023.189062openalex-snapshot
Dietary approaches for exploiting metabolic vulnerabilities in cancer
inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115074openalex-snapshot
Amino acid metabolism, transport and signalling in the liver revisited
inferred← citeshttps://doi.org/10.1016/j.bcp.2026.117703openalex-snapshot
ATF4 in cardiovascular diseases: an emerging therapeutic target
inferred← citeshttps://doi.org/10.1016/j.biochi.2025.06.013openalex-snapshot
Regulation of ferroptosis by transcription factor E2F1
inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130642openalex-snapshot
Nitroxoline-O-protected derivatives inhibit MetAP2 and activate ATF4 through mTORC1 to inhibit cancer cell growth
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.111055openalex-snapshot
Targeting PI3K/AKT/mTOR signaling to overcome drug resistance in cancer
inferred← citeshttps://doi.org/10.1016/j.cell.2025.04.020openalex-snapshot
m6A alters ribosome dynamics to initiate mRNA degradation
inferred← citeshttps://doi.org/10.1016/j.celrep.2022.111187openalex-snapshot
Multiomics assessment of dietary protein titration reveals altered hepatic glucose utilization
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112724openalex-snapshot
The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.113615openalex-snapshot
Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.113863openalex-snapshot
Integrated stress response signaling acts as a metabolic sensor in fat tissues to regulate oocyte maturation and ovulation
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116735openalex-snapshot
Afg3l2 couples mitochondrial vitamin B12 trafficking to amino acid metabolism to safeguard hematopoietic stem cell homeostasis
inferred← citeshttps://doi.org/10.1016/j.clim.2023.109698openalex-snapshot
ATF4 knockdown in macrophage impairs glycolysis and mediates immune tolerance by targeting HK2 and HIF-1α ubiquitination in sepsis
inferred← citeshttps://doi.org/10.1016/j.cmet.2021.07.015openalex-snapshot
Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2022.08.017openalex-snapshot
OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy
inferred← citeshttps://doi.org/10.1016/j.cmet.2024.07.022openalex-snapshot
The crosstalk between metabolism and translation
inferred← citeshttps://doi.org/10.1016/j.cmet.2025.05.010openalex-snapshot
The integrated stress response fine-tunes stem cell fate decisions upon serine deprivation and tissue injury
inferred← citeshttps://doi.org/10.1016/j.cophys.2022.100555openalex-snapshot
The integrated stress response as a key pathway downstream of mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1016/j.crmeth.2025.101027openalex-snapshot
Integrated analysis of transcriptional and metabolic responses to mitochondrial stress
inferred← citeshttps://doi.org/10.1016/j.ctarc.2026.101303openalex-snapshot
Molecular determinants of Bortezomib sensitivity and resistance in multiple myeloma
inferred← citeshttps://doi.org/10.1016/j.diabres.2026.113320openalex-snapshot
Long noncoding RNAs in insulin signaling: mechanisms, metabolic roles, and therapeutic prospects
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.124145openalex-snapshot
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.11.036openalex-snapshot
WITHDRAWN: Mitochondria need their sleep: Sleep-wake cycling and the role of redox, bioenergetics, and temperature regulation, involving cysteine-mediated redox signaling, uncoupling proteins, and substrate cycles
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.129607openalex-snapshot
A comprehensive review on signaling attributes of serine and serine metabolism in health and disease
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.142388openalex-snapshot
The glutamine starvation-induced lncRNA FERRIN suppresses ferroptosis via the stabilization of SLC7A11 mRNA
inferred← citeshttps://doi.org/10.1016/j.immuni.2026.04.004openalex-snapshot
Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress
inferred← citeshttps://doi.org/10.1016/j.isci.2022.105458openalex-snapshot
Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
inferred← citeshttps://doi.org/10.1016/j.isci.2025.112138openalex-snapshot
Ribosomal protein deficiencies linked to Diamond-Blackfan anemia induce distinctive alterations of ATF4 expression
