On the public citation graph
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
0 signed · 418 inferred · view as graph
Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.
Is this your work? Sign in with ORCID and put your name on the
claims that are yours.
Reference health. See whether every reference in this work resolves to a
known work and none has been retracted — and get a dated CiteStamped
badge you can embed.
What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s00125-011-2369-0openalex-snapshot
Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
inferredcites →https://doi.org/10.1007/s00125-013-2930-0openalex-snapshot
Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing
inferredcites →https://doi.org/10.1007/s11033-011-0900-5openalex-snapshot
Association between Type 2 Diabetes and CDKN2A/B: a meta-analysis study
inferredcites →https://doi.org/10.1007/s11605-012-1914-6openalex-snapshot
Improved Quality of Life Following Total Pancreatectomy and Auto-islet Transplantation for Chronic Pancreatitis
inferredcites →https://doi.org/10.1016/j.bbabio.2015.05.017openalex-snapshot
Mitochondria: Are they causal players in cellular senescence?
inferredcites →https://doi.org/10.1016/j.ccr.2010.01.023openalex-snapshot
Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
inferredcites →https://doi.org/10.1016/j.cell.2006.10.003openalex-snapshot
The Regulation of INK4/ARF in Cancer and Aging
inferredcites →https://doi.org/10.1016/j.cell.2011.03.035openalex-snapshot
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
inferredcites →https://doi.org/10.1016/j.cell.2012.12.010openalex-snapshot
Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
inferredcites →https://doi.org/10.1016/j.cell.2013.03.020openalex-snapshot
Non-Cell-Autonomous Tumor Suppression by p53
inferredcites →https://doi.org/10.1016/j.cell.2013.10.019openalex-snapshot
Programmed Cell Senescence during Mammalian Embryonic Development
inferredcites →https://doi.org/10.1016/j.cell.2013.10.041openalex-snapshot
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
inferredcites →https://doi.org/10.1016/j.celrep.2014.12.055openalex-snapshot
Global Reorganization of the Nuclear Landscape in Senescent Cells
inferredcites →https://doi.org/10.1016/j.cmet.2005.09.003openalex-snapshot
Cdk4 promotes adipogenesis through PPARγ activation
inferredcites →https://doi.org/10.1016/j.cmet.2009.07.002openalex-snapshot
PDX1 Deficiency Causes Mitochondrial Dysfunction and Defective Insulin Secretion through TFAM Suppression
inferredcites →https://doi.org/10.1016/j.cmet.2013.10.001openalex-snapshot
mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation
inferredcites →https://doi.org/10.1016/j.cmet.2015.07.025openalex-snapshot
Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function
inferredcites →https://doi.org/10.1016/j.devcel.2015.01.002openalex-snapshot
Weaning Triggers a Maturation Step of Pancreatic β Cells
inferredcites →https://doi.org/10.1016/j.mce.2011.07.016openalex-snapshot
Mitochondrial signals drive insulin secretion in the pancreatic β-cell
inferredcites →https://doi.org/10.1016/s0092-8674(03)00401-xopenalex-snapshot
Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence
inferredcites →https://doi.org/10.1016/s2213-8587(15)00336-8openalex-snapshot
10-year trajectory of β-cell function and insulin sensitivity in the development of type 2 diabetes: a community-based prospective cohort study
inferredcites →https://doi.org/10.1038/35092592openalex-snapshot
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
inferredcites →https://doi.org/10.1038/8751openalex-snapshot
Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia
inferredcites →https://doi.org/10.1038/nature02520openalex-snapshot
Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
inferredcites →https://doi.org/10.1038/nature05091openalex-snapshot
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
inferredcites →https://doi.org/10.1038/nature05092openalex-snapshot
p16INK4a induces an age-dependent decline in islet regenerative potential
inferredcites →https://doi.org/10.1038/nature05159openalex-snapshot
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
inferredcites →https://doi.org/10.1038/nature10600openalex-snapshot
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
inferredcites →https://doi.org/10.1038/nature12154openalex-snapshot
A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
inferredcites →https://doi.org/10.1038/nature12437openalex-snapshot
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy
inferredcites →https://doi.org/10.1038/nature13193openalex-snapshot
The role of senescent cells in ageing
inferredcites →https://doi.org/10.1038/nature13267openalex-snapshot
Cyclin D1–Cdk4 controls glucose metabolism independently of cell cycle progression
