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Pyrrolopyridine Inhibitors of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK-2)
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Outgoing claims: the papers this work cites, builds on, or argues with.
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The Synthesis of 2‐Amino‐4‐(4‐imidazolyl)pyridines
inferredcites →https://doi.org/10.1016/0014-5793(92)81216-9openalex-snapshot
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
inferredcites →https://doi.org/10.1016/j.bmcl.2005.01.067openalex-snapshot
Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferredcites →https://doi.org/10.1016/j.chembiol.2005.04.011openalex-snapshot
Features of Selective Kinase Inhibitors
inferredcites →https://doi.org/10.1038/10061openalex-snapshot
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
inferredcites →https://doi.org/10.1038/372746a0openalex-snapshot
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
inferredcites →https://doi.org/10.1038/nrd1500openalex-snapshot
Biochemical mechanisms of drug action: what does it take for success?
inferredcites →https://doi.org/10.1038/nrm1834openalex-snapshot
MAPKAP kinases — MKs — two's company, three's a crowd
inferredcites →https://doi.org/10.1046/j.1365-2125.2001.00321.xopenalex-snapshot
Anti‐TNF agents for rheumatoid arthritis
inferredcites →https://doi.org/10.1093/emboj/18.18.4969openalex-snapshot
The p38 MAP kinase pathway signals for cytokine‐induced mRNA stabilization via MAP kinase‐activated protein kinase 2 and an AU‐rich region‐targeted mechanism
inferredcites →https://doi.org/10.2165/00003495-199855050-00001openalex-snapshot
The Future Role of Anti-Tumour Necrosis Factor (TNF) Products in the Treatment of Rheumatoid Arthritis
inferredcites →https://doi.org/10.2165/00063030-200115040-00005openalex-snapshot
Tumour Necrosis Factor-?? Blockers in Rheumatoid Arthritis
inferredcites →https://doi.org/10.2165/00063030-200317030-00005openalex-snapshot
Role of Novel Biological Therapies in Psoriatic Arthritis
inferredcites →https://doi.org/10.2174/1568026054985911openalex-snapshot
Potential Adverse Effects Associated with Inhibition of p38α/β MAP Kinases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Selective Inhibition of the MK2 Pathway: Data From a Phase IIa Randomized Clinical Trial in Rheumatoid Arthritis
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A General and Efficient Method for the Suzuki–Miyaura Coupling of 2‐Pyridyl Nucleophiles
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A General and Efficient Method for the Suzuki–Miyaura Coupling of 2‐Pyridyl Nucleophiles
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A General Direct Arylation of Polyfluoroarenes with Heteroaryl and Aryl Chlorides Catalyzed by Palladium Indolylphosphine Complexes
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Direct ortho‐Arylation of N‐Phenacylpyridinium Bromide by Palladium‐Catalyzed CH‐Bond Activation
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Towards an Integrated Description of Hydrogen Bonding and Dehydration: Decreasing False Positives in Virtual Screening with the HYDE Scoring Function
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Expedient Solution‐Phase Synthesis and NMR Studies of Arylopeptoids
inferred← citeshttps://doi.org/10.1002/mc.23348openalex-snapshot
Mitogen‐activated protein kinase‐activated protein kinase‐2 (MK2) and its role in cell survival, inflammatory signaling, and migration in promoting cancer
inferred← citeshttps://doi.org/10.1002/mco2.634openalex-snapshot
Remodeling tumor‐associated macrophage for anti‐cancer effects by rational design of irreversible inhibition of mitogen‐activated protein kinase‐activated protein kinase 2
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High‐resolution crystal structure of human Mapkap kinase 3 in complex with a high affinity ligand
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Substrate‐Directed C‐H Functionalization of 2‐Aryl Pyridines by Transition Metal Complexes
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Mechanisms of Action and Indications of Cyclin‐Dependent Kinase Inhibitors with Benzoheterocycle Scaffolds
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Small-Molecule Protein and Lipid Kinase Inhibitors in Inflammation and Specific Models for Their Evaluation
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Mitogen-Activated Protein Kinase-Activated Protein Kinases and Metastasis