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114148openalex-snapshot
Angiogenesis-independent VEGF signaling enhances exercise capacity by increasing fat oxidation in mice fed sulfur amino acid-restricted diets
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114277openalex-snapshot
Basal level of ATF4 promotes T cell readiness for activation-induced proliferation
inferred← citeshttps://doi.org/10.1016/j.isci.2026.116074openalex-snapshot
Integration of single-cell transcriptome of female early gonadal development in bovine, goats, and pigs
inferred← citeshttps://doi.org/10.1016/j.jare.2026.03.017openalex-snapshot
The stress responsive transcription factor ATF4: from molecular structure to disease mechanisms
inferred← citeshttps://doi.org/10.1016/j.jbc.2022.102629openalex-snapshot
A cell-based chemical-genetic screen for amino acid stress response inhibitors reveals torins reverse stress kinase GCN2 signaling
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105220openalex-snapshot
Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of Raptor in zebrafish
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107151openalex-snapshot
The integrated stress response in metabolic adaptation
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.107575openalex-snapshot
Phosphorylation of GCN2 by mTOR confers adaptation to conditions of hyper-mTOR activation under stress
inferred← citeshttps://doi.org/10.1016/j.jgg.2022.06.002openalex-snapshot
Understanding the mechanistic regulation of ferroptosis in cancer: the gene matters
inferred← citeshttps://doi.org/10.1016/j.metabol.2023.155719openalex-snapshot
Transcriptional regulation of amino acid metabolism by KDM2B, in the context of ncPRC1.1 and in concert with MYC and ATF4
inferred← citeshttps://doi.org/10.1016/j.mmm.2024.10.006openalex-snapshot
Les voies de signalisation régulées par la disponibilité en acides aminés : contrôle de fonctions physiologiques et impacts en santé
inferred← citeshttps://doi.org/10.1016/j.mocell.2025.100210openalex-snapshot
Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.02.007openalex-snapshot
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
inferred← citeshttps://doi.org/10.1016/j.molcel.2022.06.008openalex-snapshot
The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.04.016openalex-snapshot
eIF4F complex dynamics are important for the activation of the integrated stress response
inferred← citeshttps://doi.org/10.1016/j.molcel.2024.07.020openalex-snapshot
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101309openalex-snapshot
Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101615openalex-snapshot
Resistance exercise enhances long-term mTORC1 sensitivity to leucine
inferred← citeshttps://doi.org/10.1016/j.neures.2026.105091openalex-snapshot
Cellular and molecular networks governing myelination dynamics in the central nervous system
inferred← citeshttps://doi.org/10.1016/j.redox.2022.102282openalex-snapshot
PRMT5 regulates ATF4 transcript splicing and oxidative stress response
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102833openalex-snapshot
Loss of PERK function promotes ferroptosis by downregulating SLC7A11 (System Xc⁻) in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2024.103286openalex-snapshot
Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.stemcr.2026.102950openalex-snapshot
PCBP1 orchestrates amino acid metabolism burst during the naïve-to-primed pluripotency transition
inferred← citeshttps://doi.org/10.1016/j.tcb.2023.03.003openalex-snapshot
Regulation of nucleotide metabolism in cancers and immune disorders
inferred← citeshttps://doi.org/10.1016/j.ygeno.2025.110992openalex-snapshot
Further insights into the molecular mechanisms underlying tobacco straw cultivation of Pleurotus ostreatus by comparative transcriptome analyses
inferred← citeshttps://doi.org/10.1021/acs.est.4c00074openalex-snapshot
Gestational Exposure to PM2.5 and Specific Constituents, Meconium Metabolites, and Neonatal Neurobehavioral Development: A Cohort Study
inferred← citeshttps://doi.org/10.1038/s41388-023-02632-7openalex-snapshot
L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis
inferred← citeshttps://doi.org/10.1038/s41392-025-02493-4openalex-snapshot