inferredcites →https://doi.org/10.1038/nature16932openalex-snapshot
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
inferredcites →https://doi.org/10.1038/nbt.2450openalex-snapshot
Differential analysis of gene regulation at transcript resolution with RNA-seq
inferredcites →https://doi.org/10.1038/ncb1915openalex-snapshot
The CDK4–pRB–E2F1 pathway controls insulin secretion
inferredcites →https://doi.org/10.1038/ncb2784openalex-snapshot
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
inferredcites →https://doi.org/10.1038/nm.3159openalex-snapshot
PPARγ signaling and metabolism: the good, the bad and the future
inferredcites →https://doi.org/10.1038/nm.4010openalex-snapshot
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
inferredcites →https://doi.org/10.1038/nprot.2009.191openalex-snapshot
Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo
inferredcites →https://doi.org/10.1038/nrc3057openalex-snapshot
Pro-senescence therapy for cancer treatment
inferredcites →https://doi.org/10.1038/nrm3823openalex-snapshot
Cellular senescence: from physiology to pathology
inferredcites →https://doi.org/10.1056/nejmoa1505270openalex-snapshot
Palbociclib in Hormone-Receptor–Positive Advanced Breast Cancer
inferredcites →https://doi.org/10.1073/pnas.192255099openalex-snapshot
Experimental control of pancreatic development and maintenance
inferredcites →https://doi.org/10.1097/tp.0b013e3181e117ceopenalex-snapshot
Comparison of Human Islet Isolation Outcomes Using a New Mammalian Tissue-Free Enzyme Versus Collagenase NB-1
inferredcites →https://doi.org/10.1101/gad.1742509openalex-snapshot
Polycomb protein Ezh2 regulates pancreatic β-cell Ink4a/Arf expression and regeneration in diabetes mellitus
inferredcites →https://doi.org/10.1101/gad.235184.113openalex-snapshot
Cellular senescence and its effector programs
inferredcites →https://doi.org/10.1101/gad.264127.115openalex-snapshot
Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation
inferredcites →https://doi.org/10.1101/gad.351605openalex-snapshot
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
inferredcites →https://doi.org/10.1101/gad.995802openalex-snapshot
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
inferredcites →https://doi.org/10.1101/gr.101709.109openalex-snapshot
Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program
inferredcites →https://doi.org/10.1111/acel.12023openalex-snapshot
Increased dosage of Ink4/Arf protects against glucose intolerance and insulin resistance associated with aging
inferredcites →https://doi.org/10.1111/acel.12351openalex-snapshot
Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene‐induced senescent cells
inferredcites →https://doi.org/10.1111/j.1474-9726.2007.00308.xopenalex-snapshot
Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi
inferredcites →https://doi.org/10.1152/ajpcell.1993.265.2.c358openalex-snapshot
B-cell size influences glucose-stimulated insulin secretion
inferredcites →https://doi.org/10.1158/0008-5472.can-12-3730openalex-snapshot
Dynamics of Senescent Cell Formation and Retention Revealed by p14ARF Induction in the Epidermis
inferredcites →https://doi.org/10.1172/jci22475openalex-snapshot
Ink4a/Arf expression is a biomarker of aging
inferredcites →https://doi.org/10.1172/jci32959openalex-snapshot
Recovery from diabetes in mice by β cell regeneration
inferredcites →https://doi.org/10.1172/jci64095openalex-snapshot
The role of aging upon β cell turnover
inferredcites →https://doi.org/10.1172/jci72674openalex-snapshot
Development of a conditionally immortalized human pancreatic β cell line
inferredcites →https://doi.org/10.1210/jc.84.3.863openalex-snapshot
Independent Influence of Age on Basal Insulin Secretion in Nondiabetic Humans
inferredcites →https://doi.org/10.1371/journal.pone.0023238openalex-snapshot
Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1
inferredcites →https://doi.org/10.2337/db10-0624openalex-snapshot
Conditional Gene Targeting in Mouse Pancreatic β-Cells
inferredcites →https://doi.org/10.2337/diab.38.12.1549openalex-snapshot
Effects of Aging on Insulin Secretion
inferredcites →https://doi.org/10.2337/diabetes.52.7.1738openalex-snapshot
Mechanisms of the Age-Associated Deterioration in Glucose Tolerance
inferredcites →https://doi.org/10.3727/000000001783986422openalex-snapshot
Correction of Hyperglycemia in Diabetic Mice Transplanted with Reversibly Immortalized Pancreatic β Cells Controlled by the tet-on Regulatory System
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4789208openalex-extracted
Unlocking Regenerative Potential: Beta-Cell Neogenesis and Novel Myokines Involved in Adaptation to Insulin Resistance in Mice
inferred← citeshttps://doi.org/10.1002/1873-3468.70037openalex-snapshot
