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Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
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STAR: ultrafast universal RNA-seq aligner
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A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
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Cell Reprogramming Requires Silencing of a Core Subset of Polycomb Targets
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Genetic Background Drives Transcriptional Variation in Human Induced Pluripotent Stem Cells
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Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature
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Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs
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Matrix eQTL: Ultra fast eQTL analysis via large matrix operations
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Reshaping Data with the reshape Package
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R: A Language and Environment for Statistical Computing
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Temporal changes in Hox gene expression accompany endothelial cell differentiation of embryonic stem cells
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1038/nature22403openalex-snapshot
Common genetic variation drives molecular heterogeneity in human iPSCs
inferred← citeshttps://doi.org/10.1038/nature25032openalex-snapshot
The rise of three-dimensional human brain cultures
inferred← citeshttps://doi.org/10.1038/s41380-018-0029-1openalex-snapshot
New considerations for hiPSC-based models of neuropsychiatric disorders
inferred← citeshttps://doi.org/10.1038/s41380-022-01514-wopenalex-snapshot
Dopamine-induced pruning in monocyte-derived-neuronal-like cells (MDNCs) from patients with schizophrenia
inferred← citeshttps://doi.org/10.1038/s41380-022-01866-3openalex-snapshot
Power and optimal study design in iPSC-based brain disease modelling
inferred← citeshttps://doi.org/10.1038/s41398-023-02397-3openalex-snapshot
Methadone alters transcriptional programs associated with synapse formation in human cortical organoids
inferred← citeshttps://doi.org/10.1038/s41398-024-02780-8openalex-snapshot
Comparing stem cells, transdifferentiation and brain organoids as tools for psychiatric research
inferred← citeshttps://doi.org/10.1038/s41419-017-0141-1openalex-snapshot
iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors
inferred← citeshttps://doi.org/10.1038/s41419-019-1498-0openalex-snapshot
Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals differentiation-dependent metabolic responses to IFNG stimulation
inferred← citeshttps://doi.org/10.1038/s41431-026-02071-4openalex-snapshot
Bridging population and cell: modelling complex diseases with human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41467-017-02330-5openalex-snapshot
Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains
inferred← citeshttps://doi.org/10.1038/s41467-020-14457-zopenalex-snapshot
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
inferred← citeshttps://doi.org/10.1038/s41467-020-16482-4openalex-snapshot
Properties of structural variants and short tandem repeats associated with gene expression and complex traits
inferred← citeshttps://doi.org/10.1038/s41467-020-20750-8openalex-snapshot
An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
inferred← citeshttps://doi.org/10.1038/s41467-021-25482-xopenalex-snapshot
Cell reprogramming shapes the mitochondrial DNA landscape
inferred← citeshttps://doi.org/10.1038/s41467-022-35388-xopenalex-snapshot
Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation
inferred← citeshttps://doi.org/10.1038/s41467-025-56569-4openalex-snapshot
iPSCs and iPSC-derived cells as a model of human genetic and epigenetic variation
inferred← citeshttps://doi.org/10.1038/s41531-021-00198-3openalex-snapshot
Parkinson’s disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration
inferred← citeshttps://doi.org/10.1038/s41537-018-0066-4openalex-snapshot
Studying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems
inferred← citeshttps://doi.org/10.1038/s41576-022-00568-4openalex-snapshot
Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution
inferred← citeshttps://doi.org/10.1038/s41578-019-0129-9openalex-snapshot
Engineered materials for organoid systems
inferred← citeshttps://doi.org/10.1038/s41587-026-03254-6openalex-snapshot
Reversible epiblast regionalization determines differentiation potential of human pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41588-017-0017-4openalex-snapshot
Mapping regulatory variants in hiPSC models