mTOR signaling networks: mechanistic insights and translational frontiers in disease therapeutics
inferred← citeshttps://doi.org/10.1038/s41401-023-01225-0openalex-snapshot
Mammalian integrated stress responses in stressed organelles and their functions
inferred← citeshttps://doi.org/10.1038/s41416-023-02412-wopenalex-snapshot
Fumarate hydratase (FH) and cancer: a paradigm of oncometabolism
inferred← citeshttps://doi.org/10.1038/s41419-022-05421-4openalex-snapshot
An mTORC1 to HRI signaling axis promotes cytotoxicity of proteasome inhibitors in multiple myeloma
inferred← citeshttps://doi.org/10.1038/s41419-023-06204-1openalex-snapshot
Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells
inferred← citeshttps://doi.org/10.1038/s41420-022-01156-5openalex-snapshot
Elucidation of an mTORC2-PKC-NRF2 pathway that sustains the ATF4 stress response and identification of Sirt5 as a key ATF4 effector
inferred← citeshttps://doi.org/10.1038/s41420-025-02683-7openalex-snapshot
The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting
inferred← citeshttps://doi.org/10.1038/s41421-023-00589-1openalex-snapshot
Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation
inferred← citeshttps://doi.org/10.1038/s41467-021-25563-xopenalex-snapshot
Quantitative modelling of amino acid transport and homeostasis in mammalian cells
inferred← citeshttps://doi.org/10.1038/s41467-023-40621-2openalex-snapshot
An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
inferred← citeshttps://doi.org/10.1038/s41467-023-41317-3openalex-snapshot
Germinal center output is sustained by HELLS-dependent DNA-methylation-maintenance in B cells
inferred← citeshttps://doi.org/10.1038/s41467-024-46696-9openalex-snapshot
A fast-acting lipid checkpoint in G1 prevents mitotic defects
inferred← citeshttps://doi.org/10.1038/s41467-024-52538-5openalex-snapshot
Specific activation of the integrated stress response uncovers regulation of central carbon metabolism and lipid droplet biogenesis
inferred← citeshttps://doi.org/10.1038/s41467-025-64320-2openalex-snapshot
Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses
inferred← citeshttps://doi.org/10.1038/s41467-025-65760-6openalex-snapshot
The CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane
inferred← citeshttps://doi.org/10.1038/s41556-024-01523-7openalex-snapshot
Spatial and functional separation of mTORC1 signalling in response to different amino acid sources
inferred← citeshttps://doi.org/10.1038/s41556-025-01765-zopenalex-snapshot
Translational regulation in stress biology
inferred← citeshttps://doi.org/10.1038/s41580-021-00332-2openalex-snapshot
Mechanisms and regulation of protein synthesis in mitochondria
inferred← citeshttps://doi.org/10.1038/s41594-026-01756-0openalex-snapshot
Stress adaptation of mitochondrial protein import by OMA1-mediated degradation of DNAJC15
inferred← citeshttps://doi.org/10.1038/s41598-024-74391-8openalex-snapshot
Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells
inferred← citeshttps://doi.org/10.1038/s41598-025-95883-1openalex-snapshot
MiR-204-5p mediates PERK inhibition to suppress growth and induce apoptosis in ovarian cancer through the eIF2α/ATF-4/CHOP pathway
inferred← citeshttps://doi.org/10.1038/s42003-024-06547-1openalex-snapshot
Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK
inferred← citeshttps://doi.org/10.1038/s42003-026-10226-8openalex-snapshot
Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
inferred← citeshttps://doi.org/10.1038/s42255-022-00645-2openalex-snapshot
Principles and functions of metabolic compartmentalization
inferred← citeshttps://doi.org/10.1038/s42255-023-00915-7openalex-snapshot
Vitamin B5 supports MYC oncogenic metabolism and tumor progression in breast cancer
inferred← citeshttps://doi.org/10.1038/s43018-024-00739-8openalex-snapshot
Cycling back to folate metabolism in cancer
inferred← citeshttps://doi.org/10.1038/s43587-021-00112-9openalex-snapshot
Modulating the integrated stress response to slow aging and ameliorate age-related pathology
inferred← citeshttps://doi.org/10.1038/s44318-024-00184-4openalex-snapshot
Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis
inferred← citeshttps://doi.org/10.1038/s44321-026-00409-5openalex-snapshot