Cells of all trades – on the importance of spatial positioning of senescent cells in development, healing and aging
inferred← citeshttps://doi.org/10.1002/1878-0261.13042openalex-snapshot
Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer
inferred← citeshttps://doi.org/10.1002/advs.202509263openalex-snapshot
DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss
inferred← citeshttps://doi.org/10.1002/cbf.70127openalex-snapshot
Dissecting Spatiotemporal Heterogeneity of Senescence Markers p16/p21 Across Tissues During Type 2 Diabetes Progression
inferred← citeshttps://doi.org/10.1002/ctm2.70417openalex-snapshot
Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments
inferred← citeshttps://doi.org/10.1002/edm2.70204openalex-snapshot
Implications of Genetic Elements on Type 2 Diabetes Mellitus Pathogenesis and Management
inferred← citeshttps://doi.org/10.1002/fft2.168openalex-snapshot
Nutritional assessment models for diabetes and aging
inferred← citeshttps://doi.org/10.1002/mco2.695openalex-snapshot
The dual role of cellular senescence in human tumor progression and therapy
inferred← citeshttps://doi.org/10.1002/med.21985openalex-snapshot
The entrancing role of dietary polyphenols against the most frequent aging‐associated diseases
inferred← citeshttps://doi.org/10.1007/978-3-030-44903-2_11openalex-snapshot
Mitochondria: Potential Targets for Interventions to Counteract Senescence
inferred← citeshttps://doi.org/10.1007/978-3-030-84965-8_12openalex-snapshot
Senolytic Phytocompounds in Redox Signaling
inferred← citeshttps://doi.org/10.1007/978-3-031-21410-3_7openalex-snapshot
Cellular Senescence and Ageing
inferred← citeshttps://doi.org/10.1007/978-3-031-26576-1_5openalex-snapshot
Chronic Kidney Disease and the Exposome of Ageing
inferred← citeshttps://doi.org/10.1007/978-981-99-7269-2_15openalex-snapshot
Repurposing of Drugs in Aging
inferred← citeshttps://doi.org/10.1007/s00018-018-2879-8openalex-snapshot
Cellular senescence: a view throughout organismal life
inferred← citeshttps://doi.org/10.1007/s00018-023-04950-1openalex-snapshot
Loss of fragile WWOX gene leads to senescence escape and genome instability
inferred← citeshttps://doi.org/10.1007/s00018-025-05962-9openalex-snapshot
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence
inferred← citeshttps://doi.org/10.1007/s00125-019-4890-5openalex-snapshot
Long-term c-Kit overexpression in beta cells compromises their function in ageing mice
inferred← citeshttps://doi.org/10.1007/s00125-019-4934-xopenalex-snapshot
Cellular senescence: at the nexus between ageing and diabetes
inferred← citeshttps://doi.org/10.1007/s00125-020-05185-6openalex-snapshot
Functional changes in beta cells during ageing and senescence
inferred← citeshttps://doi.org/10.1007/s00125-022-05718-1openalex-snapshot
RETRACTED ARTICLE: Calcium-dependent transcriptional changes in human pancreatic islet cells reveal functional diversity in islet cell subtypes
inferred← citeshttps://doi.org/10.1007/s00125-022-05750-1openalex-snapshot
Glucose-mediated insulin secretion is improved in FHL2-deficient mice and elevated FHL2 expression in humans is associated with type 2 diabetes
inferred← citeshttps://doi.org/10.1007/s00125-025-06603-3openalex-snapshot
Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells
inferred← citeshttps://doi.org/10.1007/s10522-018-9763-7openalex-snapshot
Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
inferred← citeshttps://doi.org/10.1007/s10522-024-10107-9openalex-snapshot
Inhibition of mTOR prevents glucotoxicity-mediated increase of SA-beta-gal, p16INK4a, and insulin hypersecretion, without restoring electrical features of mouse pancreatic islets
inferred← citeshttps://doi.org/10.1007/s10522-025-10200-7openalex-snapshot
Regulatory Roles of Exosomes in Aging and Aging-Related Diseases
inferred← citeshttps://doi.org/10.1007/s11010-016-2736-8openalex-snapshot
Differential influence of tacrolimus and sirolimus on mitochondrial-dependent signaling for apoptosis in pancreatic cells
inferred← citeshttps://doi.org/10.1007/s11357-023-00854-xopenalex-snapshot
Mapping cellular senescence networks in human diabetic foot ulcers
inferred← citeshttps://doi.org/10.1007/s11357-023-00960-wopenalex-snapshot
Cellular senescence and frailty: a comprehensive insight into the causal links
inferred← citeshttps://doi.org/10.1007/s11357-026-02184-0openalex-snapshot
Development and characterization of experimental β-cell senescence models revealing autophagy defects and altered stimulus–secretion coupling
inferred← citeshttps://doi.org/10.1007/s11684-025-1125-7openalex-snapshot
Cellular senescence in age-related musculoskeletal diseases
inferred← citeshttps://doi.org/10.1007/s40610-020-00129-wopenalex-snapshot
The Pivotal Role of Senescence in Cell Death and Aging: Where Do We Stand?