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Heat shock protein 27 phosphorylation: kinases, phosphatases, functions and pathology
inferred← citeshttps://doi.org/10.1007/s00018-010-0452-1openalex-snapshot
The diterpenoid alkaloid noroxoaconitine is a Mapkap kinase 5 (MK5/PRAK) inhibitor
inferred← citeshttps://doi.org/10.1007/s00044-011-9910-zopenalex-snapshot
Computation of pharmacophore models for the prediction of mitogen-activated protein kinase activated protein kinase-2 inhibitory activity of pyrrolopyridines
inferred← citeshttps://doi.org/10.1007/s00044-013-0492-9openalex-snapshot
Applications of 3D-QSAR and structure-based pharmacophore modeling, virtual screening, ADMET, and molecular docking of putative MAPKAP-K2 (MK2) inhibitors
inferred← citeshttps://doi.org/10.1007/s00044-013-0820-0openalex-snapshot
Molecular docking and 3D-QSAR studies on the MAPKAP-K2 inhibitors
inferred← citeshttps://doi.org/10.1007/s10522-014-9530-3openalex-snapshot
Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBNp70 protein undergo p38/MK2-dependent premature senescence
inferred← citeshttps://doi.org/10.1007/s10522-015-9610-zopenalex-snapshot
Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
inferred← citeshttps://doi.org/10.1007/s13205-018-1405-xopenalex-snapshot
In silico insights into prediction and analysis of potential novel pyrrolopyridine analogs against human MAPKAPK-2: a new SAR-based hierarchical clustering approach
inferred← citeshttps://doi.org/10.1016/b978-0-12-417205-0.00031-6openalex-snapshot
Improving the Water-Solubility of Compounds by Molecular Modification to Disrupt Crystal Packing
inferred← citeshttps://doi.org/10.1016/b978-0-12-801944-3.00002-3openalex-snapshot
Targeting the Protein Quality Control (PQC) Machinery
inferred← citeshttps://doi.org/10.1016/b978-008044992-0.00906-8openalex-snapshot
Bicyclic 5-6 Systems: Two Heteroatoms 1:1
inferred← citeshttps://doi.org/10.1016/j.abb.2023.109537openalex-snapshot
Untangling the complexity of heat shock protein 27 in cancer and metastasis
inferred← citeshttps://doi.org/10.1016/j.bcp.2010.06.021openalex-snapshot
MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.03.041openalex-snapshot
Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.12.036openalex-snapshot
β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.05.070openalex-snapshot
Novel tetrahydro-β-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2007.12.037openalex-snapshot
Pyrazinoindolone inhibitors of MAPKAP-K2
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.01.119openalex-snapshot
Synthesis and SAR studies of indole-based MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.06.104openalex-snapshot
Achieving multi-isoform PI3K inhibition in a series of substituted 3,4-dihydro-2H-benzo[1,4]oxazines
inferred← citeshttps://doi.org/10.1016/j.bmcl.2008.10.039openalex-snapshot
Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.02.015openalex-snapshot
Benzothiophene inhibitors of MK2. Part 1: Structure–activity relationships, assessments of selectivity and cellular potency
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.02.017openalex-snapshot
Benzothiophene inhibitors of MK2. Part 2: Improvements in kinase selectivity and cell potency
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.04.088openalex-snapshot
Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas as potent inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.10.102openalex-snapshot
2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.10.103openalex-snapshot
2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization
inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.10.138openalex-snapshot
Novel 3-aminopyrazole inhibitors of MK-2 discovered by scaffold hopping strategy
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.04.023openalex-snapshot
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II
inferred← citeshttps://doi.org/10.1016/j.bmcl.2010.04.024openalex-snapshot
In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part I
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.04.016openalex-snapshot
Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.04.018openalex-snapshot
Structure-based lead identification of ATP-competitive MK2 inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.10.071openalex-snapshot
Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series
inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.11.113openalex-snapshot