The lipid transfer protein STARD7 controls intestinal tumor development in a context-dependent manner
inferred← citeshttps://doi.org/10.1073/pnas.2122840119openalex-snapshot
Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11
inferred← citeshttps://doi.org/10.1073/pnas.2537017123openalex-snapshot
Distinct cell type–specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation
inferred← citeshttps://doi.org/10.1080/15548627.2025.2512884openalex-snapshot
RETREG1-mediated reticulophagy is activated by an ATF4-CEBPG/C/EBPγ heterodimer and confers protection against lipotoxicity
inferred← citeshttps://doi.org/10.1083/jcb.202205045openalex-snapshot
V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans
inferred← citeshttps://doi.org/10.1083/jcb.202208103openalex-snapshot
mTORC1 beyond anabolic metabolism: Regulation of cell death
inferred← citeshttps://doi.org/10.1089/ars.2022.0123openalex-snapshot
Surviving and Adapting to Stress: Translational Control and the Integrated Stress Response
inferred← citeshttps://doi.org/10.1089/ars.2023.0339openalex-snapshot
Nuclear Factor Erythroid 2 Related Factor 2 and Mitochondria Form a Mutually Regulating Circuit in the Prevention and Treatment of Metabolic Syndrome
inferred← citeshttps://doi.org/10.1089/ars.2023.0409openalex-snapshot
A Core NRF2 Gene Set Defined Through Comprehensive Transcriptomic Analysis Predicts Selective Drug Resistance and Poor Multicancer Prognosis
inferred← citeshttps://doi.org/10.1093/cvr/cvac050openalex-snapshot
A mitochondrial long-chain fatty acid oxidation defect leads to transfer RNA uncharging and activation of the integrated stress response in the mouse heart
inferred← citeshttps://doi.org/10.1093/dnares/dsag011openalex-snapshot
Enrichment-free deep proteomics enables proteome-scale analysis of methionine oxidation
inferred← citeshttps://doi.org/10.1093/jn/nxab342openalex-snapshot
Amino Acid Homeostasis in Mammalian Cells with a Focus on Amino Acid Transport
inferred← citeshttps://doi.org/10.1093/jn/nxab440openalex-snapshot
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
inferred← citeshttps://doi.org/10.1093/nar/gkag152openalex-snapshot
TDG orchestrates ATF4-dependent gene transcription during retinoic acid-induced cell fate acquisition
inferred← citeshttps://doi.org/10.1093/nar/gkag832openalex-snapshot
hY3 RNA binds and inhibits ribosomes and modulates the starvation-induced integrated stress response
inferred← citeshttps://doi.org/10.1093/nargab/lqag069openalex-snapshot
The role of ATF4 in neurons under mitochondrial stress
inferred← citeshttps://doi.org/10.1093/pnasnexus/pgae429openalex-snapshot
Peroxisomal import stress activates integrated stress response and inhibits ribosome biogenesis
inferred← citeshttps://doi.org/10.1096/fj.202200204rropenalex-snapshot
Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific
inferred← citeshttps://doi.org/10.1096/fj.202502855ropenalex-snapshot
Atf4a Regulates Mitochondrial Homeostasis Through Parkin‐Mediated Mitophagy to Enhance Hypoxia Tolerance in Zebrafish ( Danio rerio )
inferred← citeshttps://doi.org/10.1101/2021.02.08.430327openalex-snapshot
A unified model of amino acid homeostasis in mammalian cells
inferred← citeshttps://doi.org/10.1101/2022.04.01.486707openalex-snapshot
Farnesyltransferase inhibition overcomes the adaptive resistance to osimertinib in EGFR -mutant NSCLC
inferred← citeshttps://doi.org/10.1101/2022.12.10.519872openalex-snapshot
Comprehensive Evaluation of Rapamycin’s Specificity as an mTOR Inhibitor
inferred← citeshttps://doi.org/10.1101/2023.03.28.534659openalex-snapshot
PERK arm of UPR selectively regulates ferroptosis in colon cancer cells by modulating the expression of SLC7A11 (System Xc-)
inferred← citeshttps://doi.org/10.1101/2023.10.03.559930openalex-snapshot
Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
inferred← citeshttps://doi.org/10.1101/2024.04.11.589139openalex-snapshot
MAPK-mediated PHGDH induction is essential for melanoma formation and represents an actionable vulnerability
inferred← citeshttps://doi.org/10.1101/2024.12.19.629301openalex-snapshot
BRAF V600 and ErbB inhibitors directly activate GCN2 in an off-target manner to limit cancer cell proliferation
inferred← citeshttps://doi.org/10.1101/2024.12.23.630120openalex-snapshot