inferred← citeshttps://doi.org/10.1038/s41588-019-0499-3openalex-snapshot
Allele-specific NKX2-5 binding underlies multiple genetic associations with human electrocardiographic traits
inferred← citeshttps://doi.org/10.1038/s41588-021-00800-7openalex-snapshot
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics
inferred← citeshttps://doi.org/10.1038/s41589-026-02339-2openalex-snapshot
PUS7 pseudouridylation of 7SK orchestrates human somatic cell reprogramming into iPS cells
inferred← citeshttps://doi.org/10.1038/s41591-026-04584-3openalex-snapshot
Induced pluripotent stem cells from discovery to translation
inferred← citeshttps://doi.org/10.1038/s41593-023-01399-0openalex-snapshot
Modeling idiopathic autism in forebrain organoids reveals an imbalance of excitatory cortical neuron subtypes during early neurogenesis
inferred← citeshttps://doi.org/10.1038/s41596-023-00880-1openalex-snapshot
Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41598-018-35506-0openalex-snapshot
Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium
inferred← citeshttps://doi.org/10.1038/s41598-020-59941-0openalex-snapshot
Transplantation of iPSC-TM stimulates division of trabecular meshwork cells in human eyes
inferred← citeshttps://doi.org/10.1038/s41598-020-77274-wopenalex-snapshot
Quantitative proteomics reveal lineage-specific protein profiles in iPSC-derived Marfan syndrome smooth muscle cells
inferred← citeshttps://doi.org/10.1038/s41598-021-85230-5openalex-snapshot
Modeling preeclampsia using human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1038/s41598-026-48097-yopenalex-snapshot
Base editing restores CDKL5 expression and rescues neuronal deficits in a patient-derived model of CDKL5 deficiency disorder
inferred← citeshttps://doi.org/10.1038/s42003-021-01722-0openalex-snapshot
Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases
inferred← citeshttps://doi.org/10.1038/s42003-023-04791-5openalex-snapshot
Predictive network analysis identifies JMJD6 and other potential key drivers in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1039/c7bm00323dopenalex-snapshot
Anisotropic microfibrous scaffolds enhance the organization and function of cardiomyocytes derived from induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1080/17460751.2025.2526253openalex-snapshot
Developing stem cells for corneal disease: recent developments and future perspectives
inferred← citeshttps://doi.org/10.1080/17460751.2026.2634720openalex-snapshot
Quality control strategy for differentiating induced pluripotent stem cells into pancreatic β-cells before transplantation
inferred← citeshttps://doi.org/10.1080/28361512.2025.2599802openalex-snapshot
KMT2D-deficiency destabilizes lineage progression in immature neural progenitors
inferred← citeshttps://doi.org/10.1089/cell.2024.0073openalex-snapshot
Reprogramming of Expanded Cord Blood-Derived CD34 + Cells from Umbilical Cord-Mesenchymal Stromal Cell Co-Culture to Generate Human-Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1089/scd.2020.0084openalex-snapshot
Efficient Reprogramming of Canine Peripheral Blood Mononuclear Cells into Induced Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaa687openalex-snapshot
Dream: powerful differential expression analysis for repeated measures designs
inferred← citeshttps://doi.org/10.1093/cvr/cvz018openalex-snapshot
hiPSCs in cardio-oncology: deciphering the genomics
inferred← citeshttps://doi.org/10.1093/cvr/cvz024openalex-snapshot
Personalized medicine in cardio-oncology: the role of induced pluripotent stem cell
inferred← citeshttps://doi.org/10.1093/hmg/ddae035openalex-snapshot
Reduced synaptic depression in human neurons carrying homozygous disease-causing STXBP1 variant L446F
inferred← citeshttps://doi.org/10.1093/jbmr/zjae178openalex-snapshot
Modeling of skeletal development and diseases using human pluripotent stem cells
inferred← citeshttps://doi.org/10.1093/molecular-omics/aaiag006openalex-snapshot
Zooming into rearranged genome: applying pipeline of cytological, genomic, and transcriptomic methods for structural variant interpretation
inferred← citeshttps://doi.org/10.1093/molehr/gay007openalex-snapshot
The role of the reprogramming method and pluripotency state in gamete differentiation from patient-specific human pluripotent stem cells
inferred← citeshttps://doi.org/10.1093/oncolo/oyaf327openalex-snapshot
Pathomic immune biomarkers define recurrence risk in early-stage melanoma
inferred← citeshttps://doi.org/10.1093/stcltm/szad028openalex-snapshot
Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement
inferred← citeshttps://doi.org/10.1093/stmcls/sxag027openalex-snapshot
Application of human induced pluripotent stem cells for tissue modeling and therapy: are we on track?