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.05.054openalex-snapshot
Discovery of novel indolinone-based, potent, selective and brain penetrant inhibitors of LRRK2
inferred← citeshttps://doi.org/10.1016/j.bmcl.2015.09.016openalex-snapshot
Design, synthesis, and biological evaluation of aminopyrazine derivatives as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2)
inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128588openalex-snapshot
Development of dihydropyrrolopyridinone-based PKN2/PRK2 chemical tools to enable drug discovery
inferred← citeshttps://doi.org/10.1016/j.canlet.2018.04.030openalex-snapshot
Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin
inferred← citeshttps://doi.org/10.1016/j.ceb.2009.01.015openalex-snapshot
Targeting protein kinases for the development of anti-inflammatory drugs
inferred← citeshttps://doi.org/10.1016/j.cellsig.2016.09.002openalex-snapshot
Treatment with MAPKAP2 (MK2) inhibitor and DNA methylation inhibitor, 5-aza dC, synergistically triggers apoptosis in hepatocellular carcinoma (HCC) via tristetraprolin (TTP)
inferred← citeshttps://doi.org/10.1016/j.celrep.2020.108664openalex-snapshot
Non-ionotropic NMDA receptor signaling gates bidirectional structural plasticity of dendritic spines
inferred← citeshttps://doi.org/10.1016/j.chembiol.2017.05.010openalex-snapshot
Proteasome Activation by Small Molecules
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Direct access to chiral nitrogen-rich (semi-)saturated heterocycles
inferred← citeshttps://doi.org/10.1016/j.ddtec.2010.04.002openalex-snapshot
Cell-based assays for kinase drug discovery
inferred← citeshttps://doi.org/10.1016/j.ejmech.2009.09.030openalex-snapshot
Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2015.07.011openalex-snapshot
Mitogen-activated protein kinase-activated protein kinase 2 mediates resistance to hydrogen peroxide-induced oxidative stress in human hepatobiliary cancer cells
inferred← citeshttps://doi.org/10.1016/j.jmb.2010.03.064openalex-snapshot
The Crystal Structure of the Active Form of the C-Terminal Kinase Domain of Mitogen- and Stress-Activated Protein Kinase 1
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2016.12.004openalex-snapshot
Innate immune regulation of autoimmunity in multiple sclerosis: Focus on the role of Toll-like receptor 2
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Inflammatory cytokines in depression: Neurobiological mechanisms and therapeutic implications
inferred← citeshttps://doi.org/10.1016/j.pharep.2017.03.023openalex-snapshot
Biological functions and role of mitogen-activated protein kinase activated protein kinase 2 (MK2) in inflammatory diseases
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The synthesis of novel pyrrololactams and their boronate ester derivatives
inferred← citeshttps://doi.org/10.1016/j.urology.2011.09.049openalex-snapshot
Increased Cell Apoptosis of Urothelium Mediated by Inflammation in Interstitial Cystitis/Painful Bladder Syndrome
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c09504openalex-snapshot
Combinatorial Targeting of Common Docking and ATP Binding Sites on Mps1 MAPK for Management of Pathogenic Fungi
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00098openalex-snapshot
Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors To Explore a MEK Resistance Hypothesis
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b01457openalex-snapshot
Targeting Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAPK2, MK2): Medicinal Chemistry Efforts To Lead Small Molecule Inhibitors to Clinical Trials
inferred← citeshttps://doi.org/10.1021/acs.orglett.6b03786openalex-snapshot
Substituted Pyrrololactams via Ring Expansion of Spiro-2H-pyrroles from Intermolecular Alkyne–Isocyanide Click Reactions
inferred← citeshttps://doi.org/10.1021/acsami.6c04172openalex-snapshot
Cross-Linked Reticular Magnetic Beads Immobilizing Streptavidin for Fishing the Protein of Interest with High Sensitivity
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.5b00403openalex-snapshot
Discovery and Optimization of Macrocyclic Quinoxaline-pyrrolo-dihydropiperidinones as Potent Pim-1/2 Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acsomega.7b00626openalex-snapshot
Ammonium Acetate-Promoted One-Pot Tandem Aldol Condensation/Aza-Addition Reactions: Synthesis of 2,3,6,7-Tetrahydro-1 H -pyrrolo[3,2- c ]pyridin-4(5 H )-ones
inferred← citeshttps://doi.org/10.1021/cb300610sopenalex-snapshot
Kinase Drug Discovery – What’s Next in the Field?