The cytosolic cysteinyl-tRNA synthetase is capable of regulating ATF4 translation independent of eIF2α phosphorylation state
inferred← citeshttps://doi.org/10.1101/2025.02.10.637516openalex-snapshot
Lineage plasticity of the integrated stress response is a hallmark of cancer evolution
inferred← citeshttps://doi.org/10.1101/2025.02.28.640905openalex-snapshot
Mapping the ISR Landscape in Cognitive Disorders via single-cell multi-omics
inferred← citeshttps://doi.org/10.1101/2025.05.07.652698openalex-snapshot
Metabolic immunity to infection is driven by mitochondrial one-carbon metabolism
inferred← citeshttps://doi.org/10.1101/cshperspect.a041543openalex-snapshot
Growth Signaling Networks Orchestrate Cancer Metabolic Networks
inferred← citeshttps://doi.org/10.1111/acel.13888openalex-snapshot
Unbiased evaluation of rapamycin's specificity as an mTOR inhibitor
inferred← citeshttps://doi.org/10.1111/acel.14165openalex-snapshot
The integrated stress response promotes neural stem cell survival under conditions of mitochondrial dysfunction in neurodegeneration
inferred← citeshttps://doi.org/10.1111/apha.14111openalex-snapshot
Parkin is a critical player in the effects of caffeine over mitochondrial quality control pathways during skeletal muscle regeneration in mice
inferred← citeshttps://doi.org/10.1111/febs.17076openalex-snapshot
Translation regulation in response to stress
inferred← citeshttps://doi.org/10.1111/febs.70113openalex-snapshot
Glucose sensing and the unfolded protein response
inferred← citeshttps://doi.org/10.1111/imm.13827openalex-snapshot
PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody‐secreting cells from oxidative stress
inferred← citeshttps://doi.org/10.1124/pharmrev.123.001028openalex-snapshot
The Art of Finding the Right Drug Target: Emerging Methods and Strategies
inferred← citeshttps://doi.org/10.1126/sciadv.adh2023openalex-snapshot
Loss of attachment promotes proline accumulation and excretion in cancer cells
inferred← citeshttps://doi.org/10.1126/sciadv.aec0131openalex-snapshot
mTOR signaling contributes to system-driven rhythmic gene expression in mouse liver
inferred← citeshttps://doi.org/10.1126/science.abi9547openalex-snapshot
Zonated leucine sensing by Sestrin-mTORC1 in the liver controls the response to dietary leucine
inferred← citeshttps://doi.org/10.1126/science.adr6326openalex-snapshot
Mitochondria protect against an intracellular pathogen by restricting access to folate
inferred← citeshttps://doi.org/10.1126/sciimmunol.adl4613openalex-snapshot
Asparagine availability controls germinal center B cell homeostasis
inferred← citeshttps://doi.org/10.1128/mbio.00689-24openalex-snapshot
Differential stability of Gcn4p controls its cell-specific activity in differentiated yeast colonies
inferred← citeshttps://doi.org/10.1134/s1990750824601371openalex-snapshot
Serine Hydroxymethyltransferase in Cancer Cells
inferred← citeshttps://doi.org/10.1152/ajpcell.00080.2023openalex-snapshot
Activating transcription factor 4 regulates mitochondrial content, morphology, and function in differentiating skeletal muscle myotubes
inferred← citeshttps://doi.org/10.1152/ajpcell.00195.2021openalex-snapshot
Nicotinamide N-methyltransferase upregulation via the mTORC1-ATF4 pathway activation contributes to palmitate-induced lipotoxicity in hepatocytes
inferred← citeshttps://doi.org/10.1152/ajpgi.00027.2025openalex-snapshot
Saturated phosphatidic acids induce mTORC1-driven integrated stress response contributing to glucolipotoxicity in hepatocytes
inferred← citeshttps://doi.org/10.1152/ajplung.00189.2024openalex-snapshot
mTOR signaling regulates multiple metabolic pathways in human lung fibroblasts after TGF-β and in pulmonary fibrosis
inferred← citeshttps://doi.org/10.1152/physiolgenomics.00152.2026openalex-snapshot
Mathematical modeling of dietary timing- and protein quality-responsive liver circadian clock and its function on ribosome biogenesis
inferred← citeshttps://doi.org/10.1158/0008-5472.c.6513160.v1openalex-snapshot
Data from Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression
inferred← citeshttps://doi.org/10.1158/0008-5472.can-20-3956openalex-snapshot
Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression
inferred← citeshttps://doi.org/10.1158/0008-5472.can-23-2910openalex-snapshot