inferred← citeshttps://doi.org/10.1007/s42000-019-00132-6openalex-snapshot
The role of cellular senescence in diabetes mellitus and osteoporosis: molecular pathways and potential interventions
inferred← citeshttps://doi.org/10.1007/s44258-026-00093-7openalex-snapshot
Modulating senescence for therapeutic delivery
inferred← citeshttps://doi.org/10.1016/b978-0-12-815962-0.00012-3openalex-snapshot
Senotherapeutics: Experimental therapy of cellular senescence
inferred← citeshttps://doi.org/10.1016/b978-0-12-822514-1.00009-2openalex-snapshot
Senescence in obesity
inferred← citeshttps://doi.org/10.1016/b978-0-323-95582-9.00013-9openalex-snapshot
The role of cellular lipid metabolism in aging
inferred← citeshttps://doi.org/10.1016/b978-0-443-15500-0.00012-8openalex-snapshot
Age-related disease: Diabetes
inferred← citeshttps://doi.org/10.1016/b978-0-443-33159-6.00004-7openalex-snapshot
Overview of hallmarks of aging
inferred← citeshttps://doi.org/10.1016/b978-0-443-33159-6.00019-9openalex-snapshot
Rejuvenating stem cells to reverse aging
inferred← citeshttps://doi.org/10.1016/bs.acr.2021.02.001openalex-snapshot
Autophagy and senescence, converging roles in pathophysiology as seen through mouse models
inferred← citeshttps://doi.org/10.1016/j.ajpath.2021.09.008openalex-snapshot
Chronic Exposure to Palmitic Acid Down-Regulates AKT in Beta-Cells through Activation of mTOR
inferred← citeshttps://doi.org/10.1016/j.apsb.2026.03.050openalex-snapshot
Advanced drug delivery platforms targeting cellular senescence: A promising strategy for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.arr.2017.10.003openalex-snapshot
Inflammageing and metaflammation: The yin and yang of type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.arr.2017.10.004openalex-snapshot
The role of cellular senescence in aging through the prism of Koch-like criteria
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101262openalex-snapshot
Hydrogen sulfide in longevity and pathologies: Inconsistency is malodorous
inferred← citeshttps://doi.org/10.1016/j.arr.2021.101268openalex-snapshot
Obesity and aging: Molecular mechanisms and therapeutic approaches
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101674openalex-snapshot
The pancreatic β-cell in ageing: Implications in age-related diabetes
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102760openalex-snapshot
The context-dependent effect of cellular senescence: From embryogenesis and wound healing to aging
inferred← citeshttps://doi.org/10.1016/j.arr.2025.102783openalex-snapshot
Advancing T-cell immunotherapy for cellular senescence and disease: Mechanisms, challenges, and clinical prospects
inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188826openalex-snapshot
The microbiota and aging microenvironment in pancreatic cancer: Cell origin and fate
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117314openalex-snapshot
Advances in targeted therapies for age-related osteoarthritis: A comprehensive review of current research
inferred← citeshttps://doi.org/10.1016/j.canlet.2019.11.017openalex-snapshot
Human telomerase reverse transcriptase depletion potentiates the growth-inhibitory activity of imatinib in chronic myeloid leukemia stem cells
inferred← citeshttps://doi.org/10.1016/j.carbpol.2025.124651openalex-snapshot
Comparative study on the mechanisms of citrus pectin and polygalacturonic acid in alleviating food allergies
inferred← citeshttps://doi.org/10.1016/j.ceca.2017.04.001openalex-snapshot
Calcium signaling and cellular senescence
inferred← citeshttps://doi.org/10.1016/j.cell.2017.05.015openalex-snapshot
Senescence in Health and Disease
inferred← citeshttps://doi.org/10.1016/j.cell.2024.09.021openalex-snapshot
Identifying specific functional roles for senescence across cell types
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.02.021openalex-snapshot
The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling
inferred← citeshttps://doi.org/10.1016/j.celrep.2018.11.031openalex-snapshot
Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function
inferred← citeshttps://doi.org/10.1016/j.celrep.2019.05.095openalex-snapshot
Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.108690openalex-snapshot
CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109813openalex-snapshot
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112593openalex-snapshot
Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging
inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116283openalex-snapshot
Beta-cell adaptation unveiled: The role of myokines in insulin-resistant mice
inferred← citeshttps://doi.org/10.1016/j.clnu.2024.05.043openalex-snapshot
Inhibiting arachidonic acid generation mitigates aging-induced hyperinsulinemia and insulin resistance in mice
inferred← citeshttps://doi.org/10.1016/j.cmet.2017.03.015openalex-snapshot
β Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.01.021openalex-snapshot
Targeted Elimination of Senescent Beta Cells Prevents Type 1 Diabetes
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.05.006openalex-snapshot
Acceleration of β Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.12.009openalex-snapshot
Identification of a LIF-Responsive, Replication-Competent Subpopulation of Human β Cells