inferred← citeshttps://doi.org/10.1021/cb5002125openalex-snapshot
ATP-Mediated Kinome Selectivity: The Missing Link in Understanding the Contribution of Individual JAK Kinase Isoforms to Cellular Signaling
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Comprehensive Survey of Chemical Libraries for Drug Discovery and Chemical Biology: 2007
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Rank Order Entropy: Why One Metric Is Not Enough
inferred← citeshttps://doi.org/10.1021/jacs.0c02637openalex-snapshot
NHC-Copper Mediated Ligand-Directed Radiofluorination of Aryl Halides
inferred← citeshttps://doi.org/10.1021/jm1005513openalex-snapshot
Discovery of Mitogen-Activated Protein Kinase-Interacting Kinase 1 Inhibitors by a Comprehensive Fragment-Oriented Virtual Screening Approach
inferred← citeshttps://doi.org/10.1021/jm101356popenalex-snapshot
Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry
inferred← citeshttps://doi.org/10.1021/jm201217qopenalex-snapshot
Binding Affinity Prediction for Ligands and Receptors Forming Tautomers and Ionization Species: Inhibition of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MK2)
inferred← citeshttps://doi.org/10.1021/jm300411kopenalex-snapshot
Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach
inferred← citeshttps://doi.org/10.1021/jm300452popenalex-snapshot
Discovery of Selective LRRK2 Inhibitors Guided by Computational Analysis and Molecular Modeling
inferred← citeshttps://doi.org/10.1021/jm301020qopenalex-snapshot
Discovery of Highly Potent, Selective, and Brain-Penetrable Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors
inferred← citeshttps://doi.org/10.1021/jm501038sopenalex-snapshot
Discovery and Characterization of MAPK-activated Protein Kinase-2 Prevention of Activation Inhibitors
inferred← citeshttps://doi.org/10.1021/jm700956ropenalex-snapshot
Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potential Antitumor Agents. 1. Synthesis and Structure–Activity Relationships
inferred← citeshttps://doi.org/10.1021/jm800977qopenalex-snapshot
First Cdc7 Kinase Inhibitors: Pyrrolopyridinones as Potent and Orally Active Antitumor Agents. 2. Lead Discovery
inferred← citeshttps://doi.org/10.1021/jo200480hopenalex-snapshot
Synthesis of Polysubstituted 5-Azaindoles via Palladium-Catalyzed Heteroannulation of Diarylalkynes
inferred← citeshttps://doi.org/10.1021/jo400152fopenalex-snapshot
TMEDA-Assisted Effective Direct Ortho Arylation of Electron-DeficientN-Heteroarenes with Aromatic Grignard Reagents
inferred← citeshttps://doi.org/10.1021/ml200113yopenalex-snapshot
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors
inferred← citeshttps://doi.org/10.1021/ml200238gopenalex-snapshot
Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors
inferred← citeshttps://doi.org/10.1038/cddis.2015.384openalex-snapshot
Deciphering the true antiproliferative target of an MK2 activation inhibitor in glioblastoma
inferred← citeshttps://doi.org/10.1038/cddiscovery.2015.28openalex-snapshot
Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2
inferred← citeshttps://doi.org/10.1038/jid.2009.218openalex-snapshot
The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation
inferred← citeshttps://doi.org/10.1038/jid.2009.372openalex-snapshot
MK2 Signaling: Lessons on Tissue Specificity in Modulation of Inflammation
inferred← citeshttps://doi.org/10.1038/jid.2009.396openalex-snapshot
Genetic Influences on Human Body Odor: From Genes to the Axillae
inferred← citeshttps://doi.org/10.1038/nchembio.90openalex-snapshot
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
inferred← citeshttps://doi.org/10.1038/nrd.2016.266openalex-snapshot
Non-kinase targets of protein kinase inhibitors
inferred← citeshttps://doi.org/10.1038/nrd2829openalex-snapshot
Targeting innate immunity protein kinase signalling in inflammation