Asparagine Dependency Is a Targetable Metabolic Vulnerability in TP53 -Altered Castration-Resistant Prostate Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-1846openalex-snapshot
AKT and the Hallmarks of Cancer
inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-2471openalex-snapshot
PHGDH Induction by MAPK Is Essential for Melanoma Formation and Creates an Actionable Metabolic Vulnerability
inferred← citeshttps://doi.org/10.1158/0008-5472.can-24-3785openalex-snapshot
Genome-Wide CRISPR Screening Reveals That mTOR Inhibition Initiates Ferritinophagy and Ferroptosis in Head and Neck Cancer
inferred← citeshttps://doi.org/10.1158/2643-3230.bcd-22-0098openalex-snapshot
A Therapeutically Targetable NOTCH1–SIRT1–KAT7 Axis in T-cell Leukemia
inferred← citeshttps://doi.org/10.1161/circresaha.122.321050openalex-snapshot
ATF4 Protects the Heart From Failure by Antagonizing Oxidative Stress
inferred← citeshttps://doi.org/10.1172/jci.insight.170387openalex-snapshot
Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism
inferred← citeshttps://doi.org/10.1172/jci.insight.174220openalex-snapshot
CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon
inferred← citeshttps://doi.org/10.1172/jci.insight.175462openalex-snapshot
Lack of SPNS1 results in accumulation of lysolipids and lysosomal storage disease in mouse models
inferred← citeshttps://doi.org/10.1172/jci.insight.177857openalex-snapshot
4EBP1-mediated SLC7A11 protein synthesis restrains ferroptosis triggered by MEK inhibitors in advanced ovarian cancer
inferred← citeshttps://doi.org/10.1172/jci153943openalex-snapshot
SCF-SKP2 E3 ubiquitin ligase links mTORC1/ER stress/ISR with YAP activation in murine renal cystogenesis
inferred← citeshttps://doi.org/10.1182/blood.2023022147openalex-snapshot
Neutral sphingomyelinase blockade enhances hematopoietic stem cell fitness through an integrated stress response
inferred← citeshttps://doi.org/10.1182/blood.2024025396openalex-snapshot
Dual biological role and clinical impact of de novo chromatin activation in chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1186/s12864-021-08226-5openalex-snapshot
Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration
inferred← citeshttps://doi.org/10.1186/s12885-026-16066-3openalex-snapshot
Systematic transcriptomic analysis of UDP-glucuronosyltransferases reveals UGT2B11 as a diagnostic and metabolic marker in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1186/s12935-026-04171-zopenalex-snapshot
MiR-181a-5p/CDK6 axis attenuates cell proliferation, migration and glycolytic reprogramming in oral squamous cell carcinoma
inferred← citeshttps://doi.org/10.1186/s12964-024-01699-3openalex-snapshot
Targeting mTOR signaling pathways in multiple myeloma: biology and implication for therapy
inferred← citeshttps://doi.org/10.1186/s12967-025-06664-3openalex-snapshot
Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets
inferred← citeshttps://doi.org/10.1186/s12974-026-03869-1openalex-snapshot
Butyrate-producing gut bacteria restrain PBAT microplastic-triggered brain microglial lipotoxicity via a microbiota–butyrate–mTORC1–ISR relay along the gut–brain axis
inferred← citeshttps://doi.org/10.1186/s13045-024-01615-9openalex-snapshot
Unraveling the roles and mechanisms of mitochondrial translation in normal and malignant hematopoiesis
inferred← citeshttps://doi.org/10.1186/s13046-024-03039-2openalex-snapshot
Augmented ERO1α upon mTORC1 activation induces ferroptosis resistance and tumor progression via upregulation of SLC7A11
inferred← citeshttps://doi.org/10.1242/dev.203124openalex-snapshot
Development of a hepatic cryoinjury model to study liver regeneration
inferred← citeshttps://doi.org/10.1242/dmm.052690openalex-snapshot
Multiple mechanisms lead to loss-of-function effects of pathogenic SARS2 variants
inferred← citeshttps://doi.org/10.1371/journal.pone.0303742openalex-snapshot
Activation of the integrated stress response in human hair follicles
inferred← citeshttps://doi.org/10.15252/embj.2021109365openalex-snapshot
Airway secretory cell fate conversion via YAP‐mTORC1‐dependent essential amino acid metabolism
inferred← citeshttps://doi.org/10.15252/embj.2022112415openalex-snapshot
Making liver cancer cells go ARGh!