inferred← citeshttps://doi.org/10.1016/j.cmet.2020.04.004openalex-snapshot
A Nutrient-Sensing Transition at Birth Triggers Glucose-Responsive Insulin Secretion
inferred← citeshttps://doi.org/10.1016/j.cmet.2023.10.014openalex-snapshot
Stress-induced β cell early senescence confers protection against type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.cmet.2023.11.011openalex-snapshot
Disrupted RNA editing in beta cells mimics early-stage type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.devcel.2021.04.030openalex-snapshot
Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
inferred← citeshttps://doi.org/10.1016/j.diff.2020.02.001openalex-snapshot
The RB gene family controls the maturation state of the EndoC-βH2 human pancreatic β-cells
inferred← citeshttps://doi.org/10.1016/j.ebiom.2016.11.020openalex-snapshot
Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
inferred← citeshttps://doi.org/10.1016/j.ebiom.2018.11.056openalex-snapshot
Heme oxygenase-1 prevents heart against myocardial infarction by attenuating ischemic injury-induced cardiomyocytes senescence
inferred← citeshttps://doi.org/10.1016/j.ebiom.2019.05.012openalex-snapshot
p16INK4A-expressing mesenchymal stromal cells restore the senescence–clearance–regeneration sequence that is impaired in chronic muscle inflammation
inferred← citeshttps://doi.org/10.1016/j.ejcb.2020.151108openalex-snapshot
Aging of the cells: Insight into cellular senescence and detection Methods
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126972openalex-snapshot
Nanoplastics: An emerging environmental concern in age-related diseases
inferred← citeshttps://doi.org/10.1016/j.exger.2019.110750openalex-snapshot
Biomarkers in the path from cellular senescence to frailty
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2018.10.417openalex-snapshot
Mitochondria and cellular senescence: Implications for musculoskeletal ageing
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.05.003openalex-snapshot
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
inferred← citeshttps://doi.org/10.1016/j.gene.2024.148319openalex-snapshot
Cellular senescence molecules expression in type 2 diabetes mellitus: CDKN2A, CDKN2B, and lncRNA ANRIL
inferred← citeshttps://doi.org/10.1016/j.isci.2021.103250openalex-snapshot
IL-1beta promotes the age-associated decline of beta cell function
inferred← citeshttps://doi.org/10.1016/j.isci.2025.113508openalex-snapshot
Nucleolar stress facilitates islet β cell senescence via hijacking the DNA damage response pathways
inferred← citeshttps://doi.org/10.1016/j.jds.2023.10.016openalex-snapshot
Resveratrol attenuates advanced glycation end product-induced senescence and inflammation in human gingival fibroblasts
inferred← citeshttps://doi.org/10.1016/j.jhepr.2021.100301openalex-snapshot
Evaluating causality of cellular senescence in non-alcoholic fatty liver disease
inferred← citeshttps://doi.org/10.1016/j.jiec.2017.08.053openalex-snapshot
Senotherapy for attenuation of cellular senescence in aging and organ implantation
inferred← citeshttps://doi.org/10.1016/j.mad.2017.07.001openalex-snapshot
Stress, cell senescence and organismal ageing
inferred← citeshttps://doi.org/10.1016/j.mad.2020.111308openalex-snapshot
Cellular senescence in vivo: From cells to tissues to pathologies
inferred← citeshttps://doi.org/10.1016/j.mce.2016.08.047openalex-snapshot
Cellular senescence: Implications for metabolic disease
inferred← citeshttps://doi.org/10.1016/j.mce.2016.08.049openalex-snapshot
Targeting metabolism in cellular senescence, a role for intervention
inferred← citeshttps://doi.org/10.1016/j.metabol.2021.154863openalex-snapshot
Rheb1 promotes glucose-stimulated insulin secretion in human and mouse β-cells by upregulating GLUT expression
inferred← citeshttps://doi.org/10.1016/j.mocell.2024.100113openalex-snapshot
The role of p21 in cellular senescence and aging-related diseases
inferred← citeshttps://doi.org/10.1016/j.molmed.2020.03.005openalex-snapshot
Reducing Senescent Cell Burden in Aging and Disease
inferred← citeshttps://doi.org/10.1016/j.molmet.2017.03.011openalex-snapshot
Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion
inferred← citeshttps://doi.org/10.1016/j.molmet.2017.04.012openalex-snapshot
Interrogating islets in health and disease with single-cell technologies
inferred← citeshttps://doi.org/10.1016/j.molmet.2017.11.012openalex-snapshot
Cdkn2a deficiency promotes adipose tissue browning
inferred← citeshttps://doi.org/10.1016/j.molmet.2021.101414openalex-snapshot
Increased glycolysis affects β-cell function and identity in aging and diabetes
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101524openalex-snapshot
DNA damage to β cells in culture recapitulates features of senescent β cells that accumulate in type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.molmet.2022.101601openalex-snapshot
Targeting cellular senescence in metabolic disease
inferred← citeshttps://doi.org/10.1016/j.molmet.2025.102297openalex-snapshot
Protein kinase D deficiency induces a senescence-like phenotype in β-cells and improves glucose and insulin tolerance under high-fat diet conditions
inferred← citeshttps://doi.org/10.1016/j.mtbio.2023.100544openalex-snapshot
Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence
inferred← citeshttps://doi.org/10.1016/j.pan.2019.11.006openalex-snapshot
Differences between KC and KPC pancreatic ductal adenocarcinoma mice models, in terms of their modeling biology and their clinical relevance
inferred← citeshttps://doi.org/10.1016/j.phrs.2016.05.015openalex-snapshot
Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction
inferred← citeshttps://doi.org/10.1016/j.psj.2024.104529openalex-snapshot
Protective effect of adiponectin on oxidative stress-induced ovarian granulosa cell senescence in geese
inferred← citeshttps://doi.org/10.1016/j.redox.2016.12.001openalex-snapshot
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
inferred← citeshttps://doi.org/10.1016/j.redox.2017.12.015openalex-snapshot
Age-related oxidative changes in pancreatic islets are predominantly located in the vascular system
inferred← citeshttps://doi.org/10.1016/j.reprotox.2025.109030openalex-snapshot
All-trans Retinoic Acid regulates cellular senescence of mouse embryonic palatal mesenchyme (MEPM) cells in developing cleft palates
inferred← citeshttps://doi.org/10.1016/j.semcancer.2017.05.008openalex-snapshot
Hypoxia driven glycation: Mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.stem.2016.11.020openalex-snapshot
Injury-Induced Senescence Enables In Vivo Reprogramming in Skeletal Muscle
inferred← citeshttps://doi.org/10.1016/j.steroids.2019.108570openalex-snapshot
25-Hydroxyvitamin D3 positively regulates periodontal inflammaging via SOCS3/STAT signaling in diabetic mice
inferred← citeshttps://doi.org/10.1016/j.tcb.2022.04.011openalex-snapshot
The heterogeneity of cellular senescence: insights at the single-cell level
inferred← citeshttps://doi.org/10.1016/j.tem.2024.01.003openalex-snapshot
Establishing evidence for immune surveillance of β-cell senescence
inferred← citeshttps://doi.org/10.1016/j.tibs.2019.06.011openalex-snapshot
Expansion and Cell-Cycle Arrest: Common Denominators of Cellular Senescence
inferred← citeshttps://doi.org/10.1016/j.tig.2024.08.008openalex-snapshot
On correlative and causal links of replicative epimutations
inferred← citeshttps://doi.org/10.1016/j.tins.2024.09.006openalex-snapshot
Defining and characterizing neuronal senescence, ‘neurescence’, as GX arrested cells
inferred← citeshttps://doi.org/10.1016/j.tox.2020.152502openalex-snapshot
Nicotine triggers islet β cell senescence to facilitate the progression of type 2 diabetes
inferred← citeshttps://doi.org/10.1016/j.trecan.2022.09.002openalex-snapshot
Senescent stromal cells: roles in the tumor microenvironment
inferred← citeshttps://doi.org/10.1016/j.xpro.2024.102923openalex-snapshot
Protocol for quantifying SA-β-gal activity as a measure of senescence in islets of a mouse model of type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.yexcr.2017.03.050openalex-snapshot
The pancreas: Bandmaster of glucose homeostasis
inferred← citeshttps://doi.org/10.1016/s1155-1941(23)43263-5openalex-snapshot
10.1016/s1155-1941(23)43263-5
inferred← citeshttps://doi.org/10.1021/acsomega.3c07480openalex-snapshot
Molecular Mechanisms and the Interplay of Important Chronic Obstructive Pulmonary Disease Biomarkers Reveals Novel Therapeutic Targets
inferred← citeshttps://doi.org/10.1038/nrd.2017.116openalex-snapshot
Senescent cells: an emerging target for diseases of ageing
inferred← citeshttps://doi.org/10.1038/s12276-023-01100-2openalex-snapshot
Multiparity increases the risk of diabetes by impairing the proliferative capacity of pancreatic β cells
inferred← citeshttps://doi.org/10.1038/s12276-025-01521-1openalex-snapshot
Mitochondrial-encoded peptide MOTS-c prevents pancreatic islet cell senescence to delay diabetes
inferred← citeshttps://doi.org/10.1038/s41374-021-00670-xopenalex-snapshot
ATP synthase inhibitory factor subunit 1 regulates islet β-cell function via repression of mitochondrial homeostasis
inferred← citeshttps://doi.org/10.1038/s41419-018-0300-zopenalex-snapshot
Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
inferred← citeshttps://doi.org/10.1038/s41419-019-1550-0openalex-snapshot
FASN activity is important for the initial stages of the induction of senescence
inferred← citeshttps://doi.org/10.1038/s41420-024-01831-9openalex-snapshot
Cellular senescence of renal tubular epithelial cells in acute kidney injury
inferred← citeshttps://doi.org/10.1038/s41437-025-00769-7openalex-snapshot
CDK-4 regulates nucleolar size and metabolism at the cost of late-life fitness in C. elegans
inferred← citeshttps://doi.org/10.1038/s41467-017-00461-3openalex-snapshot
Different developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth
inferred← citeshttps://doi.org/10.1038/s41467-020-16475-3openalex-snapshot
Chronic expression of p16INK4a in the epidermis induces Wnt-mediated hyperplasia and promotes tumor initiation
inferred← citeshttps://doi.org/10.1038/s41467-020-18734-9openalex-snapshot
G3BP1 controls the senescence-associated secretome and its impact on cancer progression
inferred← citeshttps://doi.org/10.1038/s41467-023-38471-zopenalex-snapshot
Genetically prolonged beige fat in male mice confers long-lasting metabolic health
inferred← citeshttps://doi.org/10.1038/s41467-025-56929-0openalex-snapshot
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype
inferred← citeshttps://doi.org/10.1038/s41467-026-69752-yopenalex-snapshot
iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining
inferred← citeshttps://doi.org/10.1038/s41467-026-76075-5openalex-snapshot
β-cell FMO3-produced TMAO prevents NF-κB-mediated senescence and inflammation in ageing and diabetic conditions
inferred← citeshttps://doi.org/10.1038/s41569-018-0064-2openalex-snapshot
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
inferred← citeshttps://doi.org/10.1038/s41570-019-0108-0openalex-snapshot
The chemistry of senescence
inferred← citeshttps://doi.org/10.1038/s41573-024-01074-4openalex-snapshot
Senescence as a therapeutic target in cancer and age-related diseases
inferred← citeshttps://doi.org/10.1038/s41573-024-01126-9openalex-snapshot
Enhancing immunity during ageing by targeting interactions within the tissue environment
inferred← citeshttps://doi.org/10.1038/s41574-020-0335-yopenalex-snapshot
The role of cellular senescence in ageing and endocrine disease
inferred← citeshttps://doi.org/10.1038/s41576-026-00982-yopenalex-snapshot
Genomic, epigenomic and transcriptomic regulation of cellular senescence
inferred← citeshttps://doi.org/10.1038/s41583-020-0325-zopenalex-snapshot
Cellular senescence and Alzheimer disease: the egg and the chicken scenario
inferred← citeshttps://doi.org/10.1038/s41587-025-02740-7openalex-snapshot
Senolytics under scrutiny in the quest to slow aging
inferred← citeshttps://doi.org/10.1038/s41591-018-0092-9openalex-snapshot
Senolytics improve physical function and increase lifespan in old age
inferred← citeshttps://doi.org/10.1038/s41598-017-06868-8openalex-snapshot
RETRACTED ARTICLE: P16INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency
inferred← citeshttps://doi.org/10.1038/s41598-025-24506-6openalex-snapshot
Circulating senescence-associated secretory phenotype factors across the stages of type 1 diabetes in a cross-sectional cohort
inferred← citeshttps://doi.org/10.1038/s42003-021-02257-0openalex-snapshot
When dormancy fuels tumour relapse
inferred← citeshttps://doi.org/10.1038/s42003-021-02840-5openalex-snapshot
Cellular senescence links mitochondria-ER contacts and aging
inferred← citeshttps://doi.org/10.1038/s42255-021-00483-8openalex-snapshot
The metabolic roots of senescence: mechanisms and opportunities for intervention
inferred← citeshttps://doi.org/10.1038/s42255-023-00876-xopenalex-snapshot
Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas
inferred← citeshttps://doi.org/10.1038/s43587-023-00447-5openalex-snapshot
The meaning of adaptation in aging: insights from cellular senescence, epigenetic clocks and stem cell alterations
inferred← citeshttps://doi.org/10.1038/s43587-025-00811-7openalex-snapshot
A BCL-xL/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice
inferred← citeshttps://doi.org/10.1038/s43587-025-00953-8openalex-snapshot
CD4 T cells acquire Eomesodermin to modulate cellular senescence and aging
inferred← citeshttps://doi.org/10.1038/s44319-025-00502-9openalex-snapshot
JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects
inferred← citeshttps://doi.org/10.1038/s44319-026-00752-1openalex-snapshot
Response to Kawamoto et al
inferred← citeshttps://doi.org/10.1042/bst20190109openalex-snapshot
Functional heterogeneity in senescence
inferred← citeshttps://doi.org/10.1051/medsci/2022186openalex-snapshot
L’accumulation de cellules sénescentes dans un organe ne conduit pas toujours à son déclin fonctionnel
inferred← citeshttps://doi.org/10.1055/a-2044-8873openalex-snapshot
Increased Galactosidase Beta 1 Expression as a Senescent Key Factor in β-Cells Function Modulation at the Early Steps of Type 2 Diabetes
inferred← citeshttps://doi.org/10.1063/5.0066876openalex-snapshot
Role of Zonulin level as new metabolic biomarker in diabetes mellitus patients and associated complications
inferred← citeshttps://doi.org/10.1073/pnas.1818313116openalex-snapshot
Cells exhibiting strong p16 INK4a promoter activation in vivo display features of senescence
inferred← citeshttps://doi.org/10.1073/pnas.2401218121openalex-snapshot
The mitochondrial enzyme pyruvate carboxylase restricts pancreatic β-cell senescence by blocking p53 activation
inferred← citeshttps://doi.org/10.1073/pnas.2507877123openalex-snapshot
Genetic recording of pancreatic beta cell proliferation
inferred← citeshttps://doi.org/10.1074/jbc.m116.754077openalex-snapshot
Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes
inferred← citeshttps://doi.org/10.1080/14728222.2021.1992385openalex-snapshot
Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseases
inferred← citeshttps://doi.org/10.1080/19382014.2019.1599708openalex-snapshot
Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets
inferred← citeshttps://doi.org/10.1080/19382014.2020.1783162openalex-snapshot
Melatonin protects INS-1 pancreatic β-cells from apoptosis and senescence induced by glucotoxicity and glucolipotoxicity
inferred← citeshttps://doi.org/10.1080/19382014.2026.2706228openalex-snapshot
Importance of antibody validation in detecting cell cycle regulatory protein p16 INK4A by immunohistochemistry on pancreas tissue
inferred← citeshttps://doi.org/10.1080/23723556.2020.1850161openalex-snapshot
The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?