inferred← citeshttps://doi.org/10.1038/s41586-018-0056-8openalex-snapshot
Nanoscale synthesis and affinity ranking
inferred← citeshttps://doi.org/10.1038/srep18710openalex-snapshot
Osmotic stress induces the phosphorylation of WNK4 Ser575 via the p38MAPK-MK pathway
inferred← citeshttps://doi.org/10.1039/9781849735346-00158openalex-snapshot
MAPKAP Kinase 2 (MK2) as a Target for Anti-inflammatory Drug Discovery
inferred← citeshttps://doi.org/10.1039/d0ob00287aopenalex-snapshot
Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis
inferred← citeshttps://doi.org/10.1055/s-0040-1719873openalex-snapshot
Synthesis of Novel Pyrazine-Substituted 1H-Pyrrole-2-carboxamides and Related Tethered Heterocycles
inferred← citeshttps://doi.org/10.1073/pnas.1304355110openalex-snapshot
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
inferred← citeshttps://doi.org/10.1073/pnas.1805683115openalex-snapshot
Mesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis
inferred← citeshttps://doi.org/10.1074/jbc.m110.108001openalex-snapshot
A Novel Aminosaccharide Compound Blocks Immune Responses by Toll-like Receptors and Nucleotide-binding Domain, Leucine-rich Repeat Proteins
inferred← citeshttps://doi.org/10.1074/jbc.m110.147025openalex-snapshot
Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 at Ser34 Enhances Platelet-activating Factor Production in Endotoxin-stimulated Macrophages
inferred← citeshttps://doi.org/10.1074/jbc.m111.277434openalex-snapshot
Reactive Oxygen Species and p38 Mitogen-activated Protein Kinase Mediate Tumor Necrosis Factor α-Converting Enzyme (TACE/ADAM-17) Activation in Primary Human Monocytes
inferred← citeshttps://doi.org/10.1074/jbc.m111.306209openalex-snapshot
Cell Division Cycle 7 Is a Novel Regulator of Transforming Growth Factor-β-induced Smooth Muscle Cell Differentiation
inferred← citeshttps://doi.org/10.1080/07391102.2020.1824811openalex-snapshot
Dihydroartemisinin as a potential drug candidate for cancer therapy: a structural-based virtual screening for multitarget profiling
inferred← citeshttps://doi.org/10.1080/07391102.2023.2265993openalex-snapshot
Novel pyrrolone-fused benzosuberene MK2 inhibitors: synthesis, pharmacophore modelling, molecular docking, and anti-cancer efficacy evaluation in HNSCC cells
inferred← citeshttps://doi.org/10.1080/15476286.2021.2021676openalex-snapshot
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2
inferred← citeshttps://doi.org/10.1097/tp.0000000000003606openalex-snapshot
Overexpression of the MSK1 Kinase in Patients With Chronic Lung Allograft Dysfunction and Its Confirmed Role in a Murine Model
inferred← citeshttps://doi.org/10.1101/2020.01.09.898684openalex-snapshot
Centrosome impairment causes DNA replication stress through MLK3/MK2 signaling and R-loop formation
inferred← citeshttps://doi.org/10.1107/s0907444909046411openalex-snapshot
Structural analysis of an MK2–inhibitor complex: insight into the regulation of the secondary structure of the Gly-rich loop by TEI-I01800
inferred← citeshttps://doi.org/10.1107/s0909049513020736openalex-snapshot
Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity
inferred← citeshttps://doi.org/10.1107/s1744309113030534openalex-snapshot
Structure of the β-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090
inferred← citeshttps://doi.org/10.1111/j.1462-5822.2009.01414.xopenalex-snapshot
The MAP kinase-activated protein kinase 2 (MK2) contributes to the Shiga toxin-induced inflammatory response
inferred← citeshttps://doi.org/10.1111/j.1751-2980.2011.00525.xopenalex-snapshot
The role of p38 mitogen‐activated protein kinase in the pathogenesis of inflammatory bowel disease
inferred← citeshttps://doi.org/10.1124/jpet.110.166173openalex-snapshot