inferred← citeshttps://doi.org/10.1530/joe-22-0280openalex-snapshot
Serotonin alters the response to a glucose challenge in lactating cows
inferred← citeshttps://doi.org/10.1681/asn.0000001053openalex-snapshot
The Impact of Low-Protein Diet on the Molecular and Cellular Development of the Fetal Kidney
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2493335/v1openalex-snapshot
Regulation of Ferroptosis by Transcription Factor E2F1 and RB
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5002395/v1openalex-snapshot
The amino acid transporter SLC7A5 drives progression of PI3K-mutant intestinal cancer models and enhances response to MAPK-targeted therapy
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6857127/v1openalex-snapshot
mTOR inhibition enhances the antitumor efficacy of RAF dimer-MEK blockade by inhibiting the ATF4-MTHFD2 pathway
inferred← citeshttps://doi.org/10.21203/rs.3.rs-7829324/v1openalex-snapshot
ATF4 and ATF6 produce diverse transcriptional signatures affecting metabolic genes and cell death under glucose deprivation
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9269383/v1openalex-snapshot
ATF4 and ATF6 Orchestrate Transcriptional Responses to Glucose Deprivation in NSCLC
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9287896/v1openalex-snapshot
Integrated bulk and single-cell transcriptomic analysis reveals a tryptophan metabolism-driven prognostic signature and therapeutic landscape in triple- negative breast cancer
inferred← citeshttps://doi.org/10.21248/gups.71574openalex-snapshot
Elucidating the molecular pathology of DEPDC5 mutation induced mTOR-hyperactivation associated with epilepsy and autism spectrum disorder
inferred← citeshttps://doi.org/10.21248/gups.79347openalex-snapshot
Einfluss einer mTOR-Überaktivierung auf die neuronale Zellmorphologie in-vitro
inferred← citeshttps://doi.org/10.2174/0113894501328461240921062056openalex-snapshot
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4
inferred← citeshttps://doi.org/10.2174/0115734056296733250514081236openalex-snapshot
Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats
inferred← citeshttps://doi.org/10.22074/cellj.2023.2004011.1319openalex-snapshot
Bioinformatic Analysis of The Prognostic Value of A Panel of Six Amino Acid Transporters in Human Cancers.
inferred← citeshttps://doi.org/10.23889/suthesis.69835openalex-snapshot
Targeting Ferroptosis in Tuberous Sclerosis Cell Line Models
inferred← citeshttps://doi.org/10.26508/lsa.202503324openalex-snapshot
Differential cell survival outcomes in response to diverse amino acid stress
inferred← citeshttps://doi.org/10.3389/fcell.2021.655731openalex-snapshot
The mTOR–Autophagy Axis and the Control of Metabolism
inferred← citeshttps://doi.org/10.3389/fcell.2022.930250openalex-snapshot
Connecting Metabolic Rewiring With Phenotype Switching in Melanoma
inferred← citeshttps://doi.org/10.3389/fcell.2023.1271141openalex-snapshot
Signaling plasticity in the integrated stress response
inferred← citeshttps://doi.org/10.3389/fcell.2024.1370012openalex-snapshot
Activating transcription factor 4: a regulator of stress response in human cancers
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