inferred← citeshttps://doi.org/10.1093/synbio/ysaa024openalex-snapshot
Engineering precision therapies: lessons and motivations from the clinic
inferred← citeshttps://doi.org/10.1101/2020.06.09.143529openalex-snapshot
Single Cell-type Integrative Network Modeling Identified Novel Microglial-specific Targets for the Phagosome in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1101/2021.03.17.435870openalex-snapshot
Expression bias in retinoic acid responsive genes defines variations in neural differentiation of human pluripotent stem cells
inferred← citeshttps://doi.org/10.1101/2022.03.19.484988openalex-snapshot
ASD modelling in organoids reveals imbalance of excitatory cortical neuron subtypes during early neurogenesis
inferred← citeshttps://doi.org/10.1101/2022.05.26.493589openalex-snapshot
Ventral forebrain organoids derived from individuals with schizophrenia recapitulate perturbed striatal gene expression dynamics of the donor’s brains
inferred← citeshttps://doi.org/10.1101/2022.06.27.497613openalex-snapshot
Single nuclei RNAseq analysis of HD mouse models and human brain reveals impaired oligodendrocyte maturation and potential role for thiamine metabolism
inferred← citeshttps://doi.org/10.1101/2022.07.18.500490openalex-snapshot
RMeDPower2 for Biology: guiding the design, experimental structure and analyses of experiments generating repeated measures datasets
inferred← citeshttps://doi.org/10.1101/2022.10.19.512949openalex-snapshot
Predictive Network Analysis Identifies JMJD6 and Other Novel Key Drivers in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1101/2022.10.19.512953openalex-snapshot
Novel Master Regulators of Microglial Phagocytosis and Repurposed FDA-approved Drug for Treatment of Alzheimer Disease
inferred← citeshttps://doi.org/10.1101/2024.02.11.579844openalex-snapshot
Integrated transcriptomic analysis of human induced pluripotent stem cell-derived osteogenic differentiation reveals a regulatory role of KLF16
inferred← citeshttps://doi.org/10.1101/2024.04.18.584138openalex-snapshot
Transcriptional Variabilities in Human hiPSC-derived Cardiomyocytes: All Genes Are Not Equal and Their Robustness May Foretell Donor’s Disease Susceptibility
inferred← citeshttps://doi.org/10.1101/2024.12.27.630149openalex-snapshot
Epigenetic restoration of differentiation competency via reversal of epiblast regionalisation
inferred← citeshttps://doi.org/10.1101/2025.07.25.666753openalex-snapshot
Signatures of digital Polycomb regulation in functional iPSC heterogeneity between individuals
inferred← citeshttps://doi.org/10.1101/285627openalex-snapshot
Identifying the genetic basis of variation in cell behaviour in human iPS cell lines from healthy donors
inferred← citeshttps://doi.org/10.1101/439216openalex-snapshot
Population-scale proteome variation in human induced pluripotent stem cells
inferred← citeshttps://doi.org/10.1101/552059openalex-snapshot
Genetic variation influences pluripotent ground state stability in mouse embryonic stem cells through a hierarchy of molecular phenotypes
inferred← citeshttps://doi.org/10.1101/577544openalex-snapshot
Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates
inferred← citeshttps://doi.org/10.1101/630996openalex-snapshot
Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression
inferred← citeshttps://doi.org/10.1101/714477openalex-snapshot
Genomic properties of structural variants and short tandem repeats that impact gene expression and complex traits in humans
inferred← citeshttps://doi.org/10.1101/802629openalex-snapshot
Eliminating accidental deviations to minimize generalization error and maximize replicability: applications in connectomics and genomics
inferred← citeshttps://doi.org/10.1111/cts.12674openalex-snapshot
Clinical Trial in a Dish: Personalized Stem Cell–Derived Cardiomyocyte Assay Compared With Clinical Trial Results for Two QT ‐Prolonging Drugs
inferred← citeshttps://doi.org/10.1111/exd.14358openalex-snapshot
Human pluripotent stem cells: An alternative for 3D in vitro modelling of skin disease
inferred← citeshttps://doi.org/10.1111/febs.15258openalex-snapshot
Angelman syndrome: a journey through the brain
inferred← citeshttps://doi.org/10.1111/febs.15885openalex-snapshot
Harnessing pluripotent stem cells as models to decipher human evolution
inferred← citeshttps://doi.org/10.1111/jnc.15289openalex-snapshot
Neuromuscular junction‐on‐a‐chip: ALS disease modeling and read‐out development in microfluidic devices
inferred← citeshttps://doi.org/10.1124/pharmrev.120.000238openalex-snapshot
Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development—Current State-of-the-Art and Future Perspectives
inferred← citeshttps://doi.org/10.1124/pharmrev.124.001297openalex-snapshot
Promising tools for future drug discovery and development in antiarrhythmic therapy
inferred← citeshttps://doi.org/10.1126/sciadv.abm5559openalex-snapshot
Specific mesoderm subset derived from human pluripotent stem cells ameliorates microvascular pathology in type 2 diabetic mice
inferred← citeshttps://doi.org/10.1126/scitranslmed.add4666openalex-snapshot
Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons
inferred← citeshttps://doi.org/10.1146/annurev-genom-111522-014009openalex-snapshot
Brain Organoids: Tools for Understanding the Uniqueness and Individual Variability of the Human Brain
inferred← citeshttps://doi.org/10.1146/annurev-pathmechdis-012418-013046openalex-snapshot
Systems-Wide Approaches in Induced Pluripotent Stem Cell Models
inferred← citeshttps://doi.org/10.1146/annurev-pathol-020117-043634openalex-snapshot
Modeling Disease with Human Inducible Pluripotent Stem Cells
inferred← citeshttps://doi.org/10.1159/000512716openalex-snapshot
Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia
inferred← citeshttps://doi.org/10.1161/atvbaha.117.309195openalex-snapshot
Human Induced Pluripotent Stem Cell–Derived Macrophages for Unraveling Human Macrophage Biology
inferred← citeshttps://doi.org/10.1161/atvbaha.117.309291openalex-snapshot
Induced Pluripotent Stem Cell–Derived Endothelial Cells in Insulin Resistance and Metabolic Syndrome
inferred← citeshttps://doi.org/10.1161/circgen.117.001946openalex-snapshot
From Genotype to Phenotype
inferred← citeshttps://doi.org/10.1161/circgen.120.003249openalex-snapshot
Evaluating the Contribution of Cell Type–Specific Alternative Splicing to Variation in Lipid Levels
inferred← citeshttps://doi.org/10.1161/circresaha.116.310456openalex-snapshot
Genome-Wide Temporal Profiling of Transcriptome and Open Chromatin of Early Cardiomyocyte Differentiation Derived From hiPSCs and hESCs
inferred← citeshttps://doi.org/10.1161/circresaha.117.311080openalex-snapshot
Induced Pluripotent Stem Cells 10 Years Later
inferred← citeshttps://doi.org/10.1161/circresaha.122.320305openalex-snapshot
Cellular and Engineered Organoids for Cardiovascular Models
inferred← citeshttps://doi.org/10.1161/hcg.0000000000000046openalex-snapshot
Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association
inferred← citeshttps://doi.org/10.1161/jaha.119.012941openalex-snapshot
Spatiotemporal Gene Coexpression and Regulation in Mouse Cardiomyocytes of Early Cardiac Morphogenesis
inferred← citeshttps://doi.org/10.1172/jci151818openalex-snapshot
Signaling defects associated with insulin resistance in nondiabetic and diabetic individuals and modification by sex
inferred← citeshttps://doi.org/10.1172/jci172333openalex-snapshot
Interactions among insulin resistance, epigenetics, and donor sex in gene expression regulation of iPSC-derived myoblasts
inferred← citeshttps://doi.org/10.1176/appi.ajp.20220723openalex-snapshot
Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors’ Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia
inferred← citeshttps://doi.org/10.1186/s13024-022-00531-1openalex-snapshot
Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro
inferred← citeshttps://doi.org/10.1186/s13059-017-1276-1openalex-snapshot
Understanding the genetics behind complex human disease with large-scale iPSC collections
inferred← citeshttps://doi.org/10.1186/s13059-020-02136-7openalex-snapshot
pipeComp, a general framework for the evaluation of computational pipelines, reveals performant single cell RNA-seq preprocessing tools
inferred← citeshttps://doi.org/10.1186/s13073-022-01026-wopenalex-snapshot
A guide for the diagnosis of rare and undiagnosed disease: beyond the exome
inferred← citeshttps://doi.org/10.1186/s13229-020-00322-9openalex-snapshot
Using human pluripotent stem cell models to study autism in the era of big data
inferred← citeshttps://doi.org/10.1186/s13229-021-00417-xopenalex-snapshot
Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets
inferred← citeshttps://doi.org/10.1186/s13287-018-0796-2openalex-snapshot
Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming
inferred← citeshttps://doi.org/10.1186/s13287-019-1319-5openalex-snapshot
The role of insulin as a key regulator of seeding, proliferation, and mRNA transcription of human pluripotent stem cells
inferred← citeshttps://doi.org/10.1186/s13287-020-01925-yopenalex-snapshot
Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors
inferred← citeshttps://doi.org/10.1186/s13287-023-03546-7openalex-snapshot
Induced pluripotent stem cells derived from patients carrying mitochondrial mutations exhibit altered bioenergetics and aberrant differentiation potential
inferred← citeshttps://doi.org/10.1186/s13287-025-04861-xopenalex-snapshot
Human pluripotent stem cell models of Friedreich’s ataxia: innovations, considerations, and future perspectives
inferred← citeshttps://doi.org/10.1186/s13619-022-00125-8openalex-snapshot
Stepwise differentiation of functional pancreatic β cells from human pluripotent stem cells
inferred← citeshttps://doi.org/10.1242/dev.157404openalex-snapshot
Mechanisms of gene regulation in human embryos and pluripotent stem cells
inferred← citeshttps://doi.org/10.1242/dmm.042317openalex-snapshot
Addressing variability in iPSC-derived models of human disease: guidelines to promote reproducibility
inferred← citeshttps://doi.org/10.1242/dmm.052478openalex-snapshot
Generating cerebellar organoids from pluripotent stem cells
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