A Benzothiophene Inhibitor of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 Inhibits Tumor Necrosis Factor α Production and Has Oral Anti-Inflammatory Efficacy in Acute and Chronic Models of Inflammation
inferred← citeshttps://doi.org/10.1124/mol.113.090365openalex-snapshot
Mitogen-Activated Protein Kinase–Activated Protein Kinase 2 in Neuroinflammation, Heat Shock Protein 27 Phosphorylation, and Cell Cycle: Role and Targeting
inferred← citeshttps://doi.org/10.1128/iai.00186-12openalex-snapshot
MAPK-Activated Protein Kinase 2 Contributes to Clostridium difficile-Associated Inflammation
inferred← citeshttps://doi.org/10.1134/s1234567824604194openalex-snapshot
Intramolecular Cyclization of Grignard or Blaise Intermediates for the Synthesis of a Chiral Piperidine-2,4-dione Derived from (R)-(‒)-Phenylglycinol
inferred← citeshttps://doi.org/10.1152/ajplung.00046.2012openalex-snapshot
Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells
inferred← citeshttps://doi.org/10.1152/ajprenal.00661.2010openalex-snapshot
Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-11-2364openalex-snapshot
MAPKAP Kinase 2 Overexpression Influences Prognosis in Gastrointestinal Stromal Tumors and Associates with Copy Number Variations on Chromosome 1 and Expression of p38 MAP Kinase and ETV1
inferred← citeshttps://doi.org/10.1161/circresaha.109.213199openalex-snapshot
MAPK-Activated Protein Kinase-2 in Cardiac Hypertrophy and Cyclooxygenase-2 Regulation in Heart
inferred← citeshttps://doi.org/10.1177/154405910708600902openalex-snapshot
p38 Pathway Kinases as Anti-inflammatory Drug Targets
inferred← citeshttps://doi.org/10.1186/1423-0127-17-53openalex-snapshot
Regulation of cytokines by small RNAs during skin inflammation
inferred← citeshttps://doi.org/10.1186/1471-2105-9-491openalex-snapshot
Prediction of specificity-determining residues for small-molecule kinase inhibitors
inferred← citeshttps://doi.org/10.1186/1472-6807-9-16openalex-snapshot
Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study
inferred← citeshttps://doi.org/10.1186/1750-2187-6-4openalex-snapshot
Distinct roles of MK2 and MK5 in cAMP/PKA- and stress/p38MAPK-induced heat shock protein 27 phosphorylation
inferred← citeshttps://doi.org/10.1186/1752-0509-4-23openalex-snapshot
Two additive mechanisms impair the differentiation of 'substrate-selective' p38 inhibitors from classical p38 inhibitors in vitro
inferred← citeshttps://doi.org/10.1186/1752-153x-7-18openalex-snapshot
The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome
inferred← citeshttps://doi.org/10.1186/s12885-023-11319-xopenalex-snapshot
Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment
inferred← citeshttps://doi.org/10.1186/s13046-019-1115-1openalex-snapshot
MAPKAPK2: the master regulator of RNA-binding proteins modulates transcript stability and tumor progression
inferred← citeshttps://doi.org/10.1261/rna.048090.114openalex-snapshot
p38MAPK/MK2-mediated phosphorylation of RBM7 regulates the human nuclear exosome targeting complex
inferred← citeshttps://doi.org/10.1371/journal.pone.0054239openalex-snapshot
Crucial Roles of the Protein Kinases MK2 and MK3 in a Mouse Model of Glomerulonephritis
inferred← citeshttps://doi.org/10.1371/journal.pone.0113300openalex-snapshot
The Potent Cdc7-Dbf4 (DDK) Kinase Inhibitor XL413 Has Limited Activity in Many Cancer Cell Lines and Discovery of Potential New DDK Inhibitor Scaffolds
inferred← citeshttps://doi.org/10.1371/journal.ppat.1004597openalex-snapshot
Viral Activation of MK2-hsp27-p115RhoGEF-RhoA Signaling Axis Causes Cytoskeletal Rearrangements, P-body Disruption and ARE-mRNA Stabilization
inferred← citeshttps://doi.org/10.1515/hsz-2013-0197openalex-snapshot
What goes up must come down: molecular basis of MAPKAP kinase 2/3-dependent regulation of the inflammatory response and its inhibition
inferred← citeshttps://doi.org/10.1517/14728222.12.8.921openalex-snapshot