inferred← citeshttps://doi.org/10.1080/87559129.2026.2736062openalex-snapshot
Emerging Strategies for Type 2 Diabetes Management: Synergistic Approaches Integrating Food-Based Interventions
inferred← citeshttps://doi.org/10.1083/jcb.201708092openalex-snapshot
Senescence and aging: Causes, consequences, and therapeutic avenues
inferred← citeshttps://doi.org/10.1083/jcb.202401112openalex-snapshot
Regulation of cell function and identity by cellular senescence
inferred← citeshttps://doi.org/10.1089/ars.2020.8043openalex-snapshot
Cell Senescence, DNA Damage, and Metabolism
inferred← citeshttps://doi.org/10.1089/ars.2021.0224openalex-snapshot
TXNIP Exacerbates the Senescence and Aging-Related Dysfunction of β Cells by Inducing Cell Cycle Arrest Through p38-p16/p21-CDK-Rb Pathway
inferred← citeshttps://doi.org/10.1093/gerona/glab276openalex-snapshot
The Effects of Aging on Male Mouse Pancreatic β-Cell Function Involve Multiple Events in the Regulation of Secretion: Influence of Insulin Sensitivity
inferred← citeshttps://doi.org/10.1093/gerona/glad214openalex-snapshot
Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial
inferred← citeshttps://doi.org/10.1093/nar/gkae313openalex-snapshot
Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness
inferred← citeshttps://doi.org/10.1093/nsr/nwaa127openalex-snapshot
A single-cell transcriptomic atlas of primate pancreatic islet aging
inferred← citeshttps://doi.org/10.1093/oxfimm/iqad004openalex-snapshot
The ageing immune system as a potential target of senolytics
inferred← citeshttps://doi.org/10.1096/fj.202000111rropenalex-snapshot
In vivo analysis of γH2AX+ cells in skeletal muscle from aged and obese humans
inferred← citeshttps://doi.org/10.1097/cm9.0000000000003034openalex-snapshot
Pancreatic β-cell failure, clinical implications, and therapeutic strategies in type 2 diabetes
inferred← citeshttps://doi.org/10.1097/md.0000000000049400openalex-snapshot
Exploring the therapeutic targets and signaling mechanisms of quercetin activity against radiation skin ulcer based on the observational research of network pharmacology
inferred← citeshttps://doi.org/10.1101/2020.06.29.177527openalex-snapshot
Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males
inferred← citeshttps://doi.org/10.1101/2021.06.07.447428openalex-snapshot
DNA damage models phenotypes of β cell senescence in Type 1 Diabetes
inferred← citeshttps://doi.org/10.1101/2022.12.21.521514openalex-snapshot
Cdkn2a regulates beige fat maintenance through BECN1-mediated autophagy
inferred← citeshttps://doi.org/10.1101/2023.09.08.556709openalex-snapshot
Calcium-dependent transcriptional profiles of human pancreatic islet cells reveal functional diversity in islet subpopulations
inferred← citeshttps://doi.org/10.1101/2024.10.03.616489openalex-snapshot
Mosaic Regulation of Stress Pathways Underlies Senescent Cell Heterogeneity
inferred← citeshttps://doi.org/10.1101/2025.04.09.647991openalex-snapshot
The mitochondrial NAD transporter SLC25A51 is a modulator of beta cell senescence and type 2 diabetes
inferred← citeshttps://doi.org/10.1101/2025.05.07.648438openalex-snapshot
A human and mouse subpopulation of senescent β-cells induces pathologic dysfunction through targetable paracrine signaling
inferred← citeshttps://doi.org/10.1101/2025.08.14.670255openalex-snapshot
Aging-associated metabolomic and lipidomic remodeling in mouse brain endothelial cell senescence in vitro
inferred← citeshttps://doi.org/10.1101/470500openalex-snapshot
Senescent cells and the dynamics of aging
inferred← citeshttps://doi.org/10.1101/729541openalex-snapshot
Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific
inferred← citeshttps://doi.org/10.1101/759530openalex-snapshot
Senolytic treatment targets aberrant p21-expression to restore liver regeneration in adult mice
showing the first 200 of 353 · page through all 353
Editorial review for independent work. ICSAC — the Institute for Complexity
Science and Advanced Computing — runs a structured editorial panel for researchers
publishing outside journals, and publishes on CiteStamp rails. Submission is free
and goes through ORCID: icsacinstitute.org/submit.