MK2: a novel molecular target for anti-inflammatory therapy
inferred← citeshttps://doi.org/10.2174/1385272827666221219114255openalex-snapshot
Synthesis of 5-membered Heteroaryl-substituted Benzyloxy-benzaldehydes by the Suzuki-Miyaura Coupling Reaction
inferred← citeshttps://doi.org/10.2174/138945009789735101openalex-snapshot
Targeting Toll-like Receptors in Autoimmunity
inferred← citeshttps://doi.org/10.2174/1570180816666181106123809openalex-snapshot
Synthesis of Phenyl- and Pyridyl-substituted Benzyloxybenzaldehydes by Suzuki-Miyaura Coupling Reactions
inferred← citeshttps://doi.org/10.3310/hta22660openalex-snapshot
Assessing prognosis and prediction of treatment response in early rheumatoid arthritis: systematic reviews
inferred← citeshttps://doi.org/10.3389/fchem.2022.884517openalex-snapshot
Fluorine-18: Radiochemistry and Target-Specific PET Molecular Probes Design
inferred← citeshttps://doi.org/10.3389/fgene.2014.00346openalex-snapshot
Heat shock protein 27 phosphorylation state is associated with cancer progression
inferred← citeshttps://doi.org/10.3390/ijms13067057openalex-snapshot
A Computational Study on Thiourea Analogs as Potent MK-2 Inhibitors
inferred← citeshttps://doi.org/10.3390/ijms15034878openalex-snapshot
Comparative Molecular Dynamics Simulations of Mitogen-Activated Protein Kinase-Activated Protein Kinase 5
inferred← citeshttps://doi.org/10.3390/ijms18122508openalex-snapshot
Microtubule Depolymerization by Kinase Inhibitors: Unexpected Findings of Dual Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules26020391openalex-snapshot
Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model
inferred← citeshttps://doi.org/10.3390/ph3061842openalex-snapshot
Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome
inferred← citeshttps://doi.org/10.3390/ph8020257openalex-snapshot
Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells
inferred← citeshttps://doi.org/10.4155/fmc.09.98openalex-snapshot
Low-Molecular-Weight Mk2 Inhibitors: A Tough Nut to Crack!
inferred← citeshttps://doi.org/10.4155/fseb2013.13.130openalex-snapshot
Microwave-assisted synthesis of MK2 inhibitors for targeting p38 MAPK signal transduction in Werner syndrome cells
inferred← citeshttps://doi.org/10.4161/cc.28292openalex-snapshot
The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells
inferred← citeshttps://doi.org/10.5059/yukigoseikyokaishi.81.718openalex-snapshot
Development of Plant Circadian Clock Modulators
inferred← citeshttps://doi.org/10.53846/goediss-1445openalex-snapshot
The kinase MK2 in DNA replication upon genotoxic stress and chemotherapy
inferred← citeshttps://doi.org/10.53846/goediss-7816openalex-snapshot
Centrosome integrity as a determinant of replication stress
inferred← citeshttps://doi.org/10.53846/goediss-8088openalex-snapshot
Cancer drugs targeting DNA replication: Molecular strategies to enhance specificity and efficacy
inferred← citeshttps://doi.org/10.6026/97320630012172openalex-snapshot
Prediction of kinase-inhibitor binding affinity using energetic parameters
inferred← citeshttps://doi.org/10.6084/m9.figshare.24186137openalex-snapshot
Additional file 1 of Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment
inferred← citeshttps://doi.org/10.70675/94ab24b3z7dd0z43d7z8e51z9908b59c4c06openalex-snapshot
Role of the kinase MK2 in hepatobiliary tumor resistance to oxidative stress
inferred← citeshttps://doi.org/10.7554/elife.104859openalex-snapshot
Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
inferred← citeshttps://doi.org/10.7554/elife.104859.2openalex-snapshot
Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
inferred← citeshttps://doi.org/10.7554/elife.104859.3openalex-snapshot
Inhibition of p38-MK2 pathway enhances the efficacy of microtubule inhibitors in breast cancer cells
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